Influence of Lymphangio (L), Vascular (V), and Perineural (Pn) Invasion on Recurrence and Survival of Resected Intrahepatic Cholangiocarcinoma Article Swipe
F. Bartsch
,
Lisa-Katharina Heuft
,
J. Baumgart
,
Maria Hoppe‐Lotichius
,
Rabea Margies
,
Tiemo Sven Gerber
,
Friedrich Foerster
,
Arndt Weinmann
,
Beate K. Straub
,
Jens Mittler
,
Stefan Heinrich
,
Hauke Lang
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.3390/jcm10112426
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.3390/jcm10112426
(1) Background: Intrahepatic cholangiocarcinoma (ICC) is a rare malignancy. Besides tumor, nodal, and metastatic status, the UICC TNM classification describes further parameters such as lymphangio- (L0/L1), vascular (V0/V1/V2), and perineural invasion (Pn0/Pn1). The aim of this study was to analyze the influence of these parameters on recurrence and survival. (2) Methods: All surgical explorations for patients with ICC between January 2008 and June 2018 were collected and further analyzed in our institutional database. Statistical analyses focused on perineural, lymphangio-, and vascular invasion examined histologically and their influence on tumor recurrence and survival. (3) Results: Of 210 patients who underwent surgical exploration, 150 underwent curative-intended resection. Perineural invasion was present in 41, lymphangioinvasion in 21, and vascular invasion in 37 patients (V1 n = 34, V2 n = 3). Presence of P1, V+ and L1 was significantly associated with positivity of each other of these factors (p < 0.001, each). None of the three parameters showed direct influence on tumor recurrence in general, but perineural invasion influenced extrahepatic recurrence significantly (p = 0.019). Whereas lymphangio and vascular invasion was neither associated with overall nor recurrence-free survival, perineural invasion was significantly associated with a poor 1-, 3- and 5-year overall survival (OS) of 80%, 35%, and 23% for Pn0 versus 75%, 23%, and 0% for Pn1 (p = 0.027). Concerning recurrence-free survival (RFS), Pn0 showed a 1-, 3- and 5-year RFS of 42%, 18%, and 16% versus 28%, 11%, and 0% for Pn1, but no significance was reached (p = 0.091). (4) Conclusions: Whereas lymphangio- and vascular invasion showed no significant influence in several analyses, the presence of perineural invasion was associated with a significantly higher risk of extrahepatic tumor recurrence and worse overall survival.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/jcm10112426
- https://www.mdpi.com/2077-0383/10/11/2426/pdf?version=1622359444
- OA Status
- gold
- Cited By
- 23
- References
- 34
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3164186109
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3164186109Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3390/jcm10112426Digital Object Identifier
- Title
-
Influence of Lymphangio (L), Vascular (V), and Perineural (Pn) Invasion on Recurrence and Survival of Resected Intrahepatic CholangiocarcinomaWork title
- Type
-
articleOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2021Year of publication
- Publication date
-
2021-05-30Full publication date if available
- Authors
-
F. Bartsch, Lisa-Katharina Heuft, J. Baumgart, Maria Hoppe‐Lotichius, Rabea Margies, Tiemo Sven Gerber, Friedrich Foerster, Arndt Weinmann, Beate K. Straub, Jens Mittler, Stefan Heinrich, Hauke LangList of authors in order
- Landing page
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https://doi.org/10.3390/jcm10112426Publisher landing page
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https://www.mdpi.com/2077-0383/10/11/2426/pdf?version=1622359444Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.mdpi.com/2077-0383/10/11/2426/pdf?version=1622359444Direct OA link when available
- Concepts
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Medicine, Perineural invasion, Vascular invasion, Intrahepatic Cholangiocarcinoma, Malignancy, Gastroenterology, Internal medicine, Proportional hazards model, Overall survival, Surgery, Oncology, CancerTop concepts (fields/topics) attached by OpenAlex
- Cited by
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23Total citation count in OpenAlex
- Citations by year (recent)
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2025: 8, 2024: 5, 2023: 9, 2022: 1Per-year citation counts (last 5 years)
- References (count)
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34Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.23%, | 209 |
| abstract_inverted_index.28%, | 235 |
| abstract_inverted_index.35%, | 202 |
| abstract_inverted_index.42%, | 230 |
| abstract_inverted_index.75%, | 208 |
| abstract_inverted_index.80%, | 201 |
| abstract_inverted_index.June | 62 |
| abstract_inverted_index.None | 149 |
| abstract_inverted_index.Pn1, | 240 |
| abstract_inverted_index.UICC | 16 |
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| abstract_inverted_index.rare | 7 |
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| abstract_inverted_index.their | 85 |
| abstract_inverted_index.these | 43, 143 |
| abstract_inverted_index.three | 152 |
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| abstract_inverted_index.worse | 280 |
| abstract_inverted_index.(RFS), | 220 |
| abstract_inverted_index.0.001, | 147 |
| abstract_inverted_index.5-year | 196, 227 |
| abstract_inverted_index.direct | 155 |
| abstract_inverted_index.each). | 148 |
| abstract_inverted_index.higher | 273 |
| abstract_inverted_index.nodal, | 11 |
| abstract_inverted_index.showed | 154, 222, 256 |
| abstract_inverted_index.tumor, | 10 |
| abstract_inverted_index.versus | 207, 234 |
| abstract_inverted_index.0.019). | 171 |
| abstract_inverted_index.0.027). | 216 |
| abstract_inverted_index.0.091). | 248 |
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| abstract_inverted_index.January | 59 |
| abstract_inverted_index.Whereas | 172, 251 |
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| abstract_inverted_index.reached | 245 |
| abstract_inverted_index.several | 261 |
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| abstract_inverted_index.analyzed | 68 |
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| abstract_inverted_index.patients | 55, 96, 119 |
| abstract_inverted_index.presence | 264 |
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| abstract_inverted_index.database. | 72 |
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| abstract_inverted_index.resection. | 104 |
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| corresponding_author_ids | https://openalex.org/A5048426715 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 12 |
| corresponding_institution_ids | https://openalex.org/I197323543, https://openalex.org/I4210094062 |
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| sustainable_development_goals[0].display_name | No poverty |
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| citation_normalized_percentile.is_in_top_10_percent | True |