Inclusion body myositis: The interplay between ageing, muscle degeneration and autoimmunity Article Swipe
Emily McLeish
,
Nataliya Slater
,
Anuradha Sooda
,
Andrew D. Wilson
,
Jérôme D. Coudert
,
Thomas E. Lloyd
,
Merrilee Needham
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1016/j.berh.2022.101761
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1016/j.berh.2022.101761
Inclusion body myositis (IBM) is a slowly progressive muscle disease affecting ageing individuals. IBM presents with a distinctive pattern of weakness involving the quadriceps and finger flexor muscles, although other muscles including pharyngeal muscles become affected over time. Pathological hallmarks of IBM include autoimmune features, including endomysial infiltration by highly differentiated T cells, as well as degenerative features marked by intramyofibre protein aggregates organised into inclusion bodies. Despite some progress in understanding the cellular pathways involved in IBM, it remains untreatable, and the progression of the disease leads to progressive weakness, disability, wheelchair dependency and loss of independence. Therefore, there is an urgent need to improve our understanding of the underlying mechanisms and pathways involved in this disease to identify new treatment targets. Here, we discuss the current understanding of aetiopathogenesis, the interrelationship between autoimmunity and degeneration, and how ageing is a major influencer of both these features.
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Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.1016/j.berh.2022.101761
- OA Status
- hybrid
- Cited By
- 18
- References
- 102
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4283463193
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4283463193Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1016/j.berh.2022.101761Digital Object Identifier
- Title
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Inclusion body myositis: The interplay between ageing, muscle degeneration and autoimmunityWork title
- Type
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reviewOpenAlex work type
- Language
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enPrimary language
- Publication year
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2022Year of publication
- Publication date
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2022-06-01Full publication date if available
- Authors
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Emily McLeish, Nataliya Slater, Anuradha Sooda, Andrew D. Wilson, Jérôme D. Coudert, Thomas E. Lloyd, Merrilee NeedhamList of authors in order
- Landing page
-
https://doi.org/10.1016/j.berh.2022.101761Publisher landing page
- Open access
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YesWhether a free full text is available
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hybridOpen access status per OpenAlex
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https://doi.org/10.1016/j.berh.2022.101761Direct OA link when available
- Concepts
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Inclusion body myositis, Medicine, Degeneration (medical), Myositis, Autoimmunity, Ageing, Weakness, Muscle weakness, Disease, Sarcopenia, Neuroscience, Physical medicine and rehabilitation, Pathology, Anatomy, Biology, Internal medicineTop concepts (fields/topics) attached by OpenAlex
- Cited by
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18Total citation count in OpenAlex
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2025: 5, 2024: 10, 2023: 3Per-year citation counts (last 5 years)
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10Other works algorithmically related by OpenAlex
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