Inhibition of EED-mediated histone methylation alleviates neuroinflammation by suppressing WNT-mediated dendritic cell migration Article Swipe
Wenxiang Hong
,
Hongbo Ma
,
Zhibin Li
,
Yiwen Du
,
Wenjing Xia
,
Han Yin
,
Han Huang
,
Zhifu Sun
,
Renhua Gai
,
Lexian Tong
,
Hongliang Zhu
,
Jincheng Wang
,
Bo Yang
,
Qiaojun He
,
Qinjie Weng
,
Jiajia Wang
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1186/s12974-025-03429-z
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1186/s12974-025-03429-z
The epigenetic modification of histone H3 lysine 27 trimethylation (H3K27me3) by the embryonic ectoderm development (EED) protein is closely associated with the regulation of transcriptional programs and is implicated in autoimmune diseases. However, the efficacy of targeting H3K27me3 for the treatment of neuroinflammation remains unclear. In this study, we demonstrate that systemic administration of an EED inhibitor diminishes the inflammatory response mediated by dendritic cells (DCs), thereby alleviating experimental autoimmune encephalitis (EAE), a representative mouse model of autoimmune diseases in the central nervous system (CNS). Our findings indicate that EED inhibitors suppress DC migration by upregulating genes in the WNT signaling pathway that are epigenetically marked by H3K27me3. Conversely, inhibiting the WNT pathway partially reverses the impaired DC migration caused by EED inhibitors. Additionally, the genetic deletion of Eed inhibits DC migration and effectively mitigates autoimmune symptoms and inflammatory infiltration into the CNS in EAE. These results highlight EED as a critical regulator of DC migration and suggest its potential as a therapeutic target for autoimmune disorders.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1186/s12974-025-03429-z
- https://jneuroinflammation.biomedcentral.com/counter/pdf/10.1186/s12974-025-03429-z
- OA Status
- gold
- Cited By
- 2
- References
- 60
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4409048476
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Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4409048476Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1186/s12974-025-03429-zDigital Object Identifier
- Title
-
Inhibition of EED-mediated histone methylation alleviates neuroinflammation by suppressing WNT-mediated dendritic cell migrationWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2025Year of publication
- Publication date
-
2025-04-01Full publication date if available
- Authors
-
Wenxiang Hong, Hongbo Ma, Zhibin Li, Yiwen Du, Wenjing Xia, Han Yin, Han Huang, Zhifu Sun, Renhua Gai, Lexian Tong, Hongliang Zhu, Jincheng Wang, Bo Yang, Qiaojun He, Qinjie Weng, Jiajia WangList of authors in order
- Landing page
-
https://doi.org/10.1186/s12974-025-03429-zPublisher landing page
- PDF URL
-
https://jneuroinflammation.biomedcentral.com/counter/pdf/10.1186/s12974-025-03429-zDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://jneuroinflammation.biomedcentral.com/counter/pdf/10.1186/s12974-025-03429-zDirect OA link when available
- Concepts
-
Neuroinflammation, Histone, Wnt signaling pathway, Epigenetics, DNA methylation, Methylation, Cell biology, Neuroscience, Biology, Cancer research, Immunology, Genetics, Signal transduction, Inflammation, Gene expression, GeneTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
2Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 2Per-year citation counts (last 5 years)
- References (count)
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60Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.infiltration | 139 |
| abstract_inverted_index.inflammatory | 59, 138 |
| abstract_inverted_index.modification | 2 |
| abstract_inverted_index.upregulating | 95 |
| abstract_inverted_index.Additionally, | 123 |
| abstract_inverted_index.administration | 52 |
| abstract_inverted_index.epigenetically | 104 |
| abstract_inverted_index.representative | 73 |
| abstract_inverted_index.trimethylation | 8 |
| abstract_inverted_index.transcriptional | 24 |
| abstract_inverted_index.neuroinflammation | 42 |
| cited_by_percentile_year.max | 97 |
| cited_by_percentile_year.min | 95 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 16 |
| citation_normalized_percentile.value | 0.9025461 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |