Increased risk of incident diabetes in patients with MAFLD not meeting the criteria for NAFLD Article Swipe
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· 2023
· Open Access
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· DOI: https://doi.org/10.1038/s41598-023-37858-8
We aimed to compare the risk of incident diabetes according to fatty liver disease (FLD) definition, focusing on the comparison between those who met criteria for either metabolic dysfunction-associated fatty liver disease (MAFLD) or nonalcoholic fatty liver disease (NAFLD) but not the other. This was a 5.0-year (interquartile range, 2.4–8.2) retrospective longitudinal cohort study of 21,178 adults who underwent at least two serial health checkup examinations. The presence of hepatic steatosis was determined by abdominal ultrasonography at the first health examination. Cox proportional hazard analyses were used to compare the risk of incident diabetes among five groups. Incident diabetes cases occurred in 1296 participants (6.1%). When non-FLD without metabolic dysfunction (MD) group was set as a reference, the risk of incident diabetes increased in the order of NAFLD-only, non-FLD with MD, both FLD, and MAFLD-only groups. The presence of excessive alcohol consumption and/or hepatitis B virus (HBV)/hepatitis C virus (HCV) infection, FLD, and MD synergistically increased the risk of incident diabetes. MAFLD-only group showed a greater increase in incidence of diabetes than non-FLD with MD and NAFLD-only groups. The interaction among excessive alcohol consumption, HBV/HCV infection, MD, and hepatic steatosis on the development of diabetes should not be overlooked.
Related Topics
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1038/s41598-023-37858-8
- https://www.nature.com/articles/s41598-023-37858-8.pdf
- OA Status
- gold
- Cited By
- 5
- References
- 47
- Related Works
- 10
- OpenAlex ID
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Raw OpenAlex JSON
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https://openalex.org/W4382797651Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1038/s41598-023-37858-8Digital Object Identifier
- Title
-
Increased risk of incident diabetes in patients with MAFLD not meeting the criteria for NAFLDWork title
- Type
-
articleOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2023Year of publication
- Publication date
-
2023-07-01Full publication date if available
- Authors
-
Sohee Park, Jiyun Park, So Yoon Kwon, You‐Bin Lee, Gyuri Kim, Kyu Yeon Hur, Janghyun Koh, Jae Hwan Jee, Jae Hyeon Kim, Mira Kang, Sang‐Man JinList of authors in order
- Landing page
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https://doi.org/10.1038/s41598-023-37858-8Publisher landing page
- PDF URL
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https://www.nature.com/articles/s41598-023-37858-8.pdfDirect link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.nature.com/articles/s41598-023-37858-8.pdfDirect OA link when available
- Concepts
-
Medicine, Fatty liver, Diabetes mellitus, Internal medicine, Nonalcoholic fatty liver disease, Hazard ratio, Type 2 diabetes, Steatosis, Interquartile range, Incidence (geometry), Liver disease, Gastroenterology, Disease, Endocrinology, Confidence interval, Physics, OpticsTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
5Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 2, 2023: 3Per-year citation counts (last 5 years)
- References (count)
-
47Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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