Inflammasome-Independent Leukotriene B4 Production Drives Crystalline Silica–Induced Sterile Inflammation Article Swipe
Bindu Hegde
,
Sobha R. Bodduluri
,
Shuchismita R. Satpathy
,
Ruqaih S. Alghsham
,
Venkatakrishna R. Jala
,
Silvia M. Uriarte
,
Donghoon Chung
,
Matthew B. Lawrenz
,
Bodduluri Haribabu
·
YOU?
·
· 2018
· Open Access
·
· DOI: https://doi.org/10.4049/jimmunol.1701504
YOU?
·
· 2018
· Open Access
·
· DOI: https://doi.org/10.4049/jimmunol.1701504
Silicosis is a lung inflammatory disease caused by chronic exposure to crystalline silica (CS). Leukotriene B4 (LTB4) plays an important role in neutrophilic inflammation, which drives silicosis and promotes lung cancer. In this study, we examined the mechanisms involved in CS-induced inflammatory pathways. Phagocytosis of CS particles is essential for the production of LTB4 and IL-1β in mouse macrophages, mast cells, and neutrophils. Phagosomes enclosing CS particles trigger the assembly of lipidosome in the cytoplasm, which is likely the primary source of CS-induced LTB4 production. Activation of the JNK pathway is essential for both CS-induced LTB4 and IL-1β production. Studies with bafilomycin-A1– and NLRP3-deficient mice revealed that LTB4 synthesis in the lipidosome is independent of inflammasome activation. Small interfering RNA knockdown and confocal microscopy studies showed that GTPases Rab5c, Rab40c along with JNK1 are essential for lipidosome formation and LTB4 production. BI-78D3, a JNK inhibitor, abrogated CS-induced neutrophilic inflammation in vivo in an air pouch model. These results highlight an inflammasome-independent and JNK activation–dependent lipidosome pathway as a regulator of LTB4 synthesis and CS-induced sterile inflammation.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.4049/jimmunol.1701504
- https://www.jimmunol.org/content/jimmunol/200/10/3556.full.pdf
- OA Status
- bronze
- Cited By
- 31
- References
- 54
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2796011620
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W2796011620Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.4049/jimmunol.1701504Digital Object Identifier
- Title
-
Inflammasome-Independent Leukotriene B4 Production Drives Crystalline Silica–Induced Sterile InflammationWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2018Year of publication
- Publication date
-
2018-04-02Full publication date if available
- Authors
-
Bindu Hegde, Sobha R. Bodduluri, Shuchismita R. Satpathy, Ruqaih S. Alghsham, Venkatakrishna R. Jala, Silvia M. Uriarte, Donghoon Chung, Matthew B. Lawrenz, Bodduluri HaribabuList of authors in order
- Landing page
-
https://doi.org/10.4049/jimmunol.1701504Publisher landing page
- PDF URL
-
https://www.jimmunol.org/content/jimmunol/200/10/3556.full.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
bronzeOpen access status per OpenAlex
- OA URL
-
https://www.jimmunol.org/content/jimmunol/200/10/3556.full.pdfDirect OA link when available
- Concepts
-
Inflammasome, Leukotriene B4, Inflammation, Silicosis, Cell biology, Phagosome, Chemistry, Autophagy, Phagocytosis, Immunology, Biology, Materials science, Biochemistry, Composite material, ApoptosisTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
31Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 3, 2024: 5, 2023: 1, 2022: 2, 2021: 2Per-year citation counts (last 5 years)
- References (count)
-
54Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.These | 157 |
| abstract_inverted_index.along | 131 |
| abstract_inverted_index.mouse | 58 |
| abstract_inverted_index.plays | 18 |
| abstract_inverted_index.pouch | 155 |
| abstract_inverted_index.which | 25, 76 |
| abstract_inverted_index.(LTB4) | 17 |
| abstract_inverted_index.IL-1β | 56, 98 |
| abstract_inverted_index.Rab40c | 130 |
| abstract_inverted_index.Rab5c, | 129 |
| abstract_inverted_index.caused | 7 |
| abstract_inverted_index.cells, | 61 |
| abstract_inverted_index.drives | 26 |
| abstract_inverted_index.likely | 78 |
| abstract_inverted_index.model. | 156 |
| abstract_inverted_index.showed | 126 |
| abstract_inverted_index.silica | 13 |
| abstract_inverted_index.source | 81 |
| abstract_inverted_index.study, | 34 |
| abstract_inverted_index.GTPases | 128 |
| abstract_inverted_index.Studies | 100 |
| abstract_inverted_index.cancer. | 31 |
| abstract_inverted_index.chronic | 9 |
| abstract_inverted_index.disease | 6 |
| abstract_inverted_index.pathway | 90, 166 |
| abstract_inverted_index.primary | 80 |
| abstract_inverted_index.results | 158 |
| abstract_inverted_index.sterile | 175 |
| abstract_inverted_index.studies | 125 |
| abstract_inverted_index.trigger | 68 |
| abstract_inverted_index.Abstract | 0 |
| abstract_inverted_index.BI-78D3, | 142 |
| abstract_inverted_index.assembly | 70 |
| abstract_inverted_index.confocal | 123 |
| abstract_inverted_index.examined | 36 |
| abstract_inverted_index.exposure | 10 |
| abstract_inverted_index.involved | 39 |
| abstract_inverted_index.promotes | 29 |
| abstract_inverted_index.revealed | 106 |
| abstract_inverted_index.Silicosis | 1 |
| abstract_inverted_index.abrogated | 146 |
| abstract_inverted_index.enclosing | 65 |
| abstract_inverted_index.essential | 49, 92, 135 |
| abstract_inverted_index.formation | 138 |
| abstract_inverted_index.highlight | 159 |
| abstract_inverted_index.important | 20 |
| abstract_inverted_index.knockdown | 121 |
| abstract_inverted_index.particles | 47, 67 |
| abstract_inverted_index.pathways. | 43 |
| abstract_inverted_index.regulator | 169 |
| abstract_inverted_index.silicosis | 27 |
| abstract_inverted_index.synthesis | 109, 172 |
| abstract_inverted_index.Activation | 86 |
| abstract_inverted_index.CS-induced | 41, 83, 95, 147, 174 |
| abstract_inverted_index.Phagosomes | 64 |
| abstract_inverted_index.cytoplasm, | 75 |
| abstract_inverted_index.inhibitor, | 145 |
| abstract_inverted_index.lipidosome | 72, 112, 137, 165 |
| abstract_inverted_index.mechanisms | 38 |
| abstract_inverted_index.microscopy | 124 |
| abstract_inverted_index.production | 52 |
| abstract_inverted_index.Leukotriene | 15 |
| abstract_inverted_index.activation. | 117 |
| abstract_inverted_index.crystalline | 12 |
| abstract_inverted_index.independent | 114 |
| abstract_inverted_index.interfering | 119 |
| abstract_inverted_index.production. | 85, 99, 141 |
| abstract_inverted_index.Phagocytosis | 44 |
| abstract_inverted_index.inflammasome | 116 |
| abstract_inverted_index.inflammation | 149 |
| abstract_inverted_index.inflammatory | 5, 42 |
| abstract_inverted_index.macrophages, | 59 |
| abstract_inverted_index.neutrophilic | 23, 148 |
| abstract_inverted_index.neutrophils. | 63 |
| abstract_inverted_index.inflammation, | 24 |
| abstract_inverted_index.inflammation. | 176 |
| abstract_inverted_index.NLRP3-deficient | 104 |
| abstract_inverted_index.bafilomycin-A1– | 102 |
| abstract_inverted_index.activation–dependent | 164 |
| abstract_inverted_index.inflammasome-independent | 161 |
| cited_by_percentile_year.max | 99 |
| cited_by_percentile_year.min | 89 |
| corresponding_author_ids | https://openalex.org/A5058082625 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 9 |
| corresponding_institution_ids | https://openalex.org/I142740786 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.800000011920929 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.86080573 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |