In Vivo Imaging of Acute Hindlimb Ischaemia in Rat Model: A Pre-Clinical PET Study Article Swipe
Gergely Farkasinszky
,
Judit Szabó Péliné
,
Péter Károlyi
,
Szilvia Rácz
,
Noémi Dénes
,
Tamás Papp
,
József Király
,
Zsuzsanna Szabó
,
István Kertész
,
Gábor Mező
,
Gábor Halmos
,
Zita Képes
,
György Trencsényi
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3390/pharmaceutics16040542
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3390/pharmaceutics16040542
Background: To better understand ischaemia-related molecular alterations, temporal changes in angiogenic Aminopeptidase N (APN/CD13) expression and glucose metabolism were assessed with PET using a rat model of peripheral arterial disease (PAD). Methods: The mechanical occlusion of the base of the left hindlimb triggered using a tourniquet was applied to establish the ischaemia/reperfusion injury model in Fischer-344 rats. 2-[18F]FDG and [68Ga]Ga-NOTA-c(NGR) PET imaging performed 1, 3, 5, 7, and 10 days post-ischaemia induction was followed by Western blotting and immunohistochemical staining for APN/CD13 in ischaemic and control muscle tissue extracts. Results: Due to a cellular adaptation to hypoxia, a gradual increase in [68Ga]Ga-NOTA-c(NGR) and 2-[18F]FDG uptake was observed from post-intervention day 1 to 7 in the ischaemic hindlimbs, which was followed by a drop on day 10. Conforming pronounced angiogenic recovery, the NGR accretion of the ischaemic extremities differed significantly from the controls 5, 7, and 10 days after ischaemia induction (p ≤ 0.05), which correlated with the Western blot and immunohistochemical results. No remarkable radioactivity was depicted between the normally perfused hindlimbs of either the ischaemic or the control groups. Conclusions: The PET-based longitudinal assessment of angiogenesis-associated APN/CD13 expression and glucose metabolism during ischaemia may continue to broaden our knowledge on the pathophysiology of PAD.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/pharmaceutics16040542
- https://www.mdpi.com/1999-4923/16/4/542/pdf?version=1713162061
- OA Status
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- Cited By
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- References
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- Related Works
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- OpenAlex ID
- https://openalex.org/W4394806203
All OpenAlex metadata
Raw OpenAlex JSON
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https://openalex.org/W4394806203Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/pharmaceutics16040542Digital Object Identifier
- Title
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In Vivo Imaging of Acute Hindlimb Ischaemia in Rat Model: A Pre-Clinical PET StudyWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2024Year of publication
- Publication date
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2024-04-15Full publication date if available
- Authors
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Gergely Farkasinszky, Judit Szabó Péliné, Péter Károlyi, Szilvia Rácz, Noémi Dénes, Tamás Papp, József Király, Zsuzsanna Szabó, István Kertész, Gábor Mező, Gábor Halmos, Zita Képes, György TrencsényiList of authors in order
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https://doi.org/10.3390/pharmaceutics16040542Publisher landing page
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https://www.mdpi.com/1999-4923/16/4/542/pdf?version=1713162061Direct link to full text PDF
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goldOpen access status per OpenAlex
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https://www.mdpi.com/1999-4923/16/4/542/pdf?version=1713162061Direct OA link when available
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In vivo, Hindlimb, Medicine, Ischemia, Cardiology, Internal medicine, Biology, BiotechnologyTop concepts (fields/topics) attached by OpenAlex
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10Other works algorithmically related by OpenAlex
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