In Vivo Nanodetoxication for Acute Uranium Exposure Article Swipe

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Uranium In vivo Uranyl Toxicity Acute toxicity Chemistry Pharmacology Nephrotoxicity Dendrimer Chemical toxicity In vitro Chelation Depleted uranium Radiochemistry Environmental chemistry Nuclear chemistry Toxicology Biochemistry Medicine Biology Organic chemistry Materials science Biotechnology Metallurgy

Luís Guzmán , Esteban F. Durán‐Lara , Wendy Donoso , Fabiane M. Nachtigall , Leonardo S. Santos ·

YOU? · · 2015 · Open Access · · DOI: https://doi.org/10.3390/molecules200611017 · OA: W1572766219

Accidental exposure to uranium is a matter of concern, as U(VI) is nephrotoxic in both human and animal models, and its toxicity is associated to chemical toxicity instead of radioactivity. We synthesized different PAMAM G4 and G5 derivatives in order to prove their interaction with uranium and their effect on the viability of red blood cells in vitro. Furthermore, we prove the effectiveness of the selected dendrimers in an animal model of acute uranium intoxication. The dendrimer PAMAM G4-Lys-Fmoc-Cbz demonstrated the ability to chelate the uranyl ion in vivo, improving the biochemical and histopathologic features caused by acute intoxication with uranium.