Indirubin-3′-monoxime exhibits potent antiviral and anti-inflammatory effects against human adenoviruses in vitro and in vivo Article Swipe
Junyu Wang
,
Chaojie Yang
,
Zhixin Liang
,
Junping Sun
,
Mingyue Zhang
,
Shaofu Qiu
,
Xinying Du
,
Xi He
,
Xiaoying Pang
,
Xidong Ma
,
Mei Xie
,
Xinjie Han
,
Rui Fan
,
Enlu Zhou
,
Hairong Yu
,
Danyang She
,
Hongbin Song
,
Wang Jian-xin
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1016/j.biopha.2024.116558
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1016/j.biopha.2024.116558
Human adenovirus (HAdV) infection is a major cause of respiratory disease, yet no antiviral drugs have been approved for its treatment. Herein, we evaluated the antiviral and anti-inflammatory effects of cyclin-dependent protein kinase (CDK) inhibitor indirubin-3'-monoxime (IM) against HAdV infection in cells and a transgenic mouse model. After evaluating its cytotoxicity, cytopathic effect reduction, antiviral replication kinetics, and viral yield reduction assays were performed to assess the anti-HAdV activity of IM. Quantitative real-time polymerase chain reaction (qPCR), quantitative reverse transcription PCR (qRT-PCR), and western blotting were used to assess the effects of IM on HAdV DNA replication, transcription, and protein expression, respectively. IM significantly inhibited HAdV DNA replication as well as E1A and Hexon transcription, in addition to significantly suppressing the phosphorylation of the RNA polymerase II C-terminal domain (CTD). IM mitigated body weight loss, reduced viral burden, and lung injury, decreasing cytokine and chemokine secretion to a greater extent than cidofovir. Altogether, IM inhibits HAdV replication by downregulating CTD phosphorylation to suppress viral infection and corresponding innate immune reactions as a promising therapeutic agent.
Related Topics
Concepts
Biology
Viral replication
Virology
In vivo
Chemokine
Cyclin-dependent kinase
Molecular biology
Virus
Inflammation
Apoptosis
Immunology
Cell cycle
Biochemistry
Biotechnology
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1016/j.biopha.2024.116558
- OA Status
- gold
- Cited By
- 5
- References
- 52
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4394704519
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4394704519Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1016/j.biopha.2024.116558Digital Object Identifier
- Title
-
Indirubin-3′-monoxime exhibits potent antiviral and anti-inflammatory effects against human adenoviruses in vitro and in vivoWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
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2024Year of publication
- Publication date
-
2024-04-10Full publication date if available
- Authors
-
Junyu Wang, Chaojie Yang, Zhixin Liang, Junping Sun, Mingyue Zhang, Shaofu Qiu, Xinying Du, Xi He, Xiaoying Pang, Xidong Ma, Mei Xie, Xinjie Han, Rui Fan, Enlu Zhou, Hairong Yu, Danyang She, Hongbin Song, Wang Jian-xinList of authors in order
- Landing page
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https://doi.org/10.1016/j.biopha.2024.116558Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
- OA URL
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https://doi.org/10.1016/j.biopha.2024.116558Direct OA link when available
- Concepts
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Biology, Viral replication, Virology, In vivo, Chemokine, Cyclin-dependent kinase, Molecular biology, Virus, Inflammation, Apoptosis, Immunology, Cell cycle, Biochemistry, BiotechnologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
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5Total citation count in OpenAlex
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2025: 3, 2024: 2Per-year citation counts (last 5 years)
- References (count)
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52Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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| publication_date | 2024-04-10 |
| publication_year | 2024 |
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