In vivo effects of cardiomyocyte-specific β-1 blockade on afterload- and frequency-dependent cardiac performance Article Swipe
Genri Numata
,
Yu Otsu
,
Shun Nakamura
,
Masayuki Toyoda
,
Hiroyuki Tokiwa
,
Yusuke Adachi
,
Taro Kariya
,
Kota Sueo
,
Mayo Shigeta
,
Takaya Abe
,
Tetsuo Sasano
,
Atsuhiko T. Naito
,
Issei Komuro
,
Eiki Takimoto
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1152/ajpheart.00795.2024
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1152/ajpheart.00795.2024
Although the benefits of β-1 adrenergic receptor (ADRB1) blockade to cardiovascular disease are established, in vivo role for cardiomyocyte ADRB1 remains undetermined. Generating cardiomyocyte-specific ADRB1 knockout mice, we show that ADRB1 is pivotal to cardiac functional recovery from afterload elevation and heart rate-dependent functional enhancement as well as baseline performance. Our findings highlight the importance of cardiomyocyte ADRB1 in cardiac stress adaptability, which is of clinical importance in the management of patients on β-blockers.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1152/ajpheart.00795.2024
- OA Status
- hybrid
- Cited By
- 3
- References
- 15
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4407037595
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4407037595Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1152/ajpheart.00795.2024Digital Object Identifier
- Title
-
In vivo effects of cardiomyocyte-specific β-1 blockade on afterload- and frequency-dependent cardiac performanceWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2025Year of publication
- Publication date
-
2025-01-31Full publication date if available
- Authors
-
Genri Numata, Yu Otsu, Shun Nakamura, Masayuki Toyoda, Hiroyuki Tokiwa, Yusuke Adachi, Taro Kariya, Kota Sueo, Mayo Shigeta, Takaya Abe, Tetsuo Sasano, Atsuhiko T. Naito, Issei Komuro, Eiki TakimotoList of authors in order
- Landing page
-
https://doi.org/10.1152/ajpheart.00795.2024Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
hybridOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.1152/ajpheart.00795.2024Direct OA link when available
- Concepts
-
Afterload, Internal medicine, Contractility, Cardiac function curve, Heart failure, Medicine, Cardiology, Phospholamban, Myocyte, Endocrinology, HemodynamicsTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
3Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 3Per-year citation counts (last 5 years)
- References (count)
-
15Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.from | 37 |
| abstract_inverted_index.role | 16 |
| abstract_inverted_index.show | 28 |
| abstract_inverted_index.that | 29 |
| abstract_inverted_index.vivo | 15 |
| abstract_inverted_index.well | 46 |
| abstract_inverted_index.β-1 | 4 |
| abstract_inverted_index.ADRB1 | 19, 24, 30, 57 |
| abstract_inverted_index.heart | 41 |
| abstract_inverted_index.mice, | 26 |
| abstract_inverted_index.which | 62 |
| abstract_inverted_index.stress | 60 |
| abstract_inverted_index.(ADRB1) | 7 |
| abstract_inverted_index.cardiac | 34, 59 |
| abstract_inverted_index.disease | 11 |
| abstract_inverted_index.pivotal | 32 |
| abstract_inverted_index.remains | 20 |
| abstract_inverted_index.Although | 0 |
| abstract_inverted_index.baseline | 48 |
| abstract_inverted_index.benefits | 2 |
| abstract_inverted_index.blockade | 8 |
| abstract_inverted_index.clinical | 65 |
| abstract_inverted_index.findings | 51 |
| abstract_inverted_index.knockout | 25 |
| abstract_inverted_index.patients | 71 |
| abstract_inverted_index.receptor | 6 |
| abstract_inverted_index.recovery | 36 |
| abstract_inverted_index.afterload | 38 |
| abstract_inverted_index.elevation | 39 |
| abstract_inverted_index.highlight | 52 |
| abstract_inverted_index.Generating | 22 |
| abstract_inverted_index.adrenergic | 5 |
| abstract_inverted_index.functional | 35, 43 |
| abstract_inverted_index.importance | 54, 66 |
| abstract_inverted_index.management | 69 |
| abstract_inverted_index.enhancement | 44 |
| abstract_inverted_index.established, | 13 |
| abstract_inverted_index.performance. | 49 |
| abstract_inverted_index.β-blockers. | 73 |
| abstract_inverted_index.adaptability, | 61 |
| abstract_inverted_index.cardiomyocyte | 18, 56 |
| abstract_inverted_index.undetermined. | 21 |
| abstract_inverted_index.cardiovascular | 10 |
| abstract_inverted_index.rate-dependent | 42 |
| abstract_inverted_index.cardiomyocyte-specific | 23 |
| cited_by_percentile_year.max | 97 |
| cited_by_percentile_year.min | 96 |
| countries_distinct_count | 2 |
| institutions_distinct_count | 14 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.8299999833106995 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.92246476 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |