In vitro Toxicity Evaluation of Sterol Isolate from Echinoderm Stellaster equestris against Human Peripheral Blood Article Swipe
R Sumitha
,
N Banu
,
S. Vijayalakshmi
,
V.P. Krithika
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.5530/ijpi.2021.2.33
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.5530/ijpi.2021.2.33
Background: Ocean acts as a wealthy resource of biological diversity producing prospective novel metabolites from the organisms present in the environment. Novel bioactive compounds from Echinoderms mainly from sea stars have been extensively studied procuring rich diverse compounds which exhibits in vitro cytotoxicity comparable to or better than those of the potent anticancer drug. These sea stars which reside in the benthic region serves as their habitat and they are therefore predators and persistently being attacked by various organisms subsequently they acclimatize the survival approach to defend themselves from the external pathogens. Since these metabolites are obscured as a metabolic product during their endurance an initial evaluation of these compounds is necessary to assess human risk. Objectives: The present study focuses in vitro toxicity evaluation of isolated sterol like isolate from echinoderm sea star Stellaster equestris by incorporating hemolytic, chromosomal aberration assay and the cell viability tryphan blue exclusion assay against human peripheral blood. Methods: The in vitro toxicity evaluation was studied against the human peripheral blood collected from the healthy donors with the defined concentration of the sterol like compound from the sea star Stellaster equestris. The hemolytic, cell viability trypan blue exclusion method and chromosomal aberration assay were performed to check the hemolytic, mutagenic and genotoxic effect against the lymphocytes and the red blood cells. Results and Discussion: The result suggested that the hemolytic assay and the cell viability assay even in a dose dependent manner were non-hemolytic and percentage of the viability was not affected due to the exposure of the compound. The absence of genotoxicity was evident for the chromosomal aberration assay indicated that the isolated compound from the sea star Stellaster equestris might be considered as effective novel compound.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.5530/ijpi.2021.2.33
- https://www.jpionline.org/index.php/ijpi/article/download/965/583
- OA Status
- bronze
- Cited By
- 1
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3186922287
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3186922287Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.5530/ijpi.2021.2.33Digital Object Identifier
- Title
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In vitro Toxicity Evaluation of Sterol Isolate from Echinoderm Stellaster equestris against Human Peripheral BloodWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2021Year of publication
- Publication date
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2021-07-16Full publication date if available
- Authors
-
R Sumitha, N Banu, S. Vijayalakshmi, V.P. KrithikaList of authors in order
- Landing page
-
https://doi.org/10.5530/ijpi.2021.2.33Publisher landing page
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https://www.jpionline.org/index.php/ijpi/article/download/965/583Direct link to full text PDF
- Open access
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YesWhether a free full text is available
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bronzeOpen access status per OpenAlex
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https://www.jpionline.org/index.php/ijpi/article/download/965/583Direct OA link when available
- Concepts
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Viability assay, Biology, In vitro, Toxicity, Sterol, In vitro toxicology, Cytotoxicity, Trypan blue, Echinoderm, Microbiology, Biochemistry, Medicine, Ecology, Cholesterol, Internal medicineTop concepts (fields/topics) attached by OpenAlex
- Cited by
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1Total citation count in OpenAlex
- Citations by year (recent)
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2022: 1Per-year citation counts (last 5 years)
- Related works (count)
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10Other works algorithmically related by OpenAlex
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| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |