Inhalation exposure to 2-ethyl-1-hexanol causes hepatomegaly and transient lipid accumulation without induction of peroxisome proliferator-activated receptor alpha in mice Article Swipe
Takanari Wakayama
,
Yuki Ito
,
Mio Miyake
,
Karin Nomasa
,
Kiyoshi Sakai
,
Naoko Oya
,
Hirotaka Sato
,
Hiroyuki Ohno
,
Michihiro Kamijima
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.2486/indhealth.2020-0252
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.2486/indhealth.2020-0252
2-Ethyl-1-hexanol (2EH) is a volatile organic compound known to cause sick building syndrome. However, 2EH-induced hepatotoxicity has been mainly evaluated in experiments orally administering 2EH as a metabolite of di(2-ethylhexyl) phthalate. To evaluate the hepatotoxicity risk of 2EH as an indoor air pollutant, we exposed 10-wk-old male ICR mice to 2EH by inhalation for 8 h/d, 5 d/wk for 3 months (0, 20, 60, or 150 ppm) or 6 months (0, 0.5, 10, or 100 ppm). In both experiments, relative liver weights significantly increased in the highest exposure groups. The 3-month exposure increased histopathological lipid droplets in the liver in a dose-dependent manner, hepatic triglyceride at all exposure levels, hepatic phospholipid at 150 ppm, and microsomal triglyceride transfer protein at 60 and 150 ppm; however, these changes were not observed following the 6-month of exposure. Following the 3-month exposure, alanine transaminase and peroxisomal bifunctional proteins, known markers of liver injury and peroxisome proliferation, respectively, remained unaltered. Therefore, in the present study, the inhalation concentration range of 2EH induced a toxic hypertrophic change, revealing a limited role of peroxisome proliferator-activated receptor alpha (PPARα). The liver weights may have presumably increased via a mechanism independent of PPARα activation.
Related Topics
Concepts
Peroxisome proliferator-activated receptor alpha
Peroxisome
Endocrinology
Chemistry
Internal medicine
Inhalation
Peroxisome proliferator-activated receptor
Metabolite
Phthalate
Triglyceride
Alanine transaminase
Alpha (finance)
Receptor
Nuclear receptor
Biochemistry
Medicine
Cholesterol
Anesthesia
Gene
Transcription factor
Nursing
Construct validity
Patient satisfaction
Organic chemistry
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.2486/indhealth.2020-0252
- https://www.jstage.jst.go.jp/article/indhealth/59/6/59_2020-0252/_pdf
- OA Status
- diamond
- Cited By
- 1
- References
- 46
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3204597900
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3204597900Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.2486/indhealth.2020-0252Digital Object Identifier
- Title
-
Inhalation exposure to 2-ethyl-1-hexanol causes hepatomegaly and transient lipid accumulation without induction of peroxisome proliferator-activated receptor alpha in miceWork title
- Type
-
articleOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2021Year of publication
- Publication date
-
2021-09-27Full publication date if available
- Authors
-
Takanari Wakayama, Yuki Ito, Mio Miyake, Karin Nomasa, Kiyoshi Sakai, Naoko Oya, Hirotaka Sato, Hiroyuki Ohno, Michihiro KamijimaList of authors in order
- Landing page
-
https://doi.org/10.2486/indhealth.2020-0252Publisher landing page
- PDF URL
-
https://www.jstage.jst.go.jp/article/indhealth/59/6/59_2020-0252/_pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
diamondOpen access status per OpenAlex
- OA URL
-
https://www.jstage.jst.go.jp/article/indhealth/59/6/59_2020-0252/_pdfDirect OA link when available
- Concepts
-
Peroxisome proliferator-activated receptor alpha, Peroxisome, Endocrinology, Chemistry, Internal medicine, Inhalation, Peroxisome proliferator-activated receptor, Metabolite, Phthalate, Triglyceride, Alanine transaminase, Alpha (finance), Receptor, Nuclear receptor, Biochemistry, Medicine, Cholesterol, Anesthesia, Gene, Transcription factor, Nursing, Construct validity, Patient satisfaction, Organic chemistryTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
1Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 1Per-year citation counts (last 5 years)
- References (count)
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46Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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