Inflammation-induced PFKFB3-mediated glycolysis promoting myometrium contraction through the PI3K-Akt-mTOR pathway in preterm birth mice Article Swipe
Jing He
,
Xuan Li
,
Huihui Yu
,
Chunxiao Xu
,
Ruixian Tian
,
Ping Zhou
,
Zongzhi Yin
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1152/ajpcell.00704.2024
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1152/ajpcell.00704.2024
Expression of PFKFB3, a key enzyme in glycolysis, was significantly upregulated both in the mUSMCs and myometrium of mice during late pregnancy after lipopolysaccharide stimulation. Activation of the PI3K-Akt-mTOR pathway enhanced PFKFB3 expression, which is involved in the initiation of glycolysis. Inflammation-activated PFKFB3 via the PI3K-Akt-mTOR pathway, which enhances the cellular glycolytic process and thus promotes myometrium contraction in pregnancy.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1152/ajpcell.00704.2024
- OA Status
- hybrid
- Cited By
- 3
- References
- 51
- Related Works
- 10
- OpenAlex ID
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All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4407157657Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1152/ajpcell.00704.2024Digital Object Identifier
- Title
-
Inflammation-induced PFKFB3-mediated glycolysis promoting myometrium contraction through the PI3K-Akt-mTOR pathway in preterm birth miceWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
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2025Year of publication
- Publication date
-
2025-02-05Full publication date if available
- Authors
-
Jing He, Xuan Li, Huihui Yu, Chunxiao Xu, Ruixian Tian, Ping Zhou, Zongzhi YinList of authors in order
- Landing page
-
https://doi.org/10.1152/ajpcell.00704.2024Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
-
hybridOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.1152/ajpcell.00704.2024Direct OA link when available
- Concepts
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PI3K/AKT/mTOR pathway, Inflammation, Protein kinase B, Glycolysis, Downregulation and upregulation, LY294002, Wortmannin, Chemistry, Cell biology, Biology, Endocrinology, Internal medicine, Signal transduction, Medicine, Biochemistry, Metabolism, GeneTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
3Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 3Per-year citation counts (last 5 years)
- References (count)
-
51Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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| primary_location.is_published | True |
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| primary_location.landing_page_url | https://doi.org/10.1152/ajpcell.00704.2024 |
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| publication_year | 2025 |
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