Increased intrinsic membrane excitability is associated with olivary hypertrophy in spinocerebellar ataxia type 1 Article Swipe
Logan M Morrison
,
Haoran Huang
,
Hillary P. Handler
,
Min Fu
,
Deborah M. Jones
,
David D. Bushart
,
Samuel S. Pappas
,
Harry T. Orr
,
Vikram G. Shakkottai
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1093/hmg/ddae146
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1093/hmg/ddae146
One of the characteristic regions of brainstem degeneration across multiple spinocerebellar ataxias (SCAs) is the inferior olive (IO), a medullary nucleus that plays a key role in motor learning. The vulnerability of IO neurons remains a poorly-understood area of SCA pathology. In this work, we address this by evaluating IO disease in SCA1, a prototypic inherited olivopontocerebellar atrophy, using the genetically-precise SCA1 knock-in (SCA1-KI) mouse. We find that these mice exhibit olivary hypertrophy, a phenotype reminiscent of a degenerative disorder known as hypertrophic olivary degeneration (HOD). Similar to early stages of HOD, SCA1-KI IO neurons display early dendritic lengthening and later somatic expansion without frank cell loss. Though HOD is known to be caused by brainstem lesions that disrupt IO inhibitory innervation, we observe no loss of inhibitory terminals in the SCA1-KI IO. Additionally, we find that a separate mouse model of SCA1 in which mutant ATXN1 is expressed solely in cerebellar Purkinje cells shows no evidence of olivary hypertrophy. Patch-clamp recordings from brainstem slices indicate that SCA1-KI IO neurons are hyperexcitable, generating spike trains in response to membrane depolarization. Transcriptome analysis further reveals reduced medullary expression of ion channels responsible for IO neuron spike afterhyperpolarization (AHP)—a result that appears to have a functional consequence, as SCA1-KI IO neuron spikes exhibit a diminished AHP. These findings suggest that expression of mutant ATXN1 in IO neurons results in an HOD-like olivary hypertrophy, in association with increased intrinsic membrane excitability and ion channel transcriptional dysregulation.
Related Topics
Concepts
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1093/hmg/ddae146
- https://academic.oup.com/hmg/advance-article-pdf/doi/10.1093/hmg/ddae146/60216159/ddae146.pdf
- OA Status
- hybrid
- References
- 73
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4403886755
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4403886755Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1093/hmg/ddae146Digital Object Identifier
- Title
-
Increased intrinsic membrane excitability is associated with olivary hypertrophy in spinocerebellar ataxia type 1Work title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-10-30Full publication date if available
- Authors
-
Logan M Morrison, Haoran Huang, Hillary P. Handler, Min Fu, Deborah M. Jones, David D. Bushart, Samuel S. Pappas, Harry T. Orr, Vikram G. ShakkottaiList of authors in order
- Landing page
-
https://doi.org/10.1093/hmg/ddae146Publisher landing page
- PDF URL
-
https://academic.oup.com/hmg/advance-article-pdf/doi/10.1093/hmg/ddae146/60216159/ddae146.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
hybridOpen access status per OpenAlex
- OA URL
-
https://academic.oup.com/hmg/advance-article-pdf/doi/10.1093/hmg/ddae146/60216159/ddae146.pdfDirect OA link when available
- Concepts
-
Spinocerebellar ataxia, Biology, Neuroscience, Degenerative disease, Ataxia, Central nervous system diseaseTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
0Total citation count in OpenAlex
- References (count)
-
73Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W4403886755 |
|---|---|
| doi | https://doi.org/10.1093/hmg/ddae146 |
| ids.doi | https://doi.org/10.1093/hmg/ddae146 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/39475127 |
| ids.openalex | https://openalex.org/W4403886755 |
| fwci | 0.0 |
| mesh[0].qualifier_ui | |
| mesh[0].descriptor_ui | D000818 |
| mesh[0].is_major_topic | False |
| mesh[0].qualifier_name | |
| mesh[0].descriptor_name | Animals |
| mesh[1].qualifier_ui | Q000473 |
| mesh[1].descriptor_ui | D009847 |
| mesh[1].is_major_topic | True |
| mesh[1].qualifier_name | pathology |
| mesh[1].descriptor_name | Olivary Nucleus |
| mesh[2].qualifier_ui | Q000503 |
| mesh[2].descriptor_ui | D009847 |
| mesh[2].is_major_topic | True |
| mesh[2].qualifier_name | physiopathology |
| mesh[2].descriptor_name | Olivary Nucleus |
| mesh[3].qualifier_ui | Q000378 |
| mesh[3].descriptor_ui | D009847 |
| mesh[3].is_major_topic | True |
| mesh[3].qualifier_name | metabolism |
| mesh[3].descriptor_name | Olivary Nucleus |
| mesh[4].qualifier_ui | |
| mesh[4].descriptor_ui | D051379 |
| mesh[4].is_major_topic | False |
| mesh[4].qualifier_name | |
| mesh[4].descriptor_name | Mice |
| mesh[5].qualifier_ui | Q000235 |
| mesh[5].descriptor_ui | D000067696 |
| mesh[5].is_major_topic | True |
| mesh[5].qualifier_name | genetics |
| mesh[5].descriptor_name | Ataxin-1 |
| mesh[6].qualifier_ui | Q000378 |
| mesh[6].descriptor_ui | D000067696 |
| mesh[6].is_major_topic | True |
| mesh[6].qualifier_name | metabolism |
| mesh[6].descriptor_name | Ataxin-1 |
| mesh[7].qualifier_ui | Q000235 |
| mesh[7].descriptor_ui | D020754 |
| mesh[7].is_major_topic | True |
| mesh[7].qualifier_name | genetics |
| mesh[7].descriptor_name | Spinocerebellar Ataxias |
| mesh[8].qualifier_ui | Q000503 |
| mesh[8].descriptor_ui | D020754 |
| mesh[8].is_major_topic | True |
| mesh[8].qualifier_name | physiopathology |
| mesh[8].descriptor_name | Spinocerebellar Ataxias |
| mesh[9].qualifier_ui | Q000473 |
| mesh[9].descriptor_ui | D020754 |
| mesh[9].is_major_topic | True |
| mesh[9].qualifier_name | pathology |
| mesh[9].descriptor_name | Spinocerebellar Ataxias |
| mesh[10].qualifier_ui | |
| mesh[10].descriptor_ui | D004195 |
| mesh[10].is_major_topic | True |
| mesh[10].qualifier_name | |
| mesh[10].descriptor_name | Disease Models, Animal |
| mesh[11].qualifier_ui | Q000235 |
| mesh[11].descriptor_ui | D006984 |
| mesh[11].is_major_topic | True |
| mesh[11].qualifier_name | genetics |
| mesh[11].descriptor_name | Hypertrophy |
| mesh[12].qualifier_ui | Q000503 |
| mesh[12].descriptor_ui | D006984 |
| mesh[12].is_major_topic | True |
| mesh[12].qualifier_name | physiopathology |
| mesh[12].descriptor_name | Hypertrophy |
| mesh[13].qualifier_ui | Q000378 |
| mesh[13].descriptor_ui | D011689 |
| mesh[13].is_major_topic | False |
| mesh[13].qualifier_name | metabolism |
| mesh[13].descriptor_name | Purkinje Cells |
| mesh[14].qualifier_ui | Q000473 |
| mesh[14].descriptor_ui | D011689 |
| mesh[14].is_major_topic | False |
| mesh[14].qualifier_name | pathology |
| mesh[14].descriptor_name | Purkinje Cells |
| mesh[15].qualifier_ui | Q000378 |
| mesh[15].descriptor_ui | D009474 |
| mesh[15].is_major_topic | False |
| mesh[15].qualifier_name | metabolism |
| mesh[15].descriptor_name | Neurons |
| mesh[16].qualifier_ui | Q000473 |
| mesh[16].descriptor_ui | D009474 |
| mesh[16].is_major_topic | False |
| mesh[16].qualifier_name | pathology |
| mesh[16].descriptor_name | Neurons |
| mesh[17].qualifier_ui | |
| mesh[17].descriptor_ui | D006801 |
| mesh[17].is_major_topic | False |
| mesh[17].qualifier_name | |
| mesh[17].descriptor_name | Humans |
| mesh[18].qualifier_ui | |
| mesh[18].descriptor_ui | D055879 |
| mesh[18].is_major_topic | False |
| mesh[18].qualifier_name | |
| mesh[18].descriptor_name | Gene Knock-In Techniques |
| mesh[19].qualifier_ui | |
| mesh[19].descriptor_ui | D000818 |
| mesh[19].is_major_topic | False |
| mesh[19].qualifier_name | |
| mesh[19].descriptor_name | Animals |
| mesh[20].qualifier_ui | Q000473 |
| mesh[20].descriptor_ui | D009847 |
| mesh[20].is_major_topic | True |
| mesh[20].qualifier_name | pathology |
| mesh[20].descriptor_name | Olivary Nucleus |
| mesh[21].qualifier_ui | Q000503 |
| mesh[21].descriptor_ui | D009847 |
| mesh[21].is_major_topic | True |
| mesh[21].qualifier_name | physiopathology |
| mesh[21].descriptor_name | Olivary Nucleus |
| mesh[22].qualifier_ui | Q000378 |
| mesh[22].descriptor_ui | D009847 |
| mesh[22].is_major_topic | True |
| mesh[22].qualifier_name | metabolism |
| mesh[22].descriptor_name | Olivary Nucleus |
| mesh[23].qualifier_ui | |
| mesh[23].descriptor_ui | D051379 |
| mesh[23].is_major_topic | False |
| mesh[23].qualifier_name | |
| mesh[23].descriptor_name | Mice |
| mesh[24].qualifier_ui | Q000235 |
| mesh[24].descriptor_ui | D000067696 |
| mesh[24].is_major_topic | True |
| mesh[24].qualifier_name | genetics |
| mesh[24].descriptor_name | Ataxin-1 |
| mesh[25].qualifier_ui | Q000378 |
| mesh[25].descriptor_ui | D000067696 |
| mesh[25].is_major_topic | True |
| mesh[25].qualifier_name | metabolism |
| mesh[25].descriptor_name | Ataxin-1 |
| mesh[26].qualifier_ui | Q000235 |
| mesh[26].descriptor_ui | D020754 |
| mesh[26].is_major_topic | True |
| mesh[26].qualifier_name | genetics |
| mesh[26].descriptor_name | Spinocerebellar Ataxias |
| mesh[27].qualifier_ui | Q000503 |
| mesh[27].descriptor_ui | D020754 |
| mesh[27].is_major_topic | True |
| mesh[27].qualifier_name | physiopathology |
| mesh[27].descriptor_name | Spinocerebellar Ataxias |
| mesh[28].qualifier_ui | Q000473 |
| mesh[28].descriptor_ui | D020754 |
| mesh[28].is_major_topic | True |
| mesh[28].qualifier_name | pathology |
| mesh[28].descriptor_name | Spinocerebellar Ataxias |
| mesh[29].qualifier_ui | |
| mesh[29].descriptor_ui | D004195 |
| mesh[29].is_major_topic | True |
| mesh[29].qualifier_name | |
| mesh[29].descriptor_name | Disease Models, Animal |
| mesh[30].qualifier_ui | Q000235 |
| mesh[30].descriptor_ui | D006984 |
| mesh[30].is_major_topic | True |
| mesh[30].qualifier_name | genetics |
| mesh[30].descriptor_name | Hypertrophy |
| mesh[31].qualifier_ui | Q000503 |
| mesh[31].descriptor_ui | D006984 |
| mesh[31].is_major_topic | True |
| mesh[31].qualifier_name | physiopathology |
| mesh[31].descriptor_name | Hypertrophy |
| mesh[32].qualifier_ui | Q000378 |
| mesh[32].descriptor_ui | D011689 |
| mesh[32].is_major_topic | False |
| mesh[32].qualifier_name | metabolism |
| mesh[32].descriptor_name | Purkinje Cells |
| mesh[33].qualifier_ui | Q000473 |
| mesh[33].descriptor_ui | D011689 |
| mesh[33].is_major_topic | False |
| mesh[33].qualifier_name | pathology |
| mesh[33].descriptor_name | Purkinje Cells |
| mesh[34].qualifier_ui | Q000378 |
| mesh[34].descriptor_ui | D009474 |
| mesh[34].is_major_topic | False |
| mesh[34].qualifier_name | metabolism |
| mesh[34].descriptor_name | Neurons |
| mesh[35].qualifier_ui | Q000473 |
| mesh[35].descriptor_ui | D009474 |
| mesh[35].is_major_topic | False |
| mesh[35].qualifier_name | pathology |
| mesh[35].descriptor_name | Neurons |
| mesh[36].qualifier_ui | |
| mesh[36].descriptor_ui | D006801 |
| mesh[36].is_major_topic | False |
| mesh[36].qualifier_name | |
| mesh[36].descriptor_name | Humans |
| mesh[37].qualifier_ui | |
| mesh[37].descriptor_ui | D055879 |
| mesh[37].is_major_topic | False |
| mesh[37].qualifier_name | |
| mesh[37].descriptor_name | Gene Knock-In Techniques |
| mesh[38].qualifier_ui | |
| mesh[38].descriptor_ui | D000818 |
| mesh[38].is_major_topic | False |
| mesh[38].qualifier_name | |
| mesh[38].descriptor_name | Animals |
| mesh[39].qualifier_ui | Q000473 |
| mesh[39].descriptor_ui | D009847 |
| mesh[39].is_major_topic | True |
| mesh[39].qualifier_name | pathology |
| mesh[39].descriptor_name | Olivary Nucleus |
| mesh[40].qualifier_ui | Q000503 |
| mesh[40].descriptor_ui | D009847 |
| mesh[40].is_major_topic | True |
| mesh[40].qualifier_name | physiopathology |
| mesh[40].descriptor_name | Olivary Nucleus |
| mesh[41].qualifier_ui | Q000378 |
| mesh[41].descriptor_ui | D009847 |
| mesh[41].is_major_topic | True |
| mesh[41].qualifier_name | metabolism |
| mesh[41].descriptor_name | Olivary Nucleus |
| mesh[42].qualifier_ui | |
| mesh[42].descriptor_ui | D051379 |
| mesh[42].is_major_topic | False |
| mesh[42].qualifier_name | |
| mesh[42].descriptor_name | Mice |
| mesh[43].qualifier_ui | Q000235 |
| mesh[43].descriptor_ui | D000067696 |
| mesh[43].is_major_topic | True |
| mesh[43].qualifier_name | genetics |
| mesh[43].descriptor_name | Ataxin-1 |
| mesh[44].qualifier_ui | Q000378 |
| mesh[44].descriptor_ui | D000067696 |
| mesh[44].is_major_topic | True |
| mesh[44].qualifier_name | metabolism |
| mesh[44].descriptor_name | Ataxin-1 |
| mesh[45].qualifier_ui | Q000235 |
| mesh[45].descriptor_ui | D020754 |
| mesh[45].is_major_topic | True |
| mesh[45].qualifier_name | genetics |
| mesh[45].descriptor_name | Spinocerebellar Ataxias |
| mesh[46].qualifier_ui | Q000503 |
| mesh[46].descriptor_ui | D020754 |
| mesh[46].is_major_topic | True |
| mesh[46].qualifier_name | physiopathology |
| mesh[46].descriptor_name | Spinocerebellar Ataxias |
| mesh[47].qualifier_ui | Q000473 |
| mesh[47].descriptor_ui | D020754 |
| mesh[47].is_major_topic | True |
| mesh[47].qualifier_name | pathology |
| mesh[47].descriptor_name | Spinocerebellar Ataxias |
| mesh[48].qualifier_ui | |
| mesh[48].descriptor_ui | D004195 |
| mesh[48].is_major_topic | True |
| mesh[48].qualifier_name | |
| mesh[48].descriptor_name | Disease Models, Animal |
| mesh[49].qualifier_ui | Q000235 |
| mesh[49].descriptor_ui | D006984 |
| mesh[49].is_major_topic | True |
| mesh[49].qualifier_name | genetics |
| mesh[49].descriptor_name | Hypertrophy |
| type | article |
| title | Increased intrinsic membrane excitability is associated with olivary hypertrophy in spinocerebellar ataxia type 1 |
| biblio.issue | 24 |
| biblio.volume | 33 |
| biblio.last_page | 2176 |
| biblio.first_page | 2159 |
| grants[0].funder | https://openalex.org/F4320332161 |
| grants[0].award_id | R01 NS085054 |
| grants[0].funder_display_name | National Institutes of Health |
| grants[1].funder | https://openalex.org/F4320337359 |
| grants[1].award_id | R01 NS128285 |
| grants[1].funder_display_name | National Institute of Neurological Disorders and Stroke |
| grants[2].funder | https://openalex.org/F4320337359 |
| grants[2].award_id | R37 NS022920 |
| grants[2].funder_display_name | National Institute of Neurological Disorders and Stroke |
| topics[0].id | https://openalex.org/T10949 |
| topics[0].field.id | https://openalex.org/fields/28 |
| topics[0].field.display_name | Neuroscience |
| topics[0].score | 0.9998999834060669 |
| topics[0].domain.id | https://openalex.org/domains/1 |
| topics[0].domain.display_name | Life Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/2804 |
| topics[0].subfield.display_name | Cellular and Molecular Neuroscience |
| topics[0].display_name | Genetic Neurodegenerative Diseases |
| topics[1].id | https://openalex.org/T10617 |
| topics[1].field.id | https://openalex.org/fields/13 |
| topics[1].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[1].score | 0.9975000023841858 |
| topics[1].domain.id | https://openalex.org/domains/1 |
| topics[1].domain.display_name | Life Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/1307 |
| topics[1].subfield.display_name | Cell Biology |
| topics[1].display_name | Cellular transport and secretion |
| topics[2].id | https://openalex.org/T10919 |
| topics[2].field.id | https://openalex.org/fields/27 |
| topics[2].field.display_name | Medicine |
| topics[2].score | 0.9972000122070312 |
| topics[2].domain.id | https://openalex.org/domains/4 |
| topics[2].domain.display_name | Health Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/2728 |
| topics[2].subfield.display_name | Neurology |
| topics[2].display_name | Neurological disorders and treatments |
| funders[0].id | https://openalex.org/F4320332161 |
| funders[0].ror | https://ror.org/01cwqze88 |
| funders[0].display_name | National Institutes of Health |
| funders[1].id | https://openalex.org/F4320337359 |
| funders[1].ror | https://ror.org/01s5ya894 |
| funders[1].display_name | National Institute of Neurological Disorders and Stroke |
| is_xpac | False |
| apc_list.value | 4181 |
| apc_list.currency | USD |
| apc_list.value_usd | 4181 |
| apc_paid.value | 4181 |
| apc_paid.currency | USD |
| apc_paid.value_usd | 4181 |
| concepts[0].id | https://openalex.org/C2779500118 |
| concepts[0].level | 3 |
| concepts[0].score | 0.8258858919143677 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q899726 |
| concepts[0].display_name | Spinocerebellar ataxia |
| concepts[1].id | https://openalex.org/C86803240 |
| concepts[1].level | 0 |
| concepts[1].score | 0.737914502620697 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q420 |
| concepts[1].display_name | Biology |
| concepts[2].id | https://openalex.org/C169760540 |
| concepts[2].level | 1 |
| concepts[2].score | 0.4309130907058716 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q207011 |
| concepts[2].display_name | Neuroscience |
| concepts[3].id | https://openalex.org/C2777427615 |
| concepts[3].level | 3 |
| concepts[3].score | 0.42365479469299316 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q954257 |
| concepts[3].display_name | Degenerative disease |
| concepts[4].id | https://openalex.org/C2780906641 |
| concepts[4].level | 2 |
| concepts[4].score | 0.37317466735839844 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q213373 |
| concepts[4].display_name | Ataxia |
| concepts[5].id | https://openalex.org/C2779281540 |
| concepts[5].level | 2 |
| concepts[5].score | 0.21574437618255615 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q5062122 |
| concepts[5].display_name | Central nervous system disease |
| keywords[0].id | https://openalex.org/keywords/spinocerebellar-ataxia |
| keywords[0].score | 0.8258858919143677 |
| keywords[0].display_name | Spinocerebellar ataxia |
| keywords[1].id | https://openalex.org/keywords/biology |
| keywords[1].score | 0.737914502620697 |
| keywords[1].display_name | Biology |
| keywords[2].id | https://openalex.org/keywords/neuroscience |
| keywords[2].score | 0.4309130907058716 |
| keywords[2].display_name | Neuroscience |
| keywords[3].id | https://openalex.org/keywords/degenerative-disease |
| keywords[3].score | 0.42365479469299316 |
| keywords[3].display_name | Degenerative disease |
| keywords[4].id | https://openalex.org/keywords/ataxia |
| keywords[4].score | 0.37317466735839844 |
| keywords[4].display_name | Ataxia |
| keywords[5].id | https://openalex.org/keywords/central-nervous-system-disease |
| keywords[5].score | 0.21574437618255615 |
| keywords[5].display_name | Central nervous system disease |
| language | en |
| locations[0].id | doi:10.1093/hmg/ddae146 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S166515463 |
| locations[0].source.issn | 0964-6906, 1460-2083 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | False |
| locations[0].source.issn_l | 0964-6906 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | False |
| locations[0].source.display_name | Human Molecular Genetics |
| locations[0].source.host_organization | https://openalex.org/P4310311648 |
| locations[0].source.host_organization_name | Oxford University Press |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310311648 |
| locations[0].license | cc-by |
| locations[0].pdf_url | https://academic.oup.com/hmg/advance-article-pdf/doi/10.1093/hmg/ddae146/60216159/ddae146.pdf |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | https://openalex.org/licenses/cc-by |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Human Molecular Genetics |
| locations[0].landing_page_url | https://doi.org/10.1093/hmg/ddae146 |
| locations[1].id | pmid:39475127 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | Human molecular genetics |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/39475127 |
| locations[2].id | pmh:oai:pubmedcentral.nih.gov:11630738 |
| locations[2].is_oa | True |
| locations[2].source.id | https://openalex.org/S2764455111 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | PubMed Central |
| locations[2].source.host_organization | https://openalex.org/I1299303238 |
| locations[2].source.host_organization_name | National Institutes of Health |
| locations[2].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[2].license | other-oa |
| locations[2].pdf_url | |
| locations[2].version | submittedVersion |
| locations[2].raw_type | Text |
| locations[2].license_id | https://openalex.org/licenses/other-oa |
| locations[2].is_accepted | False |
| locations[2].is_published | False |
| locations[2].raw_source_name | Hum Mol Genet |
| locations[2].landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/11630738 |
| indexed_in | crossref, pubmed |
| authorships[0].author.id | https://openalex.org/A5062173867 |
| authorships[0].author.orcid | https://orcid.org/0000-0002-7323-4137 |
| authorships[0].author.display_name | Logan M Morrison |
| authorships[0].countries | US |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I867280407 |
| authorships[0].affiliations[0].raw_affiliation_string | Peter O'Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center, 6124 Harry Hines Blvd. Dallas, TX 75390, United States |
| authorships[0].affiliations[1].institution_ids | https://openalex.org/I867280407 |
| authorships[0].affiliations[1].raw_affiliation_string | Department of Neurology, University of Texas Southwestern Medical Center, Dallas, 5323 Harry Hines Blvd., TX 75390, United States |
| authorships[0].affiliations[2].institution_ids | https://openalex.org/I27837315 |
| authorships[0].affiliations[2].raw_affiliation_string | Neuroscience Graduate Program, University of Michigan, Ann Arbor, MI 48109, United States |
| authorships[0].institutions[0].id | https://openalex.org/I867280407 |
| authorships[0].institutions[0].ror | https://ror.org/05byvp690 |
| authorships[0].institutions[0].type | education |
| authorships[0].institutions[0].lineage | https://openalex.org/I867280407 |
| authorships[0].institutions[0].country_code | US |
| authorships[0].institutions[0].display_name | The University of Texas Southwestern Medical Center |
| authorships[0].institutions[1].id | https://openalex.org/I27837315 |
| authorships[0].institutions[1].ror | https://ror.org/00jmfr291 |
| authorships[0].institutions[1].type | education |
| authorships[0].institutions[1].lineage | https://openalex.org/I27837315 |
| authorships[0].institutions[1].country_code | US |
| authorships[0].institutions[1].display_name | University of Michigan |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Logan M Morrison |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Department of Neurology, University of Texas Southwestern Medical Center, Dallas, 5323 Harry Hines Blvd., TX 75390, United States, Neuroscience Graduate Program, University of Michigan, Ann Arbor, MI 48109, United States, Peter O'Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center, 6124 Harry Hines Blvd. Dallas, TX 75390, United States |
| authorships[1].author.id | https://openalex.org/A5102719118 |
| authorships[1].author.orcid | https://orcid.org/0000-0001-6125-5996 |
| authorships[1].author.display_name | Haoran Huang |
| authorships[1].countries | US |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I52357470 |
| authorships[1].affiliations[0].raw_affiliation_string | Medical Scientist Training Program, The Ohio State University, Columbus, OH 43210, United States |
| authorships[1].affiliations[1].institution_ids | https://openalex.org/I52357470 |
| authorships[1].affiliations[1].raw_affiliation_string | College of Medicine, The Ohio State University, Columbus, OH 43210, United States |
| authorships[1].institutions[0].id | https://openalex.org/I52357470 |
| authorships[1].institutions[0].ror | https://ror.org/00rs6vg23 |
| authorships[1].institutions[0].type | education |
| authorships[1].institutions[0].lineage | https://openalex.org/I52357470 |
| authorships[1].institutions[0].country_code | US |
| authorships[1].institutions[0].display_name | The Ohio State University |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Haoran Huang |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | College of Medicine, The Ohio State University, Columbus, OH 43210, United States, Medical Scientist Training Program, The Ohio State University, Columbus, OH 43210, United States |
| authorships[2].author.id | https://openalex.org/A5075486412 |
| authorships[2].author.orcid | https://orcid.org/0000-0001-5757-4548 |
| authorships[2].author.display_name | Hillary P. Handler |
| authorships[2].countries | US |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I4210135252 |
| authorships[2].affiliations[0].raw_affiliation_string | Molecular Diagnostics Laboratory, University of Minnesota Fairview Medical Center, Minneapolis, MN 55455, United States |
| authorships[2].institutions[0].id | https://openalex.org/I4210135252 |
| authorships[2].institutions[0].ror | https://ror.org/03e1ayz78 |
| authorships[2].institutions[0].type | healthcare |
| authorships[2].institutions[0].lineage | https://openalex.org/I1309104334, https://openalex.org/I4210135252 |
| authorships[2].institutions[0].country_code | US |
| authorships[2].institutions[0].display_name | University of Minnesota Medical Center |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Hillary P Handler |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Molecular Diagnostics Laboratory, University of Minnesota Fairview Medical Center, Minneapolis, MN 55455, United States |
| authorships[3].author.id | https://openalex.org/A5101640186 |
| authorships[3].author.orcid | https://orcid.org/0000-0002-2038-9039 |
| authorships[3].author.display_name | Min Fu |
| authorships[3].countries | US |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I867280407 |
| authorships[3].affiliations[0].raw_affiliation_string | Department of Neurology, University of Texas Southwestern Medical Center, Dallas, 5323 Harry Hines Blvd., TX 75390, United States |
| authorships[3].affiliations[1].institution_ids | https://openalex.org/I867280407 |
| authorships[3].affiliations[1].raw_affiliation_string | Peter O'Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center, 6124 Harry Hines Blvd. Dallas, TX 75390, United States |
| authorships[3].institutions[0].id | https://openalex.org/I867280407 |
| authorships[3].institutions[0].ror | https://ror.org/05byvp690 |
| authorships[3].institutions[0].type | education |
| authorships[3].institutions[0].lineage | https://openalex.org/I867280407 |
| authorships[3].institutions[0].country_code | US |
| authorships[3].institutions[0].display_name | The University of Texas Southwestern Medical Center |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Min Fu |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Department of Neurology, University of Texas Southwestern Medical Center, Dallas, 5323 Harry Hines Blvd., TX 75390, United States, Peter O'Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center, 6124 Harry Hines Blvd. Dallas, TX 75390, United States |
| authorships[4].author.id | https://openalex.org/A5073898141 |
| authorships[4].author.orcid | |
| authorships[4].author.display_name | Deborah M. Jones |
| authorships[4].countries | US |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I867280407 |
| authorships[4].affiliations[0].raw_affiliation_string | Department of Neurology, University of Texas Southwestern Medical Center, Dallas, 5323 Harry Hines Blvd., TX 75390, United States |
| authorships[4].institutions[0].id | https://openalex.org/I867280407 |
| authorships[4].institutions[0].ror | https://ror.org/05byvp690 |
| authorships[4].institutions[0].type | education |
| authorships[4].institutions[0].lineage | https://openalex.org/I867280407 |
| authorships[4].institutions[0].country_code | US |
| authorships[4].institutions[0].display_name | The University of Texas Southwestern Medical Center |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Deborah M Jones |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Department of Neurology, University of Texas Southwestern Medical Center, Dallas, 5323 Harry Hines Blvd., TX 75390, United States |
| authorships[5].author.id | https://openalex.org/A5090002724 |
| authorships[5].author.orcid | https://orcid.org/0000-0002-3852-127X |
| authorships[5].author.display_name | David D. Bushart |
| authorships[5].countries | US |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I52357470 |
| authorships[5].affiliations[0].raw_affiliation_string | College of Medicine, The Ohio State University, Columbus, OH 43210, United States |
| authorships[5].institutions[0].id | https://openalex.org/I52357470 |
| authorships[5].institutions[0].ror | https://ror.org/00rs6vg23 |
| authorships[5].institutions[0].type | education |
| authorships[5].institutions[0].lineage | https://openalex.org/I52357470 |
| authorships[5].institutions[0].country_code | US |
| authorships[5].institutions[0].display_name | The Ohio State University |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | David D Bushart |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | College of Medicine, The Ohio State University, Columbus, OH 43210, United States |
| authorships[6].author.id | https://openalex.org/A5001737456 |
| authorships[6].author.orcid | https://orcid.org/0000-0002-6980-2058 |
| authorships[6].author.display_name | Samuel S. Pappas |
| authorships[6].countries | US |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I867280407 |
| authorships[6].affiliations[0].raw_affiliation_string | Department of Neurology, University of Texas Southwestern Medical Center, Dallas, 5323 Harry Hines Blvd., TX 75390, United States |
| authorships[6].affiliations[1].institution_ids | https://openalex.org/I867280407 |
| authorships[6].affiliations[1].raw_affiliation_string | Peter O'Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center, 6124 Harry Hines Blvd. Dallas, TX 75390, United States |
| authorships[6].institutions[0].id | https://openalex.org/I867280407 |
| authorships[6].institutions[0].ror | https://ror.org/05byvp690 |
| authorships[6].institutions[0].type | education |
| authorships[6].institutions[0].lineage | https://openalex.org/I867280407 |
| authorships[6].institutions[0].country_code | US |
| authorships[6].institutions[0].display_name | The University of Texas Southwestern Medical Center |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Samuel S Pappas |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | Department of Neurology, University of Texas Southwestern Medical Center, Dallas, 5323 Harry Hines Blvd., TX 75390, United States, Peter O'Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center, 6124 Harry Hines Blvd. Dallas, TX 75390, United States |
| authorships[7].author.id | https://openalex.org/A5005772078 |
| authorships[7].author.orcid | https://orcid.org/0000-0001-6118-741X |
| authorships[7].author.display_name | Harry T. Orr |
| authorships[7].countries | US |
| authorships[7].affiliations[0].institution_ids | https://openalex.org/I130238516 |
| authorships[7].affiliations[0].raw_affiliation_string | Department of Laboratory Medicine and Pathology, University of Minnesota, 420 Delaware Street SE, Minneapolis, MN 55455, United States |
| authorships[7].affiliations[1].institution_ids | https://openalex.org/I130238516 |
| authorships[7].affiliations[1].raw_affiliation_string | Institute for Translational Neuroscience, University of Minnesota, Minneapolis, 420 Delaware Street SE, MN 55455, United States |
| authorships[7].institutions[0].id | https://openalex.org/I130238516 |
| authorships[7].institutions[0].ror | https://ror.org/017zqws13 |
| authorships[7].institutions[0].type | education |
| authorships[7].institutions[0].lineage | https://openalex.org/I130238516 |
| authorships[7].institutions[0].country_code | US |
| authorships[7].institutions[0].display_name | University of Minnesota |
| authorships[7].author_position | middle |
| authorships[7].raw_author_name | Harry T Orr |
| authorships[7].is_corresponding | False |
| authorships[7].raw_affiliation_strings | Department of Laboratory Medicine and Pathology, University of Minnesota, 420 Delaware Street SE, Minneapolis, MN 55455, United States, Institute for Translational Neuroscience, University of Minnesota, Minneapolis, 420 Delaware Street SE, MN 55455, United States |
| authorships[8].author.id | https://openalex.org/A5077187605 |
| authorships[8].author.orcid | https://orcid.org/0000-0003-2742-6469 |
| authorships[8].author.display_name | Vikram G. Shakkottai |
| authorships[8].countries | US |
| authorships[8].affiliations[0].institution_ids | https://openalex.org/I867280407 |
| authorships[8].affiliations[0].raw_affiliation_string | Peter O'Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center, 6124 Harry Hines Blvd. Dallas, TX 75390, United States |
| authorships[8].affiliations[1].institution_ids | https://openalex.org/I867280407 |
| authorships[8].affiliations[1].raw_affiliation_string | Department of Neurology, University of Texas Southwestern Medical Center, Dallas, 5323 Harry Hines Blvd., TX 75390, United States |
| authorships[8].institutions[0].id | https://openalex.org/I867280407 |
| authorships[8].institutions[0].ror | https://ror.org/05byvp690 |
| authorships[8].institutions[0].type | education |
| authorships[8].institutions[0].lineage | https://openalex.org/I867280407 |
| authorships[8].institutions[0].country_code | US |
| authorships[8].institutions[0].display_name | The University of Texas Southwestern Medical Center |
| authorships[8].author_position | last |
| authorships[8].raw_author_name | Vikram G Shakkottai |
| authorships[8].is_corresponding | False |
| authorships[8].raw_affiliation_strings | Department of Neurology, University of Texas Southwestern Medical Center, Dallas, 5323 Harry Hines Blvd., TX 75390, United States, Peter O'Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center, 6124 Harry Hines Blvd. Dallas, TX 75390, United States |
| has_content.pdf | True |
| has_content.grobid_xml | False |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://academic.oup.com/hmg/advance-article-pdf/doi/10.1093/hmg/ddae146/60216159/ddae146.pdf |
| open_access.oa_status | hybrid |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | Increased intrinsic membrane excitability is associated with olivary hypertrophy in spinocerebellar ataxia type 1 |
| has_fulltext | False |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T10949 |
| primary_topic.field.id | https://openalex.org/fields/28 |
| primary_topic.field.display_name | Neuroscience |
| primary_topic.score | 0.9998999834060669 |
| primary_topic.domain.id | https://openalex.org/domains/1 |
| primary_topic.domain.display_name | Life Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/2804 |
| primary_topic.subfield.display_name | Cellular and Molecular Neuroscience |
| primary_topic.display_name | Genetic Neurodegenerative Diseases |
| related_works | https://openalex.org/W4391375266, https://openalex.org/W2082860237, https://openalex.org/W2119695867, https://openalex.org/W2130076355, https://openalex.org/W1990804418, https://openalex.org/W2019983375, https://openalex.org/W2167376420, https://openalex.org/W2088525571, https://openalex.org/W2402174938, https://openalex.org/W2016991674 |
| cited_by_count | 0 |
| locations_count | 3 |
| best_oa_location.id | doi:10.1093/hmg/ddae146 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S166515463 |
| best_oa_location.source.issn | 0964-6906, 1460-2083 |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | False |
| best_oa_location.source.issn_l | 0964-6906 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | False |
| best_oa_location.source.display_name | Human Molecular Genetics |
| best_oa_location.source.host_organization | https://openalex.org/P4310311648 |
| best_oa_location.source.host_organization_name | Oxford University Press |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310311648 |
| best_oa_location.license | cc-by |
| best_oa_location.pdf_url | https://academic.oup.com/hmg/advance-article-pdf/doi/10.1093/hmg/ddae146/60216159/ddae146.pdf |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | Human Molecular Genetics |
| best_oa_location.landing_page_url | https://doi.org/10.1093/hmg/ddae146 |
| primary_location.id | doi:10.1093/hmg/ddae146 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S166515463 |
| primary_location.source.issn | 0964-6906, 1460-2083 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | False |
| primary_location.source.issn_l | 0964-6906 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | False |
| primary_location.source.display_name | Human Molecular Genetics |
| primary_location.source.host_organization | https://openalex.org/P4310311648 |
| primary_location.source.host_organization_name | Oxford University Press |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310311648 |
| primary_location.license | cc-by |
| primary_location.pdf_url | https://academic.oup.com/hmg/advance-article-pdf/doi/10.1093/hmg/ddae146/60216159/ddae146.pdf |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | https://openalex.org/licenses/cc-by |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Human Molecular Genetics |
| primary_location.landing_page_url | https://doi.org/10.1093/hmg/ddae146 |
| publication_date | 2024-10-30 |
| publication_year | 2024 |
| referenced_works | https://openalex.org/W2408064656, https://openalex.org/W2171136974, https://openalex.org/W1999601172, https://openalex.org/W2009635803, https://openalex.org/W6646688438, https://openalex.org/W1979771842, https://openalex.org/W2432818936, https://openalex.org/W2065808064, https://openalex.org/W2594803846, https://openalex.org/W4384820010, https://openalex.org/W2417632096, https://openalex.org/W2941390758, https://openalex.org/W2070581653, https://openalex.org/W1993793878, https://openalex.org/W2406025336, https://openalex.org/W2401484292, https://openalex.org/W2039877615, https://openalex.org/W2808418292, https://openalex.org/W2051186583, https://openalex.org/W2001683794, https://openalex.org/W2137768833, https://openalex.org/W2083093103, https://openalex.org/W1990288633, https://openalex.org/W1501265948, https://openalex.org/W2006656241, https://openalex.org/W1988665933, https://openalex.org/W2092371719, https://openalex.org/W2035127927, https://openalex.org/W2042431572, https://openalex.org/W1974689666, https://openalex.org/W2060943219, https://openalex.org/W2125541859, https://openalex.org/W2106614622, https://openalex.org/W2062888345, https://openalex.org/W1989396876, https://openalex.org/W2018227909, https://openalex.org/W2018709063, https://openalex.org/W3095110265, https://openalex.org/W2093107479, https://openalex.org/W2927500404, https://openalex.org/W1968808193, https://openalex.org/W2158305904, https://openalex.org/W2068894842, https://openalex.org/W2549399852, https://openalex.org/W2053382905, https://openalex.org/W1968968097, https://openalex.org/W2155163052, https://openalex.org/W2859077248, https://openalex.org/W2201624977, https://openalex.org/W1501756216, https://openalex.org/W3088387936, https://openalex.org/W1965315140, https://openalex.org/W2029708215, https://openalex.org/W1712664294, https://openalex.org/W2120284757, https://openalex.org/W2047427596, https://openalex.org/W2898693092, https://openalex.org/W2069380892, https://openalex.org/W2043888873, https://openalex.org/W3034856796, https://openalex.org/W2767570149, https://openalex.org/W1978456045, https://openalex.org/W1983430986, https://openalex.org/W2143856195, https://openalex.org/W2097978324, https://openalex.org/W2794248168, https://openalex.org/W2791724344, https://openalex.org/W2123491442, https://openalex.org/W2903463122, https://openalex.org/W2075735168, https://openalex.org/W2807100879, https://openalex.org/W1984209601, https://openalex.org/W2886846554 |
| referenced_works_count | 73 |
| abstract_inverted_index.a | 19, 24, 36, 54, 74, 78, 138, 203, 212 |
| abstract_inverted_index.IO | 33, 50, 94, 120, 169, 193, 208, 224 |
| abstract_inverted_index.In | 42 |
| abstract_inverted_index.We | 66 |
| abstract_inverted_index.an | 228 |
| abstract_inverted_index.as | 82, 206 |
| abstract_inverted_index.be | 113 |
| abstract_inverted_index.by | 48, 115 |
| abstract_inverted_index.in | 27, 52, 130, 144, 151, 176, 223, 227, 232 |
| abstract_inverted_index.is | 14, 110, 148 |
| abstract_inverted_index.no | 125, 156 |
| abstract_inverted_index.of | 2, 6, 32, 39, 77, 91, 127, 142, 158, 188, 220 |
| abstract_inverted_index.to | 88, 112, 178, 201 |
| abstract_inverted_index.we | 45, 123, 135 |
| abstract_inverted_index.HOD | 109 |
| abstract_inverted_index.IO. | 133 |
| abstract_inverted_index.One | 1 |
| abstract_inverted_index.SCA | 40 |
| abstract_inverted_index.The | 30 |
| abstract_inverted_index.and | 100, 239 |
| abstract_inverted_index.are | 171 |
| abstract_inverted_index.for | 192 |
| abstract_inverted_index.ion | 189, 240 |
| abstract_inverted_index.key | 25 |
| abstract_inverted_index.the | 3, 15, 60, 131 |
| abstract_inverted_index.AHP. | 214 |
| abstract_inverted_index.HOD, | 92 |
| abstract_inverted_index.SCA1 | 62, 143 |
| abstract_inverted_index.area | 38 |
| abstract_inverted_index.cell | 106 |
| abstract_inverted_index.find | 67, 136 |
| abstract_inverted_index.from | 163 |
| abstract_inverted_index.have | 202 |
| abstract_inverted_index.loss | 126 |
| abstract_inverted_index.mice | 70 |
| abstract_inverted_index.role | 26 |
| abstract_inverted_index.that | 22, 68, 118, 137, 167, 199, 218 |
| abstract_inverted_index.this | 43, 47 |
| abstract_inverted_index.with | 234 |
| abstract_inverted_index.(IO), | 18 |
| abstract_inverted_index.ATXN1 | 147, 222 |
| abstract_inverted_index.SCA1, | 53 |
| abstract_inverted_index.These | 215 |
| abstract_inverted_index.cells | 154 |
| abstract_inverted_index.early | 89, 97 |
| abstract_inverted_index.frank | 105 |
| abstract_inverted_index.known | 81, 111 |
| abstract_inverted_index.later | 101 |
| abstract_inverted_index.loss. | 107 |
| abstract_inverted_index.model | 141 |
| abstract_inverted_index.motor | 28 |
| abstract_inverted_index.mouse | 140 |
| abstract_inverted_index.olive | 17 |
| abstract_inverted_index.plays | 23 |
| abstract_inverted_index.shows | 155 |
| abstract_inverted_index.spike | 174, 195 |
| abstract_inverted_index.these | 69 |
| abstract_inverted_index.using | 59 |
| abstract_inverted_index.which | 145 |
| abstract_inverted_index.work, | 44 |
| abstract_inverted_index.(HOD). | 86 |
| abstract_inverted_index.(SCAs) | 13 |
| abstract_inverted_index.Though | 108 |
| abstract_inverted_index.across | 9 |
| abstract_inverted_index.caused | 114 |
| abstract_inverted_index.mouse. | 65 |
| abstract_inverted_index.mutant | 146, 221 |
| abstract_inverted_index.neuron | 194, 209 |
| abstract_inverted_index.result | 198 |
| abstract_inverted_index.slices | 165 |
| abstract_inverted_index.solely | 150 |
| abstract_inverted_index.spikes | 210 |
| abstract_inverted_index.stages | 90 |
| abstract_inverted_index.trains | 175 |
| abstract_inverted_index.SCA1-KI | 93, 132, 168, 207 |
| abstract_inverted_index.Similar | 87 |
| abstract_inverted_index.address | 46 |
| abstract_inverted_index.appears | 200 |
| abstract_inverted_index.ataxias | 12 |
| abstract_inverted_index.channel | 241 |
| abstract_inverted_index.disease | 51 |
| abstract_inverted_index.display | 96 |
| abstract_inverted_index.disrupt | 119 |
| abstract_inverted_index.exhibit | 71, 211 |
| abstract_inverted_index.further | 183 |
| abstract_inverted_index.lesions | 117 |
| abstract_inverted_index.neurons | 34, 95, 170, 225 |
| abstract_inverted_index.nucleus | 21 |
| abstract_inverted_index.observe | 124 |
| abstract_inverted_index.olivary | 72, 84, 159, 230 |
| abstract_inverted_index.reduced | 185 |
| abstract_inverted_index.regions | 5 |
| abstract_inverted_index.remains | 35 |
| abstract_inverted_index.results | 226 |
| abstract_inverted_index.reveals | 184 |
| abstract_inverted_index.somatic | 102 |
| abstract_inverted_index.suggest | 217 |
| abstract_inverted_index.without | 104 |
| abstract_inverted_index.Abstract | 0 |
| abstract_inverted_index.HOD-like | 229 |
| abstract_inverted_index.Purkinje | 153 |
| abstract_inverted_index.analysis | 182 |
| abstract_inverted_index.atrophy, | 58 |
| abstract_inverted_index.channels | 190 |
| abstract_inverted_index.disorder | 80 |
| abstract_inverted_index.evidence | 157 |
| abstract_inverted_index.findings | 216 |
| abstract_inverted_index.indicate | 166 |
| abstract_inverted_index.inferior | 16 |
| abstract_inverted_index.knock-in | 63 |
| abstract_inverted_index.membrane | 179, 237 |
| abstract_inverted_index.multiple | 10 |
| abstract_inverted_index.response | 177 |
| abstract_inverted_index.separate | 139 |
| abstract_inverted_index.(AHP)—a | 197 |
| abstract_inverted_index.(SCA1-KI) | 64 |
| abstract_inverted_index.brainstem | 7, 116, 164 |
| abstract_inverted_index.dendritic | 98 |
| abstract_inverted_index.expansion | 103 |
| abstract_inverted_index.expressed | 149 |
| abstract_inverted_index.increased | 235 |
| abstract_inverted_index.inherited | 56 |
| abstract_inverted_index.intrinsic | 236 |
| abstract_inverted_index.learning. | 29 |
| abstract_inverted_index.medullary | 20, 186 |
| abstract_inverted_index.phenotype | 75 |
| abstract_inverted_index.terminals | 129 |
| abstract_inverted_index.cerebellar | 152 |
| abstract_inverted_index.diminished | 213 |
| abstract_inverted_index.evaluating | 49 |
| abstract_inverted_index.expression | 187, 219 |
| abstract_inverted_index.functional | 204 |
| abstract_inverted_index.generating | 173 |
| abstract_inverted_index.inhibitory | 121, 128 |
| abstract_inverted_index.pathology. | 41 |
| abstract_inverted_index.prototypic | 55 |
| abstract_inverted_index.recordings | 162 |
| abstract_inverted_index.Patch-clamp | 161 |
| abstract_inverted_index.association | 233 |
| abstract_inverted_index.lengthening | 99 |
| abstract_inverted_index.reminiscent | 76 |
| abstract_inverted_index.responsible | 191 |
| abstract_inverted_index.consequence, | 205 |
| abstract_inverted_index.degeneration | 8, 85 |
| abstract_inverted_index.degenerative | 79 |
| abstract_inverted_index.excitability | 238 |
| abstract_inverted_index.hypertrophic | 83 |
| abstract_inverted_index.hypertrophy, | 73, 231 |
| abstract_inverted_index.hypertrophy. | 160 |
| abstract_inverted_index.innervation, | 122 |
| abstract_inverted_index.Additionally, | 134 |
| abstract_inverted_index.Transcriptome | 181 |
| abstract_inverted_index.vulnerability | 31 |
| abstract_inverted_index.characteristic | 4 |
| abstract_inverted_index.dysregulation. | 243 |
| abstract_inverted_index.depolarization. | 180 |
| abstract_inverted_index.hyperexcitable, | 172 |
| abstract_inverted_index.spinocerebellar | 11 |
| abstract_inverted_index.transcriptional | 242 |
| abstract_inverted_index.poorly-understood | 37 |
| abstract_inverted_index.genetically-precise | 61 |
| abstract_inverted_index.olivopontocerebellar | 57 |
| abstract_inverted_index.afterhyperpolarization | 196 |
| cited_by_percentile_year | |
| countries_distinct_count | 1 |
| institutions_distinct_count | 9 |
| citation_normalized_percentile.value | 0.24860049 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |