Inflammation characteristics and anti-inflammation treatment with tocilizumab of severe/critical COVID-19 patients: A retrospective cohort study Article Swipe
Qin Hu
,
Yu Xu
,
Ying Xiang
,
Bin Wang
,
Zhiquan Yuan
,
Yifan Shan
,
Wenjing Zhang
,
Na Wu
,
Tingting Xia
,
Chengying Li
,
Weijia Xie
,
Xiaoyue Jia
,
Zubin Yu
,
Li Bai
,
Yafei Li
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.7150/ijbs.56952
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.7150/ijbs.56952
The efficacy of tocilizumab on the prognosis of severe/critical COVID-19 patients is still controversial so far. We aimed to delineate the inflammation characteristics of severe/critical COVID-19 patients and determine the impact of tocilizumab on hospital mortality. Here, we performed a retrospective cohort study which enrolled 727 severe or critical inpatients (≥18 years old) with laboratory-confirmed COVID-19 from Huoshenshan Hospital (Wuhan, China), among which 50 patients received tocilizumab. This study confirmed that most recovered patients manifested relatively normal inflammation levels at admission, whereas most of the deceased cases presented visibly severe inflammation at admission and even progressed into extremely aggravated inflammation before their deaths, proved by some extremely high concentrations of interleukin-6, procalcitonin, C-reactive protein and neutrophil count. Moreover, based on the Cox proportional-hazards models before or after propensity score matching, we demonstrated that tocilizumab treatment could lessen mortality by gradually alleviating excessive inflammation and meanwhile continuously enhancing the levels of lymphocytes within 14 days for severe/critical COVID-19 patients, indicating potential effectiveness for treating COVID-19.
Related Topics
Concepts
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.7150/ijbs.56952
- https://www.ijbs.com/v17p2124.pdf
- OA Status
- gold
- Cited By
- 4
- References
- 30
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3171559254
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W3171559254Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.7150/ijbs.56952Digital Object Identifier
- Title
-
Inflammation characteristics and anti-inflammation treatment with tocilizumab of severe/critical COVID-19 patients: A retrospective cohort studyWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2021Year of publication
- Publication date
-
2021-01-01Full publication date if available
- Authors
-
Qin Hu, Yu Xu, Ying Xiang, Bin Wang, Zhiquan Yuan, Yifan Shan, Wenjing Zhang, Na Wu, Tingting Xia, Chengying Li, Weijia Xie, Xiaoyue Jia, Zubin Yu, Li Bai, Yafei LiList of authors in order
- Landing page
-
https://doi.org/10.7150/ijbs.56952Publisher landing page
- PDF URL
-
https://www.ijbs.com/v17p2124.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.ijbs.com/v17p2124.pdfDirect OA link when available
- Concepts
-
Tocilizumab, Procalcitonin, Medicine, Retrospective cohort study, Internal medicine, Propensity score matching, Inflammation, Coronavirus disease 2019 (COVID-19), Cohort, Systemic inflammation, Sepsis, Rheumatoid arthritis, Disease, Infectious disease (medical specialty)Top concepts (fields/topics) attached by OpenAlex
- Cited by
-
4Total citation count in OpenAlex
- Citations by year (recent)
-
2024: 1, 2023: 1, 2022: 1, 2021: 1Per-year citation counts (last 5 years)
- References (count)
-
30Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W3171559254 |
|---|---|
| doi | https://doi.org/10.7150/ijbs.56952 |
| ids.doi | https://doi.org/10.7150/ijbs.56952 |
| ids.mag | 3171559254 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/34131411 |
| ids.openalex | https://openalex.org/W3171559254 |
| fwci | 0.2925748 |
| mesh[0].qualifier_ui | |
| mesh[0].descriptor_ui | D000368 |
| mesh[0].is_major_topic | False |
| mesh[0].qualifier_name | |
| mesh[0].descriptor_name | Aged |
| mesh[1].qualifier_ui | |
| mesh[1].descriptor_ui | D000369 |
| mesh[1].is_major_topic | False |
| mesh[1].qualifier_name | |
| mesh[1].descriptor_name | Aged, 80 and over |
| mesh[2].qualifier_ui | Q000627 |
| mesh[2].descriptor_ui | D000893 |
| mesh[2].is_major_topic | False |
| mesh[2].qualifier_name | therapeutic use |
| mesh[2].descriptor_name | Anti-Inflammatory Agents |
| mesh[3].qualifier_ui | Q000627 |
| mesh[3].descriptor_ui | D061067 |
| mesh[3].is_major_topic | False |
| mesh[3].qualifier_name | therapeutic use |
| mesh[3].descriptor_name | Antibodies, Monoclonal, Humanized |
| mesh[4].qualifier_ui | Q000032 |
| mesh[4].descriptor_ui | D002097 |
| mesh[4].is_major_topic | False |
| mesh[4].qualifier_name | analysis |
| mesh[4].descriptor_name | C-Reactive Protein |
| mesh[5].qualifier_ui | Q000097 |
| mesh[5].descriptor_ui | D000086382 |
| mesh[5].is_major_topic | False |
| mesh[5].qualifier_name | blood |
| mesh[5].descriptor_name | COVID-19 |
| mesh[6].qualifier_ui | Q000401 |
| mesh[6].descriptor_ui | D000086382 |
| mesh[6].is_major_topic | False |
| mesh[6].qualifier_name | mortality |
| mesh[6].descriptor_name | COVID-19 |
| mesh[7].qualifier_ui | Q000503 |
| mesh[7].descriptor_ui | D000086382 |
| mesh[7].is_major_topic | False |
| mesh[7].qualifier_name | physiopathology |
| mesh[7].descriptor_name | COVID-19 |
| mesh[8].qualifier_ui | |
| mesh[8].descriptor_ui | D015897 |
| mesh[8].is_major_topic | False |
| mesh[8].qualifier_name | |
| mesh[8].descriptor_name | Comorbidity |
| mesh[9].qualifier_ui | |
| mesh[9].descriptor_ui | D005260 |
| mesh[9].is_major_topic | False |
| mesh[9].qualifier_name | |
| mesh[9].descriptor_name | Female |
| mesh[10].qualifier_ui | |
| mesh[10].descriptor_ui | D006801 |
| mesh[10].is_major_topic | False |
| mesh[10].qualifier_name | |
| mesh[10].descriptor_name | Humans |
| mesh[11].qualifier_ui | Q000097 |
| mesh[11].descriptor_ui | D007249 |
| mesh[11].is_major_topic | False |
| mesh[11].qualifier_name | blood |
| mesh[11].descriptor_name | Inflammation |
| mesh[12].qualifier_ui | Q000188 |
| mesh[12].descriptor_ui | D007249 |
| mesh[12].is_major_topic | False |
| mesh[12].qualifier_name | drug therapy |
| mesh[12].descriptor_name | Inflammation |
| mesh[13].qualifier_ui | Q000097 |
| mesh[13].descriptor_ui | D015850 |
| mesh[13].is_major_topic | False |
| mesh[13].qualifier_name | blood |
| mesh[13].descriptor_name | Interleukin-6 |
| mesh[14].qualifier_ui | Q000706 |
| mesh[14].descriptor_ui | D007902 |
| mesh[14].is_major_topic | False |
| mesh[14].qualifier_name | statistics & numerical data |
| mesh[14].descriptor_name | Length of Stay |
| mesh[15].qualifier_ui | |
| mesh[15].descriptor_ui | D007958 |
| mesh[15].is_major_topic | False |
| mesh[15].qualifier_name | |
| mesh[15].descriptor_name | Leukocyte Count |
| mesh[16].qualifier_ui | |
| mesh[16].descriptor_ui | D008297 |
| mesh[16].is_major_topic | False |
| mesh[16].qualifier_name | |
| mesh[16].descriptor_name | Male |
| mesh[17].qualifier_ui | |
| mesh[17].descriptor_ui | D008875 |
| mesh[17].is_major_topic | False |
| mesh[17].qualifier_name | |
| mesh[17].descriptor_name | Middle Aged |
| mesh[18].qualifier_ui | |
| mesh[18].descriptor_ui | D009504 |
| mesh[18].is_major_topic | False |
| mesh[18].qualifier_name | |
| mesh[18].descriptor_name | Neutrophils |
| mesh[19].qualifier_ui | Q000097 |
| mesh[19].descriptor_ui | D000077740 |
| mesh[19].is_major_topic | False |
| mesh[19].qualifier_name | blood |
| mesh[19].descriptor_name | Procalcitonin |
| mesh[20].qualifier_ui | |
| mesh[20].descriptor_ui | D057216 |
| mesh[20].is_major_topic | False |
| mesh[20].qualifier_name | |
| mesh[20].descriptor_name | Propensity Score |
| mesh[21].qualifier_ui | |
| mesh[21].descriptor_ui | D016016 |
| mesh[21].is_major_topic | False |
| mesh[21].qualifier_name | |
| mesh[21].descriptor_name | Proportional Hazards Models |
| mesh[22].qualifier_ui | |
| mesh[22].descriptor_ui | D012189 |
| mesh[22].is_major_topic | False |
| mesh[22].qualifier_name | |
| mesh[22].descriptor_name | Retrospective Studies |
| mesh[23].qualifier_ui | |
| mesh[23].descriptor_ui | D000086402 |
| mesh[23].is_major_topic | True |
| mesh[23].qualifier_name | |
| mesh[23].descriptor_name | SARS-CoV-2 |
| mesh[24].qualifier_ui | |
| mesh[24].descriptor_ui | D000093485 |
| mesh[24].is_major_topic | True |
| mesh[24].qualifier_name | |
| mesh[24].descriptor_name | COVID-19 Drug Treatment |
| mesh[25].qualifier_ui | |
| mesh[25].descriptor_ui | D000368 |
| mesh[25].is_major_topic | False |
| mesh[25].qualifier_name | |
| mesh[25].descriptor_name | Aged |
| mesh[26].qualifier_ui | |
| mesh[26].descriptor_ui | D000369 |
| mesh[26].is_major_topic | False |
| mesh[26].qualifier_name | |
| mesh[26].descriptor_name | Aged, 80 and over |
| mesh[27].qualifier_ui | Q000627 |
| mesh[27].descriptor_ui | D000893 |
| mesh[27].is_major_topic | False |
| mesh[27].qualifier_name | therapeutic use |
| mesh[27].descriptor_name | Anti-Inflammatory Agents |
| mesh[28].qualifier_ui | Q000627 |
| mesh[28].descriptor_ui | D061067 |
| mesh[28].is_major_topic | False |
| mesh[28].qualifier_name | therapeutic use |
| mesh[28].descriptor_name | Antibodies, Monoclonal, Humanized |
| mesh[29].qualifier_ui | Q000032 |
| mesh[29].descriptor_ui | D002097 |
| mesh[29].is_major_topic | False |
| mesh[29].qualifier_name | analysis |
| mesh[29].descriptor_name | C-Reactive Protein |
| mesh[30].qualifier_ui | Q000097 |
| mesh[30].descriptor_ui | D000086382 |
| mesh[30].is_major_topic | False |
| mesh[30].qualifier_name | blood |
| mesh[30].descriptor_name | COVID-19 |
| mesh[31].qualifier_ui | Q000401 |
| mesh[31].descriptor_ui | D000086382 |
| mesh[31].is_major_topic | False |
| mesh[31].qualifier_name | mortality |
| mesh[31].descriptor_name | COVID-19 |
| mesh[32].qualifier_ui | Q000503 |
| mesh[32].descriptor_ui | D000086382 |
| mesh[32].is_major_topic | False |
| mesh[32].qualifier_name | physiopathology |
| mesh[32].descriptor_name | COVID-19 |
| mesh[33].qualifier_ui | |
| mesh[33].descriptor_ui | D015897 |
| mesh[33].is_major_topic | False |
| mesh[33].qualifier_name | |
| mesh[33].descriptor_name | Comorbidity |
| mesh[34].qualifier_ui | |
| mesh[34].descriptor_ui | D005260 |
| mesh[34].is_major_topic | False |
| mesh[34].qualifier_name | |
| mesh[34].descriptor_name | Female |
| mesh[35].qualifier_ui | |
| mesh[35].descriptor_ui | D006801 |
| mesh[35].is_major_topic | False |
| mesh[35].qualifier_name | |
| mesh[35].descriptor_name | Humans |
| mesh[36].qualifier_ui | Q000097 |
| mesh[36].descriptor_ui | D007249 |
| mesh[36].is_major_topic | False |
| mesh[36].qualifier_name | blood |
| mesh[36].descriptor_name | Inflammation |
| mesh[37].qualifier_ui | Q000188 |
| mesh[37].descriptor_ui | D007249 |
| mesh[37].is_major_topic | False |
| mesh[37].qualifier_name | drug therapy |
| mesh[37].descriptor_name | Inflammation |
| mesh[38].qualifier_ui | Q000097 |
| mesh[38].descriptor_ui | D015850 |
| mesh[38].is_major_topic | False |
| mesh[38].qualifier_name | blood |
| mesh[38].descriptor_name | Interleukin-6 |
| mesh[39].qualifier_ui | Q000706 |
| mesh[39].descriptor_ui | D007902 |
| mesh[39].is_major_topic | False |
| mesh[39].qualifier_name | statistics & numerical data |
| mesh[39].descriptor_name | Length of Stay |
| mesh[40].qualifier_ui | |
| mesh[40].descriptor_ui | D007958 |
| mesh[40].is_major_topic | False |
| mesh[40].qualifier_name | |
| mesh[40].descriptor_name | Leukocyte Count |
| mesh[41].qualifier_ui | |
| mesh[41].descriptor_ui | D008297 |
| mesh[41].is_major_topic | False |
| mesh[41].qualifier_name | |
| mesh[41].descriptor_name | Male |
| mesh[42].qualifier_ui | |
| mesh[42].descriptor_ui | D008875 |
| mesh[42].is_major_topic | False |
| mesh[42].qualifier_name | |
| mesh[42].descriptor_name | Middle Aged |
| mesh[43].qualifier_ui | |
| mesh[43].descriptor_ui | D009504 |
| mesh[43].is_major_topic | False |
| mesh[43].qualifier_name | |
| mesh[43].descriptor_name | Neutrophils |
| mesh[44].qualifier_ui | Q000097 |
| mesh[44].descriptor_ui | D000077740 |
| mesh[44].is_major_topic | False |
| mesh[44].qualifier_name | blood |
| mesh[44].descriptor_name | Procalcitonin |
| mesh[45].qualifier_ui | |
| mesh[45].descriptor_ui | D057216 |
| mesh[45].is_major_topic | False |
| mesh[45].qualifier_name | |
| mesh[45].descriptor_name | Propensity Score |
| mesh[46].qualifier_ui | |
| mesh[46].descriptor_ui | D016016 |
| mesh[46].is_major_topic | False |
| mesh[46].qualifier_name | |
| mesh[46].descriptor_name | Proportional Hazards Models |
| mesh[47].qualifier_ui | |
| mesh[47].descriptor_ui | D012189 |
| mesh[47].is_major_topic | False |
| mesh[47].qualifier_name | |
| mesh[47].descriptor_name | Retrospective Studies |
| mesh[48].qualifier_ui | |
| mesh[48].descriptor_ui | D000086402 |
| mesh[48].is_major_topic | True |
| mesh[48].qualifier_name | |
| mesh[48].descriptor_name | SARS-CoV-2 |
| mesh[49].qualifier_ui | |
| mesh[49].descriptor_ui | D000093485 |
| mesh[49].is_major_topic | True |
| mesh[49].qualifier_name | |
| mesh[49].descriptor_name | COVID-19 Drug Treatment |
| type | article |
| title | Inflammation characteristics and anti-inflammation treatment with tocilizumab of severe/critical COVID-19 patients: A retrospective cohort study |
| biblio.issue | 8 |
| biblio.volume | 17 |
| biblio.last_page | 2134 |
| biblio.first_page | 2124 |
| topics[0].id | https://openalex.org/T10041 |
| topics[0].field.id | https://openalex.org/fields/27 |
| topics[0].field.display_name | Medicine |
| topics[0].score | 0.9998000264167786 |
| topics[0].domain.id | https://openalex.org/domains/4 |
| topics[0].domain.display_name | Health Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/2725 |
| topics[0].subfield.display_name | Infectious Diseases |
| topics[0].display_name | COVID-19 Clinical Research Studies |
| topics[1].id | https://openalex.org/T11368 |
| topics[1].field.id | https://openalex.org/fields/27 |
| topics[1].field.display_name | Medicine |
| topics[1].score | 0.9988999962806702 |
| topics[1].domain.id | https://openalex.org/domains/4 |
| topics[1].domain.display_name | Health Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/2728 |
| topics[1].subfield.display_name | Neurology |
| topics[1].display_name | Long-Term Effects of COVID-19 |
| topics[2].id | https://openalex.org/T10118 |
| topics[2].field.id | https://openalex.org/fields/27 |
| topics[2].field.display_name | Medicine |
| topics[2].score | 0.9887999892234802 |
| topics[2].domain.id | https://openalex.org/domains/4 |
| topics[2].domain.display_name | Health Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/2725 |
| topics[2].subfield.display_name | Infectious Diseases |
| topics[2].display_name | SARS-CoV-2 and COVID-19 Research |
| is_xpac | False |
| apc_list.value | 2000 |
| apc_list.currency | AUD |
| apc_list.value_usd | 1337 |
| apc_paid.value | 2000 |
| apc_paid.currency | AUD |
| apc_paid.value_usd | 1337 |
| concepts[0].id | https://openalex.org/C2777178219 |
| concepts[0].level | 3 |
| concepts[0].score | 0.9677828550338745 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q425154 |
| concepts[0].display_name | Tocilizumab |
| concepts[1].id | https://openalex.org/C10936531 |
| concepts[1].level | 3 |
| concepts[1].score | 0.9024657011032104 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q786600 |
| concepts[1].display_name | Procalcitonin |
| concepts[2].id | https://openalex.org/C71924100 |
| concepts[2].level | 0 |
| concepts[2].score | 0.8833863735198975 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q11190 |
| concepts[2].display_name | Medicine |
| concepts[3].id | https://openalex.org/C167135981 |
| concepts[3].level | 2 |
| concepts[3].score | 0.6768696308135986 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q2146302 |
| concepts[3].display_name | Retrospective cohort study |
| concepts[4].id | https://openalex.org/C126322002 |
| concepts[4].level | 1 |
| concepts[4].score | 0.6038991808891296 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q11180 |
| concepts[4].display_name | Internal medicine |
| concepts[5].id | https://openalex.org/C17923572 |
| concepts[5].level | 2 |
| concepts[5].score | 0.597384512424469 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q7250160 |
| concepts[5].display_name | Propensity score matching |
| concepts[6].id | https://openalex.org/C2776914184 |
| concepts[6].level | 2 |
| concepts[6].score | 0.5702184438705444 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q101991 |
| concepts[6].display_name | Inflammation |
| concepts[7].id | https://openalex.org/C3008058167 |
| concepts[7].level | 4 |
| concepts[7].score | 0.4612542390823364 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q84263196 |
| concepts[7].display_name | Coronavirus disease 2019 (COVID-19) |
| concepts[8].id | https://openalex.org/C72563966 |
| concepts[8].level | 2 |
| concepts[8].score | 0.4433116316795349 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q1303415 |
| concepts[8].display_name | Cohort |
| concepts[9].id | https://openalex.org/C2776252253 |
| concepts[9].level | 3 |
| concepts[9].score | 0.42487287521362305 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q7663815 |
| concepts[9].display_name | Systemic inflammation |
| concepts[10].id | https://openalex.org/C2778384902 |
| concepts[10].level | 2 |
| concepts[10].score | 0.10122737288475037 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q183134 |
| concepts[10].display_name | Sepsis |
| concepts[11].id | https://openalex.org/C2777575956 |
| concepts[11].level | 2 |
| concepts[11].score | 0.08770954608917236 |
| concepts[11].wikidata | https://www.wikidata.org/wiki/Q187255 |
| concepts[11].display_name | Rheumatoid arthritis |
| concepts[12].id | https://openalex.org/C2779134260 |
| concepts[12].level | 2 |
| concepts[12].score | 0.08248323202133179 |
| concepts[12].wikidata | https://www.wikidata.org/wiki/Q12136 |
| concepts[12].display_name | Disease |
| concepts[13].id | https://openalex.org/C524204448 |
| concepts[13].level | 3 |
| concepts[13].score | 0.0 |
| concepts[13].wikidata | https://www.wikidata.org/wiki/Q788926 |
| concepts[13].display_name | Infectious disease (medical specialty) |
| keywords[0].id | https://openalex.org/keywords/tocilizumab |
| keywords[0].score | 0.9677828550338745 |
| keywords[0].display_name | Tocilizumab |
| keywords[1].id | https://openalex.org/keywords/procalcitonin |
| keywords[1].score | 0.9024657011032104 |
| keywords[1].display_name | Procalcitonin |
| keywords[2].id | https://openalex.org/keywords/medicine |
| keywords[2].score | 0.8833863735198975 |
| keywords[2].display_name | Medicine |
| keywords[3].id | https://openalex.org/keywords/retrospective-cohort-study |
| keywords[3].score | 0.6768696308135986 |
| keywords[3].display_name | Retrospective cohort study |
| keywords[4].id | https://openalex.org/keywords/internal-medicine |
| keywords[4].score | 0.6038991808891296 |
| keywords[4].display_name | Internal medicine |
| keywords[5].id | https://openalex.org/keywords/propensity-score-matching |
| keywords[5].score | 0.597384512424469 |
| keywords[5].display_name | Propensity score matching |
| keywords[6].id | https://openalex.org/keywords/inflammation |
| keywords[6].score | 0.5702184438705444 |
| keywords[6].display_name | Inflammation |
| keywords[7].id | https://openalex.org/keywords/coronavirus-disease-2019 |
| keywords[7].score | 0.4612542390823364 |
| keywords[7].display_name | Coronavirus disease 2019 (COVID-19) |
| keywords[8].id | https://openalex.org/keywords/cohort |
| keywords[8].score | 0.4433116316795349 |
| keywords[8].display_name | Cohort |
| keywords[9].id | https://openalex.org/keywords/systemic-inflammation |
| keywords[9].score | 0.42487287521362305 |
| keywords[9].display_name | Systemic inflammation |
| keywords[10].id | https://openalex.org/keywords/sepsis |
| keywords[10].score | 0.10122737288475037 |
| keywords[10].display_name | Sepsis |
| keywords[11].id | https://openalex.org/keywords/rheumatoid-arthritis |
| keywords[11].score | 0.08770954608917236 |
| keywords[11].display_name | Rheumatoid arthritis |
| keywords[12].id | https://openalex.org/keywords/disease |
| keywords[12].score | 0.08248323202133179 |
| keywords[12].display_name | Disease |
| language | en |
| locations[0].id | doi:10.7150/ijbs.56952 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S26312460 |
| locations[0].source.issn | 1449-2288 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | True |
| locations[0].source.issn_l | 1449-2288 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | True |
| locations[0].source.display_name | International Journal of Biological Sciences |
| locations[0].source.host_organization | https://openalex.org/P4310317973 |
| locations[0].source.host_organization_name | Ivyspring International Publisher |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310317973 |
| locations[0].license | cc-by-nc |
| locations[0].pdf_url | https://www.ijbs.com/v17p2124.pdf |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | https://openalex.org/licenses/cc-by-nc |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | International Journal of Biological Sciences |
| locations[0].landing_page_url | https://doi.org/10.7150/ijbs.56952 |
| locations[1].id | pmid:34131411 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | International journal of biological sciences |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/34131411 |
| locations[2].id | pmh:oai:pubmedcentral.nih.gov:8193270 |
| locations[2].is_oa | True |
| locations[2].source.id | https://openalex.org/S2764455111 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | PubMed Central |
| locations[2].source.host_organization | https://openalex.org/I1299303238 |
| locations[2].source.host_organization_name | National Institutes of Health |
| locations[2].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[2].license | other-oa |
| locations[2].pdf_url | |
| locations[2].version | submittedVersion |
| locations[2].raw_type | Text |
| locations[2].license_id | https://openalex.org/licenses/other-oa |
| locations[2].is_accepted | False |
| locations[2].is_published | False |
| locations[2].raw_source_name | Int J Biol Sci |
| locations[2].landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/8193270 |
| indexed_in | crossref, doaj, pubmed |
| authorships[0].author.id | https://openalex.org/A5027388023 |
| authorships[0].author.orcid | https://orcid.org/0000-0001-6359-9215 |
| authorships[0].author.display_name | Qin Hu |
| authorships[0].countries | CN |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I151075929 |
| authorships[0].affiliations[0].raw_affiliation_string | . Republic of China. Department of Respiratory and Critical Care Medicine, the Second Affiliated Hospital of Army Medical University, Chongqing 400037, People's Republic of |
| authorships[0].institutions[0].id | https://openalex.org/I151075929 |
| authorships[0].institutions[0].ror | https://ror.org/05w21nn13 |
| authorships[0].institutions[0].type | education |
| authorships[0].institutions[0].lineage | https://openalex.org/I151075929 |
| authorships[0].institutions[0].country_code | CN |
| authorships[0].institutions[0].display_name | Army Medical University |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Qin Hu |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | . Republic of China. Department of Respiratory and Critical Care Medicine, the Second Affiliated Hospital of Army Medical University, Chongqing 400037, People's Republic of |
| authorships[1].author.id | https://openalex.org/A5104066769 |
| authorships[1].author.orcid | |
| authorships[1].author.display_name | Yu Xu |
| authorships[1].countries | CN |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I151075929, https://openalex.org/I191996457, https://openalex.org/I4210097509, https://openalex.org/I87780372 |
| authorships[1].affiliations[0].raw_affiliation_string | . China. Department of Thoracic Surgery, the Second Affiliated Hospital of Army Medical University, Chongqing 400037, People's Republic of China. |
| authorships[1].institutions[0].id | https://openalex.org/I151075929 |
| authorships[1].institutions[0].ror | https://ror.org/05w21nn13 |
| authorships[1].institutions[0].type | education |
| authorships[1].institutions[0].lineage | https://openalex.org/I151075929 |
| authorships[1].institutions[0].country_code | CN |
| authorships[1].institutions[0].display_name | Army Medical University |
| authorships[1].institutions[1].id | https://openalex.org/I87780372 |
| authorships[1].institutions[1].ror | https://ror.org/017z00e58 |
| authorships[1].institutions[1].type | education |
| authorships[1].institutions[1].lineage | https://openalex.org/I87780372 |
| authorships[1].institutions[1].country_code | CN |
| authorships[1].institutions[1].display_name | Chongqing Medical University |
| authorships[1].institutions[2].id | https://openalex.org/I191996457 |
| authorships[1].institutions[2].ror | https://ror.org/04c8eg608 |
| authorships[1].institutions[2].type | education |
| authorships[1].institutions[2].lineage | https://openalex.org/I191996457 |
| authorships[1].institutions[2].country_code | CN |
| authorships[1].institutions[2].display_name | Dalian Medical University |
| authorships[1].institutions[3].id | https://openalex.org/I4210097509 |
| authorships[1].institutions[3].ror | https://ror.org/00r67fz39 |
| authorships[1].institutions[3].type | healthcare |
| authorships[1].institutions[3].lineage | https://openalex.org/I4210097509 |
| authorships[1].institutions[3].country_code | CN |
| authorships[1].institutions[3].display_name | Second Affiliated Hospital of Chongqing Medical University |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Yu Xu |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | . China. Department of Thoracic Surgery, the Second Affiliated Hospital of Army Medical University, Chongqing 400037, People's Republic of China. |
| authorships[2].author.id | https://openalex.org/A5036968274 |
| authorships[2].author.orcid | https://orcid.org/0000-0001-6727-9999 |
| authorships[2].author.display_name | Ying Xiang |
| authorships[2].countries | CN |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I151075929 |
| authorships[2].affiliations[0].raw_affiliation_string | . Republic of China. Department of Respiratory and Critical Care Medicine, the Second Affiliated Hospital of Army Medical University, Chongqing 400037, People's Republic of |
| authorships[2].institutions[0].id | https://openalex.org/I151075929 |
| authorships[2].institutions[0].ror | https://ror.org/05w21nn13 |
| authorships[2].institutions[0].type | education |
| authorships[2].institutions[0].lineage | https://openalex.org/I151075929 |
| authorships[2].institutions[0].country_code | CN |
| authorships[2].institutions[0].display_name | Army Medical University |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Ying Xiang |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | . Republic of China. Department of Respiratory and Critical Care Medicine, the Second Affiliated Hospital of Army Medical University, Chongqing 400037, People's Republic of |
| authorships[3].author.id | https://openalex.org/A5100372378 |
| authorships[3].author.orcid | https://orcid.org/0000-0002-6242-7726 |
| authorships[3].author.display_name | Bin Wang |
| authorships[3].countries | CN |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I151075929, https://openalex.org/I191996457, https://openalex.org/I4210097509, https://openalex.org/I87780372 |
| authorships[3].affiliations[0].raw_affiliation_string | . China. Department of Thoracic Surgery, the Second Affiliated Hospital of Army Medical University, Chongqing 400037, People's Republic of China. |
| authorships[3].institutions[0].id | https://openalex.org/I151075929 |
| authorships[3].institutions[0].ror | https://ror.org/05w21nn13 |
| authorships[3].institutions[0].type | education |
| authorships[3].institutions[0].lineage | https://openalex.org/I151075929 |
| authorships[3].institutions[0].country_code | CN |
| authorships[3].institutions[0].display_name | Army Medical University |
| authorships[3].institutions[1].id | https://openalex.org/I87780372 |
| authorships[3].institutions[1].ror | https://ror.org/017z00e58 |
| authorships[3].institutions[1].type | education |
| authorships[3].institutions[1].lineage | https://openalex.org/I87780372 |
| authorships[3].institutions[1].country_code | CN |
| authorships[3].institutions[1].display_name | Chongqing Medical University |
| authorships[3].institutions[2].id | https://openalex.org/I191996457 |
| authorships[3].institutions[2].ror | https://ror.org/04c8eg608 |
| authorships[3].institutions[2].type | education |
| authorships[3].institutions[2].lineage | https://openalex.org/I191996457 |
| authorships[3].institutions[2].country_code | CN |
| authorships[3].institutions[2].display_name | Dalian Medical University |
| authorships[3].institutions[3].id | https://openalex.org/I4210097509 |
| authorships[3].institutions[3].ror | https://ror.org/00r67fz39 |
| authorships[3].institutions[3].type | healthcare |
| authorships[3].institutions[3].lineage | https://openalex.org/I4210097509 |
| authorships[3].institutions[3].country_code | CN |
| authorships[3].institutions[3].display_name | Second Affiliated Hospital of Chongqing Medical University |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Bin Wang |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | . China. Department of Thoracic Surgery, the Second Affiliated Hospital of Army Medical University, Chongqing 400037, People's Republic of China. |
| authorships[4].author.id | https://openalex.org/A5104102306 |
| authorships[4].author.orcid | |
| authorships[4].author.display_name | Zhiquan Yuan |
| authorships[4].countries | CN |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I151075929 |
| authorships[4].affiliations[0].raw_affiliation_string | . Republic of China. Department of Respiratory and Critical Care Medicine, the Second Affiliated Hospital of Army Medical University, Chongqing 400037, People's Republic of |
| authorships[4].institutions[0].id | https://openalex.org/I151075929 |
| authorships[4].institutions[0].ror | https://ror.org/05w21nn13 |
| authorships[4].institutions[0].type | education |
| authorships[4].institutions[0].lineage | https://openalex.org/I151075929 |
| authorships[4].institutions[0].country_code | CN |
| authorships[4].institutions[0].display_name | Army Medical University |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Zhiquan Yuan |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | . Republic of China. Department of Respiratory and Critical Care Medicine, the Second Affiliated Hospital of Army Medical University, Chongqing 400037, People's Republic of |
| authorships[5].author.id | https://openalex.org/A5044009365 |
| authorships[5].author.orcid | https://orcid.org/0009-0007-5585-0298 |
| authorships[5].author.display_name | Yifan Shan |
| authorships[5].countries | CN |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I151075929 |
| authorships[5].affiliations[0].raw_affiliation_string | . Republic of China. Department of Respiratory and Critical Care Medicine, the Second Affiliated Hospital of Army Medical University, Chongqing 400037, People's Republic of |
| authorships[5].institutions[0].id | https://openalex.org/I151075929 |
| authorships[5].institutions[0].ror | https://ror.org/05w21nn13 |
| authorships[5].institutions[0].type | education |
| authorships[5].institutions[0].lineage | https://openalex.org/I151075929 |
| authorships[5].institutions[0].country_code | CN |
| authorships[5].institutions[0].display_name | Army Medical University |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Yifan Shan |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | . Republic of China. Department of Respiratory and Critical Care Medicine, the Second Affiliated Hospital of Army Medical University, Chongqing 400037, People's Republic of |
| authorships[6].author.id | https://openalex.org/A5100407181 |
| authorships[6].author.orcid | https://orcid.org/0000-0001-6263-5384 |
| authorships[6].author.display_name | Wenjing Zhang |
| authorships[6].countries | CN |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I151075929, https://openalex.org/I191996457, https://openalex.org/I4210097509, https://openalex.org/I87780372 |
| authorships[6].affiliations[0].raw_affiliation_string | . China. Department of Thoracic Surgery, the Second Affiliated Hospital of Army Medical University, Chongqing 400037, People's Republic of China. |
| authorships[6].institutions[0].id | https://openalex.org/I151075929 |
| authorships[6].institutions[0].ror | https://ror.org/05w21nn13 |
| authorships[6].institutions[0].type | education |
| authorships[6].institutions[0].lineage | https://openalex.org/I151075929 |
| authorships[6].institutions[0].country_code | CN |
| authorships[6].institutions[0].display_name | Army Medical University |
| authorships[6].institutions[1].id | https://openalex.org/I87780372 |
| authorships[6].institutions[1].ror | https://ror.org/017z00e58 |
| authorships[6].institutions[1].type | education |
| authorships[6].institutions[1].lineage | https://openalex.org/I87780372 |
| authorships[6].institutions[1].country_code | CN |
| authorships[6].institutions[1].display_name | Chongqing Medical University |
| authorships[6].institutions[2].id | https://openalex.org/I191996457 |
| authorships[6].institutions[2].ror | https://ror.org/04c8eg608 |
| authorships[6].institutions[2].type | education |
| authorships[6].institutions[2].lineage | https://openalex.org/I191996457 |
| authorships[6].institutions[2].country_code | CN |
| authorships[6].institutions[2].display_name | Dalian Medical University |
| authorships[6].institutions[3].id | https://openalex.org/I4210097509 |
| authorships[6].institutions[3].ror | https://ror.org/00r67fz39 |
| authorships[6].institutions[3].type | healthcare |
| authorships[6].institutions[3].lineage | https://openalex.org/I4210097509 |
| authorships[6].institutions[3].country_code | CN |
| authorships[6].institutions[3].display_name | Second Affiliated Hospital of Chongqing Medical University |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Wenjing Zhang |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | . China. Department of Thoracic Surgery, the Second Affiliated Hospital of Army Medical University, Chongqing 400037, People's Republic of China. |
| authorships[7].author.id | https://openalex.org/A5072242179 |
| authorships[7].author.orcid | https://orcid.org/0000-0001-6521-9458 |
| authorships[7].author.display_name | Na Wu |
| authorships[7].countries | CN |
| authorships[7].affiliations[0].institution_ids | https://openalex.org/I151075929 |
| authorships[7].affiliations[0].raw_affiliation_string | . Republic of China. Department of Respiratory and Critical Care Medicine, the Second Affiliated Hospital of Army Medical University, Chongqing 400037, People's Republic of |
| authorships[7].institutions[0].id | https://openalex.org/I151075929 |
| authorships[7].institutions[0].ror | https://ror.org/05w21nn13 |
| authorships[7].institutions[0].type | education |
| authorships[7].institutions[0].lineage | https://openalex.org/I151075929 |
| authorships[7].institutions[0].country_code | CN |
| authorships[7].institutions[0].display_name | Army Medical University |
| authorships[7].author_position | middle |
| authorships[7].raw_author_name | Na Wu |
| authorships[7].is_corresponding | False |
| authorships[7].raw_affiliation_strings | . Republic of China. Department of Respiratory and Critical Care Medicine, the Second Affiliated Hospital of Army Medical University, Chongqing 400037, People's Republic of |
| authorships[8].author.id | https://openalex.org/A5102990599 |
| authorships[8].author.orcid | https://orcid.org/0000-0002-5318-1779 |
| authorships[8].author.display_name | Tingting Xia |
| authorships[8].countries | CN |
| authorships[8].affiliations[0].institution_ids | https://openalex.org/I151075929 |
| authorships[8].affiliations[0].raw_affiliation_string | . Republic of China. Department of Respiratory and Critical Care Medicine, the Second Affiliated Hospital of Army Medical University, Chongqing 400037, People's Republic of |
| authorships[8].institutions[0].id | https://openalex.org/I151075929 |
| authorships[8].institutions[0].ror | https://ror.org/05w21nn13 |
| authorships[8].institutions[0].type | education |
| authorships[8].institutions[0].lineage | https://openalex.org/I151075929 |
| authorships[8].institutions[0].country_code | CN |
| authorships[8].institutions[0].display_name | Army Medical University |
| authorships[8].author_position | middle |
| authorships[8].raw_author_name | Tingting Xia |
| authorships[8].is_corresponding | False |
| authorships[8].raw_affiliation_strings | . Republic of China. Department of Respiratory and Critical Care Medicine, the Second Affiliated Hospital of Army Medical University, Chongqing 400037, People's Republic of |
| authorships[9].author.id | https://openalex.org/A5102892993 |
| authorships[9].author.orcid | https://orcid.org/0000-0001-5540-0966 |
| authorships[9].author.display_name | Chengying Li |
| authorships[9].countries | CN |
| authorships[9].affiliations[0].institution_ids | https://openalex.org/I151075929 |
| authorships[9].affiliations[0].raw_affiliation_string | . Republic of China. Department of Respiratory and Critical Care Medicine, the Second Affiliated Hospital of Army Medical University, Chongqing 400037, People's Republic of |
| authorships[9].institutions[0].id | https://openalex.org/I151075929 |
| authorships[9].institutions[0].ror | https://ror.org/05w21nn13 |
| authorships[9].institutions[0].type | education |
| authorships[9].institutions[0].lineage | https://openalex.org/I151075929 |
| authorships[9].institutions[0].country_code | CN |
| authorships[9].institutions[0].display_name | Army Medical University |
| authorships[9].author_position | middle |
| authorships[9].raw_author_name | Chengying Li |
| authorships[9].is_corresponding | False |
| authorships[9].raw_affiliation_strings | . Republic of China. Department of Respiratory and Critical Care Medicine, the Second Affiliated Hospital of Army Medical University, Chongqing 400037, People's Republic of |
| authorships[10].author.id | https://openalex.org/A5101402915 |
| authorships[10].author.orcid | https://orcid.org/0000-0002-2099-4247 |
| authorships[10].author.display_name | Weijia Xie |
| authorships[10].countries | CN |
| authorships[10].affiliations[0].institution_ids | https://openalex.org/I151075929 |
| authorships[10].affiliations[0].raw_affiliation_string | . Republic of China. Department of Respiratory and Critical Care Medicine, the Second Affiliated Hospital of Army Medical University, Chongqing 400037, People's Republic of |
| authorships[10].institutions[0].id | https://openalex.org/I151075929 |
| authorships[10].institutions[0].ror | https://ror.org/05w21nn13 |
| authorships[10].institutions[0].type | education |
| authorships[10].institutions[0].lineage | https://openalex.org/I151075929 |
| authorships[10].institutions[0].country_code | CN |
| authorships[10].institutions[0].display_name | Army Medical University |
| authorships[10].author_position | middle |
| authorships[10].raw_author_name | Weijia Xie |
| authorships[10].is_corresponding | False |
| authorships[10].raw_affiliation_strings | . Republic of China. Department of Respiratory and Critical Care Medicine, the Second Affiliated Hospital of Army Medical University, Chongqing 400037, People's Republic of |
| authorships[11].author.id | https://openalex.org/A5107823849 |
| authorships[11].author.orcid | |
| authorships[11].author.display_name | Xiaoyue Jia |
| authorships[11].countries | CN |
| authorships[11].affiliations[0].institution_ids | https://openalex.org/I151075929 |
| authorships[11].affiliations[0].raw_affiliation_string | Department of Epidemiology, College of Preventive Medicine, Army Medical University (Third Military Medical University), Chongqing 400038, People's |
| authorships[11].institutions[0].id | https://openalex.org/I151075929 |
| authorships[11].institutions[0].ror | https://ror.org/05w21nn13 |
| authorships[11].institutions[0].type | education |
| authorships[11].institutions[0].lineage | https://openalex.org/I151075929 |
| authorships[11].institutions[0].country_code | CN |
| authorships[11].institutions[0].display_name | Army Medical University |
| authorships[11].author_position | middle |
| authorships[11].raw_author_name | Xiaoyue Jia |
| authorships[11].is_corresponding | False |
| authorships[11].raw_affiliation_strings | Department of Epidemiology, College of Preventive Medicine, Army Medical University (Third Military Medical University), Chongqing 400038, People's |
| authorships[12].author.id | https://openalex.org/A5100524267 |
| authorships[12].author.orcid | |
| authorships[12].author.display_name | Zubin Yu |
| authorships[12].countries | CN |
| authorships[12].affiliations[0].institution_ids | https://openalex.org/I151075929 |
| authorships[12].affiliations[0].raw_affiliation_string | . Republic of China. Department of Respiratory and Critical Care Medicine, the Second Affiliated Hospital of Army Medical University, Chongqing 400037, People's Republic of |
| authorships[12].institutions[0].id | https://openalex.org/I151075929 |
| authorships[12].institutions[0].ror | https://ror.org/05w21nn13 |
| authorships[12].institutions[0].type | education |
| authorships[12].institutions[0].lineage | https://openalex.org/I151075929 |
| authorships[12].institutions[0].country_code | CN |
| authorships[12].institutions[0].display_name | Army Medical University |
| authorships[12].author_position | middle |
| authorships[12].raw_author_name | Zubin Yu |
| authorships[12].is_corresponding | False |
| authorships[12].raw_affiliation_strings | . Republic of China. Department of Respiratory and Critical Care Medicine, the Second Affiliated Hospital of Army Medical University, Chongqing 400037, People's Republic of |
| authorships[13].author.id | https://openalex.org/A5100608940 |
| authorships[13].author.orcid | https://orcid.org/0000-0003-2706-9799 |
| authorships[13].author.display_name | Li Bai |
| authorships[13].countries | CN |
| authorships[13].affiliations[0].institution_ids | https://openalex.org/I151075929, https://openalex.org/I191996457, https://openalex.org/I4210097509, https://openalex.org/I87780372 |
| authorships[13].affiliations[0].raw_affiliation_string | . China. Department of Thoracic Surgery, the Second Affiliated Hospital of Army Medical University, Chongqing 400037, People's Republic of China. |
| authorships[13].institutions[0].id | https://openalex.org/I151075929 |
| authorships[13].institutions[0].ror | https://ror.org/05w21nn13 |
| authorships[13].institutions[0].type | education |
| authorships[13].institutions[0].lineage | https://openalex.org/I151075929 |
| authorships[13].institutions[0].country_code | CN |
| authorships[13].institutions[0].display_name | Army Medical University |
| authorships[13].institutions[1].id | https://openalex.org/I87780372 |
| authorships[13].institutions[1].ror | https://ror.org/017z00e58 |
| authorships[13].institutions[1].type | education |
| authorships[13].institutions[1].lineage | https://openalex.org/I87780372 |
| authorships[13].institutions[1].country_code | CN |
| authorships[13].institutions[1].display_name | Chongqing Medical University |
| authorships[13].institutions[2].id | https://openalex.org/I191996457 |
| authorships[13].institutions[2].ror | https://ror.org/04c8eg608 |
| authorships[13].institutions[2].type | education |
| authorships[13].institutions[2].lineage | https://openalex.org/I191996457 |
| authorships[13].institutions[2].country_code | CN |
| authorships[13].institutions[2].display_name | Dalian Medical University |
| authorships[13].institutions[3].id | https://openalex.org/I4210097509 |
| authorships[13].institutions[3].ror | https://ror.org/00r67fz39 |
| authorships[13].institutions[3].type | healthcare |
| authorships[13].institutions[3].lineage | https://openalex.org/I4210097509 |
| authorships[13].institutions[3].country_code | CN |
| authorships[13].institutions[3].display_name | Second Affiliated Hospital of Chongqing Medical University |
| authorships[13].author_position | middle |
| authorships[13].raw_author_name | Li Bai |
| authorships[13].is_corresponding | False |
| authorships[13].raw_affiliation_strings | . China. Department of Thoracic Surgery, the Second Affiliated Hospital of Army Medical University, Chongqing 400037, People's Republic of China. |
| authorships[14].author.id | https://openalex.org/A5100440728 |
| authorships[14].author.orcid | https://orcid.org/0000-0003-1158-7671 |
| authorships[14].author.display_name | Yafei Li |
| authorships[14].countries | CN |
| authorships[14].affiliations[0].institution_ids | https://openalex.org/I151075929 |
| authorships[14].affiliations[0].raw_affiliation_string | . Republic of China. Department of Respiratory and Critical Care Medicine, the Second Affiliated Hospital of Army Medical University, Chongqing 400037, People's Republic of |
| authorships[14].institutions[0].id | https://openalex.org/I151075929 |
| authorships[14].institutions[0].ror | https://ror.org/05w21nn13 |
| authorships[14].institutions[0].type | education |
| authorships[14].institutions[0].lineage | https://openalex.org/I151075929 |
| authorships[14].institutions[0].country_code | CN |
| authorships[14].institutions[0].display_name | Army Medical University |
| authorships[14].author_position | last |
| authorships[14].raw_author_name | Yafei Li |
| authorships[14].is_corresponding | False |
| authorships[14].raw_affiliation_strings | . Republic of China. Department of Respiratory and Critical Care Medicine, the Second Affiliated Hospital of Army Medical University, Chongqing 400037, People's Republic of |
| has_content.pdf | True |
| has_content.grobid_xml | True |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://www.ijbs.com/v17p2124.pdf |
| open_access.oa_status | gold |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | Inflammation characteristics and anti-inflammation treatment with tocilizumab of severe/critical COVID-19 patients: A retrospective cohort study |
| has_fulltext | True |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T10041 |
| primary_topic.field.id | https://openalex.org/fields/27 |
| primary_topic.field.display_name | Medicine |
| primary_topic.score | 0.9998000264167786 |
| primary_topic.domain.id | https://openalex.org/domains/4 |
| primary_topic.domain.display_name | Health Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/2725 |
| primary_topic.subfield.display_name | Infectious Diseases |
| primary_topic.display_name | COVID-19 Clinical Research Studies |
| related_works | https://openalex.org/W2093329967, https://openalex.org/W2354235723, https://openalex.org/W2363932347, https://openalex.org/W2350249326, https://openalex.org/W3113794875, https://openalex.org/W3029928016, https://openalex.org/W3207423560, https://openalex.org/W4394692040, https://openalex.org/W2417762754, https://openalex.org/W2763707224 |
| cited_by_count | 4 |
| counts_by_year[0].year | 2024 |
| counts_by_year[0].cited_by_count | 1 |
| counts_by_year[1].year | 2023 |
| counts_by_year[1].cited_by_count | 1 |
| counts_by_year[2].year | 2022 |
| counts_by_year[2].cited_by_count | 1 |
| counts_by_year[3].year | 2021 |
| counts_by_year[3].cited_by_count | 1 |
| locations_count | 3 |
| best_oa_location.id | doi:10.7150/ijbs.56952 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S26312460 |
| best_oa_location.source.issn | 1449-2288 |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | True |
| best_oa_location.source.issn_l | 1449-2288 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | True |
| best_oa_location.source.display_name | International Journal of Biological Sciences |
| best_oa_location.source.host_organization | https://openalex.org/P4310317973 |
| best_oa_location.source.host_organization_name | Ivyspring International Publisher |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310317973 |
| best_oa_location.license | cc-by-nc |
| best_oa_location.pdf_url | https://www.ijbs.com/v17p2124.pdf |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by-nc |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | International Journal of Biological Sciences |
| best_oa_location.landing_page_url | https://doi.org/10.7150/ijbs.56952 |
| primary_location.id | doi:10.7150/ijbs.56952 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S26312460 |
| primary_location.source.issn | 1449-2288 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | True |
| primary_location.source.issn_l | 1449-2288 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | True |
| primary_location.source.display_name | International Journal of Biological Sciences |
| primary_location.source.host_organization | https://openalex.org/P4310317973 |
| primary_location.source.host_organization_name | Ivyspring International Publisher |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310317973 |
| primary_location.license | cc-by-nc |
| primary_location.pdf_url | https://www.ijbs.com/v17p2124.pdf |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | https://openalex.org/licenses/cc-by-nc |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | International Journal of Biological Sciences |
| primary_location.landing_page_url | https://doi.org/10.7150/ijbs.56952 |
| publication_date | 2021-01-01 |
| publication_year | 2021 |
| referenced_works | https://openalex.org/W3012655019, https://openalex.org/W3011610993, https://openalex.org/W3002108456, https://openalex.org/W3022970339, https://openalex.org/W3009885589, https://openalex.org/W3021915688, https://openalex.org/W3042214572, https://openalex.org/W3046159736, https://openalex.org/W3021859907, https://openalex.org/W3093604087, https://openalex.org/W3092004162, https://openalex.org/W2617620062, https://openalex.org/W3016538467, https://openalex.org/W3165656738, https://openalex.org/W3007940623, https://openalex.org/W3012421327, https://openalex.org/W3087425309, https://openalex.org/W3127007629, https://openalex.org/W3118570220, https://openalex.org/W3025502129, https://openalex.org/W3094609299, https://openalex.org/W2063634757, https://openalex.org/W2895305242, https://openalex.org/W2610356532, https://openalex.org/W2001941062, https://openalex.org/W3014333693, https://openalex.org/W3014050022, https://openalex.org/W2148658155, https://openalex.org/W3046740571, https://openalex.org/W3092623037 |
| referenced_works_count | 30 |
| abstract_inverted_index.a | 39 |
| abstract_inverted_index.14 | 152 |
| abstract_inverted_index.50 | 63 |
| abstract_inverted_index.We | 16 |
| abstract_inverted_index.at | 79, 91 |
| abstract_inverted_index.by | 104, 138 |
| abstract_inverted_index.is | 11 |
| abstract_inverted_index.of | 2, 7, 23, 31, 83, 109, 149 |
| abstract_inverted_index.on | 4, 33, 119 |
| abstract_inverted_index.or | 47, 125 |
| abstract_inverted_index.so | 14 |
| abstract_inverted_index.to | 18 |
| abstract_inverted_index.we | 37, 130 |
| abstract_inverted_index.727 | 45 |
| abstract_inverted_index.Cox | 121 |
| abstract_inverted_index.The | 0 |
| abstract_inverted_index.and | 27, 93, 114, 143 |
| abstract_inverted_index.for | 154, 161 |
| abstract_inverted_index.the | 5, 20, 29, 84, 120, 147 |
| abstract_inverted_index.This | 67 |
| abstract_inverted_index.days | 153 |
| abstract_inverted_index.even | 94 |
| abstract_inverted_index.far. | 15 |
| abstract_inverted_index.from | 56 |
| abstract_inverted_index.high | 107 |
| abstract_inverted_index.into | 96 |
| abstract_inverted_index.most | 71, 82 |
| abstract_inverted_index.old) | 52 |
| abstract_inverted_index.some | 105 |
| abstract_inverted_index.that | 70, 132 |
| abstract_inverted_index.with | 53 |
| abstract_inverted_index.Here, | 36 |
| abstract_inverted_index.after | 126 |
| abstract_inverted_index.aimed | 17 |
| abstract_inverted_index.among | 61 |
| abstract_inverted_index.based | 118 |
| abstract_inverted_index.cases | 86 |
| abstract_inverted_index.could | 135 |
| abstract_inverted_index.score | 128 |
| abstract_inverted_index.still | 12 |
| abstract_inverted_index.study | 42, 68 |
| abstract_inverted_index.their | 101 |
| abstract_inverted_index.which | 43, 62 |
| abstract_inverted_index.years | 51 |
| abstract_inverted_index.(≥18 | 50 |
| abstract_inverted_index.before | 100, 124 |
| abstract_inverted_index.cohort | 41 |
| abstract_inverted_index.count. | 116 |
| abstract_inverted_index.impact | 30 |
| abstract_inverted_index.lessen | 136 |
| abstract_inverted_index.levels | 78, 148 |
| abstract_inverted_index.models | 123 |
| abstract_inverted_index.normal | 76 |
| abstract_inverted_index.proved | 103 |
| abstract_inverted_index.severe | 46, 89 |
| abstract_inverted_index.within | 151 |
| abstract_inverted_index.(Wuhan, | 59 |
| abstract_inverted_index.China), | 60 |
| abstract_inverted_index.deaths, | 102 |
| abstract_inverted_index.protein | 113 |
| abstract_inverted_index.visibly | 88 |
| abstract_inverted_index.whereas | 81 |
| abstract_inverted_index.COVID-19 | 9, 25, 55, 156 |
| abstract_inverted_index.Hospital | 58 |
| abstract_inverted_index.critical | 48 |
| abstract_inverted_index.deceased | 85 |
| abstract_inverted_index.efficacy | 1 |
| abstract_inverted_index.enrolled | 44 |
| abstract_inverted_index.hospital | 34 |
| abstract_inverted_index.patients | 10, 26, 64, 73 |
| abstract_inverted_index.received | 65 |
| abstract_inverted_index.treating | 162 |
| abstract_inverted_index.COVID-19. | 163 |
| abstract_inverted_index.Moreover, | 117 |
| abstract_inverted_index.admission | 92 |
| abstract_inverted_index.confirmed | 69 |
| abstract_inverted_index.delineate | 19 |
| abstract_inverted_index.determine | 28 |
| abstract_inverted_index.enhancing | 146 |
| abstract_inverted_index.excessive | 141 |
| abstract_inverted_index.extremely | 97, 106 |
| abstract_inverted_index.gradually | 139 |
| abstract_inverted_index.matching, | 129 |
| abstract_inverted_index.meanwhile | 144 |
| abstract_inverted_index.mortality | 137 |
| abstract_inverted_index.patients, | 157 |
| abstract_inverted_index.performed | 38 |
| abstract_inverted_index.potential | 159 |
| abstract_inverted_index.presented | 87 |
| abstract_inverted_index.prognosis | 6 |
| abstract_inverted_index.recovered | 72 |
| abstract_inverted_index.treatment | 134 |
| abstract_inverted_index.C-reactive | 112 |
| abstract_inverted_index.admission, | 80 |
| abstract_inverted_index.aggravated | 98 |
| abstract_inverted_index.indicating | 158 |
| abstract_inverted_index.inpatients | 49 |
| abstract_inverted_index.manifested | 74 |
| abstract_inverted_index.mortality. | 35 |
| abstract_inverted_index.neutrophil | 115 |
| abstract_inverted_index.progressed | 95 |
| abstract_inverted_index.propensity | 127 |
| abstract_inverted_index.relatively | 75 |
| abstract_inverted_index.Huoshenshan | 57 |
| abstract_inverted_index.alleviating | 140 |
| abstract_inverted_index.lymphocytes | 150 |
| abstract_inverted_index.tocilizumab | 3, 32, 133 |
| abstract_inverted_index.continuously | 145 |
| abstract_inverted_index.demonstrated | 131 |
| abstract_inverted_index.inflammation | 21, 77, 90, 99, 142 |
| abstract_inverted_index.tocilizumab. | 66 |
| abstract_inverted_index.controversial | 13 |
| abstract_inverted_index.effectiveness | 160 |
| abstract_inverted_index.retrospective | 40 |
| abstract_inverted_index.concentrations | 108 |
| abstract_inverted_index.interleukin-6, | 110 |
| abstract_inverted_index.procalcitonin, | 111 |
| abstract_inverted_index.characteristics | 22 |
| abstract_inverted_index.severe/critical | 8, 24, 155 |
| abstract_inverted_index.laboratory-confirmed | 54 |
| abstract_inverted_index.proportional-hazards | 122 |
| cited_by_percentile_year.max | 94 |
| cited_by_percentile_year.min | 89 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 15 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.8799999952316284 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.57452757 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |