Infliximab Plus Intravenous Immunoglobulin (IVIG) Versus IVIG Alone as Initial Therapy in Children With Kawasaki Disease Presenting With Coronary Artery Lesions Article Swipe
Pei‐Ni Jone
,
Marsha S. Anderson
,
Matthew Mulvahill
,
Heather Heizer
,
Mary P. Glodé
,
Samuel R. Dominguez
·
YOU?
·
· 2018
· Open Access
·
· DOI: https://doi.org/10.1097/inf.0000000000001951
YOU?
·
· 2018
· Open Access
·
· DOI: https://doi.org/10.1097/inf.0000000000001951
Background: We previously demonstrated that 80% of Kawasaki disease (KD) patients who develop coronary artery lesions (CALs) have them at diagnosis. We postulated that KD patients presenting with CALs represent a group that may benefit from more aggressive initial therapy. Infliximab has been shown to decrease inflammation in KD patients when added to standard therapy. We compared outcomes of KD patients with CALs initially treated with intravenous immunoglobulin (IVIG) alone versus IVIG plus infliximab. Methods: Medical records of KD patients from January 2009 to July 2016 were retrospectively reviewed. CALs were defined as a left anterior descending or right coronary artery Z score ≥2.5. KD patients with CALs on initial echocardiogram treated with IVIG alone were compared with those treated with IVIG plus infliximab. Clinical characteristics were compared between groups using Wilcoxon rank-sum test, χ 2 test and Fischer’s exact tests; length of stay was analyzed using log-normal regression and need for additional therapy using logistic regression. Effect of treatment on CALs between groups was assessed using linear mixed models. Results: Sixty-nine KD patients with CALs at presentation were included. Fifteen of 34 (44%) patients treated with IVIG alone required additional therapy compared with 4 of 35 (11%) patients treated with IVIG plus infliximab ( P = 0.003). There were no significant differences between treatment groups for length of stay, CALs or C-reactive protein fall. Conclusions: IVIG plus infliximab as initial therapy reduces the need for additional therapy in KD patients presenting with CALs. Intensified initial therapy, consisting of infliximab plus IVIG, could be considered for this group of KD patients.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1097/inf.0000000000001951
- OA Status
- green
- Cited By
- 34
- References
- 24
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2793398312
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W2793398312Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1097/inf.0000000000001951Digital Object Identifier
- Title
-
Infliximab Plus Intravenous Immunoglobulin (IVIG) Versus IVIG Alone as Initial Therapy in Children With Kawasaki Disease Presenting With Coronary Artery LesionsWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
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2018Year of publication
- Publication date
-
2018-02-16Full publication date if available
- Authors
-
Pei‐Ni Jone, Marsha S. Anderson, Matthew Mulvahill, Heather Heizer, Mary P. Glodé, Samuel R. DominguezList of authors in order
- Landing page
-
https://doi.org/10.1097/inf.0000000000001951Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
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greenOpen access status per OpenAlex
- OA URL
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https://www.ncbi.nlm.nih.gov/pmc/articles/6093799Direct OA link when available
- Concepts
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Infliximab, Medicine, Kawasaki disease, Internal medicine, Artery, Logistic regression, Surgery, Gastroenterology, DiseaseTop concepts (fields/topics) attached by OpenAlex
- Cited by
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34Total citation count in OpenAlex
- Citations by year (recent)
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2025: 5, 2024: 5, 2023: 2, 2022: 2, 2021: 7Per-year citation counts (last 5 years)
- References (count)
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24Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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