Inclusive Clinical Trials in Alzheimer’s Disease: A Latin American Perspective from LatAm FINGERS Article Swipe
YOU?
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· 2024
· Open Access
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· DOI: https://doi.org/10.1002/alz.085948
Background The LatAm‐FINGERS trial marks a pioneering initiative as the first non‐pharmacological clinical trial encompassing participants from 12 Latin American countries, including Argentina, Brazil, Bolivia, Chile, Colombia, Costa Rica, Ecuador, Dominican Republic, Mexico, Peru, Puerto Rico, and Uruguay. This initiative represents a significant advancement in promoting inclusivity and diversity in clinical trial recruitment, particularly in underserved populations. Method The LatAm‐FINGERS trial is a multicenter randomized clinical trial evaluating a lifestyle intervention tailored for the Latin American population. Innovative and culturally sensitive recruitment methods were employed, utilizing social media, community outreach, and partnerships with religious groups to ensure inclusivity. The multidomain intervention includes diet, physical exercise, cognitive training, and health coaching and socialization. The intervention was delivered in teams of ten, with adherence strategies including moderated chat groups, dietary adaptations to local customs, shared cultural celebrations, recognition awards, personalized video tutorials, engagement calls, and motivational elements. These approaches facilitated participant retention and engagement despite socio‐economic challenges. Result Despite challenges such as transportation difficulties and risks of violence in certain regions, the trial effectively implemented prevention strategies across a diverse demographic spectrum. Recruitment for LatAm‐FINGERS began in December 2021. To date, 1186 participants (98.8%) have been randomized into the intervention group. The average age of participants is 69 (SD = 2.5) years, with an average educational level of 12.4 (SD = 3.4) years, and an MMSE score of 27.32 (SD = 1.68). The diversity of the Latin American population is evident in the self‐reported ethnicity data: 57.1% Mestizo, 27.7% White, 5.5% Mixed, 2% Black, 1% Native American, and 5.7% other. Conclusion Preliminary findings from LatAm‐FINGERS highlight the feasibility of conducting intervention trials within diverse populations. These findings underscore the importance of creating recruitment strategies that effectively engage underrepresented groups. This contributes significantly to global Alzheimer’s disease research efforts. The trial’s experience offers a valuable model for inclusive enrollment practices in Alzheimer’s disease and related dementia research, aligning with contemporary trends toward equitable and evidence‐based trial design.
Related Topics
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1002/alz.085948
- OA Status
- hybrid
- Related Works
- 10
- OpenAlex ID
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Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4406224028Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1002/alz.085948Digital Object Identifier
- Title
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Inclusive Clinical Trials in Alzheimer’s Disease: A Latin American Perspective from LatAm FINGERSWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2024Year of publication
- Publication date
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2024-12-01Full publication date if available
- Authors
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Lucía Crivelli, Ismael Luis Calandri, Paulo Caramelli, Francisco Lopera, Ricardo Nitríni, Ana Luisa Sosa, Rosa Maria Salinas‐Contreras, Cláudia Kimie Suemoto, Lina Velilla, Monica Sanches Yassuda, Gustavo Sevlever, Daisy Acosta, Ana Charamelo, María Isabel Cusicanqui, Nilton Custodio, Carolina Delgado, Lissette Duque, Ivonne Z. Jiménez Velázquez, Jorge M Leon‐Salas, Heather M. Snyder, Miia Kivipelto, Marı́a C. Carrillo, Ricardo Allegri, LatAm‐FINGERS ConsortiumList of authors in order
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https://doi.org/10.1002/alz.085948Publisher landing page
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YesWhether a free full text is available
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hybridOpen access status per OpenAlex
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https://doi.org/10.1002/alz.085948Direct OA link when available
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Latin Americans, Outreach, Population, Intervention (counseling), Clinical trial, Randomized controlled trial, Health equity, Ethnic group, Socialization, Medicine, Gerontology, Psychology, Family medicine, Political science, Public health, Nursing, Social psychology, Environmental health, Pathology, Surgery, LawTop concepts (fields/topics) attached by OpenAlex
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0Total citation count in OpenAlex
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.2% | 251 |
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| abstract_inverted_index.as | 9, 160 |
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| institutions_distinct_count | 24 |
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| citation_normalized_percentile.is_in_top_10_percent | False |