Infection, Rejection, and the Connection Article Swipe
Lauren E. Higdon
,
Jane C. Tan
,
Jonathan S. Maltzman
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1097/tp.0000000000004297
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1097/tp.0000000000004297
Solid organ transplantation is a life-saving treatment for people with end-stage organ disease. Immune-mediated transplant rejection is a common complication that decreases allograft survival. Although immunosuppression is required to prevent rejection, it also increases the risk of infection. Some infections, such as cytomegalovirus and BK virus, can promote inflammatory gene expression that can further tip the balance toward rejection. BK virus and other infections can induce damage that resembles the clinical pathology of rejection, and this complicates accurate diagnosis. Moreover, T cells specific for viral infection can lead to rejection through heterologous immunity to donor antigen directly mediated by antiviral cells. Thus, viral infections and allograft rejection interact in multiple ways that are important to maintain immunologic homeostasis in solid organ transplant recipients. Better insight into this dynamic interplay will help promote long-term transplant survival.
Related Topics
Concepts
Immunosuppression
Immunology
Immune system
Transplant rejection
Immunity
Cytomegalovirus
Organ transplantation
Transplantation
Virus
Heterologous
Medicine
BK virus
Biology
Herpesviridae
Kidney transplantation
Viral disease
Gene
Internal medicine
Biochemistry
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1097/tp.0000000000004297
- OA Status
- green
- Cited By
- 32
- References
- 195
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4293176392
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4293176392Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1097/tp.0000000000004297Digital Object Identifier
- Title
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Infection, Rejection, and the ConnectionWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2022Year of publication
- Publication date
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2022-08-26Full publication date if available
- Authors
-
Lauren E. Higdon, Jane C. Tan, Jonathan S. MaltzmanList of authors in order
- Landing page
-
https://doi.org/10.1097/tp.0000000000004297Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
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https://www.ncbi.nlm.nih.gov/pmc/articles/9968362Direct OA link when available
- Concepts
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Immunosuppression, Immunology, Immune system, Transplant rejection, Immunity, Cytomegalovirus, Organ transplantation, Transplantation, Virus, Heterologous, Medicine, BK virus, Biology, Herpesviridae, Kidney transplantation, Viral disease, Gene, Internal medicine, BiochemistryTop concepts (fields/topics) attached by OpenAlex
- Cited by
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32Total citation count in OpenAlex
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2025: 18, 2024: 8, 2023: 6Per-year citation counts (last 5 years)
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195Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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