Influence of CYP2D6 phenotype on adherence, adverse effects, and attitudes in aripiprazole and risperidone users Article Swipe
Elina Hietala
,
Anssi Solismaa
,
Markku Lähteenvuo
,
Ari Ahola‐Olli
,
Katja Häkkinen
,
Kimmo Suokas
,
Erkki Isometsä
,
Jaana Suvisaari
,
Tuula Kieseppä
,
Minna Torniainen‐Holm
,
Jari Tiihonen
,
Jouko Lönnqvist
,
Jarmo Hietala
,
Asko Wegelius
,
Kaisla Lahdensuo
,
Willehard Haaki
,
Olli Kampman
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1017/neu.2025.11
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1017/neu.2025.11
Non-adherence and negative attitudes towards medication are major problems in treating psychotic disorders. Cytochrome P450 2D6 (CYP2D6) contributes to the metabolism of aripiprazole and risperidone, and variations in CYP2D6 activity may affect treatment response or adverse effects. However, the impact of these variations on adherence and medication attitudes is unclear. This study investigates the relationships between CYP2D6 phenotype, self-reported adherence, adverse effects, and attitudes among aripiprazole and risperidone users. The study analysed data from the SUPER-Finland cohort of 10,474 adults with psychotic episodes, including 1,429 aripiprazole and 828 risperidone users. The Attitudes towards Neuroleptic Treatment (ANT) questionnaire assessed adherence and adverse effects in all patients, while medication-related attitudes were examined in a subgroup of 1,000 participants. Associations between CYP2D6 phenotypes and outcomes were analysed using logistic regression and beta regression in aripiprazole and risperidone groups separately. Among risperidone users, we observed no association between CYP2D6 phenotypes and adherence, adverse effects, or attitudes. Similarly, we found no link between adherence and CYP2D6 phenotypes among aripiprazole users. However, aripiprazole users with the ultrarapid CYP2D6 phenotype had more adverse effects (OR = 1.71, 95 % CI 1.03–2.90, p = 0.041). Among aripiprazole users, CYP2D6 ultrarapid phenotype was associated with less favourable attitudes towards antipsychotic treatment (β = −0.48, p = 0.023). These findings provide preliminary evidence that the ultrarapid CYP2D6 phenotype is associated with increased adverse effects and negative attitudes towards antipsychotic medication among aripiprazole users. CYP2D6 phenotype did not influence adherence, adverse effects, or attitudes among risperidone users.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1017/neu.2025.11
- OA Status
- hybrid
- References
- 50
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4408832728
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4408832728Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1017/neu.2025.11Digital Object Identifier
- Title
-
Influence of CYP2D6 phenotype on adherence, adverse effects, and attitudes in aripiprazole and risperidone usersWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2025Year of publication
- Publication date
-
2025-01-01Full publication date if available
- Authors
-
Elina Hietala, Anssi Solismaa, Markku Lähteenvuo, Ari Ahola‐Olli, Katja Häkkinen, Kimmo Suokas, Erkki Isometsä, Jaana Suvisaari, Tuula Kieseppä, Minna Torniainen‐Holm, Jari Tiihonen, Jouko Lönnqvist, Jarmo Hietala, Asko Wegelius, Kaisla Lahdensuo, Willehard Haaki, Olli KampmanList of authors in order
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https://doi.org/10.1017/neu.2025.11Publisher landing page
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YesWhether a free full text is available
- OA status
-
hybridOpen access status per OpenAlex
- OA URL
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https://doi.org/10.1017/neu.2025.11Direct OA link when available
- Concepts
-
Aripiprazole, Risperidone, CYP2D6, Adverse effect, Medicine, Antipsychotic, Logistic regression, Psychiatry, Atypical antipsychotic, Internal medicine, Clinical psychology, Pharmacology, Psychology, Schizophrenia (object-oriented programming), Cytochrome P450, MetabolismTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
- References (count)
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50Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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