Frontiers in Immunology • Vol 14
Incorporating inflammatory biomarkers into a prognostic risk score in patients with non-ischemic heart failure: a machine learning approach
August 2023 • Jiayu Feng, Xuemei Zhao, Boping Huang, Liyan Huang, Yihang Wu, Jing Wang, Jingyuan Guan, Xinqing Li, Yuhui Zhang, Jian Zhang
Objectives Inflammation is involved in the mechanisms of non-ischemic heart failure (NIHF). We aimed to investigate the prognostic value of 21 inflammatory biomarkers and construct a biomarker risk score to improve risk prediction for patients with NIHF. Methods Patients diagnosed with NIHF without infection during hospitalization were included. The primary outcome was defined as all-cause mortality and heart transplantations. We used elastic net Cox regression with cross-validation to select inflammatory biomarke…