Increased migratory/activated CD8+ T cell and low avidity SARS-CoV-2 reactive cellular response in post-acute COVID-19 syndrome Article Swipe
Krystallenia Paniskaki
,
Margarethe Konik
,
Moritz Anft
,
Harald Heidecke
,
Toni Luise Meister
,
Stephanie Pfaender
,
Adalbert Krawczyk
,
Markus Zettler
,
Jasmin Jäger
,
Anja Gaeckler
,
Sebastian Dolff
,
Timm H. Westhoff
,
Hana Rohn
,
Ulrik Stervbo
,
Carmen Scheibenbogen
,
Oliver Witzke
,
Nina Babel
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1101/2022.12.03.519007
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1101/2022.12.03.519007
The role of autoimmunity in post-acute sequelae of COVID-19 (PASC) is not well explored, although clinicians observe a growing population of convalescent COVID-19 patients with manifestation of post-acute sequelae of COVID-19. We analyzed the immune response in 40 post-acute sequelae of COVID-19 patients with non-specific PASC manifestation and 15 COVID-19 convalescent healthy donors. The phenotyping of lymphocytes showed a significantly higher number of CD8+ T cells expressing the Epstein-Barr virus induced G protein coupled receptor 2, chemokine receptor CXCR3 and C-C chemokine receptor type 5 playing an important role in inflammation and migration in PASC patients compared to controls. Additionally, a stronger, SARS-CoV-2 reactive CD8+ T cell response, characterized by IFNγ production and predominant T EMRA phenotype but low SARS-CoV-2 avidity was detected in PASC patients compared to controls. Furthermore, higher titers of several autoantibodies were detected among PASC patients. Our data suggest that a persistent inflammatory response triggered by SARS-CoV-2 might be responsible for the observed sequelae in PASC patients. These results may have implications on future therapeutic strategies.
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Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.1101/2022.12.03.519007
- https://www.biorxiv.org/content/biorxiv/early/2022/12/07/2022.12.03.519007.full.pdf
- OA Status
- green
- Cited By
- 1
- References
- 94
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4311730113
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4311730113Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1101/2022.12.03.519007Digital Object Identifier
- Title
-
Increased migratory/activated CD8+ T cell and low avidity SARS-CoV-2 reactive cellular response in post-acute COVID-19 syndromeWork title
- Type
-
preprintOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2022Year of publication
- Publication date
-
2022-12-07Full publication date if available
- Authors
-
Krystallenia Paniskaki, Margarethe Konik, Moritz Anft, Harald Heidecke, Toni Luise Meister, Stephanie Pfaender, Adalbert Krawczyk, Markus Zettler, Jasmin Jäger, Anja Gaeckler, Sebastian Dolff, Timm H. Westhoff, Hana Rohn, Ulrik Stervbo, Carmen Scheibenbogen, Oliver Witzke, Nina BabelList of authors in order
- Landing page
-
https://doi.org/10.1101/2022.12.03.519007Publisher landing page
- PDF URL
-
https://www.biorxiv.org/content/biorxiv/early/2022/12/07/2022.12.03.519007.full.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
-
https://www.biorxiv.org/content/biorxiv/early/2022/12/07/2022.12.03.519007.full.pdfDirect OA link when available
- Concepts
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Immunology, CD8, CXCR3, Chemokine, Avidity, Medicine, Chemokine receptor, Population, Convalescence, Inflammation, Receptor, Cytotoxic T cell, Immune system, Virology, Biology, Antibody, Internal medicine, In vitro, Biochemistry, Environmental healthTop concepts (fields/topics) attached by OpenAlex
- Cited by
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1Total citation count in OpenAlex
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2023: 1Per-year citation counts (last 5 years)
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94Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.5400000214576721 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.51502579 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |