‘Inflammaging’ in Major Depressive Disorder: Associations between markers of inflammation and brain ageing in depression across two large community-based cohorts Article Swipe
Claire Green
,
Marco Squillace
,
Anna J. Stevenson
,
Aleks Stolicyn
,
Mathew A. Harris
,
Ellen V. Backhouse
,
Emma L. Hawkins
,
Adele M. Taylor
,
Zoë Morris
,
Joanna M. Wardlaw
,
J. Douglas Steele
,
Gordon D. Waiter
,
Anca‐Larisa Sandu
,
David J. Porteous
,
James H. Cole
,
Stephen M. Lawrie
,
Jonathan Cavanagh
,
Simon R. Cox
,
Andrew M. McIntosh
,
Heather C. Whalley
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1101/2021.12.17.21267979
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1101/2021.12.17.21267979
Background Major Depressive Disorder (MDD) is associated with accelerated ageing trajectories including functional markers of ageing, cellular ageing and markers of poor brain health. The biological mechanisms underlying these associations remain poorly understood. Chronic inflammation is also associated with advanced ageing; however, the degree to which long-term inflammation plays a role in ageing in MDD remains unclear, partly due to difficulties differentiating long-term inflammation from acute cross-sectional measures. Methods Here, we use a longer-term measure of inflammation: a DNA methylation-based marker of C-reactive protein (DNAm CRP), in a large cohort of individuals deeply phenotyped for MDD (Generation Scotland, GS; N =804). We investigate associations between DNAm CRP and serum CRP using linear modelling with two brain ageing neuroimaging-derived phenotypes: (i) a machine learning based measure of brain-predicted age difference (brain-PAD) and (ii) white matter hyperintensities (WMH). We then examine inflammation by depression interaction effects for these brain ageing phenotypes. We sought to replicate findings in an independent sample of older community-dwelling adults (Lothian Birth Cohort 1936, LBC1936; N =615). Results DNAm CRP was significantly associated with increased brain-PAD (β=0.111, p=0.015), which was replicated in the independent sample with a similar significant effect size (β=0.114, p=0.012). There were no associations between the inflammation markers and WMH phenotypes in the GS-imaging sample, however in the LBC1936 sample, DNAm CRP was significantly associated with both Wahlund infratentorial (β=0.15, P FDR = 0.006) and Fazekas deep white matter hyperintensity scores (β= 0.116, P FDR =0.033). There were no interaction effects between inflammation and MDD in either cohort. Conclusions This study found robust associations between a longer-term marker of inflammation and brain ageing as measured by brain-PAD, consistent across two large independent samples. However, we found no evidence for interaction effects between inflammation and MDD on any brain ageing phenotype in these community-based cohorts. These findings provide evidence that chronic inflammation is associated with increased brain ageing, which is not specific to MDD. Future work should investigate these relationships in clinical samples including with other inflammatory biomarkers and should furthermore aim to determine causal directionality.
Related Topics
Concepts
Ageing
Late life depression
Inflammation
Cohort
Hyperintensity
Depression (economics)
Medicine
Major depressive disorder
White matter
dNaM
Internal medicine
Neuroimaging
Psychology
Oncology
Magnetic resonance imaging
Psychiatry
Biology
DNA methylation
Amygdala
Genetics
Gene expression
Macroeconomics
Economics
Radiology
Hippocampal formation
Gene
Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.1101/2021.12.17.21267979
- https://www.medrxiv.org/content/medrxiv/early/2021/12/17/2021.12.17.21267979.full.pdf
- OA Status
- green
- Cited By
- 2
- References
- 62
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4200214457
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4200214457Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1101/2021.12.17.21267979Digital Object Identifier
- Title
-
‘Inflammaging’ in Major Depressive Disorder: Associations between markers of inflammation and brain ageing in depression across two large community-based cohortsWork title
- Type
-
preprintOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2021Year of publication
- Publication date
-
2021-12-17Full publication date if available
- Authors
-
Claire Green, Marco Squillace, Anna J. Stevenson, Aleks Stolicyn, Mathew A. Harris, Ellen V. Backhouse, Emma L. Hawkins, Adele M. Taylor, Zoë Morris, Joanna M. Wardlaw, J. Douglas Steele, Gordon D. Waiter, Anca‐Larisa Sandu, David J. Porteous, James H. Cole, Stephen M. Lawrie, Jonathan Cavanagh, Simon R. Cox, Andrew M. McIntosh, Heather C. WhalleyList of authors in order
- Landing page
-
https://doi.org/10.1101/2021.12.17.21267979Publisher landing page
- PDF URL
-
https://www.medrxiv.org/content/medrxiv/early/2021/12/17/2021.12.17.21267979.full.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
-
https://www.medrxiv.org/content/medrxiv/early/2021/12/17/2021.12.17.21267979.full.pdfDirect OA link when available
- Concepts
-
Ageing, Late life depression, Inflammation, Cohort, Hyperintensity, Depression (economics), Medicine, Major depressive disorder, White matter, dNaM, Internal medicine, Neuroimaging, Psychology, Oncology, Magnetic resonance imaging, Psychiatry, Biology, DNA methylation, Amygdala, Genetics, Gene expression, Macroeconomics, Economics, Radiology, Hippocampal formation, GeneTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
2Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 2Per-year citation counts (last 5 years)
- References (count)
-
62Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W4200214457 |
|---|---|
| doi | https://doi.org/10.1101/2021.12.17.21267979 |
| ids.doi | https://doi.org/10.1101/2021.12.17.21267979 |
| ids.openalex | https://openalex.org/W4200214457 |
| fwci | 0.0 |
| type | preprint |
| title | ‘Inflammaging’ in Major Depressive Disorder: Associations between markers of inflammation and brain ageing in depression across two large community-based cohorts |
| biblio.issue | |
| biblio.volume | |
| biblio.last_page | |
| biblio.first_page | |
| topics[0].id | https://openalex.org/T11337 |
| topics[0].field.id | https://openalex.org/fields/28 |
| topics[0].field.display_name | Neuroscience |
| topics[0].score | 0.9998000264167786 |
| topics[0].domain.id | https://openalex.org/domains/1 |
| topics[0].domain.display_name | Life Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/2803 |
| topics[0].subfield.display_name | Biological Psychiatry |
| topics[0].display_name | Tryptophan and brain disorders |
| topics[1].id | https://openalex.org/T10529 |
| topics[1].field.id | https://openalex.org/fields/28 |
| topics[1].field.display_name | Neuroscience |
| topics[1].score | 0.9948999881744385 |
| topics[1].domain.id | https://openalex.org/domains/1 |
| topics[1].domain.display_name | Life Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/2802 |
| topics[1].subfield.display_name | Behavioral Neuroscience |
| topics[1].display_name | Stress Responses and Cortisol |
| topics[2].id | https://openalex.org/T10786 |
| topics[2].field.id | https://openalex.org/fields/27 |
| topics[2].field.display_name | Medicine |
| topics[2].score | 0.9868000149726868 |
| topics[2].domain.id | https://openalex.org/domains/4 |
| topics[2].domain.display_name | Health Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/2739 |
| topics[2].subfield.display_name | Public Health, Environmental and Occupational Health |
| topics[2].display_name | Maternal Mental Health During Pregnancy and Postpartum |
| is_xpac | False |
| apc_list | |
| apc_paid | |
| concepts[0].id | https://openalex.org/C500499127 |
| concepts[0].level | 2 |
| concepts[0].score | 0.7284094095230103 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q332154 |
| concepts[0].display_name | Ageing |
| concepts[1].id | https://openalex.org/C2781357127 |
| concepts[1].level | 3 |
| concepts[1].score | 0.5656310319900513 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q438896 |
| concepts[1].display_name | Late life depression |
| concepts[2].id | https://openalex.org/C2776914184 |
| concepts[2].level | 2 |
| concepts[2].score | 0.553745687007904 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q101991 |
| concepts[2].display_name | Inflammation |
| concepts[3].id | https://openalex.org/C72563966 |
| concepts[3].level | 2 |
| concepts[3].score | 0.5398707985877991 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q1303415 |
| concepts[3].display_name | Cohort |
| concepts[4].id | https://openalex.org/C146638467 |
| concepts[4].level | 3 |
| concepts[4].score | 0.5300701856613159 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q10529587 |
| concepts[4].display_name | Hyperintensity |
| concepts[5].id | https://openalex.org/C2776867660 |
| concepts[5].level | 2 |
| concepts[5].score | 0.5276374220848083 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q1814941 |
| concepts[5].display_name | Depression (economics) |
| concepts[6].id | https://openalex.org/C71924100 |
| concepts[6].level | 0 |
| concepts[6].score | 0.49822521209716797 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q11190 |
| concepts[6].display_name | Medicine |
| concepts[7].id | https://openalex.org/C2780051608 |
| concepts[7].level | 3 |
| concepts[7].score | 0.4810529053211212 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q42844 |
| concepts[7].display_name | Major depressive disorder |
| concepts[8].id | https://openalex.org/C2781192897 |
| concepts[8].level | 3 |
| concepts[8].score | 0.47634127736091614 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q822050 |
| concepts[8].display_name | White matter |
| concepts[9].id | https://openalex.org/C2775921022 |
| concepts[9].level | 5 |
| concepts[9].score | 0.45934659242630005 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q25104749 |
| concepts[9].display_name | dNaM |
| concepts[10].id | https://openalex.org/C126322002 |
| concepts[10].level | 1 |
| concepts[10].score | 0.44088485836982727 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q11180 |
| concepts[10].display_name | Internal medicine |
| concepts[11].id | https://openalex.org/C58693492 |
| concepts[11].level | 2 |
| concepts[11].score | 0.43365633487701416 |
| concepts[11].wikidata | https://www.wikidata.org/wiki/Q551875 |
| concepts[11].display_name | Neuroimaging |
| concepts[12].id | https://openalex.org/C15744967 |
| concepts[12].level | 0 |
| concepts[12].score | 0.35241398215293884 |
| concepts[12].wikidata | https://www.wikidata.org/wiki/Q9418 |
| concepts[12].display_name | Psychology |
| concepts[13].id | https://openalex.org/C143998085 |
| concepts[13].level | 1 |
| concepts[13].score | 0.34914541244506836 |
| concepts[13].wikidata | https://www.wikidata.org/wiki/Q162555 |
| concepts[13].display_name | Oncology |
| concepts[14].id | https://openalex.org/C143409427 |
| concepts[14].level | 2 |
| concepts[14].score | 0.24223294854164124 |
| concepts[14].wikidata | https://www.wikidata.org/wiki/Q161238 |
| concepts[14].display_name | Magnetic resonance imaging |
| concepts[15].id | https://openalex.org/C118552586 |
| concepts[15].level | 1 |
| concepts[15].score | 0.18614792823791504 |
| concepts[15].wikidata | https://www.wikidata.org/wiki/Q7867 |
| concepts[15].display_name | Psychiatry |
| concepts[16].id | https://openalex.org/C86803240 |
| concepts[16].level | 0 |
| concepts[16].score | 0.17682576179504395 |
| concepts[16].wikidata | https://www.wikidata.org/wiki/Q420 |
| concepts[16].display_name | Biology |
| concepts[17].id | https://openalex.org/C190727270 |
| concepts[17].level | 4 |
| concepts[17].score | 0.16544976830482483 |
| concepts[17].wikidata | https://www.wikidata.org/wiki/Q874745 |
| concepts[17].display_name | DNA methylation |
| concepts[18].id | https://openalex.org/C2779144063 |
| concepts[18].level | 2 |
| concepts[18].score | 0.10097804665565491 |
| concepts[18].wikidata | https://www.wikidata.org/wiki/Q338924 |
| concepts[18].display_name | Amygdala |
| concepts[19].id | https://openalex.org/C54355233 |
| concepts[19].level | 1 |
| concepts[19].score | 0.09073793888092041 |
| concepts[19].wikidata | https://www.wikidata.org/wiki/Q7162 |
| concepts[19].display_name | Genetics |
| concepts[20].id | https://openalex.org/C150194340 |
| concepts[20].level | 3 |
| concepts[20].score | 0.0 |
| concepts[20].wikidata | https://www.wikidata.org/wiki/Q26972 |
| concepts[20].display_name | Gene expression |
| concepts[21].id | https://openalex.org/C139719470 |
| concepts[21].level | 1 |
| concepts[21].score | 0.0 |
| concepts[21].wikidata | https://www.wikidata.org/wiki/Q39680 |
| concepts[21].display_name | Macroeconomics |
| concepts[22].id | https://openalex.org/C162324750 |
| concepts[22].level | 0 |
| concepts[22].score | 0.0 |
| concepts[22].wikidata | https://www.wikidata.org/wiki/Q8134 |
| concepts[22].display_name | Economics |
| concepts[23].id | https://openalex.org/C126838900 |
| concepts[23].level | 1 |
| concepts[23].score | 0.0 |
| concepts[23].wikidata | https://www.wikidata.org/wiki/Q77604 |
| concepts[23].display_name | Radiology |
| concepts[24].id | https://openalex.org/C148762608 |
| concepts[24].level | 2 |
| concepts[24].score | 0.0 |
| concepts[24].wikidata | https://www.wikidata.org/wiki/Q3748185 |
| concepts[24].display_name | Hippocampal formation |
| concepts[25].id | https://openalex.org/C104317684 |
| concepts[25].level | 2 |
| concepts[25].score | 0.0 |
| concepts[25].wikidata | https://www.wikidata.org/wiki/Q7187 |
| concepts[25].display_name | Gene |
| keywords[0].id | https://openalex.org/keywords/ageing |
| keywords[0].score | 0.7284094095230103 |
| keywords[0].display_name | Ageing |
| keywords[1].id | https://openalex.org/keywords/late-life-depression |
| keywords[1].score | 0.5656310319900513 |
| keywords[1].display_name | Late life depression |
| keywords[2].id | https://openalex.org/keywords/inflammation |
| keywords[2].score | 0.553745687007904 |
| keywords[2].display_name | Inflammation |
| keywords[3].id | https://openalex.org/keywords/cohort |
| keywords[3].score | 0.5398707985877991 |
| keywords[3].display_name | Cohort |
| keywords[4].id | https://openalex.org/keywords/hyperintensity |
| keywords[4].score | 0.5300701856613159 |
| keywords[4].display_name | Hyperintensity |
| keywords[5].id | https://openalex.org/keywords/depression |
| keywords[5].score | 0.5276374220848083 |
| keywords[5].display_name | Depression (economics) |
| keywords[6].id | https://openalex.org/keywords/medicine |
| keywords[6].score | 0.49822521209716797 |
| keywords[6].display_name | Medicine |
| keywords[7].id | https://openalex.org/keywords/major-depressive-disorder |
| keywords[7].score | 0.4810529053211212 |
| keywords[7].display_name | Major depressive disorder |
| keywords[8].id | https://openalex.org/keywords/white-matter |
| keywords[8].score | 0.47634127736091614 |
| keywords[8].display_name | White matter |
| keywords[9].id | https://openalex.org/keywords/dnam |
| keywords[9].score | 0.45934659242630005 |
| keywords[9].display_name | dNaM |
| keywords[10].id | https://openalex.org/keywords/internal-medicine |
| keywords[10].score | 0.44088485836982727 |
| keywords[10].display_name | Internal medicine |
| keywords[11].id | https://openalex.org/keywords/neuroimaging |
| keywords[11].score | 0.43365633487701416 |
| keywords[11].display_name | Neuroimaging |
| keywords[12].id | https://openalex.org/keywords/psychology |
| keywords[12].score | 0.35241398215293884 |
| keywords[12].display_name | Psychology |
| keywords[13].id | https://openalex.org/keywords/oncology |
| keywords[13].score | 0.34914541244506836 |
| keywords[13].display_name | Oncology |
| keywords[14].id | https://openalex.org/keywords/magnetic-resonance-imaging |
| keywords[14].score | 0.24223294854164124 |
| keywords[14].display_name | Magnetic resonance imaging |
| keywords[15].id | https://openalex.org/keywords/psychiatry |
| keywords[15].score | 0.18614792823791504 |
| keywords[15].display_name | Psychiatry |
| keywords[16].id | https://openalex.org/keywords/biology |
| keywords[16].score | 0.17682576179504395 |
| keywords[16].display_name | Biology |
| keywords[17].id | https://openalex.org/keywords/dna-methylation |
| keywords[17].score | 0.16544976830482483 |
| keywords[17].display_name | DNA methylation |
| keywords[18].id | https://openalex.org/keywords/amygdala |
| keywords[18].score | 0.10097804665565491 |
| keywords[18].display_name | Amygdala |
| keywords[19].id | https://openalex.org/keywords/genetics |
| keywords[19].score | 0.09073793888092041 |
| keywords[19].display_name | Genetics |
| language | en |
| locations[0].id | doi:10.1101/2021.12.17.21267979 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S4306402567 |
| locations[0].source.issn | |
| locations[0].source.type | repository |
| locations[0].source.is_oa | False |
| locations[0].source.issn_l | |
| locations[0].source.is_core | False |
| locations[0].source.is_in_doaj | False |
| locations[0].source.display_name | bioRxiv (Cold Spring Harbor Laboratory) |
| locations[0].source.host_organization | https://openalex.org/I2750212522 |
| locations[0].source.host_organization_name | Cold Spring Harbor Laboratory |
| locations[0].source.host_organization_lineage | https://openalex.org/I2750212522 |
| locations[0].license | cc-by |
| locations[0].pdf_url | https://www.medrxiv.org/content/medrxiv/early/2021/12/17/2021.12.17.21267979.full.pdf |
| locations[0].version | acceptedVersion |
| locations[0].raw_type | posted-content |
| locations[0].license_id | https://openalex.org/licenses/cc-by |
| locations[0].is_accepted | True |
| locations[0].is_published | False |
| locations[0].raw_source_name | |
| locations[0].landing_page_url | https://doi.org/10.1101/2021.12.17.21267979 |
| indexed_in | crossref |
| authorships[0].author.id | https://openalex.org/A5067455273 |
| authorships[0].author.orcid | https://orcid.org/0000-0003-2146-8545 |
| authorships[0].author.display_name | Claire Green |
| authorships[0].countries | GB |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I98677209 |
| authorships[0].affiliations[0].raw_affiliation_string | Division of Psychiatry, University of Edinburgh, Edinburgh, UK |
| authorships[0].institutions[0].id | https://openalex.org/I98677209 |
| authorships[0].institutions[0].ror | https://ror.org/01nrxwf90 |
| authorships[0].institutions[0].type | education |
| authorships[0].institutions[0].lineage | https://openalex.org/I98677209 |
| authorships[0].institutions[0].country_code | GB |
| authorships[0].institutions[0].display_name | University of Edinburgh |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Claire Green |
| authorships[0].is_corresponding | True |
| authorships[0].raw_affiliation_strings | Division of Psychiatry, University of Edinburgh, Edinburgh, UK |
| authorships[1].author.id | https://openalex.org/A5067420050 |
| authorships[1].author.orcid | https://orcid.org/0000-0002-0218-1816 |
| authorships[1].author.display_name | Marco Squillace |
| authorships[1].countries | GB |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I98677209 |
| authorships[1].affiliations[0].raw_affiliation_string | Division of Psychiatry, University of Edinburgh, Edinburgh, UK |
| authorships[1].institutions[0].id | https://openalex.org/I98677209 |
| authorships[1].institutions[0].ror | https://ror.org/01nrxwf90 |
| authorships[1].institutions[0].type | education |
| authorships[1].institutions[0].lineage | https://openalex.org/I98677209 |
| authorships[1].institutions[0].country_code | GB |
| authorships[1].institutions[0].display_name | University of Edinburgh |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Marco Squillace |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Division of Psychiatry, University of Edinburgh, Edinburgh, UK |
| authorships[2].author.id | https://openalex.org/A5020054146 |
| authorships[2].author.orcid | https://orcid.org/0000-0002-0435-3562 |
| authorships[2].author.display_name | Anna J. Stevenson |
| authorships[2].countries | GB |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I2802581871 |
| authorships[2].affiliations[0].raw_affiliation_string | Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK |
| authorships[2].institutions[0].id | https://openalex.org/I2802581871 |
| authorships[2].institutions[0].ror | https://ror.org/05a7t9b67 |
| authorships[2].institutions[0].type | facility |
| authorships[2].institutions[0].lineage | https://openalex.org/I2801316944, https://openalex.org/I2802581871, https://openalex.org/I98677209 |
| authorships[2].institutions[0].country_code | GB |
| authorships[2].institutions[0].display_name | Edinburgh Cancer Research |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Anna J. Stevenson |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK |
| authorships[3].author.id | https://openalex.org/A5041941725 |
| authorships[3].author.orcid | https://orcid.org/0000-0002-1147-7539 |
| authorships[3].author.display_name | Aleks Stolicyn |
| authorships[3].countries | GB |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I98677209 |
| authorships[3].affiliations[0].raw_affiliation_string | Division of Psychiatry, University of Edinburgh, Edinburgh, UK |
| authorships[3].institutions[0].id | https://openalex.org/I98677209 |
| authorships[3].institutions[0].ror | https://ror.org/01nrxwf90 |
| authorships[3].institutions[0].type | education |
| authorships[3].institutions[0].lineage | https://openalex.org/I98677209 |
| authorships[3].institutions[0].country_code | GB |
| authorships[3].institutions[0].display_name | University of Edinburgh |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Aleks Stolicyn |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Division of Psychiatry, University of Edinburgh, Edinburgh, UK |
| authorships[4].author.id | https://openalex.org/A5036897832 |
| authorships[4].author.orcid | https://orcid.org/0000-0002-1135-4141 |
| authorships[4].author.display_name | Mathew A. Harris |
| authorships[4].countries | GB |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I98677209 |
| authorships[4].affiliations[0].raw_affiliation_string | Division of Psychiatry, University of Edinburgh, Edinburgh, UK |
| authorships[4].institutions[0].id | https://openalex.org/I98677209 |
| authorships[4].institutions[0].ror | https://ror.org/01nrxwf90 |
| authorships[4].institutions[0].type | education |
| authorships[4].institutions[0].lineage | https://openalex.org/I98677209 |
| authorships[4].institutions[0].country_code | GB |
| authorships[4].institutions[0].display_name | University of Edinburgh |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Mathew A. Harris |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Division of Psychiatry, University of Edinburgh, Edinburgh, UK |
| authorships[5].author.id | https://openalex.org/A5073939984 |
| authorships[5].author.orcid | https://orcid.org/0000-0001-5083-9945 |
| authorships[5].author.display_name | Ellen V. Backhouse |
| authorships[5].countries | GB |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I98677209 |
| authorships[5].affiliations[0].raw_affiliation_string | Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK |
| authorships[5].institutions[0].id | https://openalex.org/I98677209 |
| authorships[5].institutions[0].ror | https://ror.org/01nrxwf90 |
| authorships[5].institutions[0].type | education |
| authorships[5].institutions[0].lineage | https://openalex.org/I98677209 |
| authorships[5].institutions[0].country_code | GB |
| authorships[5].institutions[0].display_name | University of Edinburgh |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Ellen V. Backhouse |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK |
| authorships[6].author.id | https://openalex.org/A5003657127 |
| authorships[6].author.orcid | https://orcid.org/0000-0002-0241-7251 |
| authorships[6].author.display_name | Emma L. Hawkins |
| authorships[6].countries | GB |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I98677209 |
| authorships[6].affiliations[0].raw_affiliation_string | Division of Psychiatry, University of Edinburgh, Edinburgh, UK |
| authorships[6].institutions[0].id | https://openalex.org/I98677209 |
| authorships[6].institutions[0].ror | https://ror.org/01nrxwf90 |
| authorships[6].institutions[0].type | education |
| authorships[6].institutions[0].lineage | https://openalex.org/I98677209 |
| authorships[6].institutions[0].country_code | GB |
| authorships[6].institutions[0].display_name | University of Edinburgh |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Emma L. Hawkins |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | Division of Psychiatry, University of Edinburgh, Edinburgh, UK |
| authorships[7].author.id | https://openalex.org/A5107192894 |
| authorships[7].author.orcid | https://orcid.org/0000-0003-4541-4568 |
| authorships[7].author.display_name | Adele M. Taylor |
| authorships[7].countries | GB |
| authorships[7].affiliations[0].institution_ids | https://openalex.org/I1324252669, https://openalex.org/I98677209 |
| authorships[7].affiliations[0].raw_affiliation_string | Lothian Birth Cohorts, University of Edinburgh, Edinburgh, UK |
| authorships[7].institutions[0].id | https://openalex.org/I1324252669 |
| authorships[7].institutions[0].ror | https://ror.org/03q82t418 |
| authorships[7].institutions[0].type | healthcare |
| authorships[7].institutions[0].lineage | https://openalex.org/I1324252669 |
| authorships[7].institutions[0].country_code | GB |
| authorships[7].institutions[0].display_name | NHS Lothian |
| authorships[7].institutions[1].id | https://openalex.org/I98677209 |
| authorships[7].institutions[1].ror | https://ror.org/01nrxwf90 |
| authorships[7].institutions[1].type | education |
| authorships[7].institutions[1].lineage | https://openalex.org/I98677209 |
| authorships[7].institutions[1].country_code | GB |
| authorships[7].institutions[1].display_name | University of Edinburgh |
| authorships[7].author_position | middle |
| authorships[7].raw_author_name | Adele M. Taylor |
| authorships[7].is_corresponding | False |
| authorships[7].raw_affiliation_strings | Lothian Birth Cohorts, University of Edinburgh, Edinburgh, UK |
| authorships[8].author.id | https://openalex.org/A5057186020 |
| authorships[8].author.orcid | https://orcid.org/0000-0002-0288-1708 |
| authorships[8].author.display_name | Zoë Morris |
| authorships[8].countries | GB |
| authorships[8].affiliations[0].institution_ids | https://openalex.org/I2802789809 |
| authorships[8].affiliations[0].raw_affiliation_string | Department of Clinical Neurosciences (Imaging), Royal Infirmary of Edinburgh, UK |
| authorships[8].institutions[0].id | https://openalex.org/I2802789809 |
| authorships[8].institutions[0].ror | https://ror.org/009bsy196 |
| authorships[8].institutions[0].type | healthcare |
| authorships[8].institutions[0].lineage | https://openalex.org/I2802789809 |
| authorships[8].institutions[0].country_code | GB |
| authorships[8].institutions[0].display_name | Edinburgh Royal Infirmary |
| authorships[8].author_position | middle |
| authorships[8].raw_author_name | Zoe Morris |
| authorships[8].is_corresponding | False |
| authorships[8].raw_affiliation_strings | Department of Clinical Neurosciences (Imaging), Royal Infirmary of Edinburgh, UK |
| authorships[9].author.id | https://openalex.org/A5004889443 |
| authorships[9].author.orcid | https://orcid.org/0000-0002-9812-6642 |
| authorships[9].author.display_name | Joanna M. Wardlaw |
| authorships[9].countries | GB |
| authorships[9].affiliations[0].institution_ids | https://openalex.org/I98677209 |
| authorships[9].affiliations[0].raw_affiliation_string | Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK |
| authorships[9].affiliations[1].institution_ids | https://openalex.org/I4210126463, https://openalex.org/I98677209 |
| authorships[9].affiliations[1].raw_affiliation_string | UK Dementia Research Institute, Edinburgh Medical School, University of Edinburgh, Edinburgh, UK |
| authorships[9].institutions[0].id | https://openalex.org/I4210126463 |
| authorships[9].institutions[0].ror | https://ror.org/02wedp412 |
| authorships[9].institutions[0].type | facility |
| authorships[9].institutions[0].lineage | https://openalex.org/I4210126463 |
| authorships[9].institutions[0].country_code | GB |
| authorships[9].institutions[0].display_name | UK Dementia Research Institute |
| authorships[9].institutions[1].id | https://openalex.org/I98677209 |
| authorships[9].institutions[1].ror | https://ror.org/01nrxwf90 |
| authorships[9].institutions[1].type | education |
| authorships[9].institutions[1].lineage | https://openalex.org/I98677209 |
| authorships[9].institutions[1].country_code | GB |
| authorships[9].institutions[1].display_name | University of Edinburgh |
| authorships[9].author_position | middle |
| authorships[9].raw_author_name | Joanna M. Wardlaw |
| authorships[9].is_corresponding | False |
| authorships[9].raw_affiliation_strings | Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK, UK Dementia Research Institute, Edinburgh Medical School, University of Edinburgh, Edinburgh, UK |
| authorships[10].author.id | https://openalex.org/A5055301974 |
| authorships[10].author.orcid | https://orcid.org/0000-0002-9822-8753 |
| authorships[10].author.display_name | J. Douglas Steele |
| authorships[10].countries | GB |
| authorships[10].affiliations[0].institution_ids | https://openalex.org/I177639307 |
| authorships[10].affiliations[0].raw_affiliation_string | Division of Imaging Science and Technology, School of Medicine, University of Dundee, Dundee, UK |
| authorships[10].institutions[0].id | https://openalex.org/I177639307 |
| authorships[10].institutions[0].ror | https://ror.org/03h2bxq36 |
| authorships[10].institutions[0].type | education |
| authorships[10].institutions[0].lineage | https://openalex.org/I177639307 |
| authorships[10].institutions[0].country_code | GB |
| authorships[10].institutions[0].display_name | University of Dundee |
| authorships[10].author_position | middle |
| authorships[10].raw_author_name | J Douglas Steele |
| authorships[10].is_corresponding | False |
| authorships[10].raw_affiliation_strings | Division of Imaging Science and Technology, School of Medicine, University of Dundee, Dundee, UK |
| authorships[11].author.id | https://openalex.org/A5071117337 |
| authorships[11].author.orcid | https://orcid.org/0000-0002-5313-9845 |
| authorships[11].author.display_name | Gordon D. Waiter |
| authorships[11].countries | GB |
| authorships[11].affiliations[0].institution_ids | https://openalex.org/I195460627 |
| authorships[11].affiliations[0].raw_affiliation_string | Aberdeen Biomedical Imaging Centre, Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK |
| authorships[11].institutions[0].id | https://openalex.org/I195460627 |
| authorships[11].institutions[0].ror | https://ror.org/016476m91 |
| authorships[11].institutions[0].type | education |
| authorships[11].institutions[0].lineage | https://openalex.org/I195460627 |
| authorships[11].institutions[0].country_code | GB |
| authorships[11].institutions[0].display_name | University of Aberdeen |
| authorships[11].author_position | middle |
| authorships[11].raw_author_name | Gordon D. Waiter |
| authorships[11].is_corresponding | False |
| authorships[11].raw_affiliation_strings | Aberdeen Biomedical Imaging Centre, Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK |
| authorships[12].author.id | https://openalex.org/A5081082126 |
| authorships[12].author.orcid | https://orcid.org/0000-0002-5555-4129 |
| authorships[12].author.display_name | Anca‐Larisa Sandu |
| authorships[12].countries | GB |
| authorships[12].affiliations[0].institution_ids | https://openalex.org/I195460627 |
| authorships[12].affiliations[0].raw_affiliation_string | Aberdeen Biomedical Imaging Centre, Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK |
| authorships[12].institutions[0].id | https://openalex.org/I195460627 |
| authorships[12].institutions[0].ror | https://ror.org/016476m91 |
| authorships[12].institutions[0].type | education |
| authorships[12].institutions[0].lineage | https://openalex.org/I195460627 |
| authorships[12].institutions[0].country_code | GB |
| authorships[12].institutions[0].display_name | University of Aberdeen |
| authorships[12].author_position | middle |
| authorships[12].raw_author_name | Anca-Larisa Sandu |
| authorships[12].is_corresponding | False |
| authorships[12].raw_affiliation_strings | Aberdeen Biomedical Imaging Centre, Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK |
| authorships[13].author.id | https://openalex.org/A5084175530 |
| authorships[13].author.orcid | https://orcid.org/0000-0003-1249-6106 |
| authorships[13].author.display_name | David J. Porteous |
| authorships[13].countries | GB |
| authorships[13].affiliations[0].institution_ids | https://openalex.org/I2802581871 |
| authorships[13].affiliations[0].raw_affiliation_string | Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK |
| authorships[13].institutions[0].id | https://openalex.org/I2802581871 |
| authorships[13].institutions[0].ror | https://ror.org/05a7t9b67 |
| authorships[13].institutions[0].type | facility |
| authorships[13].institutions[0].lineage | https://openalex.org/I2801316944, https://openalex.org/I2802581871, https://openalex.org/I98677209 |
| authorships[13].institutions[0].country_code | GB |
| authorships[13].institutions[0].display_name | Edinburgh Cancer Research |
| authorships[13].author_position | middle |
| authorships[13].raw_author_name | David J. Porteous |
| authorships[13].is_corresponding | False |
| authorships[13].raw_affiliation_strings | Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK |
| authorships[14].author.id | https://openalex.org/A5003288277 |
| authorships[14].author.orcid | https://orcid.org/0000-0003-1908-5588 |
| authorships[14].author.display_name | James H. Cole |
| authorships[14].countries | GB |
| authorships[14].affiliations[0].institution_ids | https://openalex.org/I4210126463, https://openalex.org/I4210151618, https://openalex.org/I45129253 |
| authorships[14].affiliations[0].raw_affiliation_string | Dementia Research Centre, Queen Square Institute of Neurology, University College London, London, UK |
| authorships[14].affiliations[1].institution_ids | https://openalex.org/I45129253 |
| authorships[14].affiliations[1].raw_affiliation_string | Centre for Medical Image Computing, Department of Computer Science, University College London, UK |
| authorships[14].institutions[0].id | https://openalex.org/I4210151618 |
| authorships[14].institutions[0].ror | https://ror.org/048b34d51 |
| authorships[14].institutions[0].type | healthcare |
| authorships[14].institutions[0].lineage | https://openalex.org/I1340918713, https://openalex.org/I4210151618 |
| authorships[14].institutions[0].country_code | GB |
| authorships[14].institutions[0].display_name | National Hospital for Neurology and Neurosurgery |
| authorships[14].institutions[1].id | https://openalex.org/I4210126463 |
| authorships[14].institutions[1].ror | https://ror.org/02wedp412 |
| authorships[14].institutions[1].type | facility |
| authorships[14].institutions[1].lineage | https://openalex.org/I4210126463 |
| authorships[14].institutions[1].country_code | GB |
| authorships[14].institutions[1].display_name | UK Dementia Research Institute |
| authorships[14].institutions[2].id | https://openalex.org/I45129253 |
| authorships[14].institutions[2].ror | https://ror.org/02jx3x895 |
| authorships[14].institutions[2].type | education |
| authorships[14].institutions[2].lineage | https://openalex.org/I124357947, https://openalex.org/I45129253 |
| authorships[14].institutions[2].country_code | GB |
| authorships[14].institutions[2].display_name | University College London |
| authorships[14].author_position | middle |
| authorships[14].raw_author_name | James H. Cole |
| authorships[14].is_corresponding | False |
| authorships[14].raw_affiliation_strings | Centre for Medical Image Computing, Department of Computer Science, University College London, UK, Dementia Research Centre, Queen Square Institute of Neurology, University College London, London, UK |
| authorships[15].author.id | https://openalex.org/A5066795737 |
| authorships[15].author.orcid | https://orcid.org/0000-0002-2444-5675 |
| authorships[15].author.display_name | Stephen M. Lawrie |
| authorships[15].countries | GB |
| authorships[15].affiliations[0].institution_ids | https://openalex.org/I98677209 |
| authorships[15].affiliations[0].raw_affiliation_string | Division of Psychiatry, University of Edinburgh, Edinburgh, UK |
| authorships[15].institutions[0].id | https://openalex.org/I98677209 |
| authorships[15].institutions[0].ror | https://ror.org/01nrxwf90 |
| authorships[15].institutions[0].type | education |
| authorships[15].institutions[0].lineage | https://openalex.org/I98677209 |
| authorships[15].institutions[0].country_code | GB |
| authorships[15].institutions[0].display_name | University of Edinburgh |
| authorships[15].author_position | middle |
| authorships[15].raw_author_name | Stephen M. Lawrie |
| authorships[15].is_corresponding | False |
| authorships[15].raw_affiliation_strings | Division of Psychiatry, University of Edinburgh, Edinburgh, UK |
| authorships[16].author.id | https://openalex.org/A5047863656 |
| authorships[16].author.orcid | https://orcid.org/0000-0003-0640-8050 |
| authorships[16].author.display_name | Jonathan Cavanagh |
| authorships[16].countries | GB |
| authorships[16].affiliations[0].institution_ids | https://openalex.org/I7882870 |
| authorships[16].affiliations[0].raw_affiliation_string | Institute of Infection, Immunity & Inflammation, College of Medical and Veterinary Life Sciences, University of Glasgow, Glasgow, UK |
| authorships[16].institutions[0].id | https://openalex.org/I7882870 |
| authorships[16].institutions[0].ror | https://ror.org/00vtgdb53 |
| authorships[16].institutions[0].type | education |
| authorships[16].institutions[0].lineage | https://openalex.org/I7882870 |
| authorships[16].institutions[0].country_code | GB |
| authorships[16].institutions[0].display_name | University of Glasgow |
| authorships[16].author_position | middle |
| authorships[16].raw_author_name | Jonathan Cavanagh |
| authorships[16].is_corresponding | False |
| authorships[16].raw_affiliation_strings | Institute of Infection, Immunity & Inflammation, College of Medical and Veterinary Life Sciences, University of Glasgow, Glasgow, UK |
| authorships[17].author.id | https://openalex.org/A5071569249 |
| authorships[17].author.orcid | https://orcid.org/0000-0003-4036-3642 |
| authorships[17].author.display_name | Simon R. Cox |
| authorships[17].countries | GB |
| authorships[17].affiliations[0].institution_ids | https://openalex.org/I98677209 |
| authorships[17].affiliations[0].raw_affiliation_string | Department of Psychology, University of Edinburgh, Edinburgh, UK |
| authorships[17].affiliations[1].institution_ids | https://openalex.org/I1324252669, https://openalex.org/I98677209 |
| authorships[17].affiliations[1].raw_affiliation_string | Lothian Birth Cohorts, University of Edinburgh, Edinburgh, UK |
| authorships[17].institutions[0].id | https://openalex.org/I1324252669 |
| authorships[17].institutions[0].ror | https://ror.org/03q82t418 |
| authorships[17].institutions[0].type | healthcare |
| authorships[17].institutions[0].lineage | https://openalex.org/I1324252669 |
| authorships[17].institutions[0].country_code | GB |
| authorships[17].institutions[0].display_name | NHS Lothian |
| authorships[17].institutions[1].id | https://openalex.org/I98677209 |
| authorships[17].institutions[1].ror | https://ror.org/01nrxwf90 |
| authorships[17].institutions[1].type | education |
| authorships[17].institutions[1].lineage | https://openalex.org/I98677209 |
| authorships[17].institutions[1].country_code | GB |
| authorships[17].institutions[1].display_name | University of Edinburgh |
| authorships[17].author_position | middle |
| authorships[17].raw_author_name | Simon R. Cox |
| authorships[17].is_corresponding | False |
| authorships[17].raw_affiliation_strings | Department of Psychology, University of Edinburgh, Edinburgh, UK, Lothian Birth Cohorts, University of Edinburgh, Edinburgh, UK |
| authorships[18].author.id | https://openalex.org/A5007623614 |
| authorships[18].author.orcid | https://orcid.org/0000-0002-0198-4588 |
| authorships[18].author.display_name | Andrew M. McIntosh |
| authorships[18].countries | GB |
| authorships[18].affiliations[0].institution_ids | https://openalex.org/I98677209 |
| authorships[18].affiliations[0].raw_affiliation_string | Division of Psychiatry, University of Edinburgh, Edinburgh, UK |
| authorships[18].affiliations[1].institution_ids | https://openalex.org/I195460627 |
| authorships[18].affiliations[1].raw_affiliation_string | Aberdeen Biomedical Imaging Centre, Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK |
| authorships[18].institutions[0].id | https://openalex.org/I195460627 |
| authorships[18].institutions[0].ror | https://ror.org/016476m91 |
| authorships[18].institutions[0].type | education |
| authorships[18].institutions[0].lineage | https://openalex.org/I195460627 |
| authorships[18].institutions[0].country_code | GB |
| authorships[18].institutions[0].display_name | University of Aberdeen |
| authorships[18].institutions[1].id | https://openalex.org/I98677209 |
| authorships[18].institutions[1].ror | https://ror.org/01nrxwf90 |
| authorships[18].institutions[1].type | education |
| authorships[18].institutions[1].lineage | https://openalex.org/I98677209 |
| authorships[18].institutions[1].country_code | GB |
| authorships[18].institutions[1].display_name | University of Edinburgh |
| authorships[18].author_position | middle |
| authorships[18].raw_author_name | Andrew M. McIntosh |
| authorships[18].is_corresponding | False |
| authorships[18].raw_affiliation_strings | Aberdeen Biomedical Imaging Centre, Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK, Division of Psychiatry, University of Edinburgh, Edinburgh, UK |
| authorships[19].author.id | https://openalex.org/A5089456652 |
| authorships[19].author.orcid | https://orcid.org/0000-0002-4505-8869 |
| authorships[19].author.display_name | Heather C. Whalley |
| authorships[19].countries | GB |
| authorships[19].affiliations[0].institution_ids | https://openalex.org/I98677209 |
| authorships[19].affiliations[0].raw_affiliation_string | Division of Psychiatry, University of Edinburgh, Edinburgh, UK |
| authorships[19].institutions[0].id | https://openalex.org/I98677209 |
| authorships[19].institutions[0].ror | https://ror.org/01nrxwf90 |
| authorships[19].institutions[0].type | education |
| authorships[19].institutions[0].lineage | https://openalex.org/I98677209 |
| authorships[19].institutions[0].country_code | GB |
| authorships[19].institutions[0].display_name | University of Edinburgh |
| authorships[19].author_position | last |
| authorships[19].raw_author_name | Heather C. Whalley |
| authorships[19].is_corresponding | False |
| authorships[19].raw_affiliation_strings | Division of Psychiatry, University of Edinburgh, Edinburgh, UK |
| has_content.pdf | True |
| has_content.grobid_xml | True |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://www.medrxiv.org/content/medrxiv/early/2021/12/17/2021.12.17.21267979.full.pdf |
| open_access.oa_status | green |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | ‘Inflammaging’ in Major Depressive Disorder: Associations between markers of inflammation and brain ageing in depression across two large community-based cohorts |
| has_fulltext | True |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T11337 |
| primary_topic.field.id | https://openalex.org/fields/28 |
| primary_topic.field.display_name | Neuroscience |
| primary_topic.score | 0.9998000264167786 |
| primary_topic.domain.id | https://openalex.org/domains/1 |
| primary_topic.domain.display_name | Life Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/2803 |
| primary_topic.subfield.display_name | Biological Psychiatry |
| primary_topic.display_name | Tryptophan and brain disorders |
| related_works | https://openalex.org/W2996570328, https://openalex.org/W4323537959, https://openalex.org/W4304811496, https://openalex.org/W4401928073, https://openalex.org/W3044392860, https://openalex.org/W4386303601, https://openalex.org/W2934489113, https://openalex.org/W2983358776, https://openalex.org/W2000450383, https://openalex.org/W2150798281 |
| cited_by_count | 2 |
| counts_by_year[0].year | 2025 |
| counts_by_year[0].cited_by_count | 2 |
| locations_count | 1 |
| best_oa_location.id | doi:10.1101/2021.12.17.21267979 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S4306402567 |
| best_oa_location.source.issn | |
| best_oa_location.source.type | repository |
| best_oa_location.source.is_oa | False |
| best_oa_location.source.issn_l | |
| best_oa_location.source.is_core | False |
| best_oa_location.source.is_in_doaj | False |
| best_oa_location.source.display_name | bioRxiv (Cold Spring Harbor Laboratory) |
| best_oa_location.source.host_organization | https://openalex.org/I2750212522 |
| best_oa_location.source.host_organization_name | Cold Spring Harbor Laboratory |
| best_oa_location.source.host_organization_lineage | https://openalex.org/I2750212522 |
| best_oa_location.license | cc-by |
| best_oa_location.pdf_url | https://www.medrxiv.org/content/medrxiv/early/2021/12/17/2021.12.17.21267979.full.pdf |
| best_oa_location.version | acceptedVersion |
| best_oa_location.raw_type | posted-content |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | False |
| best_oa_location.raw_source_name | |
| best_oa_location.landing_page_url | https://doi.org/10.1101/2021.12.17.21267979 |
| primary_location.id | doi:10.1101/2021.12.17.21267979 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S4306402567 |
| primary_location.source.issn | |
| primary_location.source.type | repository |
| primary_location.source.is_oa | False |
| primary_location.source.issn_l | |
| primary_location.source.is_core | False |
| primary_location.source.is_in_doaj | False |
| primary_location.source.display_name | bioRxiv (Cold Spring Harbor Laboratory) |
| primary_location.source.host_organization | https://openalex.org/I2750212522 |
| primary_location.source.host_organization_name | Cold Spring Harbor Laboratory |
| primary_location.source.host_organization_lineage | https://openalex.org/I2750212522 |
| primary_location.license | cc-by |
| primary_location.pdf_url | https://www.medrxiv.org/content/medrxiv/early/2021/12/17/2021.12.17.21267979.full.pdf |
| primary_location.version | acceptedVersion |
| primary_location.raw_type | posted-content |
| primary_location.license_id | https://openalex.org/licenses/cc-by |
| primary_location.is_accepted | True |
| primary_location.is_published | False |
| primary_location.raw_source_name | |
| primary_location.landing_page_url | https://doi.org/10.1101/2021.12.17.21267979 |
| publication_date | 2021-12-17 |
| publication_year | 2021 |
| referenced_works | https://openalex.org/W1976038311, https://openalex.org/W2285307127, https://openalex.org/W2162510673, https://openalex.org/W2076143792, https://openalex.org/W2306793661, https://openalex.org/W2127064468, https://openalex.org/W2032784244, https://openalex.org/W2602552939, https://openalex.org/W3213694919, https://openalex.org/W2149984789, https://openalex.org/W2126795224, https://openalex.org/W2467613733, https://openalex.org/W3006826700, https://openalex.org/W2131298552, https://openalex.org/W2969767589, https://openalex.org/W2021652661, https://openalex.org/W2091931051, https://openalex.org/W2127848069, https://openalex.org/W2129155846, https://openalex.org/W2605671917, https://openalex.org/W2993908729, https://openalex.org/W3202373886, https://openalex.org/W3105171788, https://openalex.org/W2608727369, https://openalex.org/W581977681, https://openalex.org/W2989823571, https://openalex.org/W2800301228, https://openalex.org/W3024838586, https://openalex.org/W3184779465, https://openalex.org/W2127484731, https://openalex.org/W2018887826, https://openalex.org/W2969829094, https://openalex.org/W2803884614, https://openalex.org/W2127124395, https://openalex.org/W2009665549, https://openalex.org/W2562655012, https://openalex.org/W2293108050, https://openalex.org/W2531569042, https://openalex.org/W1993608602, https://openalex.org/W2969144267, https://openalex.org/W2737161124, https://openalex.org/W1561650855, https://openalex.org/W2084158133, https://openalex.org/W2091259554, https://openalex.org/W2020402140, https://openalex.org/W2020935778, https://openalex.org/W2951913395, https://openalex.org/W2950587587, https://openalex.org/W2043957026, https://openalex.org/W3045068183, https://openalex.org/W3132892285, https://openalex.org/W1922605075, https://openalex.org/W2782975316, https://openalex.org/W2060852029, https://openalex.org/W2101934488, https://openalex.org/W2131943911, https://openalex.org/W2766927536, https://openalex.org/W1994257697, https://openalex.org/W2034510106, https://openalex.org/W2765863765, https://openalex.org/W1969425174, https://openalex.org/W2166281097 |
| referenced_works_count | 62 |
| abstract_inverted_index.= | 228 |
| abstract_inverted_index.N | 100, 168 |
| abstract_inverted_index.P | 226, 239 |
| abstract_inverted_index.a | 50, 73, 78, 88, 121, 189, 261 |
| abstract_inverted_index.We | 102, 137, 150 |
| abstract_inverted_index.an | 156 |
| abstract_inverted_index.as | 269 |
| abstract_inverted_index.by | 141, 271 |
| abstract_inverted_index.in | 52, 54, 87, 155, 184, 207, 212, 251, 296, 325 |
| abstract_inverted_index.is | 6, 36, 307, 314 |
| abstract_inverted_index.no | 198, 244, 282 |
| abstract_inverted_index.of | 15, 21, 76, 82, 91, 126, 159, 264 |
| abstract_inverted_index.on | 291 |
| abstract_inverted_index.to | 45, 60, 152, 317, 337 |
| abstract_inverted_index.we | 71, 280 |
| abstract_inverted_index.(i) | 120 |
| abstract_inverted_index.CRP | 107, 110, 172, 217 |
| abstract_inverted_index.DNA | 79 |
| abstract_inverted_index.FDR | 227, 240 |
| abstract_inverted_index.GS; | 99 |
| abstract_inverted_index.MDD | 55, 96, 250, 290 |
| abstract_inverted_index.The | 25 |
| abstract_inverted_index.WMH | 205 |
| abstract_inverted_index.age | 128 |
| abstract_inverted_index.aim | 336 |
| abstract_inverted_index.and | 19, 108, 131, 204, 230, 249, 266, 289, 333 |
| abstract_inverted_index.any | 292 |
| abstract_inverted_index.due | 59 |
| abstract_inverted_index.for | 95, 145, 284 |
| abstract_inverted_index.not | 315 |
| abstract_inverted_index.the | 43, 185, 201, 208, 213 |
| abstract_inverted_index.two | 115, 275 |
| abstract_inverted_index.use | 72 |
| abstract_inverted_index.was | 173, 182, 218 |
| abstract_inverted_index.(ii) | 132 |
| abstract_inverted_index.(β= | 237 |
| abstract_inverted_index.DNAm | 106, 171, 216 |
| abstract_inverted_index.MDD. | 318 |
| abstract_inverted_index.This | 255 |
| abstract_inverted_index.also | 37 |
| abstract_inverted_index.both | 222 |
| abstract_inverted_index.deep | 232 |
| abstract_inverted_index.from | 65 |
| abstract_inverted_index.poor | 22 |
| abstract_inverted_index.role | 51 |
| abstract_inverted_index.size | 193 |
| abstract_inverted_index.that | 304 |
| abstract_inverted_index.then | 138 |
| abstract_inverted_index.were | 197, 243 |
| abstract_inverted_index.with | 8, 39, 114, 176, 188, 221, 309, 329 |
| abstract_inverted_index.work | 320 |
| abstract_inverted_index.(DNAm | 85 |
| abstract_inverted_index.(MDD) | 5 |
| abstract_inverted_index.1936, | 166 |
| abstract_inverted_index.Birth | 164 |
| abstract_inverted_index.CRP), | 86 |
| abstract_inverted_index.Here, | 70 |
| abstract_inverted_index.Major | 2 |
| abstract_inverted_index.There | 196, 242 |
| abstract_inverted_index.These | 300 |
| abstract_inverted_index.acute | 66 |
| abstract_inverted_index.based | 124 |
| abstract_inverted_index.brain | 23, 116, 147, 267, 293, 311 |
| abstract_inverted_index.found | 257, 281 |
| abstract_inverted_index.large | 89, 276 |
| abstract_inverted_index.older | 160 |
| abstract_inverted_index.other | 330 |
| abstract_inverted_index.plays | 49 |
| abstract_inverted_index.serum | 109 |
| abstract_inverted_index.study | 256 |
| abstract_inverted_index.these | 29, 146, 297, 323 |
| abstract_inverted_index.using | 111 |
| abstract_inverted_index.which | 46, 181, 313 |
| abstract_inverted_index.white | 133, 233 |
| abstract_inverted_index.(WMH). | 136 |
| abstract_inverted_index.0.006) | 229 |
| abstract_inverted_index.0.116, | 238 |
| abstract_inverted_index.=615). | 169 |
| abstract_inverted_index.=804). | 101 |
| abstract_inverted_index.Cohort | 165 |
| abstract_inverted_index.Future | 319 |
| abstract_inverted_index.across | 274 |
| abstract_inverted_index.adults | 162 |
| abstract_inverted_index.ageing | 10, 18, 53, 117, 148, 268, 294 |
| abstract_inverted_index.causal | 339 |
| abstract_inverted_index.cohort | 90 |
| abstract_inverted_index.deeply | 93 |
| abstract_inverted_index.degree | 44 |
| abstract_inverted_index.effect | 192 |
| abstract_inverted_index.either | 252 |
| abstract_inverted_index.linear | 112 |
| abstract_inverted_index.marker | 81, 263 |
| abstract_inverted_index.matter | 134, 234 |
| abstract_inverted_index.partly | 58 |
| abstract_inverted_index.poorly | 32 |
| abstract_inverted_index.remain | 31 |
| abstract_inverted_index.robust | 258 |
| abstract_inverted_index.sample | 158, 187 |
| abstract_inverted_index.scores | 236 |
| abstract_inverted_index.should | 321, 334 |
| abstract_inverted_index.sought | 151 |
| abstract_inverted_index.Chronic | 34 |
| abstract_inverted_index.Fazekas | 231 |
| abstract_inverted_index.LBC1936 | 214 |
| abstract_inverted_index.Methods | 69 |
| abstract_inverted_index.Results | 170 |
| abstract_inverted_index.Wahlund | 223 |
| abstract_inverted_index.ageing, | 16, 312 |
| abstract_inverted_index.ageing; | 41 |
| abstract_inverted_index.between | 105, 200, 247, 260, 287 |
| abstract_inverted_index.chronic | 305 |
| abstract_inverted_index.cohort. | 253 |
| abstract_inverted_index.effects | 144, 246, 286 |
| abstract_inverted_index.examine | 139 |
| abstract_inverted_index.health. | 24 |
| abstract_inverted_index.however | 211 |
| abstract_inverted_index.machine | 122 |
| abstract_inverted_index.markers | 14, 20, 203 |
| abstract_inverted_index.measure | 75, 125 |
| abstract_inverted_index.protein | 84 |
| abstract_inverted_index.provide | 302 |
| abstract_inverted_index.remains | 56 |
| abstract_inverted_index.sample, | 210, 215 |
| abstract_inverted_index.samples | 327 |
| abstract_inverted_index.similar | 190 |
| abstract_inverted_index.(Lothian | 163 |
| abstract_inverted_index.=0.033). | 241 |
| abstract_inverted_index.Abstract | 0 |
| abstract_inverted_index.Disorder | 4 |
| abstract_inverted_index.However, | 279 |
| abstract_inverted_index.LBC1936; | 167 |
| abstract_inverted_index.advanced | 40 |
| abstract_inverted_index.cellular | 17 |
| abstract_inverted_index.clinical | 326 |
| abstract_inverted_index.cohorts. | 299 |
| abstract_inverted_index.evidence | 283, 303 |
| abstract_inverted_index.findings | 154, 301 |
| abstract_inverted_index.however, | 42 |
| abstract_inverted_index.learning | 123 |
| abstract_inverted_index.measured | 270 |
| abstract_inverted_index.samples. | 278 |
| abstract_inverted_index.specific | 316 |
| abstract_inverted_index.unclear, | 57 |
| abstract_inverted_index.(β=0.15, | 225 |
| abstract_inverted_index.Scotland, | 98 |
| abstract_inverted_index.brain-PAD | 178 |
| abstract_inverted_index.determine | 338 |
| abstract_inverted_index.including | 12, 328 |
| abstract_inverted_index.increased | 177, 310 |
| abstract_inverted_index.long-term | 47, 63 |
| abstract_inverted_index.measures. | 68 |
| abstract_inverted_index.modelling | 113 |
| abstract_inverted_index.p=0.012). | 195 |
| abstract_inverted_index.p=0.015), | 180 |
| abstract_inverted_index.phenotype | 295 |
| abstract_inverted_index.replicate | 153 |
| abstract_inverted_index.(β=0.111, | 179 |
| abstract_inverted_index.(β=0.114, | 194 |
| abstract_inverted_index.Background | 1 |
| abstract_inverted_index.C-reactive | 83 |
| abstract_inverted_index.Depressive | 3 |
| abstract_inverted_index.GS-imaging | 209 |
| abstract_inverted_index.associated | 7, 38, 175, 220, 308 |
| abstract_inverted_index.biological | 26 |
| abstract_inverted_index.biomarkers | 332 |
| abstract_inverted_index.brain-PAD, | 272 |
| abstract_inverted_index.consistent | 273 |
| abstract_inverted_index.depression | 142 |
| abstract_inverted_index.difference | 129 |
| abstract_inverted_index.functional | 13 |
| abstract_inverted_index.mechanisms | 27 |
| abstract_inverted_index.phenotyped | 94 |
| abstract_inverted_index.phenotypes | 206 |
| abstract_inverted_index.replicated | 183 |
| abstract_inverted_index.underlying | 28 |
| abstract_inverted_index.(Generation | 97 |
| abstract_inverted_index.(brain-PAD) | 130 |
| abstract_inverted_index.Conclusions | 254 |
| abstract_inverted_index.accelerated | 9 |
| abstract_inverted_index.furthermore | 335 |
| abstract_inverted_index.independent | 157, 186, 277 |
| abstract_inverted_index.individuals | 92 |
| abstract_inverted_index.interaction | 143, 245, 285 |
| abstract_inverted_index.investigate | 103, 322 |
| abstract_inverted_index.longer-term | 74, 262 |
| abstract_inverted_index.phenotypes. | 149 |
| abstract_inverted_index.phenotypes: | 119 |
| abstract_inverted_index.significant | 191 |
| abstract_inverted_index.understood. | 33 |
| abstract_inverted_index.associations | 30, 104, 199, 259 |
| abstract_inverted_index.difficulties | 61 |
| abstract_inverted_index.inflammation | 35, 48, 64, 140, 202, 248, 265, 288, 306 |
| abstract_inverted_index.inflammatory | 331 |
| abstract_inverted_index.trajectories | 11 |
| abstract_inverted_index.inflammation: | 77 |
| abstract_inverted_index.relationships | 324 |
| abstract_inverted_index.significantly | 174, 219 |
| abstract_inverted_index.hyperintensity | 235 |
| abstract_inverted_index.infratentorial | 224 |
| abstract_inverted_index.brain-predicted | 127 |
| abstract_inverted_index.community-based | 298 |
| abstract_inverted_index.cross-sectional | 67 |
| abstract_inverted_index.differentiating | 62 |
| abstract_inverted_index.directionality. | 340 |
| abstract_inverted_index.hyperintensities | 135 |
| abstract_inverted_index.methylation-based | 80 |
| abstract_inverted_index.community-dwelling | 161 |
| abstract_inverted_index.neuroimaging-derived | 118 |
| cited_by_percentile_year.max | 97 |
| cited_by_percentile_year.min | 95 |
| corresponding_author_ids | https://openalex.org/A5067455273 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 20 |
| corresponding_institution_ids | https://openalex.org/I98677209 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/1 |
| sustainable_development_goals[0].score | 0.7300000190734863 |
| sustainable_development_goals[0].display_name | No poverty |
| citation_normalized_percentile.value | 0.13955823 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |