Incorporating structural abnormalities in equivalent dipole layer based ECG simulations Article Swipe
Machteld Boonstra
,
Thom F. Oostendorp
,
Rob Roudijk
,
Manon Kloosterman
,
Folkert W. Asselbergs
,
Peter Loh
,
Peter van Dam
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.3389/fphys.2022.1089343
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.3389/fphys.2022.1089343
Introduction: Electrical activity of the myocardium is recorded with the 12-lead ECG. ECG simulations can improve our understanding of the relation between abnormal ventricular activation in diseased myocardium and body surface potentials (BSP). However, in equivalent dipole layer (EDL)-based ECG simulations, the presence of diseased myocardium breaks the equivalence of the dipole layer. To simulate diseased myocardium, patches with altered electrophysiological characteristics were incorporated within the model. The relation between diseased myocardium and corresponding BSP was investigated in a simulation study. Methods: Activation sequences in normal and diseased myocardium were simulated and corresponding 64-lead BSP were computed in four models with distinct patch locations. QRS-complexes were compared using correlation coefficient (CC). The effect of different types of patch activation was assessed. Of one patient, simulated electrograms were compared to electrograms recorded during invasive electro-anatomical mapping. Results: Hundred-fifty-three abnormal activation sequences were simulated. Median QRS-CC of delayed versus dyssynchronous were significantly different (1.00 vs. 0.97, p < 0.001). Depending on the location of the patch, BSP leads were affected differently. Within diseased regions, fragmentation, low bipolar voltages and late potentials were observed in both recorded and simulated electrograms. Discussion: A novel method to simulate cardiomyopathy in EDL-based ECG simulations was established and evaluated. The new patch-based approach created a realistic relation between ECG waveforms and underlying activation sequences. Findings in the simulated cases were in agreement with clinical observations. With this method, our understanding of disease progression in cardiomyopathies may be further improved and used in advanced inverse ECG procedures.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3389/fphys.2022.1089343
- https://www.frontiersin.org/articles/10.3389/fphys.2022.1089343/pdf
- OA Status
- gold
- Cited By
- 4
- References
- 51
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4312188313
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Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4312188313Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3389/fphys.2022.1089343Digital Object Identifier
- Title
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Incorporating structural abnormalities in equivalent dipole layer based ECG simulationsWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2022Year of publication
- Publication date
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2022-12-22Full publication date if available
- Authors
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Machteld Boonstra, Thom F. Oostendorp, Rob Roudijk, Manon Kloosterman, Folkert W. Asselbergs, Peter Loh, Peter van DamList of authors in order
- Landing page
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https://doi.org/10.3389/fphys.2022.1089343Publisher landing page
- PDF URL
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https://www.frontiersin.org/articles/10.3389/fphys.2022.1089343/pdfDirect link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://www.frontiersin.org/articles/10.3389/fphys.2022.1089343/pdfDirect OA link when available
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Layer (electronics), Computer science, Physics, Materials science, NanotechnologyTop concepts (fields/topics) attached by OpenAlex
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4Total citation count in OpenAlex
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2025: 1, 2024: 3Per-year citation counts (last 5 years)
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10Other works algorithmically related by OpenAlex
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