In vivo and in vitro spermatogenesis in prepubertal mouse testes exposed to low gonadotoxic doses of cytarabine or Daunorubicin Article Swipe
Marion Delessard
,
Laura Moutard
,
Coline Charnay
,
Nathalie Rives
,
Ludovic Dumont
,
Magali Basille
,
Aurélie Rives‐Feraille
,
Christine Rondanino
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1038/s41598-025-98413-1
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1038/s41598-025-98413-1
The development of experimental models treated by chemotherapy is needed for elucidating the side effects of cancer treatments administered prior to puberty on male gonad function and the feasibility of restoring fertility from exposed testicular tissues. This study investigated for the first time the effects of cytarabine and daunorubicin administered before meiotic initiation on the first wave of mouse spermatogenesis under both in vivo or in vitro conditions. Prepubertal exposure to cytarabine did not exhibit immediate detrimental effects on testicular tissues, whereas daunorubicin administration resulted in a decreased spermatogonia-to-Sertoli cell ratio and diminished intratubular cell proliferation within three days post-treatment. While the completion of in vivo spermatogenesis was not hindered by chemotherapy exposure, a significant increase in the proportion of spermatozoa with fragmented DNA was observed in mice more than one month after treatment. In vitro spermatogenesis was also accomplished using prepubertal testicular tissues exposed to chemotherapy, indicating that neither cytarabine nor daunorubicin impeded the differentiation potential of spermatogonia into spermatozoa. However, in vitro conditions revealed an arrest in meiotic progression in a substantial proportion of seminiferous tubules and an elevated incidence of DNA double-strand breaks in intratubular cells compared to in vivo controls, irrespective of the treatment administered.
Related Topics
Concepts
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1038/s41598-025-98413-1
- https://www.nature.com/articles/s41598-025-98413-1.pdf
- OA Status
- gold
- Cited By
- 2
- References
- 47
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4409732989
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4409732989Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1038/s41598-025-98413-1Digital Object Identifier
- Title
-
In vivo and in vitro spermatogenesis in prepubertal mouse testes exposed to low gonadotoxic doses of cytarabine or DaunorubicinWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2025Year of publication
- Publication date
-
2025-04-24Full publication date if available
- Authors
-
Marion Delessard, Laura Moutard, Coline Charnay, Nathalie Rives, Ludovic Dumont, Magali Basille, Aurélie Rives‐Feraille, Christine RondaninoList of authors in order
- Landing page
-
https://doi.org/10.1038/s41598-025-98413-1Publisher landing page
- PDF URL
-
https://www.nature.com/articles/s41598-025-98413-1.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.nature.com/articles/s41598-025-98413-1.pdfDirect OA link when available
- Concepts
-
Daunorubicin, Cytarabine, In vivo, Spermatogenesis, In vitro, Biology, Pharmacology, Medicine, Andrology, Internal medicine, Endocrinology, Leukemia, GeneticsTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
2Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 2Per-year citation counts (last 5 years)
- References (count)
-
47Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W4409732989 |
|---|---|
| doi | https://doi.org/10.1038/s41598-025-98413-1 |
| ids.doi | https://doi.org/10.1038/s41598-025-98413-1 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/40275009 |
| ids.openalex | https://openalex.org/W4409732989 |
| fwci | 12.94855242 |
| mesh[0].qualifier_ui | |
| mesh[0].descriptor_ui | D000818 |
| mesh[0].is_major_topic | False |
| mesh[0].qualifier_name | |
| mesh[0].descriptor_name | Animals |
| mesh[1].qualifier_ui | |
| mesh[1].descriptor_ui | D008297 |
| mesh[1].is_major_topic | False |
| mesh[1].qualifier_name | |
| mesh[1].descriptor_name | Male |
| mesh[2].qualifier_ui | Q000494 |
| mesh[2].descriptor_ui | D003630 |
| mesh[2].is_major_topic | True |
| mesh[2].qualifier_name | pharmacology |
| mesh[2].descriptor_name | Daunorubicin |
| mesh[3].qualifier_ui | Q000009 |
| mesh[3].descriptor_ui | D003630 |
| mesh[3].is_major_topic | True |
| mesh[3].qualifier_name | adverse effects |
| mesh[3].descriptor_name | Daunorubicin |
| mesh[4].qualifier_ui | Q000008 |
| mesh[4].descriptor_ui | D003630 |
| mesh[4].is_major_topic | True |
| mesh[4].qualifier_name | administration & dosage |
| mesh[4].descriptor_name | Daunorubicin |
| mesh[5].qualifier_ui | Q000009 |
| mesh[5].descriptor_ui | D003561 |
| mesh[5].is_major_topic | True |
| mesh[5].qualifier_name | adverse effects |
| mesh[5].descriptor_name | Cytarabine |
| mesh[6].qualifier_ui | Q000494 |
| mesh[6].descriptor_ui | D003561 |
| mesh[6].is_major_topic | True |
| mesh[6].qualifier_name | pharmacology |
| mesh[6].descriptor_name | Cytarabine |
| mesh[7].qualifier_ui | Q000008 |
| mesh[7].descriptor_ui | D003561 |
| mesh[7].is_major_topic | True |
| mesh[7].qualifier_name | administration & dosage |
| mesh[7].descriptor_name | Cytarabine |
| mesh[8].qualifier_ui | Q000187 |
| mesh[8].descriptor_ui | D013091 |
| mesh[8].is_major_topic | True |
| mesh[8].qualifier_name | drug effects |
| mesh[8].descriptor_name | Spermatogenesis |
| mesh[9].qualifier_ui | |
| mesh[9].descriptor_ui | D051379 |
| mesh[9].is_major_topic | False |
| mesh[9].qualifier_name | |
| mesh[9].descriptor_name | Mice |
| mesh[10].qualifier_ui | Q000187 |
| mesh[10].descriptor_ui | D013737 |
| mesh[10].is_major_topic | True |
| mesh[10].qualifier_name | drug effects |
| mesh[10].descriptor_name | Testis |
| mesh[11].qualifier_ui | Q000187 |
| mesh[11].descriptor_ui | D013093 |
| mesh[11].is_major_topic | False |
| mesh[11].qualifier_name | drug effects |
| mesh[11].descriptor_name | Spermatogonia |
| mesh[12].qualifier_ui | Q000187 |
| mesh[12].descriptor_ui | D012708 |
| mesh[12].is_major_topic | False |
| mesh[12].qualifier_name | drug effects |
| mesh[12].descriptor_name | Sertoli Cells |
| mesh[13].qualifier_ui | Q000187 |
| mesh[13].descriptor_ui | D049109 |
| mesh[13].is_major_topic | False |
| mesh[13].qualifier_name | drug effects |
| mesh[13].descriptor_name | Cell Proliferation |
| mesh[14].qualifier_ui | Q000187 |
| mesh[14].descriptor_ui | D012741 |
| mesh[14].is_major_topic | False |
| mesh[14].qualifier_name | drug effects |
| mesh[14].descriptor_name | Sexual Maturation |
| mesh[15].qualifier_ui | Q000187 |
| mesh[15].descriptor_ui | D013094 |
| mesh[15].is_major_topic | False |
| mesh[15].qualifier_name | drug effects |
| mesh[15].descriptor_name | Spermatozoa |
| mesh[16].qualifier_ui | Q000187 |
| mesh[16].descriptor_ui | D008540 |
| mesh[16].is_major_topic | False |
| mesh[16].qualifier_name | drug effects |
| mesh[16].descriptor_name | Meiosis |
| mesh[17].qualifier_ui | |
| mesh[17].descriptor_ui | D000818 |
| mesh[17].is_major_topic | False |
| mesh[17].qualifier_name | |
| mesh[17].descriptor_name | Animals |
| mesh[18].qualifier_ui | |
| mesh[18].descriptor_ui | D008297 |
| mesh[18].is_major_topic | False |
| mesh[18].qualifier_name | |
| mesh[18].descriptor_name | Male |
| mesh[19].qualifier_ui | Q000494 |
| mesh[19].descriptor_ui | D003630 |
| mesh[19].is_major_topic | True |
| mesh[19].qualifier_name | pharmacology |
| mesh[19].descriptor_name | Daunorubicin |
| mesh[20].qualifier_ui | Q000009 |
| mesh[20].descriptor_ui | D003630 |
| mesh[20].is_major_topic | True |
| mesh[20].qualifier_name | adverse effects |
| mesh[20].descriptor_name | Daunorubicin |
| mesh[21].qualifier_ui | Q000008 |
| mesh[21].descriptor_ui | D003630 |
| mesh[21].is_major_topic | True |
| mesh[21].qualifier_name | administration & dosage |
| mesh[21].descriptor_name | Daunorubicin |
| mesh[22].qualifier_ui | Q000009 |
| mesh[22].descriptor_ui | D003561 |
| mesh[22].is_major_topic | True |
| mesh[22].qualifier_name | adverse effects |
| mesh[22].descriptor_name | Cytarabine |
| mesh[23].qualifier_ui | Q000494 |
| mesh[23].descriptor_ui | D003561 |
| mesh[23].is_major_topic | True |
| mesh[23].qualifier_name | pharmacology |
| mesh[23].descriptor_name | Cytarabine |
| mesh[24].qualifier_ui | Q000008 |
| mesh[24].descriptor_ui | D003561 |
| mesh[24].is_major_topic | True |
| mesh[24].qualifier_name | administration & dosage |
| mesh[24].descriptor_name | Cytarabine |
| mesh[25].qualifier_ui | Q000187 |
| mesh[25].descriptor_ui | D013091 |
| mesh[25].is_major_topic | True |
| mesh[25].qualifier_name | drug effects |
| mesh[25].descriptor_name | Spermatogenesis |
| mesh[26].qualifier_ui | |
| mesh[26].descriptor_ui | D051379 |
| mesh[26].is_major_topic | False |
| mesh[26].qualifier_name | |
| mesh[26].descriptor_name | Mice |
| mesh[27].qualifier_ui | Q000187 |
| mesh[27].descriptor_ui | D013737 |
| mesh[27].is_major_topic | True |
| mesh[27].qualifier_name | drug effects |
| mesh[27].descriptor_name | Testis |
| mesh[28].qualifier_ui | Q000187 |
| mesh[28].descriptor_ui | D013093 |
| mesh[28].is_major_topic | False |
| mesh[28].qualifier_name | drug effects |
| mesh[28].descriptor_name | Spermatogonia |
| mesh[29].qualifier_ui | Q000187 |
| mesh[29].descriptor_ui | D012708 |
| mesh[29].is_major_topic | False |
| mesh[29].qualifier_name | drug effects |
| mesh[29].descriptor_name | Sertoli Cells |
| mesh[30].qualifier_ui | Q000187 |
| mesh[30].descriptor_ui | D049109 |
| mesh[30].is_major_topic | False |
| mesh[30].qualifier_name | drug effects |
| mesh[30].descriptor_name | Cell Proliferation |
| mesh[31].qualifier_ui | Q000187 |
| mesh[31].descriptor_ui | D012741 |
| mesh[31].is_major_topic | False |
| mesh[31].qualifier_name | drug effects |
| mesh[31].descriptor_name | Sexual Maturation |
| mesh[32].qualifier_ui | Q000187 |
| mesh[32].descriptor_ui | D013094 |
| mesh[32].is_major_topic | False |
| mesh[32].qualifier_name | drug effects |
| mesh[32].descriptor_name | Spermatozoa |
| mesh[33].qualifier_ui | Q000187 |
| mesh[33].descriptor_ui | D008540 |
| mesh[33].is_major_topic | False |
| mesh[33].qualifier_name | drug effects |
| mesh[33].descriptor_name | Meiosis |
| mesh[34].qualifier_ui | |
| mesh[34].descriptor_ui | D000818 |
| mesh[34].is_major_topic | False |
| mesh[34].qualifier_name | |
| mesh[34].descriptor_name | Animals |
| mesh[35].qualifier_ui | |
| mesh[35].descriptor_ui | D008297 |
| mesh[35].is_major_topic | False |
| mesh[35].qualifier_name | |
| mesh[35].descriptor_name | Male |
| mesh[36].qualifier_ui | Q000494 |
| mesh[36].descriptor_ui | D003630 |
| mesh[36].is_major_topic | True |
| mesh[36].qualifier_name | pharmacology |
| mesh[36].descriptor_name | Daunorubicin |
| mesh[37].qualifier_ui | Q000009 |
| mesh[37].descriptor_ui | D003630 |
| mesh[37].is_major_topic | True |
| mesh[37].qualifier_name | adverse effects |
| mesh[37].descriptor_name | Daunorubicin |
| mesh[38].qualifier_ui | Q000008 |
| mesh[38].descriptor_ui | D003630 |
| mesh[38].is_major_topic | True |
| mesh[38].qualifier_name | administration & dosage |
| mesh[38].descriptor_name | Daunorubicin |
| mesh[39].qualifier_ui | Q000009 |
| mesh[39].descriptor_ui | D003561 |
| mesh[39].is_major_topic | True |
| mesh[39].qualifier_name | adverse effects |
| mesh[39].descriptor_name | Cytarabine |
| mesh[40].qualifier_ui | Q000494 |
| mesh[40].descriptor_ui | D003561 |
| mesh[40].is_major_topic | True |
| mesh[40].qualifier_name | pharmacology |
| mesh[40].descriptor_name | Cytarabine |
| mesh[41].qualifier_ui | Q000008 |
| mesh[41].descriptor_ui | D003561 |
| mesh[41].is_major_topic | True |
| mesh[41].qualifier_name | administration & dosage |
| mesh[41].descriptor_name | Cytarabine |
| mesh[42].qualifier_ui | Q000187 |
| mesh[42].descriptor_ui | D013091 |
| mesh[42].is_major_topic | True |
| mesh[42].qualifier_name | drug effects |
| mesh[42].descriptor_name | Spermatogenesis |
| mesh[43].qualifier_ui | |
| mesh[43].descriptor_ui | D051379 |
| mesh[43].is_major_topic | False |
| mesh[43].qualifier_name | |
| mesh[43].descriptor_name | Mice |
| mesh[44].qualifier_ui | Q000187 |
| mesh[44].descriptor_ui | D013737 |
| mesh[44].is_major_topic | True |
| mesh[44].qualifier_name | drug effects |
| mesh[44].descriptor_name | Testis |
| mesh[45].qualifier_ui | Q000187 |
| mesh[45].descriptor_ui | D013093 |
| mesh[45].is_major_topic | False |
| mesh[45].qualifier_name | drug effects |
| mesh[45].descriptor_name | Spermatogonia |
| mesh[46].qualifier_ui | Q000187 |
| mesh[46].descriptor_ui | D012708 |
| mesh[46].is_major_topic | False |
| mesh[46].qualifier_name | drug effects |
| mesh[46].descriptor_name | Sertoli Cells |
| mesh[47].qualifier_ui | Q000187 |
| mesh[47].descriptor_ui | D049109 |
| mesh[47].is_major_topic | False |
| mesh[47].qualifier_name | drug effects |
| mesh[47].descriptor_name | Cell Proliferation |
| mesh[48].qualifier_ui | Q000187 |
| mesh[48].descriptor_ui | D012741 |
| mesh[48].is_major_topic | False |
| mesh[48].qualifier_name | drug effects |
| mesh[48].descriptor_name | Sexual Maturation |
| mesh[49].qualifier_ui | Q000187 |
| mesh[49].descriptor_ui | D013094 |
| mesh[49].is_major_topic | False |
| mesh[49].qualifier_name | drug effects |
| mesh[49].descriptor_name | Spermatozoa |
| type | article |
| title | In vivo and in vitro spermatogenesis in prepubertal mouse testes exposed to low gonadotoxic doses of cytarabine or Daunorubicin |
| awards[0].id | https://openalex.org/G6263025364 |
| awards[0].funder_id | https://openalex.org/F4320323585 |
| awards[0].display_name | |
| awards[0].funder_award_id | #19AMP010 |
| awards[0].funder_display_name | Agence de la Biomédecine |
| biblio.issue | 1 |
| biblio.volume | 15 |
| biblio.last_page | 14230 |
| biblio.first_page | 14230 |
| topics[0].id | https://openalex.org/T10364 |
| topics[0].field.id | https://openalex.org/fields/27 |
| topics[0].field.display_name | Medicine |
| topics[0].score | 0.9995999932289124 |
| topics[0].domain.id | https://openalex.org/domains/4 |
| topics[0].domain.display_name | Health Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/2739 |
| topics[0].subfield.display_name | Public Health, Environmental and Occupational Health |
| topics[0].display_name | Reproductive Biology and Fertility |
| topics[1].id | https://openalex.org/T10116 |
| topics[1].field.id | https://openalex.org/fields/27 |
| topics[1].field.display_name | Medicine |
| topics[1].score | 0.9994999766349792 |
| topics[1].domain.id | https://openalex.org/domains/4 |
| topics[1].domain.display_name | Health Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/2743 |
| topics[1].subfield.display_name | Reproductive Medicine |
| topics[1].display_name | Sperm and Testicular Function |
| topics[2].id | https://openalex.org/T12140 |
| topics[2].field.id | https://openalex.org/fields/13 |
| topics[2].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[2].score | 0.9833999872207642 |
| topics[2].domain.id | https://openalex.org/domains/1 |
| topics[2].domain.display_name | Life Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/1312 |
| topics[2].subfield.display_name | Molecular Biology |
| topics[2].display_name | Renal and related cancers |
| funders[0].id | https://openalex.org/F4320322363 |
| funders[0].ror | https://ror.org/00rkrv905 |
| funders[0].display_name | Ligue Contre le Cancer |
| funders[1].id | https://openalex.org/F4320323585 |
| funders[1].ror | https://ror.org/03tajza86 |
| funders[1].display_name | Agence de la Biomédecine |
| funders[2].id | https://openalex.org/F4320329938 |
| funders[2].ror | |
| funders[2].display_name | Région Normandie |
| is_xpac | False |
| apc_list.value | 1890 |
| apc_list.currency | EUR |
| apc_list.value_usd | 2190 |
| apc_paid.value | 1890 |
| apc_paid.currency | EUR |
| apc_paid.value_usd | 2190 |
| concepts[0].id | https://openalex.org/C2781021840 |
| concepts[0].level | 3 |
| concepts[0].score | 0.8916136026382446 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q411659 |
| concepts[0].display_name | Daunorubicin |
| concepts[1].id | https://openalex.org/C2778041864 |
| concepts[1].level | 3 |
| concepts[1].score | 0.845466136932373 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q180983 |
| concepts[1].display_name | Cytarabine |
| concepts[2].id | https://openalex.org/C207001950 |
| concepts[2].level | 2 |
| concepts[2].score | 0.7195116281509399 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q141124 |
| concepts[2].display_name | In vivo |
| concepts[3].id | https://openalex.org/C123765429 |
| concepts[3].level | 2 |
| concepts[3].score | 0.682253360748291 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q36961 |
| concepts[3].display_name | Spermatogenesis |
| concepts[4].id | https://openalex.org/C202751555 |
| concepts[4].level | 2 |
| concepts[4].score | 0.48877546191215515 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q221681 |
| concepts[4].display_name | In vitro |
| concepts[5].id | https://openalex.org/C86803240 |
| concepts[5].level | 0 |
| concepts[5].score | 0.4130384922027588 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q420 |
| concepts[5].display_name | Biology |
| concepts[6].id | https://openalex.org/C98274493 |
| concepts[6].level | 1 |
| concepts[6].score | 0.3811721205711365 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q128406 |
| concepts[6].display_name | Pharmacology |
| concepts[7].id | https://openalex.org/C71924100 |
| concepts[7].level | 0 |
| concepts[7].score | 0.3508743643760681 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q11190 |
| concepts[7].display_name | Medicine |
| concepts[8].id | https://openalex.org/C16685009 |
| concepts[8].level | 1 |
| concepts[8].score | 0.3328275680541992 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q335057 |
| concepts[8].display_name | Andrology |
| concepts[9].id | https://openalex.org/C126322002 |
| concepts[9].level | 1 |
| concepts[9].score | 0.3312608599662781 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q11180 |
| concepts[9].display_name | Internal medicine |
| concepts[10].id | https://openalex.org/C134018914 |
| concepts[10].level | 1 |
| concepts[10].score | 0.2784317135810852 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q162606 |
| concepts[10].display_name | Endocrinology |
| concepts[11].id | https://openalex.org/C2778461978 |
| concepts[11].level | 2 |
| concepts[11].score | 0.23940128087997437 |
| concepts[11].wikidata | https://www.wikidata.org/wiki/Q29496 |
| concepts[11].display_name | Leukemia |
| concepts[12].id | https://openalex.org/C54355233 |
| concepts[12].level | 1 |
| concepts[12].score | 0.15640440583229065 |
| concepts[12].wikidata | https://www.wikidata.org/wiki/Q7162 |
| concepts[12].display_name | Genetics |
| keywords[0].id | https://openalex.org/keywords/daunorubicin |
| keywords[0].score | 0.8916136026382446 |
| keywords[0].display_name | Daunorubicin |
| keywords[1].id | https://openalex.org/keywords/cytarabine |
| keywords[1].score | 0.845466136932373 |
| keywords[1].display_name | Cytarabine |
| keywords[2].id | https://openalex.org/keywords/in-vivo |
| keywords[2].score | 0.7195116281509399 |
| keywords[2].display_name | In vivo |
| keywords[3].id | https://openalex.org/keywords/spermatogenesis |
| keywords[3].score | 0.682253360748291 |
| keywords[3].display_name | Spermatogenesis |
| keywords[4].id | https://openalex.org/keywords/in-vitro |
| keywords[4].score | 0.48877546191215515 |
| keywords[4].display_name | In vitro |
| keywords[5].id | https://openalex.org/keywords/biology |
| keywords[5].score | 0.4130384922027588 |
| keywords[5].display_name | Biology |
| keywords[6].id | https://openalex.org/keywords/pharmacology |
| keywords[6].score | 0.3811721205711365 |
| keywords[6].display_name | Pharmacology |
| keywords[7].id | https://openalex.org/keywords/medicine |
| keywords[7].score | 0.3508743643760681 |
| keywords[7].display_name | Medicine |
| keywords[8].id | https://openalex.org/keywords/andrology |
| keywords[8].score | 0.3328275680541992 |
| keywords[8].display_name | Andrology |
| keywords[9].id | https://openalex.org/keywords/internal-medicine |
| keywords[9].score | 0.3312608599662781 |
| keywords[9].display_name | Internal medicine |
| keywords[10].id | https://openalex.org/keywords/endocrinology |
| keywords[10].score | 0.2784317135810852 |
| keywords[10].display_name | Endocrinology |
| keywords[11].id | https://openalex.org/keywords/leukemia |
| keywords[11].score | 0.23940128087997437 |
| keywords[11].display_name | Leukemia |
| keywords[12].id | https://openalex.org/keywords/genetics |
| keywords[12].score | 0.15640440583229065 |
| keywords[12].display_name | Genetics |
| language | en |
| locations[0].id | doi:10.1038/s41598-025-98413-1 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S196734849 |
| locations[0].source.issn | 2045-2322 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | True |
| locations[0].source.issn_l | 2045-2322 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | True |
| locations[0].source.display_name | Scientific Reports |
| locations[0].source.host_organization | https://openalex.org/P4310319908 |
| locations[0].source.host_organization_name | Nature Portfolio |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310319908, https://openalex.org/P4310319965 |
| locations[0].source.host_organization_lineage_names | Nature Portfolio, Springer Nature |
| locations[0].license | cc-by-nc-nd |
| locations[0].pdf_url | https://www.nature.com/articles/s41598-025-98413-1.pdf |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | https://openalex.org/licenses/cc-by-nc-nd |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Scientific Reports |
| locations[0].landing_page_url | https://doi.org/10.1038/s41598-025-98413-1 |
| locations[1].id | pmid:40275009 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | Scientific reports |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/40275009 |
| locations[2].id | pmh:oai:HAL:hal-05153236v1 |
| locations[2].is_oa | False |
| locations[2].source.id | https://openalex.org/S4306402512 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | HAL (Le Centre pour la Communication Scientifique Directe) |
| locations[2].source.host_organization | https://openalex.org/I1294671590 |
| locations[2].source.host_organization_name | Centre National de la Recherche Scientifique |
| locations[2].source.host_organization_lineage | https://openalex.org/I1294671590 |
| locations[2].license | |
| locations[2].pdf_url | |
| locations[2].version | submittedVersion |
| locations[2].raw_type | Journal articles |
| locations[2].license_id | |
| locations[2].is_accepted | False |
| locations[2].is_published | False |
| locations[2].raw_source_name | Scientific Reports, 2025, 15 (1), pp.14230. ⟨10.1038/s41598-025-98413-1⟩ |
| locations[2].landing_page_url | https://hal.science/hal-05153236 |
| locations[3].id | pmh:oai:doaj.org/article:2d4d244f99e345819e0d3da53338d049 |
| locations[3].is_oa | False |
| locations[3].source.id | https://openalex.org/S4306401280 |
| locations[3].source.issn | |
| locations[3].source.type | repository |
| locations[3].source.is_oa | False |
| locations[3].source.issn_l | |
| locations[3].source.is_core | False |
| locations[3].source.is_in_doaj | False |
| locations[3].source.display_name | DOAJ (DOAJ: Directory of Open Access Journals) |
| locations[3].source.host_organization | |
| locations[3].source.host_organization_name | |
| locations[3].license | |
| locations[3].pdf_url | |
| locations[3].version | submittedVersion |
| locations[3].raw_type | article |
| locations[3].license_id | |
| locations[3].is_accepted | False |
| locations[3].is_published | False |
| locations[3].raw_source_name | Scientific Reports, Vol 15, Iss 1, Pp 1-16 (2025) |
| locations[3].landing_page_url | https://doaj.org/article/2d4d244f99e345819e0d3da53338d049 |
| locations[4].id | pmh:oai:europepmc.org:10832436 |
| locations[4].is_oa | True |
| locations[4].source.id | https://openalex.org/S4306400806 |
| locations[4].source.issn | |
| locations[4].source.type | repository |
| locations[4].source.is_oa | False |
| locations[4].source.issn_l | |
| locations[4].source.is_core | False |
| locations[4].source.is_in_doaj | False |
| locations[4].source.display_name | Europe PMC (PubMed Central) |
| locations[4].source.host_organization | https://openalex.org/I1303153112 |
| locations[4].source.host_organization_name | European Bioinformatics Institute |
| locations[4].source.host_organization_lineage | https://openalex.org/I1303153112 |
| locations[4].license | other-oa |
| locations[4].pdf_url | |
| locations[4].version | submittedVersion |
| locations[4].raw_type | Text |
| locations[4].license_id | https://openalex.org/licenses/other-oa |
| locations[4].is_accepted | False |
| locations[4].is_published | False |
| locations[4].raw_source_name | |
| locations[4].landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/12022241 |
| indexed_in | crossref, doaj, pubmed |
| authorships[0].author.id | https://openalex.org/A5085577817 |
| authorships[0].author.orcid | https://orcid.org/0000-0001-9377-5531 |
| authorships[0].author.display_name | Marion Delessard |
| authorships[0].countries | FR |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I154526488, https://openalex.org/I4210105918, https://openalex.org/I62396329 |
| authorships[0].affiliations[0].raw_affiliation_string | Adrenal and Gonadal Pathophysiology Team, Univ Rouen Normandie, Inserm, Normandie Univ, NorDiC UMR 1239, Rouen University Hospital, Rouen, F-76000, France. |
| authorships[0].institutions[0].id | https://openalex.org/I154526488 |
| authorships[0].institutions[0].ror | https://ror.org/02vjkv261 |
| authorships[0].institutions[0].type | government |
| authorships[0].institutions[0].lineage | https://openalex.org/I154526488 |
| authorships[0].institutions[0].country_code | FR |
| authorships[0].institutions[0].display_name | Inserm |
| authorships[0].institutions[1].id | https://openalex.org/I4210105918 |
| authorships[0].institutions[1].ror | https://ror.org/01k40cz91 |
| authorships[0].institutions[1].type | education |
| authorships[0].institutions[1].lineage | https://openalex.org/I4210105918 |
| authorships[0].institutions[1].country_code | FR |
| authorships[0].institutions[1].display_name | Normandie Université |
| authorships[0].institutions[2].id | https://openalex.org/I62396329 |
| authorships[0].institutions[2].ror | https://ror.org/03nhjew95 |
| authorships[0].institutions[2].type | education |
| authorships[0].institutions[2].lineage | https://openalex.org/I4210105918, https://openalex.org/I62396329 |
| authorships[0].institutions[2].country_code | FR |
| authorships[0].institutions[2].display_name | Université de Rouen Normandie |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Marion Delessard |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Adrenal and Gonadal Pathophysiology Team, Univ Rouen Normandie, Inserm, Normandie Univ, NorDiC UMR 1239, Rouen University Hospital, Rouen, F-76000, France. |
| authorships[1].author.id | https://openalex.org/A5031810740 |
| authorships[1].author.orcid | https://orcid.org/0000-0003-2412-4377 |
| authorships[1].author.display_name | Laura Moutard |
| authorships[1].countries | FR |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I154526488, https://openalex.org/I4210105918, https://openalex.org/I62396329 |
| authorships[1].affiliations[0].raw_affiliation_string | Adrenal and Gonadal Pathophysiology Team, Univ Rouen Normandie, Inserm, Normandie Univ, NorDiC UMR 1239, Rouen University Hospital, Rouen, F-76000, France. |
| authorships[1].institutions[0].id | https://openalex.org/I154526488 |
| authorships[1].institutions[0].ror | https://ror.org/02vjkv261 |
| authorships[1].institutions[0].type | government |
| authorships[1].institutions[0].lineage | https://openalex.org/I154526488 |
| authorships[1].institutions[0].country_code | FR |
| authorships[1].institutions[0].display_name | Inserm |
| authorships[1].institutions[1].id | https://openalex.org/I4210105918 |
| authorships[1].institutions[1].ror | https://ror.org/01k40cz91 |
| authorships[1].institutions[1].type | education |
| authorships[1].institutions[1].lineage | https://openalex.org/I4210105918 |
| authorships[1].institutions[1].country_code | FR |
| authorships[1].institutions[1].display_name | Normandie Université |
| authorships[1].institutions[2].id | https://openalex.org/I62396329 |
| authorships[1].institutions[2].ror | https://ror.org/03nhjew95 |
| authorships[1].institutions[2].type | education |
| authorships[1].institutions[2].lineage | https://openalex.org/I4210105918, https://openalex.org/I62396329 |
| authorships[1].institutions[2].country_code | FR |
| authorships[1].institutions[2].display_name | Université de Rouen Normandie |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Laura Moutard |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Adrenal and Gonadal Pathophysiology Team, Univ Rouen Normandie, Inserm, Normandie Univ, NorDiC UMR 1239, Rouen University Hospital, Rouen, F-76000, France. |
| authorships[2].author.id | https://openalex.org/A5031657124 |
| authorships[2].author.orcid | |
| authorships[2].author.display_name | Coline Charnay |
| authorships[2].countries | FR |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I154526488, https://openalex.org/I4210105918, https://openalex.org/I62396329 |
| authorships[2].affiliations[0].raw_affiliation_string | Adrenal and Gonadal Pathophysiology Team, Univ Rouen Normandie, Inserm, Normandie Univ, NorDiC UMR 1239, Rouen University Hospital, Rouen, F-76000, France. |
| authorships[2].institutions[0].id | https://openalex.org/I154526488 |
| authorships[2].institutions[0].ror | https://ror.org/02vjkv261 |
| authorships[2].institutions[0].type | government |
| authorships[2].institutions[0].lineage | https://openalex.org/I154526488 |
| authorships[2].institutions[0].country_code | FR |
| authorships[2].institutions[0].display_name | Inserm |
| authorships[2].institutions[1].id | https://openalex.org/I4210105918 |
| authorships[2].institutions[1].ror | https://ror.org/01k40cz91 |
| authorships[2].institutions[1].type | education |
| authorships[2].institutions[1].lineage | https://openalex.org/I4210105918 |
| authorships[2].institutions[1].country_code | FR |
| authorships[2].institutions[1].display_name | Normandie Université |
| authorships[2].institutions[2].id | https://openalex.org/I62396329 |
| authorships[2].institutions[2].ror | https://ror.org/03nhjew95 |
| authorships[2].institutions[2].type | education |
| authorships[2].institutions[2].lineage | https://openalex.org/I4210105918, https://openalex.org/I62396329 |
| authorships[2].institutions[2].country_code | FR |
| authorships[2].institutions[2].display_name | Université de Rouen Normandie |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Coline Charnay |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Adrenal and Gonadal Pathophysiology Team, Univ Rouen Normandie, Inserm, Normandie Univ, NorDiC UMR 1239, Rouen University Hospital, Rouen, F-76000, France. |
| authorships[3].author.id | https://openalex.org/A5016681742 |
| authorships[3].author.orcid | https://orcid.org/0000-0001-9102-1111 |
| authorships[3].author.display_name | Nathalie Rives |
| authorships[3].countries | FR |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I154526488, https://openalex.org/I4210105918, https://openalex.org/I62396329 |
| authorships[3].affiliations[0].raw_affiliation_string | Adrenal and Gonadal Pathophysiology Team, Univ Rouen Normandie, Inserm, Normandie Univ, NorDiC UMR 1239, Rouen University Hospital, Rouen, F-76000, France. |
| authorships[3].institutions[0].id | https://openalex.org/I154526488 |
| authorships[3].institutions[0].ror | https://ror.org/02vjkv261 |
| authorships[3].institutions[0].type | government |
| authorships[3].institutions[0].lineage | https://openalex.org/I154526488 |
| authorships[3].institutions[0].country_code | FR |
| authorships[3].institutions[0].display_name | Inserm |
| authorships[3].institutions[1].id | https://openalex.org/I4210105918 |
| authorships[3].institutions[1].ror | https://ror.org/01k40cz91 |
| authorships[3].institutions[1].type | education |
| authorships[3].institutions[1].lineage | https://openalex.org/I4210105918 |
| authorships[3].institutions[1].country_code | FR |
| authorships[3].institutions[1].display_name | Normandie Université |
| authorships[3].institutions[2].id | https://openalex.org/I62396329 |
| authorships[3].institutions[2].ror | https://ror.org/03nhjew95 |
| authorships[3].institutions[2].type | education |
| authorships[3].institutions[2].lineage | https://openalex.org/I4210105918, https://openalex.org/I62396329 |
| authorships[3].institutions[2].country_code | FR |
| authorships[3].institutions[2].display_name | Université de Rouen Normandie |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Nathalie Rives |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Adrenal and Gonadal Pathophysiology Team, Univ Rouen Normandie, Inserm, Normandie Univ, NorDiC UMR 1239, Rouen University Hospital, Rouen, F-76000, France. |
| authorships[4].author.id | https://openalex.org/A5014877664 |
| authorships[4].author.orcid | https://orcid.org/0000-0001-6882-6413 |
| authorships[4].author.display_name | Ludovic Dumont |
| authorships[4].countries | FR |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I154526488, https://openalex.org/I4210105918, https://openalex.org/I62396329 |
| authorships[4].affiliations[0].raw_affiliation_string | Adrenal and Gonadal Pathophysiology Team, Univ Rouen Normandie, Inserm, Normandie Univ, NorDiC UMR 1239, Rouen University Hospital, Rouen, F-76000, France. |
| authorships[4].institutions[0].id | https://openalex.org/I154526488 |
| authorships[4].institutions[0].ror | https://ror.org/02vjkv261 |
| authorships[4].institutions[0].type | government |
| authorships[4].institutions[0].lineage | https://openalex.org/I154526488 |
| authorships[4].institutions[0].country_code | FR |
| authorships[4].institutions[0].display_name | Inserm |
| authorships[4].institutions[1].id | https://openalex.org/I4210105918 |
| authorships[4].institutions[1].ror | https://ror.org/01k40cz91 |
| authorships[4].institutions[1].type | education |
| authorships[4].institutions[1].lineage | https://openalex.org/I4210105918 |
| authorships[4].institutions[1].country_code | FR |
| authorships[4].institutions[1].display_name | Normandie Université |
| authorships[4].institutions[2].id | https://openalex.org/I62396329 |
| authorships[4].institutions[2].ror | https://ror.org/03nhjew95 |
| authorships[4].institutions[2].type | education |
| authorships[4].institutions[2].lineage | https://openalex.org/I4210105918, https://openalex.org/I62396329 |
| authorships[4].institutions[2].country_code | FR |
| authorships[4].institutions[2].display_name | Université de Rouen Normandie |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Ludovic Dumont |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Adrenal and Gonadal Pathophysiology Team, Univ Rouen Normandie, Inserm, Normandie Univ, NorDiC UMR 1239, Rouen University Hospital, Rouen, F-76000, France. |
| authorships[5].author.id | https://openalex.org/A5016268593 |
| authorships[5].author.orcid | https://orcid.org/0000-0001-7666-2594 |
| authorships[5].author.display_name | Magali Basille |
| authorships[5].countries | FR |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I154526488, https://openalex.org/I4210105918, https://openalex.org/I62396329 |
| authorships[5].affiliations[0].raw_affiliation_string | Adrenal and Gonadal Pathophysiology Team, Univ Rouen Normandie, Inserm, Normandie Univ, NorDiC UMR 1239, Rouen University Hospital, Rouen, F-76000, France. |
| authorships[5].institutions[0].id | https://openalex.org/I154526488 |
| authorships[5].institutions[0].ror | https://ror.org/02vjkv261 |
| authorships[5].institutions[0].type | government |
| authorships[5].institutions[0].lineage | https://openalex.org/I154526488 |
| authorships[5].institutions[0].country_code | FR |
| authorships[5].institutions[0].display_name | Inserm |
| authorships[5].institutions[1].id | https://openalex.org/I4210105918 |
| authorships[5].institutions[1].ror | https://ror.org/01k40cz91 |
| authorships[5].institutions[1].type | education |
| authorships[5].institutions[1].lineage | https://openalex.org/I4210105918 |
| authorships[5].institutions[1].country_code | FR |
| authorships[5].institutions[1].display_name | Normandie Université |
| authorships[5].institutions[2].id | https://openalex.org/I62396329 |
| authorships[5].institutions[2].ror | https://ror.org/03nhjew95 |
| authorships[5].institutions[2].type | education |
| authorships[5].institutions[2].lineage | https://openalex.org/I4210105918, https://openalex.org/I62396329 |
| authorships[5].institutions[2].country_code | FR |
| authorships[5].institutions[2].display_name | Université de Rouen Normandie |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Magali Basille-Dugay |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Adrenal and Gonadal Pathophysiology Team, Univ Rouen Normandie, Inserm, Normandie Univ, NorDiC UMR 1239, Rouen University Hospital, Rouen, F-76000, France. |
| authorships[6].author.id | https://openalex.org/A5007229405 |
| authorships[6].author.orcid | https://orcid.org/0000-0002-5748-6342 |
| authorships[6].author.display_name | Aurélie Rives‐Feraille |
| authorships[6].countries | FR |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I154526488, https://openalex.org/I4210105918, https://openalex.org/I62396329 |
| authorships[6].affiliations[0].raw_affiliation_string | Adrenal and Gonadal Pathophysiology Team, Univ Rouen Normandie, Inserm, Normandie Univ, NorDiC UMR 1239, Rouen University Hospital, Rouen, F-76000, France. |
| authorships[6].institutions[0].id | https://openalex.org/I154526488 |
| authorships[6].institutions[0].ror | https://ror.org/02vjkv261 |
| authorships[6].institutions[0].type | government |
| authorships[6].institutions[0].lineage | https://openalex.org/I154526488 |
| authorships[6].institutions[0].country_code | FR |
| authorships[6].institutions[0].display_name | Inserm |
| authorships[6].institutions[1].id | https://openalex.org/I4210105918 |
| authorships[6].institutions[1].ror | https://ror.org/01k40cz91 |
| authorships[6].institutions[1].type | education |
| authorships[6].institutions[1].lineage | https://openalex.org/I4210105918 |
| authorships[6].institutions[1].country_code | FR |
| authorships[6].institutions[1].display_name | Normandie Université |
| authorships[6].institutions[2].id | https://openalex.org/I62396329 |
| authorships[6].institutions[2].ror | https://ror.org/03nhjew95 |
| authorships[6].institutions[2].type | education |
| authorships[6].institutions[2].lineage | https://openalex.org/I4210105918, https://openalex.org/I62396329 |
| authorships[6].institutions[2].country_code | FR |
| authorships[6].institutions[2].display_name | Université de Rouen Normandie |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Aurélie Feraille |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | Adrenal and Gonadal Pathophysiology Team, Univ Rouen Normandie, Inserm, Normandie Univ, NorDiC UMR 1239, Rouen University Hospital, Rouen, F-76000, France. |
| authorships[7].author.id | https://openalex.org/A5083306009 |
| authorships[7].author.orcid | https://orcid.org/0000-0002-1100-9401 |
| authorships[7].author.display_name | Christine Rondanino |
| authorships[7].countries | FR |
| authorships[7].affiliations[0].institution_ids | https://openalex.org/I154526488, https://openalex.org/I4210105918, https://openalex.org/I62396329 |
| authorships[7].affiliations[0].raw_affiliation_string | Adrenal and Gonadal Pathophysiology Team, Univ Rouen Normandie, Inserm, Normandie Univ, NorDiC UMR 1239, Rouen University Hospital, Rouen, F-76000, France. [email protected]. |
| authorships[7].institutions[0].id | https://openalex.org/I154526488 |
| authorships[7].institutions[0].ror | https://ror.org/02vjkv261 |
| authorships[7].institutions[0].type | government |
| authorships[7].institutions[0].lineage | https://openalex.org/I154526488 |
| authorships[7].institutions[0].country_code | FR |
| authorships[7].institutions[0].display_name | Inserm |
| authorships[7].institutions[1].id | https://openalex.org/I4210105918 |
| authorships[7].institutions[1].ror | https://ror.org/01k40cz91 |
| authorships[7].institutions[1].type | education |
| authorships[7].institutions[1].lineage | https://openalex.org/I4210105918 |
| authorships[7].institutions[1].country_code | FR |
| authorships[7].institutions[1].display_name | Normandie Université |
| authorships[7].institutions[2].id | https://openalex.org/I62396329 |
| authorships[7].institutions[2].ror | https://ror.org/03nhjew95 |
| authorships[7].institutions[2].type | education |
| authorships[7].institutions[2].lineage | https://openalex.org/I4210105918, https://openalex.org/I62396329 |
| authorships[7].institutions[2].country_code | FR |
| authorships[7].institutions[2].display_name | Université de Rouen Normandie |
| authorships[7].author_position | last |
| authorships[7].raw_author_name | Christine Rondanino |
| authorships[7].is_corresponding | False |
| authorships[7].raw_affiliation_strings | Adrenal and Gonadal Pathophysiology Team, Univ Rouen Normandie, Inserm, Normandie Univ, NorDiC UMR 1239, Rouen University Hospital, Rouen, F-76000, France. [email protected]. |
| has_content.pdf | True |
| has_content.grobid_xml | False |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://www.nature.com/articles/s41598-025-98413-1.pdf |
| open_access.oa_status | gold |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | In vivo and in vitro spermatogenesis in prepubertal mouse testes exposed to low gonadotoxic doses of cytarabine or Daunorubicin |
| has_fulltext | False |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T10364 |
| primary_topic.field.id | https://openalex.org/fields/27 |
| primary_topic.field.display_name | Medicine |
| primary_topic.score | 0.9995999932289124 |
| primary_topic.domain.id | https://openalex.org/domains/4 |
| primary_topic.domain.display_name | Health Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/2739 |
| primary_topic.subfield.display_name | Public Health, Environmental and Occupational Health |
| primary_topic.display_name | Reproductive Biology and Fertility |
| related_works | https://openalex.org/W2147459960, https://openalex.org/W2801436543, https://openalex.org/W1964648983, https://openalex.org/W3046856303, https://openalex.org/W4313390310, https://openalex.org/W2187158199, https://openalex.org/W2077348867, https://openalex.org/W1818146702, https://openalex.org/W2071961017, https://openalex.org/W2902719404 |
| cited_by_count | 2 |
| counts_by_year[0].year | 2025 |
| counts_by_year[0].cited_by_count | 2 |
| locations_count | 5 |
| best_oa_location.id | doi:10.1038/s41598-025-98413-1 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S196734849 |
| best_oa_location.source.issn | 2045-2322 |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | True |
| best_oa_location.source.issn_l | 2045-2322 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | True |
| best_oa_location.source.display_name | Scientific Reports |
| best_oa_location.source.host_organization | https://openalex.org/P4310319908 |
| best_oa_location.source.host_organization_name | Nature Portfolio |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310319908, https://openalex.org/P4310319965 |
| best_oa_location.source.host_organization_lineage_names | Nature Portfolio, Springer Nature |
| best_oa_location.license | cc-by-nc-nd |
| best_oa_location.pdf_url | https://www.nature.com/articles/s41598-025-98413-1.pdf |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by-nc-nd |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | Scientific Reports |
| best_oa_location.landing_page_url | https://doi.org/10.1038/s41598-025-98413-1 |
| primary_location.id | doi:10.1038/s41598-025-98413-1 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S196734849 |
| primary_location.source.issn | 2045-2322 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | True |
| primary_location.source.issn_l | 2045-2322 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | True |
| primary_location.source.display_name | Scientific Reports |
| primary_location.source.host_organization | https://openalex.org/P4310319908 |
| primary_location.source.host_organization_name | Nature Portfolio |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310319908, https://openalex.org/P4310319965 |
| primary_location.source.host_organization_lineage_names | Nature Portfolio, Springer Nature |
| primary_location.license | cc-by-nc-nd |
| primary_location.pdf_url | https://www.nature.com/articles/s41598-025-98413-1.pdf |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | https://openalex.org/licenses/cc-by-nc-nd |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Scientific Reports |
| primary_location.landing_page_url | https://doi.org/10.1038/s41598-025-98413-1 |
| publication_date | 2025-04-24 |
| publication_year | 2025 |
| referenced_works | https://openalex.org/W2076005508, https://openalex.org/W1983426761, https://openalex.org/W2175607782, https://openalex.org/W2806365198, https://openalex.org/W2168609343, https://openalex.org/W2955953964, https://openalex.org/W2334378889, https://openalex.org/W1967757397, https://openalex.org/W4385421825, https://openalex.org/W3095543962, https://openalex.org/W2010183849, https://openalex.org/W2895953310, https://openalex.org/W2795683949, https://openalex.org/W3113836547, https://openalex.org/W2594891367, https://openalex.org/W2018462357, https://openalex.org/W2885547015, https://openalex.org/W2119685460, https://openalex.org/W2761101077, https://openalex.org/W2953335234, https://openalex.org/W2107522576, https://openalex.org/W4223462231, https://openalex.org/W3032915037, https://openalex.org/W3007595233, https://openalex.org/W2980963924, https://openalex.org/W3154240784, https://openalex.org/W3112698106, https://openalex.org/W2060108583, https://openalex.org/W2002842590, https://openalex.org/W2068389839, https://openalex.org/W2170008898, https://openalex.org/W2749017101, https://openalex.org/W2144813080, https://openalex.org/W4288045892, https://openalex.org/W2945985107, https://openalex.org/W4229045561, https://openalex.org/W2027360500, https://openalex.org/W2983157629, https://openalex.org/W2986066610, https://openalex.org/W1998008670, https://openalex.org/W2136968751, https://openalex.org/W2089828090, https://openalex.org/W4327735560, https://openalex.org/W4389735468, https://openalex.org/W1829684968, https://openalex.org/W4318392181, https://openalex.org/W4367677600 |
| referenced_works_count | 47 |
| abstract_inverted_index.a | 86, 113, 172 |
| abstract_inverted_index.In | 134 |
| abstract_inverted_index.an | 166, 179 |
| abstract_inverted_index.by | 6, 110 |
| abstract_inverted_index.in | 62, 65, 85, 104, 116, 126, 162, 168, 171, 186, 191 |
| abstract_inverted_index.is | 8 |
| abstract_inverted_index.of | 2, 15, 29, 45, 57, 103, 119, 157, 175, 182, 195 |
| abstract_inverted_index.on | 22, 53, 78 |
| abstract_inverted_index.or | 64 |
| abstract_inverted_index.to | 20, 70, 145, 190 |
| abstract_inverted_index.DNA | 123, 183 |
| abstract_inverted_index.The | 0 |
| abstract_inverted_index.and | 26, 47, 91, 178 |
| abstract_inverted_index.did | 72 |
| abstract_inverted_index.for | 10, 39 |
| abstract_inverted_index.nor | 151 |
| abstract_inverted_index.not | 73, 108 |
| abstract_inverted_index.one | 130 |
| abstract_inverted_index.the | 12, 27, 40, 43, 54, 101, 117, 154, 196 |
| abstract_inverted_index.was | 107, 124, 137 |
| abstract_inverted_index.This | 36 |
| abstract_inverted_index.also | 138 |
| abstract_inverted_index.both | 61 |
| abstract_inverted_index.cell | 89, 94 |
| abstract_inverted_index.days | 98 |
| abstract_inverted_index.from | 32 |
| abstract_inverted_index.into | 159 |
| abstract_inverted_index.male | 23 |
| abstract_inverted_index.mice | 127 |
| abstract_inverted_index.more | 128 |
| abstract_inverted_index.side | 13 |
| abstract_inverted_index.than | 129 |
| abstract_inverted_index.that | 148 |
| abstract_inverted_index.time | 42 |
| abstract_inverted_index.vivo | 63, 105, 192 |
| abstract_inverted_index.wave | 56 |
| abstract_inverted_index.with | 121 |
| abstract_inverted_index.While | 100 |
| abstract_inverted_index.after | 132 |
| abstract_inverted_index.cells | 188 |
| abstract_inverted_index.first | 41, 55 |
| abstract_inverted_index.gonad | 24 |
| abstract_inverted_index.month | 131 |
| abstract_inverted_index.mouse | 58 |
| abstract_inverted_index.prior | 19 |
| abstract_inverted_index.ratio | 90 |
| abstract_inverted_index.study | 37 |
| abstract_inverted_index.three | 97 |
| abstract_inverted_index.under | 60 |
| abstract_inverted_index.using | 140 |
| abstract_inverted_index.vitro | 66, 135, 163 |
| abstract_inverted_index.arrest | 167 |
| abstract_inverted_index.before | 50 |
| abstract_inverted_index.breaks | 185 |
| abstract_inverted_index.cancer | 16 |
| abstract_inverted_index.models | 4 |
| abstract_inverted_index.needed | 9 |
| abstract_inverted_index.within | 96 |
| abstract_inverted_index.effects | 14, 44, 77 |
| abstract_inverted_index.exhibit | 74 |
| abstract_inverted_index.exposed | 33, 144 |
| abstract_inverted_index.impeded | 153 |
| abstract_inverted_index.meiotic | 51, 169 |
| abstract_inverted_index.neither | 149 |
| abstract_inverted_index.puberty | 21 |
| abstract_inverted_index.tissues | 143 |
| abstract_inverted_index.treated | 5 |
| abstract_inverted_index.tubules | 177 |
| abstract_inverted_index.whereas | 81 |
| abstract_inverted_index.However, | 161 |
| abstract_inverted_index.compared | 189 |
| abstract_inverted_index.elevated | 180 |
| abstract_inverted_index.exposure | 69 |
| abstract_inverted_index.function | 25 |
| abstract_inverted_index.hindered | 109 |
| abstract_inverted_index.increase | 115 |
| abstract_inverted_index.observed | 125 |
| abstract_inverted_index.resulted | 84 |
| abstract_inverted_index.revealed | 165 |
| abstract_inverted_index.tissues, | 80 |
| abstract_inverted_index.tissues. | 35 |
| abstract_inverted_index.controls, | 193 |
| abstract_inverted_index.decreased | 87 |
| abstract_inverted_index.exposure, | 112 |
| abstract_inverted_index.fertility | 31 |
| abstract_inverted_index.immediate | 75 |
| abstract_inverted_index.incidence | 181 |
| abstract_inverted_index.potential | 156 |
| abstract_inverted_index.restoring | 30 |
| abstract_inverted_index.treatment | 197 |
| abstract_inverted_index.completion | 102 |
| abstract_inverted_index.conditions | 164 |
| abstract_inverted_index.cytarabine | 46, 71, 150 |
| abstract_inverted_index.diminished | 92 |
| abstract_inverted_index.fragmented | 122 |
| abstract_inverted_index.indicating | 147 |
| abstract_inverted_index.initiation | 52 |
| abstract_inverted_index.proportion | 118, 174 |
| abstract_inverted_index.testicular | 34, 79, 142 |
| abstract_inverted_index.treatment. | 133 |
| abstract_inverted_index.treatments | 17 |
| abstract_inverted_index.Prepubertal | 68 |
| abstract_inverted_index.conditions. | 67 |
| abstract_inverted_index.detrimental | 76 |
| abstract_inverted_index.development | 1 |
| abstract_inverted_index.elucidating | 11 |
| abstract_inverted_index.feasibility | 28 |
| abstract_inverted_index.prepubertal | 141 |
| abstract_inverted_index.progression | 170 |
| abstract_inverted_index.significant | 114 |
| abstract_inverted_index.spermatozoa | 120 |
| abstract_inverted_index.substantial | 173 |
| abstract_inverted_index.accomplished | 139 |
| abstract_inverted_index.administered | 18, 49 |
| abstract_inverted_index.chemotherapy | 7, 111 |
| abstract_inverted_index.daunorubicin | 48, 82, 152 |
| abstract_inverted_index.experimental | 3 |
| abstract_inverted_index.intratubular | 93, 187 |
| abstract_inverted_index.investigated | 38 |
| abstract_inverted_index.irrespective | 194 |
| abstract_inverted_index.seminiferous | 176 |
| abstract_inverted_index.spermatozoa. | 160 |
| abstract_inverted_index.administered. | 198 |
| abstract_inverted_index.chemotherapy, | 146 |
| abstract_inverted_index.double-strand | 184 |
| abstract_inverted_index.proliferation | 95 |
| abstract_inverted_index.spermatogonia | 158 |
| abstract_inverted_index.administration | 83 |
| abstract_inverted_index.differentiation | 155 |
| abstract_inverted_index.post-treatment. | 99 |
| abstract_inverted_index.spermatogenesis | 59, 106, 136 |
| abstract_inverted_index.spermatogonia-to-Sertoli | 88 |
| cited_by_percentile_year.max | 97 |
| cited_by_percentile_year.min | 95 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 8 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/2 |
| sustainable_development_goals[0].score | 0.6600000262260437 |
| sustainable_development_goals[0].display_name | Zero hunger |
| citation_normalized_percentile.value | 0.95462027 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |