In vivo vaccine generation with a topical small molecule cocktail to eradicates AML and PDAC Article Swipe
S. Lilly Zheng
,
Mengyuan Li
,
Zhaoxing Wu
,
Xuzhao Zhang
,
Xiaoxian Gan
,
Rongzhen Xu
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1101/2025.10.19.683274
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1101/2025.10.19.683274
Using vaccine to cure cancer has been expected for over 130 years, but remains a big challenge. Here we present a novel in vivo personal and off-the-shelf vaccine generation strategy with unique mechanism, which is very simple but high efficacy, using a small molecule cocktail as antigen-agnostic vaccine. In mouse AML and PDAC models, this in vivo vaccine rapidly eliminated tumors via triggering inflamed immunogenic cell death to release antigens, activating NK and DC cells, inducing innate and adaptive immunity in blood, lymph node, spleen, bone marrow and TME, and elicited a robust long-term immune memory. Importantly, this small molecule cocktail-based platform holds the potential to make in vivo vaccine more personal and accessible. It might represent a promising avenue for pan-cancer immunotherapy.
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Metadata
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- preprint
- Landing Page
- https://doi.org/10.1101/2025.10.19.683274
- https://www.biorxiv.org/content/biorxiv/early/2025/10/20/2025.10.19.683274.full.pdf
- OA Status
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- References
- 45
- OpenAlex ID
- https://openalex.org/W4415367187
All OpenAlex metadata
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https://openalex.org/W4415367187Canonical identifier for this work in OpenAlex
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https://doi.org/10.1101/2025.10.19.683274Digital Object Identifier
- Title
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In vivo vaccine generation with a topical small molecule cocktail to eradicates AML and PDACWork title
- Type
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preprintOpenAlex work type
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2025Year of publication
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2025-10-20Full publication date if available
- Authors
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S. Lilly Zheng, Mengyuan Li, Zhaoxing Wu, Xuzhao Zhang, Xiaoxian Gan, Rongzhen XuList of authors in order
- Landing page
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https://doi.org/10.1101/2025.10.19.683274Publisher landing page
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https://www.biorxiv.org/content/biorxiv/early/2025/10/20/2025.10.19.683274.full.pdfDirect link to full text PDF
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YesWhether a free full text is available
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greenOpen access status per OpenAlex
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https://www.biorxiv.org/content/biorxiv/early/2025/10/20/2025.10.19.683274.full.pdfDirect OA link when available
- Cited by
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0Total citation count in OpenAlex
- References (count)
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45Number of works referenced by this work
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