In-vivo DEXA in large animal models: Does animal anatomy and positioning hold the clinical standards? Article Swipe
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· 2017
· Open Access
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· DOI: https://doi.org/10.4172/2329-9509.1000200
· OA: W2606965355
Bone loss is assessed by radiological testing to diagnose systemic musculoskeletal diseases and aging. DEXA measurement is gold standard in diagnoses of bone loss in preclinical and clinical studies. Sheep model of osteoporotic was utilized investigate the accuracy and precision of in-vivo and ex-vivo DEXA measurements. Lumbar vertebrae, left femur and left tibia were selected to assess BMD. Descriptive statistics and significance testing confirmed the accuracy and precision of ex-vivo over in-vivo measurements. Ex-vivo DEXA can enable researchers to utilize historical samples, thereby minimizing the number of experimental animals with no loss of information. Current study shows that intra-species anatomical differences and positioning on DEXA bed could result in BMD misinterpretation. The study indicates the precision of ex-vivo DEXA in BMD measurements.
