In vivo development of immune tissue in human intestinal organoids transplanted into humanized mice Article Swipe
Carine Bouffi
,
Kathryn A. Wikenheiser‐Brokamp
,
Praneet Chaturvedi
,
Nambirajan Sundaram
,
Gillian R. Goddard
,
Mark Wunderlich
,
Nicole Brown
,
Janet F. Staab
,
Rachel Latanich
,
Nicholas C. Zachos
,
Emily M. Holloway
,
Maxime M. Mahé
,
Holly M. Poling
,
Simon Valès
,
Garrett W. Fisher
,
Jason R. Spence
,
James C. Mulloy
,
Aaron M. Zorn
,
James M. Wells
,
Michael A. Helmrath
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1038/s41587-022-01558-x
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1038/s41587-022-01558-x
Human intestinal organoids (HIOs) derived from pluripotent stem cells provide a valuable model for investigating human intestinal organogenesis and physiology, but they lack the immune components required to fully recapitulate the complexity of human intestinal biology and diseases. To address this issue and to begin to decipher human intestinal–immune crosstalk during development, we generated HIOs containing immune cells by transplanting HIOs under the kidney capsule of mice with a humanized immune system. We found that human immune cells temporally migrate to the mucosa and form cellular aggregates that resemble human intestinal lymphoid follicles. Moreover, after microbial exposure, epithelial microfold cells are increased in number, leading to immune cell activation determined by the secretion of IgA antibodies in the HIO lumen. This in vivo HIO system with human immune cells provides a framework for future studies on infection- or allergen-driven intestinal diseases.
Related Topics
Concepts
Immune system
Biology
Lymphatic system
Immunology
Humanized mouse
Induced pluripotent stem cell
Intestinal mucosa
Organoid
Cell biology
Embryonic stem cell
Medicine
Internal medicine
Gene
Biochemistry
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1038/s41587-022-01558-x
- https://www.nature.com/articles/s41587-022-01558-x.pdf
- OA Status
- hybrid
- Cited By
- 98
- References
- 41
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4318071589
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4318071589Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1038/s41587-022-01558-xDigital Object Identifier
- Title
-
In vivo development of immune tissue in human intestinal organoids transplanted into humanized miceWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2023Year of publication
- Publication date
-
2023-01-26Full publication date if available
- Authors
-
Carine Bouffi, Kathryn A. Wikenheiser‐Brokamp, Praneet Chaturvedi, Nambirajan Sundaram, Gillian R. Goddard, Mark Wunderlich, Nicole Brown, Janet F. Staab, Rachel Latanich, Nicholas C. Zachos, Emily M. Holloway, Maxime M. Mahé, Holly M. Poling, Simon Valès, Garrett W. Fisher, Jason R. Spence, James C. Mulloy, Aaron M. Zorn, James M. Wells, Michael A. HelmrathList of authors in order
- Landing page
-
https://doi.org/10.1038/s41587-022-01558-xPublisher landing page
- PDF URL
-
https://www.nature.com/articles/s41587-022-01558-x.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
hybridOpen access status per OpenAlex
- OA URL
-
https://www.nature.com/articles/s41587-022-01558-x.pdfDirect OA link when available
- Concepts
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Immune system, Biology, Lymphatic system, Immunology, Humanized mouse, Induced pluripotent stem cell, Intestinal mucosa, Organoid, Cell biology, Embryonic stem cell, Medicine, Internal medicine, Gene, BiochemistryTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
98Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 28, 2024: 50, 2023: 19, 2012: 1Per-year citation counts (last 5 years)
- References (count)
-
41Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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