Incidence and Predictors of Chronic Thromboembolic Pulmonary Hypertension Following First Episode of Acute Pulmonary Embolism Article Swipe
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· 2020
· Open Access
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· DOI: https://doi.org/10.5603/arm.a2020.0200
Introduction: Late obstructive pulmonary artery remodeling presented as CTEPH portends adverse sequelae and therapeutic challenges. Although progressive dyspnea on exertion beyond three-month period of treatment with anticoagulants is a diagnostic cornerstone, uncertainty still surrounds early identification and risk factors. Material and methods: We have conducted a prospective study among survivors of acute pulmonary embolism (PE) who were treated by anticoagulants for at least 3 months. Patients with preexisting pulmonary hypertension (PH), severe chronic obstructive pulmonary disease (COPD), and low ejection fraction (EF) in baseline echocardiography (EF < 30%) were excluded. Complete follow-up for 290 subjects were performed. According to a predetermined stepwise diagnostic protocol, patients with exertional Dyspnea and PH probable features in echocardiography underwent lung perfusion scan. Results: Cumulative two-year incidence of CTEPH was 8.6% (n = 25). There was no patient with normal baseline right ventricular (RV) function in CTEPH group. In the same way, none of these patients had only segmental involvement in baseline CT angiography (CTA) in CTEPH group. Greater proportion of CTEPH group received fibrinolytic therapy, however the difference was not significant (2.6% vs. 8 %, P = 0.16). Multivariate logistic regression demonstrated significant association of RV diameter, and PAP in baseline echocardiography as well as RV strain in CTA with development of CTEPH. Corresponding odds ratios were 1.147 (1.063–1.584) P < 0.0001) , 1.062 (1.019–1.106, P = 0.004), and 2.537 (1.041–6.674), P = 0.027), respectively. Conclusions: We found that incidence of CTEPH was relatively high in the present investigation. RV diameter, baseline PAP and RV dysfunction were independent predictors of CTEPH.
Related Topics
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.5603/arm.a2020.0200
- https://journals.viamedica.pl/advances_in_respiratory_medicine/article/download/ARM.a2020.0200/52845
- OA Status
- gold
- Cited By
- 4
- References
- 28
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3120702896
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3120702896Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.5603/arm.a2020.0200Digital Object Identifier
- Title
-
Incidence and Predictors of Chronic Thromboembolic Pulmonary Hypertension Following First Episode of Acute Pulmonary EmbolismWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2020Year of publication
- Publication date
-
2020-12-30Full publication date if available
- Authors
-
Sahar Asl Fallah, Saeed Ghodsi, Hamidreza Soleimani, Mehrnaz Mohebi, Ali Hossein Sabet, Hamid Ariannejad, shahpour shirani, Sakineh Jahanian, Yaser JenabList of authors in order
- Landing page
-
https://doi.org/10.5603/arm.a2020.0200Publisher landing page
- PDF URL
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https://journals.viamedica.pl/advances_in_respiratory_medicine/article/download/ARM.a2020.0200/52845Direct link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
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https://journals.viamedica.pl/advances_in_respiratory_medicine/article/download/ARM.a2020.0200/52845Direct OA link when available
- Concepts
-
Medicine, Cardiology, Internal medicine, Pulmonary embolism, Pulmonary angiography, Pulmonary hypertension, Pulmonary artery, Ejection fraction, Incidence (geometry), COPD, Heart failure, Optics, PhysicsTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
4Total citation count in OpenAlex
- Citations by year (recent)
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2024: 1, 2022: 2, 2021: 1Per-year citation counts (last 5 years)
- References (count)
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28Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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