Influence of CReatine Supplementation on mUScle Mass and Strength After Stroke (ICaRUS Stroke Trial): A Randomized Controlled Trial Article Swipe
Juli Thomaz de Souza
,
Marcos Ferreira Minicucci
,
Natália Cristina Ferreira
,
Bertha Furlan Polegato
,
Marina Politi Okoshi
,
Gabriel Pinheiro Módolo
,
Filipe W. Leal-Pereira
,
Bethan E. Phillips
,
Philip J. Atherton
,
Kenneth Smith
,
Daniel J. Wilkinson
,
Adam Gordon
,
Suzana Érico Tanni
,
Vladimir Eliodoro Costa
,
Maria F. Fernandes
,
Silméia Garcia Zanati Bazan
,
Leonardo Antônio Mamede Zornoff
,
Sérgio Alberto Rupp de Paiva
,
Rodrigo Bazán
,
Paula S. Azevedo
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3390/nu16234148
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3390/nu16234148
Background/Objectives: The acute phase of stroke is marked by inflammation and mobility changes that can compromise nutritional status. This study was a randomized, double-blind, placebo-controlled trial evaluating the effectiveness of creatine supplementation for older people during seven days of hospitalization for stroke compared to usual care. Method: The primary outcome measures were changes in functional capacity, strength, muscle mass, and muscle degradation. The secondary outcomes were changes in serum biomarkers related to inflammation, fibrosis, anabolism, and muscle synthesis. In addition, a follow-up 90 days after the stroke verified functional capacity, strength, quality of life, and mortality. Following admission for an acute stroke, participants received either creatine (10 g) or a visually identical placebo (10 g) orally twice daily. Both groups received supplementation with protein to achieve the goal of 1.5 g of protein/kg of body weight/day and underwent daily mobility training during seven days of hospitalization. Results: Thirty older people were included in two similar groups concerning baseline attributes (15—treatment/15—placebo). Conclusions: Creatine supplementation did not influence functional capacity, strength, or muscle mass during the first 7 days or outcomes 90 days after stroke. There were no serious adverse events associated with creatine supplementation. However, it decreased progranulin levels, raising a new possibility of creatine action. This finding needs further exploration to understand the biological significance of creatine–progranulin interaction.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/nu16234148
- OA Status
- gold
- Cited By
- 1
- References
- 45
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4404932840
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4404932840Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3390/nu16234148Digital Object Identifier
- Title
-
Influence of CReatine Supplementation on mUScle Mass and Strength After Stroke (ICaRUS Stroke Trial): A Randomized Controlled TrialWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-11-29Full publication date if available
- Authors
-
Juli Thomaz de Souza, Marcos Ferreira Minicucci, Natália Cristina Ferreira, Bertha Furlan Polegato, Marina Politi Okoshi, Gabriel Pinheiro Módolo, Filipe W. Leal-Pereira, Bethan E. Phillips, Philip J. Atherton, Kenneth Smith, Daniel J. Wilkinson, Adam Gordon, Suzana Érico Tanni, Vladimir Eliodoro Costa, Maria F. Fernandes, Silméia Garcia Zanati Bazan, Leonardo Antônio Mamede Zornoff, Sérgio Alberto Rupp de Paiva, Rodrigo Bazán, Paula S. AzevedoList of authors in order
- Landing page
-
https://doi.org/10.3390/nu16234148Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.3390/nu16234148Direct OA link when available
- Concepts
-
Randomized controlled trial, Stroke (engine), Medicine, Creatine, Physical therapy, Physical medicine and rehabilitation, Muscle mass, Internal medicine, Physics, ThermodynamicsTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
1Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 1Per-year citation counts (last 5 years)
- References (count)
-
45Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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