Inhaled Antifungal Agents for Treatment and Prophylaxis of Bronchopulmonary Invasive Mold Infections Article Swipe
Kévin Brunet
,
Jean-Philippe Martellosio
,
Frédéric Tewes
,
Sandrine Marchand
,
Blandine Rammaert
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.3390/pharmaceutics14030641
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.3390/pharmaceutics14030641
Pulmonary mold infections are life-threatening diseases with high morbi-mortalities. Treatment is based on systemic antifungal agents belonging to the families of polyenes (amphotericin B) and triazoles. Despite this treatment, mortality remains high and the doses of systemic antifungals cannot be increased as they often lead to toxicity. The pulmonary aerosolization of antifungal agents can theoretically increase their concentration at the infectious site, which could improve their efficacy while limiting their systemic exposure and toxicity. However, clinical experience is poor and thus inhaled agent utilization remains unclear in term of indications, drugs, and devices. This comprehensive literature review aims to describe the pharmacokinetic behavior and the efficacy of inhaled antifungal drugs as prophylaxes and curative treatments both in animal models and humans.
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Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.3390/pharmaceutics14030641
- https://www.mdpi.com/1999-4923/14/3/641/pdf?version=1647335294
- OA Status
- gold
- Cited By
- 23
- References
- 185
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4220811320
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4220811320Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/pharmaceutics14030641Digital Object Identifier
- Title
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Inhaled Antifungal Agents for Treatment and Prophylaxis of Bronchopulmonary Invasive Mold InfectionsWork title
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reviewOpenAlex work type
- Language
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enPrimary language
- Publication year
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2022Year of publication
- Publication date
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2022-03-14Full publication date if available
- Authors
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Kévin Brunet, Jean-Philippe Martellosio, Frédéric Tewes, Sandrine Marchand, Blandine RammaertList of authors in order
- Landing page
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https://doi.org/10.3390/pharmaceutics14030641Publisher landing page
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https://www.mdpi.com/1999-4923/14/3/641/pdf?version=1647335294Direct link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://www.mdpi.com/1999-4923/14/3/641/pdf?version=1647335294Direct OA link when available
- Concepts
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Antifungal, Amphotericin B, Medicine, Toxicity, Intensive care medicine, Antifungal drugs, Inhalation, Limiting, Pharmacokinetics, Pharmacology, Fluconazole, Anesthesia, Internal medicine, Dermatology, Mechanical engineering, EngineeringTop concepts (fields/topics) attached by OpenAlex
- Cited by
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23Total citation count in OpenAlex
- Citations by year (recent)
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2025: 6, 2024: 6, 2023: 7, 2022: 4Per-year citation counts (last 5 years)
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185Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.describe | 99 |
| abstract_inverted_index.devices. | 92 |
| abstract_inverted_index.diseases | 5 |
| abstract_inverted_index.efficacy | 66, 105 |
| abstract_inverted_index.exposure | 71 |
| abstract_inverted_index.families | 19 |
| abstract_inverted_index.increase | 55 |
| abstract_inverted_index.limiting | 68 |
| abstract_inverted_index.polyenes | 21 |
| abstract_inverted_index.systemic | 13, 36, 70 |
| abstract_inverted_index.Pulmonary | 0 |
| abstract_inverted_index.Treatment | 9 |
| abstract_inverted_index.belonging | 16 |
| abstract_inverted_index.increased | 40 |
| abstract_inverted_index.mortality | 29 |
| abstract_inverted_index.pulmonary | 48 |
| abstract_inverted_index.toxicity. | 46, 73 |
| abstract_inverted_index.antifungal | 14, 51, 108 |
| abstract_inverted_index.experience | 76 |
| abstract_inverted_index.infections | 2 |
| abstract_inverted_index.infectious | 60 |
| abstract_inverted_index.literature | 95 |
| abstract_inverted_index.treatment, | 28 |
| abstract_inverted_index.treatments | 114 |
| abstract_inverted_index.triazoles. | 25 |
| abstract_inverted_index.antifungals | 37 |
| abstract_inverted_index.prophylaxes | 111 |
| abstract_inverted_index.utilization | 83 |
| abstract_inverted_index.indications, | 89 |
| abstract_inverted_index.(amphotericin | 22 |
| abstract_inverted_index.comprehensive | 94 |
| abstract_inverted_index.concentration | 57 |
| abstract_inverted_index.theoretically | 54 |
| abstract_inverted_index.aerosolization | 49 |
| abstract_inverted_index.pharmacokinetic | 101 |
| abstract_inverted_index.life-threatening | 4 |
| abstract_inverted_index.morbi-mortalities. | 8 |
| cited_by_percentile_year.max | 99 |
| cited_by_percentile_year.min | 97 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 5 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.7799999713897705 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.90573486 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |