Influence of UGT1A1 Genetic Variants on Free Bilirubin Levels in Japanese Newborns: A Preliminary Study Article Swipe
Hiroaki Hanafusa
,
Shinya Abe
,
Shohei Ohyama
,
Yuki Kyono
,
Takumi Kido
,
Ruka Nakasone
,
Mariko Ashina
,
Kenji Tanimura
,
Kandai Nozu
,
Kazumichi Fujioka
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.3390/ijerph192013090
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.3390/ijerph192013090
Background: Free bilirubin (Bf) is a better marker than total serum bilirubin (TSB) for predicting bilirubin encephalopathy (BE). To date, two UGT1A1 genetic variants (rs4148323 and rs3064744) have been associated with neonatal hyperbilirubinemia; however, the direct association between UGT1A1 variants and Bf levels in newborns has not been elucidated. Methods: We retrospectively analyzed the clinical data of 484 infants, including the genotype data of two UGT1A1 genetic variants. We divided the infants into a high Bf group (Bf ≥ 1.0 µg/dL, n = 77) and a non-high Bf group (Bf < 1.0 µg/dL, n = 407), based on the peak Bf values. Logistic regression analysis was performed to calculate the odds ratios (ORs) for each variant allele compared to wild-type alleles. Results: The frequencies of the A allele in rs4148323 and (TA)7 allele in rs3064744 in the high Bf group (29% and 4%, respectively) were significantly different from those in the non-high Bf group (16% and 12%, respectively). In logistic regression analysis, for rs4148323, the A allele was significantly associated with an increased risk of hyper-free bilirubinemia over the G allele (adjusted OR: 1.80, 95% confidence interval [CI]: 1.19–2.72, p < 0.01). However, for rs3064744, the (TA)7 allele was significantly associated with a decreased risk of hyper-free bilirubinemia over the (TA)6 allele (adjusted OR: 0.42, 95% CI: 0.18–0.95, p = 0.04). Conclusions: This study is the first to show that the A allele in rs4148323 is a risk factor and that the (TA)7 allele in rs3064744 is a protective factor for developing hyper-free bilirubinemia in Japanese newborns.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/ijerph192013090
- https://www.mdpi.com/1660-4601/19/20/13090/pdf?version=1665565143
- OA Status
- gold
- Cited By
- 4
- References
- 49
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4304689323
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4304689323Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/ijerph192013090Digital Object Identifier
- Title
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Influence of UGT1A1 Genetic Variants on Free Bilirubin Levels in Japanese Newborns: A Preliminary StudyWork title
- Type
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articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2022Year of publication
- Publication date
-
2022-10-12Full publication date if available
- Authors
-
Hiroaki Hanafusa, Shinya Abe, Shohei Ohyama, Yuki Kyono, Takumi Kido, Ruka Nakasone, Mariko Ashina, Kenji Tanimura, Kandai Nozu, Kazumichi FujiokaList of authors in order
- Landing page
-
https://doi.org/10.3390/ijerph192013090Publisher landing page
- PDF URL
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https://www.mdpi.com/1660-4601/19/20/13090/pdf?version=1665565143Direct link to full text PDF
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-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.mdpi.com/1660-4601/19/20/13090/pdf?version=1665565143Direct OA link when available
- Concepts
-
Bilirubin, Medicine, Genetics, Biology, Internal medicineTop concepts (fields/topics) attached by OpenAlex
- Cited by
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4Total citation count in OpenAlex
- Citations by year (recent)
-
2024: 3, 2023: 1Per-year citation counts (last 5 years)
- References (count)
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49Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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