Increased breakdown of kynurenine towards its neurotoxic branch in bipolar disorder Article Swipe
Armin Birner
,
Martina Platzer
,
Susanne Bengesser
,
Nina Dalkner
,
Frederike T. Fellendorf
,
Robert Queissner
,
René Pilz
,
Philipp J. Rauch
,
Alexander Maget
,
Carlo Hamm
,
Simone Herzog-Eberhard
,
Harald Mangge
,
Dietmar Fuchs
,
Natalie Moll
,
Sieglinde Zelzer
,
Gregor Schütze
,
Markus Schwarz
,
Bernd Reininghaus
,
Hans‐Peter Kapfhammer
,
Eva Z. Reininghaus
·
YOU?
·
· 2017
· Open Access
·
· DOI: https://doi.org/10.1371/journal.pone.0172699
YOU?
·
· 2017
· Open Access
·
· DOI: https://doi.org/10.1371/journal.pone.0172699
In conclusion our findings subserve the concept of KYN -pathway alterations in the pathophysiology of BD. We present evidence of increased breakdown towards the neurotoxic branch in KYN metabolism even in a euthymic to mild depressive state in BD. From literature we know that depression and mania are accompanied by inflammatory states which should be capable to produce an even greater imbalance due to activation of key enzymes in the neurotoxic direction of KYN -conversion. These processes could finally be involved in the development of unspecific brain structural changes and cognitive deficits which are prevalent in BD. Further research should focus on state dependent changes in TRYCATs and its relation to cognition, brain structure and staging parameters.
Related Topics
Concepts
Kynurenine
Kynurenic acid
Kynurenine pathway
Neuroprotection
Quinolinic acid
Bipolar disorder
Internal medicine
Medicine
Endocrinology
Tryptophan
Chemistry
Biochemistry
Glutamate receptor
Amino acid
Lithium (medication)
Receptor
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1371/journal.pone.0172699
- https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0172699&type=printable
- OA Status
- gold
- Cited By
- 84
- References
- 45
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2592307528
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W2592307528Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1371/journal.pone.0172699Digital Object Identifier
- Title
-
Increased breakdown of kynurenine towards its neurotoxic branch in bipolar disorderWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2017Year of publication
- Publication date
-
2017-02-27Full publication date if available
- Authors
-
Armin Birner, Martina Platzer, Susanne Bengesser, Nina Dalkner, Frederike T. Fellendorf, Robert Queissner, René Pilz, Philipp J. Rauch, Alexander Maget, Carlo Hamm, Simone Herzog-Eberhard, Harald Mangge, Dietmar Fuchs, Natalie Moll, Sieglinde Zelzer, Gregor Schütze, Markus Schwarz, Bernd Reininghaus, Hans‐Peter Kapfhammer, Eva Z. ReininghausList of authors in order
- Landing page
-
https://doi.org/10.1371/journal.pone.0172699Publisher landing page
- PDF URL
-
https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0172699&type=printableDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0172699&type=printableDirect OA link when available
- Concepts
-
Kynurenine, Kynurenic acid, Kynurenine pathway, Neuroprotection, Quinolinic acid, Bipolar disorder, Internal medicine, Medicine, Endocrinology, Tryptophan, Chemistry, Biochemistry, Glutamate receptor, Amino acid, Lithium (medication), ReceptorTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
84Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 4, 2024: 10, 2023: 5, 2022: 15, 2021: 14Per-year citation counts (last 5 years)
- References (count)
-
45Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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