Inhibition of NAT10 Enhances the Antitumor Immunity by Increasing Type I Interferon Responses Article Swipe
Daoxin Ma
,
Wancheng Liu
,
Yihong Wei
,
Jinfeng Chen
,
Hexiao Jia
,
Xinyu Yang
,
Yingjian Huang
,
Xiangling Xing
,
X. W. Liu
,
Xiaodong Guo
,
Can Can
,
Amin Zhang
,
Ke Xiao
,
Na He
,
Hailei Zhang
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.21203/rs.3.rs-4352052/v1
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.21203/rs.3.rs-4352052/v1
Posttranslational modifications add tremendous complexity to cancer progression; however, gaps remain in knowledge regarding the function and immune regulatory mechanism of newly discovered mRNA acetylation modification. Here, we discovered an unexpected role of N4-acetylcytidine (ac4C) RNA acetyltransferase-NAT10 on reshaping tumor immune microenvironment. Based on analyses of patient datasets, we found that NAT10 was upregulated in tumor tissues, and negatively correlated with overall survival and immune cells infiltration. Inhibition of NAT10 significantly suppressed tumor growth in vivo and in vitro. NAT10 deficiency in cancer cells significantly upregulated immune cells infiltration and stimulated tumor-specific cellular immune responses, leading to the establishment of robust anti-tumor immunity. Mechanistically, we identified MYC as a key downstream target of NAT10, and then induced CDK2-DNMT1 expression. Meanwhile, inhibition of NAT10 down-regulated MYC-CDK2-DNMT1 expression, which enhanced double-stranded RNAs (dsRNA) formation to induce type I IFN (IFN-I) and trigger immune responses of CD8+ T cells. In terms of clinical significance, we demonstrated that inhibition of NAT10 using Remodelin or PEI/PC7A/siRNA nanoparticles combined with anti-PD1 treatment synergistically improved tumor immune microenvironment and repressed tumor progression in vivo. Therefore, inhibition of NAT10 in cancer cells improve tumor immunogenicity, resulting in tumor suppression by enhancing anti-tumor immune responses. Our study uncovers a crucial role of NAT10 in re-modulating tumor immunogenicity and demonstrates a novel concept for targeting NAT10 in cancer immunotherapy.
Related Topics
Concepts
Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.21203/rs.3.rs-4352052/v1
- https://www.researchsquare.com/article/rs-4352052/latest.pdf
- OA Status
- gold
- Cited By
- 1
- References
- 36
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4401816093
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4401816093Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.21203/rs.3.rs-4352052/v1Digital Object Identifier
- Title
-
Inhibition of NAT10 Enhances the Antitumor Immunity by Increasing Type I Interferon ResponsesWork title
- Type
-
preprintOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-08-23Full publication date if available
- Authors
-
Daoxin Ma, Wancheng Liu, Yihong Wei, Jinfeng Chen, Hexiao Jia, Xinyu Yang, Yingjian Huang, Xiangling Xing, X. W. Liu, Xiaodong Guo, Can Can, Amin Zhang, Ke Xiao, Na He, Hailei ZhangList of authors in order
- Landing page
-
https://doi.org/10.21203/rs.3.rs-4352052/v1Publisher landing page
- PDF URL
-
https://www.researchsquare.com/article/rs-4352052/latest.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.researchsquare.com/article/rs-4352052/latest.pdfDirect OA link when available
- Concepts
-
Immune system, Biology, Cancer research, Immunogenicity, Tumor microenvironment, Tumor progression, Immunity, Immunotherapy, Downregulation and upregulation, Cancer cell, CD8, Cancer, Cell biology, Immunology, Biochemistry, Gene, GeneticsTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
1Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 1Per-year citation counts (last 5 years)
- References (count)
-
36Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W4401816093 |
|---|---|
| doi | https://doi.org/10.21203/rs.3.rs-4352052/v1 |
| ids.doi | https://doi.org/10.21203/rs.3.rs-4352052/v1 |
| ids.openalex | https://openalex.org/W4401816093 |
| fwci | 0.48024723 |
| type | preprint |
| title | Inhibition of NAT10 Enhances the Antitumor Immunity by Increasing Type I Interferon Responses |
| biblio.issue | |
| biblio.volume | |
| biblio.last_page | |
| biblio.first_page | |
| topics[0].id | https://openalex.org/T11482 |
| topics[0].field.id | https://openalex.org/fields/13 |
| topics[0].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[0].score | 1.0 |
| topics[0].domain.id | https://openalex.org/domains/1 |
| topics[0].domain.display_name | Life Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/1312 |
| topics[0].subfield.display_name | Molecular Biology |
| topics[0].display_name | RNA modifications and cancer |
| topics[1].id | https://openalex.org/T10515 |
| topics[1].field.id | https://openalex.org/fields/13 |
| topics[1].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[1].score | 0.9988999962806702 |
| topics[1].domain.id | https://openalex.org/domains/1 |
| topics[1].domain.display_name | Life Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/1306 |
| topics[1].subfield.display_name | Cancer Research |
| topics[1].display_name | Cancer-related molecular mechanisms research |
| topics[2].id | https://openalex.org/T13157 |
| topics[2].field.id | https://openalex.org/fields/13 |
| topics[2].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[2].score | 0.991100013256073 |
| topics[2].domain.id | https://openalex.org/domains/1 |
| topics[2].domain.display_name | Life Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/1312 |
| topics[2].subfield.display_name | Molecular Biology |
| topics[2].display_name | Cancer-related gene regulation |
| is_xpac | False |
| apc_list | |
| apc_paid | |
| concepts[0].id | https://openalex.org/C8891405 |
| concepts[0].level | 2 |
| concepts[0].score | 0.7951976656913757 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q1059 |
| concepts[0].display_name | Immune system |
| concepts[1].id | https://openalex.org/C86803240 |
| concepts[1].level | 0 |
| concepts[1].score | 0.6893362402915955 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q420 |
| concepts[1].display_name | Biology |
| concepts[2].id | https://openalex.org/C502942594 |
| concepts[2].level | 1 |
| concepts[2].score | 0.5927345156669617 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q3421914 |
| concepts[2].display_name | Cancer research |
| concepts[3].id | https://openalex.org/C2780868878 |
| concepts[3].level | 3 |
| concepts[3].score | 0.5922940373420715 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q1660197 |
| concepts[3].display_name | Immunogenicity |
| concepts[4].id | https://openalex.org/C2776107976 |
| concepts[4].level | 3 |
| concepts[4].score | 0.5570489168167114 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q1786433 |
| concepts[4].display_name | Tumor microenvironment |
| concepts[5].id | https://openalex.org/C2779256057 |
| concepts[5].level | 3 |
| concepts[5].score | 0.48581957817077637 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q16909647 |
| concepts[5].display_name | Tumor progression |
| concepts[6].id | https://openalex.org/C2779341262 |
| concepts[6].level | 3 |
| concepts[6].score | 0.4780990779399872 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q182581 |
| concepts[6].display_name | Immunity |
| concepts[7].id | https://openalex.org/C2777701055 |
| concepts[7].level | 3 |
| concepts[7].score | 0.474855899810791 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q1427096 |
| concepts[7].display_name | Immunotherapy |
| concepts[8].id | https://openalex.org/C127561419 |
| concepts[8].level | 3 |
| concepts[8].score | 0.46781134605407715 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q224527 |
| concepts[8].display_name | Downregulation and upregulation |
| concepts[9].id | https://openalex.org/C96232424 |
| concepts[9].level | 3 |
| concepts[9].score | 0.4475489556789398 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q4118072 |
| concepts[9].display_name | Cancer cell |
| concepts[10].id | https://openalex.org/C167672396 |
| concepts[10].level | 3 |
| concepts[10].score | 0.4122907519340515 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q417800 |
| concepts[10].display_name | CD8 |
| concepts[11].id | https://openalex.org/C121608353 |
| concepts[11].level | 2 |
| concepts[11].score | 0.389512300491333 |
| concepts[11].wikidata | https://www.wikidata.org/wiki/Q12078 |
| concepts[11].display_name | Cancer |
| concepts[12].id | https://openalex.org/C95444343 |
| concepts[12].level | 1 |
| concepts[12].score | 0.3423009514808655 |
| concepts[12].wikidata | https://www.wikidata.org/wiki/Q7141 |
| concepts[12].display_name | Cell biology |
| concepts[13].id | https://openalex.org/C203014093 |
| concepts[13].level | 1 |
| concepts[13].score | 0.3103603720664978 |
| concepts[13].wikidata | https://www.wikidata.org/wiki/Q101929 |
| concepts[13].display_name | Immunology |
| concepts[14].id | https://openalex.org/C55493867 |
| concepts[14].level | 1 |
| concepts[14].score | 0.07964250445365906 |
| concepts[14].wikidata | https://www.wikidata.org/wiki/Q7094 |
| concepts[14].display_name | Biochemistry |
| concepts[15].id | https://openalex.org/C104317684 |
| concepts[15].level | 2 |
| concepts[15].score | 0.0 |
| concepts[15].wikidata | https://www.wikidata.org/wiki/Q7187 |
| concepts[15].display_name | Gene |
| concepts[16].id | https://openalex.org/C54355233 |
| concepts[16].level | 1 |
| concepts[16].score | 0.0 |
| concepts[16].wikidata | https://www.wikidata.org/wiki/Q7162 |
| concepts[16].display_name | Genetics |
| keywords[0].id | https://openalex.org/keywords/immune-system |
| keywords[0].score | 0.7951976656913757 |
| keywords[0].display_name | Immune system |
| keywords[1].id | https://openalex.org/keywords/biology |
| keywords[1].score | 0.6893362402915955 |
| keywords[1].display_name | Biology |
| keywords[2].id | https://openalex.org/keywords/cancer-research |
| keywords[2].score | 0.5927345156669617 |
| keywords[2].display_name | Cancer research |
| keywords[3].id | https://openalex.org/keywords/immunogenicity |
| keywords[3].score | 0.5922940373420715 |
| keywords[3].display_name | Immunogenicity |
| keywords[4].id | https://openalex.org/keywords/tumor-microenvironment |
| keywords[4].score | 0.5570489168167114 |
| keywords[4].display_name | Tumor microenvironment |
| keywords[5].id | https://openalex.org/keywords/tumor-progression |
| keywords[5].score | 0.48581957817077637 |
| keywords[5].display_name | Tumor progression |
| keywords[6].id | https://openalex.org/keywords/immunity |
| keywords[6].score | 0.4780990779399872 |
| keywords[6].display_name | Immunity |
| keywords[7].id | https://openalex.org/keywords/immunotherapy |
| keywords[7].score | 0.474855899810791 |
| keywords[7].display_name | Immunotherapy |
| keywords[8].id | https://openalex.org/keywords/downregulation-and-upregulation |
| keywords[8].score | 0.46781134605407715 |
| keywords[8].display_name | Downregulation and upregulation |
| keywords[9].id | https://openalex.org/keywords/cancer-cell |
| keywords[9].score | 0.4475489556789398 |
| keywords[9].display_name | Cancer cell |
| keywords[10].id | https://openalex.org/keywords/cd8 |
| keywords[10].score | 0.4122907519340515 |
| keywords[10].display_name | CD8 |
| keywords[11].id | https://openalex.org/keywords/cancer |
| keywords[11].score | 0.389512300491333 |
| keywords[11].display_name | Cancer |
| keywords[12].id | https://openalex.org/keywords/cell-biology |
| keywords[12].score | 0.3423009514808655 |
| keywords[12].display_name | Cell biology |
| keywords[13].id | https://openalex.org/keywords/immunology |
| keywords[13].score | 0.3103603720664978 |
| keywords[13].display_name | Immunology |
| keywords[14].id | https://openalex.org/keywords/biochemistry |
| keywords[14].score | 0.07964250445365906 |
| keywords[14].display_name | Biochemistry |
| language | en |
| locations[0].id | doi:10.21203/rs.3.rs-4352052/v1 |
| locations[0].is_oa | True |
| locations[0].source | |
| locations[0].license | cc-by |
| locations[0].pdf_url | https://www.researchsquare.com/article/rs-4352052/latest.pdf |
| locations[0].version | acceptedVersion |
| locations[0].raw_type | posted-content |
| locations[0].license_id | https://openalex.org/licenses/cc-by |
| locations[0].is_accepted | True |
| locations[0].is_published | False |
| locations[0].raw_source_name | |
| locations[0].landing_page_url | https://doi.org/10.21203/rs.3.rs-4352052/v1 |
| indexed_in | crossref |
| authorships[0].author.id | https://openalex.org/A5115594649 |
| authorships[0].author.orcid | |
| authorships[0].author.display_name | Daoxin Ma |
| authorships[0].countries | CN |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I4210161528 |
| authorships[0].affiliations[0].raw_affiliation_string | Qilu Hospital, Shandong University Wancheng Liu Qilu Hospital, Shandong University |
| authorships[0].affiliations[1].institution_ids | https://openalex.org/I154099455, https://openalex.org/I200296433 |
| authorships[0].affiliations[1].raw_affiliation_string | Qilu Hospital, Shandong University Jinfeng Chen Center for Systems Medicine, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China |
| authorships[0].affiliations[2].institution_ids | https://openalex.org/I4210161528 |
| authorships[0].affiliations[2].raw_affiliation_string | Department of Radiation Oncology, Qilu Hospital of Shandong University, Jinan, 250012, Shandong |
| authorships[0].affiliations[3].institution_ids | https://openalex.org/I4210161528 |
| authorships[0].affiliations[3].raw_affiliation_string | Qilu Hospital, Shandong University |
| authorships[0].affiliations[4].institution_ids | https://openalex.org/I4210161528 |
| authorships[0].affiliations[4].raw_affiliation_string | Qilu Hospital, Shandong University Xinyu Yang Qilu Hospital, Shandong University |
| authorships[0].affiliations[5].institution_ids | https://openalex.org/I4210161528 |
| authorships[0].affiliations[5].raw_affiliation_string | Department of Dermatology, Qilu Hospital of Shandong University, Jinan, 250012, Shandong |
| authorships[0].affiliations[6].institution_ids | https://openalex.org/I4210161528 |
| authorships[0].affiliations[6].raw_affiliation_string | Qilu Hospital, Shandong University Can Can Qilu Hospital, Shandong University |
| authorships[0].affiliations[7].institution_ids | https://openalex.org/I4210161528 |
| authorships[0].affiliations[7].raw_affiliation_string | Qilu Hospital, Shandong University Ke Xiao Qilu Hospital, Shandong University Na He Qilu Hospital, Shandong University |
| authorships[0].institutions[0].id | https://openalex.org/I200296433 |
| authorships[0].institutions[0].ror | https://ror.org/02drdmm93 |
| authorships[0].institutions[0].type | education |
| authorships[0].institutions[0].lineage | https://openalex.org/I200296433 |
| authorships[0].institutions[0].country_code | CN |
| authorships[0].institutions[0].display_name | Chinese Academy of Medical Sciences & Peking Union Medical College |
| authorships[0].institutions[1].id | https://openalex.org/I4210161528 |
| authorships[0].institutions[1].ror | https://ror.org/056ef9489 |
| authorships[0].institutions[1].type | healthcare |
| authorships[0].institutions[1].lineage | https://openalex.org/I4210161528 |
| authorships[0].institutions[1].country_code | CN |
| authorships[0].institutions[1].display_name | Qilu Hospital of Shandong University |
| authorships[0].institutions[2].id | https://openalex.org/I154099455 |
| authorships[0].institutions[2].ror | https://ror.org/0207yh398 |
| authorships[0].institutions[2].type | education |
| authorships[0].institutions[2].lineage | https://openalex.org/I154099455 |
| authorships[0].institutions[2].country_code | CN |
| authorships[0].institutions[2].display_name | Shandong University |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Daoxin Ma |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Department of Dermatology, Qilu Hospital of Shandong University, Jinan, 250012, Shandong, Department of Radiation Oncology, Qilu Hospital of Shandong University, Jinan, 250012, Shandong, Qilu Hospital, Shandong University, Qilu Hospital, Shandong University Can Can Qilu Hospital, Shandong University, Qilu Hospital, Shandong University Jinfeng Chen Center for Systems Medicine, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China, Qilu Hospital, Shandong University Ke Xiao Qilu Hospital, Shandong University Na He Qilu Hospital, Shandong University, Qilu Hospital, Shandong University Wancheng Liu Qilu Hospital, Shandong University, Qilu Hospital, Shandong University Xinyu Yang Qilu Hospital, Shandong University |
| authorships[1].author.id | https://openalex.org/A5004117755 |
| authorships[1].author.orcid | https://orcid.org/0000-0002-7628-0323 |
| authorships[1].author.display_name | Wancheng Liu |
| authorships[1].countries | CN |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I4210161528 |
| authorships[1].affiliations[0].raw_affiliation_string | Department of Dermatology, Qilu Hospital of Shandong University, Jinan, 250012, Shandong |
| authorships[1].affiliations[1].institution_ids | https://openalex.org/I4210161528 |
| authorships[1].affiliations[1].raw_affiliation_string | Qilu Hospital, Shandong University Wancheng Liu Qilu Hospital, Shandong University |
| authorships[1].affiliations[2].institution_ids | https://openalex.org/I154099455, https://openalex.org/I200296433 |
| authorships[1].affiliations[2].raw_affiliation_string | Qilu Hospital, Shandong University Jinfeng Chen Center for Systems Medicine, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China |
| authorships[1].affiliations[3].institution_ids | https://openalex.org/I4210161528 |
| authorships[1].affiliations[3].raw_affiliation_string | Qilu Hospital, Shandong University Can Can Qilu Hospital, Shandong University |
| authorships[1].affiliations[4].institution_ids | https://openalex.org/I4210161528 |
| authorships[1].affiliations[4].raw_affiliation_string | Qilu Hospital, Shandong University Ke Xiao Qilu Hospital, Shandong University Na He Qilu Hospital, Shandong University |
| authorships[1].affiliations[5].institution_ids | https://openalex.org/I4210161528 |
| authorships[1].affiliations[5].raw_affiliation_string | Qilu Hospital, Shandong University |
| authorships[1].affiliations[6].institution_ids | https://openalex.org/I4210161528 |
| authorships[1].affiliations[6].raw_affiliation_string | Qilu Hospital, Shandong University Xinyu Yang Qilu Hospital, Shandong University |
| authorships[1].affiliations[7].institution_ids | https://openalex.org/I4210161528 |
| authorships[1].affiliations[7].raw_affiliation_string | Department of Radiation Oncology, Qilu Hospital of Shandong University, Jinan, 250012, Shandong |
| authorships[1].institutions[0].id | https://openalex.org/I200296433 |
| authorships[1].institutions[0].ror | https://ror.org/02drdmm93 |
| authorships[1].institutions[0].type | education |
| authorships[1].institutions[0].lineage | https://openalex.org/I200296433 |
| authorships[1].institutions[0].country_code | CN |
| authorships[1].institutions[0].display_name | Chinese Academy of Medical Sciences & Peking Union Medical College |
| authorships[1].institutions[1].id | https://openalex.org/I4210161528 |
| authorships[1].institutions[1].ror | https://ror.org/056ef9489 |
| authorships[1].institutions[1].type | healthcare |
| authorships[1].institutions[1].lineage | https://openalex.org/I4210161528 |
| authorships[1].institutions[1].country_code | CN |
| authorships[1].institutions[1].display_name | Qilu Hospital of Shandong University |
| authorships[1].institutions[2].id | https://openalex.org/I154099455 |
| authorships[1].institutions[2].ror | https://ror.org/0207yh398 |
| authorships[1].institutions[2].type | education |
| authorships[1].institutions[2].lineage | https://openalex.org/I154099455 |
| authorships[1].institutions[2].country_code | CN |
| authorships[1].institutions[2].display_name | Shandong University |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Wancheng Liu |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Department of Dermatology, Qilu Hospital of Shandong University, Jinan, 250012, Shandong, Department of Radiation Oncology, Qilu Hospital of Shandong University, Jinan, 250012, Shandong, Qilu Hospital, Shandong University, Qilu Hospital, Shandong University Can Can Qilu Hospital, Shandong University, Qilu Hospital, Shandong University Jinfeng Chen Center for Systems Medicine, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China, Qilu Hospital, Shandong University Ke Xiao Qilu Hospital, Shandong University Na He Qilu Hospital, Shandong University, Qilu Hospital, Shandong University Wancheng Liu Qilu Hospital, Shandong University, Qilu Hospital, Shandong University Xinyu Yang Qilu Hospital, Shandong University |
| authorships[2].author.id | https://openalex.org/A5114212610 |
| authorships[2].author.orcid | |
| authorships[2].author.display_name | Yihong Wei |
| authorships[2].countries | CN |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I4210161528 |
| authorships[2].affiliations[0].raw_affiliation_string | Qilu Hospital, Shandong University Xinyu Yang Qilu Hospital, Shandong University |
| authorships[2].affiliations[1].institution_ids | https://openalex.org/I4210161528 |
| authorships[2].affiliations[1].raw_affiliation_string | Qilu Hospital, Shandong University Ke Xiao Qilu Hospital, Shandong University Na He Qilu Hospital, Shandong University |
| authorships[2].affiliations[2].institution_ids | https://openalex.org/I4210161528 |
| authorships[2].affiliations[2].raw_affiliation_string | Qilu Hospital, Shandong University |
| authorships[2].affiliations[3].institution_ids | https://openalex.org/I4210161528 |
| authorships[2].affiliations[3].raw_affiliation_string | Department of Dermatology, Qilu Hospital of Shandong University, Jinan, 250012, Shandong |
| authorships[2].affiliations[4].institution_ids | https://openalex.org/I4210161528 |
| authorships[2].affiliations[4].raw_affiliation_string | Qilu Hospital, Shandong University Can Can Qilu Hospital, Shandong University |
| authorships[2].affiliations[5].institution_ids | https://openalex.org/I4210161528 |
| authorships[2].affiliations[5].raw_affiliation_string | Qilu Hospital, Shandong University Wancheng Liu Qilu Hospital, Shandong University |
| authorships[2].affiliations[6].institution_ids | https://openalex.org/I154099455, https://openalex.org/I200296433 |
| authorships[2].affiliations[6].raw_affiliation_string | Qilu Hospital, Shandong University Jinfeng Chen Center for Systems Medicine, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China |
| authorships[2].affiliations[7].institution_ids | https://openalex.org/I4210161528 |
| authorships[2].affiliations[7].raw_affiliation_string | Department of Radiation Oncology, Qilu Hospital of Shandong University, Jinan, 250012, Shandong |
| authorships[2].institutions[0].id | https://openalex.org/I200296433 |
| authorships[2].institutions[0].ror | https://ror.org/02drdmm93 |
| authorships[2].institutions[0].type | education |
| authorships[2].institutions[0].lineage | https://openalex.org/I200296433 |
| authorships[2].institutions[0].country_code | CN |
| authorships[2].institutions[0].display_name | Chinese Academy of Medical Sciences & Peking Union Medical College |
| authorships[2].institutions[1].id | https://openalex.org/I4210161528 |
| authorships[2].institutions[1].ror | https://ror.org/056ef9489 |
| authorships[2].institutions[1].type | healthcare |
| authorships[2].institutions[1].lineage | https://openalex.org/I4210161528 |
| authorships[2].institutions[1].country_code | CN |
| authorships[2].institutions[1].display_name | Qilu Hospital of Shandong University |
| authorships[2].institutions[2].id | https://openalex.org/I154099455 |
| authorships[2].institutions[2].ror | https://ror.org/0207yh398 |
| authorships[2].institutions[2].type | education |
| authorships[2].institutions[2].lineage | https://openalex.org/I154099455 |
| authorships[2].institutions[2].country_code | CN |
| authorships[2].institutions[2].display_name | Shandong University |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Yihong Wei |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Department of Dermatology, Qilu Hospital of Shandong University, Jinan, 250012, Shandong, Department of Radiation Oncology, Qilu Hospital of Shandong University, Jinan, 250012, Shandong, Qilu Hospital, Shandong University, Qilu Hospital, Shandong University Can Can Qilu Hospital, Shandong University, Qilu Hospital, Shandong University Jinfeng Chen Center for Systems Medicine, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China, Qilu Hospital, Shandong University Ke Xiao Qilu Hospital, Shandong University Na He Qilu Hospital, Shandong University, Qilu Hospital, Shandong University Wancheng Liu Qilu Hospital, Shandong University, Qilu Hospital, Shandong University Xinyu Yang Qilu Hospital, Shandong University |
| authorships[3].author.id | https://openalex.org/A5063432477 |
| authorships[3].author.orcid | https://orcid.org/0000-0002-9573-5987 |
| authorships[3].author.display_name | Jinfeng Chen |
| authorships[3].countries | CN |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I200296433 |
| authorships[3].affiliations[0].raw_affiliation_string | Center for Systems Medicine, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China |
| authorships[3].institutions[0].id | https://openalex.org/I200296433 |
| authorships[3].institutions[0].ror | https://ror.org/02drdmm93 |
| authorships[3].institutions[0].type | education |
| authorships[3].institutions[0].lineage | https://openalex.org/I200296433 |
| authorships[3].institutions[0].country_code | CN |
| authorships[3].institutions[0].display_name | Chinese Academy of Medical Sciences & Peking Union Medical College |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Jinfeng Chen |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Center for Systems Medicine, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China |
| authorships[4].author.id | https://openalex.org/A5100585476 |
| authorships[4].author.orcid | |
| authorships[4].author.display_name | Hexiao Jia |
| authorships[4].countries | CN |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I4210161528 |
| authorships[4].affiliations[0].raw_affiliation_string | Department of Radiation Oncology, Qilu Hospital of Shandong University, Jinan, 250012, Shandong |
| authorships[4].affiliations[1].institution_ids | https://openalex.org/I4210161528 |
| authorships[4].affiliations[1].raw_affiliation_string | Qilu Hospital, Shandong University Xinyu Yang Qilu Hospital, Shandong University |
| authorships[4].affiliations[2].institution_ids | https://openalex.org/I4210161528 |
| authorships[4].affiliations[2].raw_affiliation_string | Qilu Hospital, Shandong University Wancheng Liu Qilu Hospital, Shandong University |
| authorships[4].affiliations[3].institution_ids | https://openalex.org/I154099455, https://openalex.org/I200296433 |
| authorships[4].affiliations[3].raw_affiliation_string | Qilu Hospital, Shandong University Jinfeng Chen Center for Systems Medicine, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China |
| authorships[4].affiliations[4].institution_ids | https://openalex.org/I4210161528 |
| authorships[4].affiliations[4].raw_affiliation_string | Department of Dermatology, Qilu Hospital of Shandong University, Jinan, 250012, Shandong |
| authorships[4].affiliations[5].institution_ids | https://openalex.org/I4210161528 |
| authorships[4].affiliations[5].raw_affiliation_string | Qilu Hospital, Shandong University Ke Xiao Qilu Hospital, Shandong University Na He Qilu Hospital, Shandong University |
| authorships[4].affiliations[6].institution_ids | https://openalex.org/I4210161528 |
| authorships[4].affiliations[6].raw_affiliation_string | Qilu Hospital, Shandong University Can Can Qilu Hospital, Shandong University |
| authorships[4].affiliations[7].institution_ids | https://openalex.org/I4210161528 |
| authorships[4].affiliations[7].raw_affiliation_string | Qilu Hospital, Shandong University |
| authorships[4].institutions[0].id | https://openalex.org/I200296433 |
| authorships[4].institutions[0].ror | https://ror.org/02drdmm93 |
| authorships[4].institutions[0].type | education |
| authorships[4].institutions[0].lineage | https://openalex.org/I200296433 |
| authorships[4].institutions[0].country_code | CN |
| authorships[4].institutions[0].display_name | Chinese Academy of Medical Sciences & Peking Union Medical College |
| authorships[4].institutions[1].id | https://openalex.org/I4210161528 |
| authorships[4].institutions[1].ror | https://ror.org/056ef9489 |
| authorships[4].institutions[1].type | healthcare |
| authorships[4].institutions[1].lineage | https://openalex.org/I4210161528 |
| authorships[4].institutions[1].country_code | CN |
| authorships[4].institutions[1].display_name | Qilu Hospital of Shandong University |
| authorships[4].institutions[2].id | https://openalex.org/I154099455 |
| authorships[4].institutions[2].ror | https://ror.org/0207yh398 |
| authorships[4].institutions[2].type | education |
| authorships[4].institutions[2].lineage | https://openalex.org/I154099455 |
| authorships[4].institutions[2].country_code | CN |
| authorships[4].institutions[2].display_name | Shandong University |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Hexiao Jia |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Department of Dermatology, Qilu Hospital of Shandong University, Jinan, 250012, Shandong, Department of Radiation Oncology, Qilu Hospital of Shandong University, Jinan, 250012, Shandong, Qilu Hospital, Shandong University, Qilu Hospital, Shandong University Can Can Qilu Hospital, Shandong University, Qilu Hospital, Shandong University Jinfeng Chen Center for Systems Medicine, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China, Qilu Hospital, Shandong University Ke Xiao Qilu Hospital, Shandong University Na He Qilu Hospital, Shandong University, Qilu Hospital, Shandong University Wancheng Liu Qilu Hospital, Shandong University, Qilu Hospital, Shandong University Xinyu Yang Qilu Hospital, Shandong University |
| authorships[5].author.id | https://openalex.org/A5115595335 |
| authorships[5].author.orcid | https://orcid.org/0009-0004-4716-8641 |
| authorships[5].author.display_name | Xinyu Yang |
| authorships[5].countries | CN |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I4210161528 |
| authorships[5].affiliations[0].raw_affiliation_string | Qilu Hospital, Shandong University |
| authorships[5].institutions[0].id | https://openalex.org/I4210161528 |
| authorships[5].institutions[0].ror | https://ror.org/056ef9489 |
| authorships[5].institutions[0].type | healthcare |
| authorships[5].institutions[0].lineage | https://openalex.org/I4210161528 |
| authorships[5].institutions[0].country_code | CN |
| authorships[5].institutions[0].display_name | Qilu Hospital of Shandong University |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Xinyu Yang |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Qilu Hospital, Shandong University |
| authorships[6].author.id | https://openalex.org/A5055131172 |
| authorships[6].author.orcid | https://orcid.org/0000-0002-9680-4120 |
| authorships[6].author.display_name | Yingjian Huang |
| authorships[6].countries | CN |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I4210161528 |
| authorships[6].affiliations[0].raw_affiliation_string | Qilu Hospital, Shandong University |
| authorships[6].affiliations[1].institution_ids | https://openalex.org/I4210161528 |
| authorships[6].affiliations[1].raw_affiliation_string | Qilu Hospital, Shandong University Ke Xiao Qilu Hospital, Shandong University Na He Qilu Hospital, Shandong University |
| authorships[6].affiliations[2].institution_ids | https://openalex.org/I4210161528 |
| authorships[6].affiliations[2].raw_affiliation_string | Department of Dermatology, Qilu Hospital of Shandong University, Jinan, 250012, Shandong |
| authorships[6].affiliations[3].institution_ids | https://openalex.org/I4210161528 |
| authorships[6].affiliations[3].raw_affiliation_string | Qilu Hospital, Shandong University Can Can Qilu Hospital, Shandong University |
| authorships[6].affiliations[4].institution_ids | https://openalex.org/I4210161528 |
| authorships[6].affiliations[4].raw_affiliation_string | Qilu Hospital, Shandong University Xinyu Yang Qilu Hospital, Shandong University |
| authorships[6].affiliations[5].institution_ids | https://openalex.org/I4210161528 |
| authorships[6].affiliations[5].raw_affiliation_string | Department of Radiation Oncology, Qilu Hospital of Shandong University, Jinan, 250012, Shandong |
| authorships[6].affiliations[6].institution_ids | https://openalex.org/I4210161528 |
| authorships[6].affiliations[6].raw_affiliation_string | Qilu Hospital, Shandong University Wancheng Liu Qilu Hospital, Shandong University |
| authorships[6].affiliations[7].institution_ids | https://openalex.org/I154099455, https://openalex.org/I200296433 |
| authorships[6].affiliations[7].raw_affiliation_string | Qilu Hospital, Shandong University Jinfeng Chen Center for Systems Medicine, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China |
| authorships[6].institutions[0].id | https://openalex.org/I200296433 |
| authorships[6].institutions[0].ror | https://ror.org/02drdmm93 |
| authorships[6].institutions[0].type | education |
| authorships[6].institutions[0].lineage | https://openalex.org/I200296433 |
| authorships[6].institutions[0].country_code | CN |
| authorships[6].institutions[0].display_name | Chinese Academy of Medical Sciences & Peking Union Medical College |
| authorships[6].institutions[1].id | https://openalex.org/I4210161528 |
| authorships[6].institutions[1].ror | https://ror.org/056ef9489 |
| authorships[6].institutions[1].type | healthcare |
| authorships[6].institutions[1].lineage | https://openalex.org/I4210161528 |
| authorships[6].institutions[1].country_code | CN |
| authorships[6].institutions[1].display_name | Qilu Hospital of Shandong University |
| authorships[6].institutions[2].id | https://openalex.org/I154099455 |
| authorships[6].institutions[2].ror | https://ror.org/0207yh398 |
| authorships[6].institutions[2].type | education |
| authorships[6].institutions[2].lineage | https://openalex.org/I154099455 |
| authorships[6].institutions[2].country_code | CN |
| authorships[6].institutions[2].display_name | Shandong University |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Yingjian Huang |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | Department of Dermatology, Qilu Hospital of Shandong University, Jinan, 250012, Shandong, Department of Radiation Oncology, Qilu Hospital of Shandong University, Jinan, 250012, Shandong, Qilu Hospital, Shandong University, Qilu Hospital, Shandong University Can Can Qilu Hospital, Shandong University, Qilu Hospital, Shandong University Jinfeng Chen Center for Systems Medicine, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China, Qilu Hospital, Shandong University Ke Xiao Qilu Hospital, Shandong University Na He Qilu Hospital, Shandong University, Qilu Hospital, Shandong University Wancheng Liu Qilu Hospital, Shandong University, Qilu Hospital, Shandong University Xinyu Yang Qilu Hospital, Shandong University |
| authorships[7].author.id | https://openalex.org/A5069679838 |
| authorships[7].author.orcid | |
| authorships[7].author.display_name | Xiangling Xing |
| authorships[7].countries | CN |
| authorships[7].affiliations[0].institution_ids | https://openalex.org/I4210161528 |
| authorships[7].affiliations[0].raw_affiliation_string | Department of Radiation Oncology, Qilu Hospital of Shandong University, Jinan, 250012, Shandong |
| authorships[7].affiliations[1].institution_ids | https://openalex.org/I4210161528 |
| authorships[7].affiliations[1].raw_affiliation_string | Qilu Hospital, Shandong University Wancheng Liu Qilu Hospital, Shandong University |
| authorships[7].affiliations[2].institution_ids | https://openalex.org/I154099455, https://openalex.org/I200296433 |
| authorships[7].affiliations[2].raw_affiliation_string | Qilu Hospital, Shandong University Jinfeng Chen Center for Systems Medicine, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China |
| authorships[7].affiliations[3].institution_ids | https://openalex.org/I4210161528 |
| authorships[7].affiliations[3].raw_affiliation_string | Department of Dermatology, Qilu Hospital of Shandong University, Jinan, 250012, Shandong |
| authorships[7].affiliations[4].institution_ids | https://openalex.org/I4210161528 |
| authorships[7].affiliations[4].raw_affiliation_string | Qilu Hospital, Shandong University |
| authorships[7].affiliations[5].institution_ids | https://openalex.org/I4210161528 |
| authorships[7].affiliations[5].raw_affiliation_string | Qilu Hospital, Shandong University Ke Xiao Qilu Hospital, Shandong University Na He Qilu Hospital, Shandong University |
| authorships[7].affiliations[6].institution_ids | https://openalex.org/I4210161528 |
| authorships[7].affiliations[6].raw_affiliation_string | Qilu Hospital, Shandong University Can Can Qilu Hospital, Shandong University |
| authorships[7].affiliations[7].institution_ids | https://openalex.org/I4210161528 |
| authorships[7].affiliations[7].raw_affiliation_string | Qilu Hospital, Shandong University Xinyu Yang Qilu Hospital, Shandong University |
| authorships[7].institutions[0].id | https://openalex.org/I200296433 |
| authorships[7].institutions[0].ror | https://ror.org/02drdmm93 |
| authorships[7].institutions[0].type | education |
| authorships[7].institutions[0].lineage | https://openalex.org/I200296433 |
| authorships[7].institutions[0].country_code | CN |
| authorships[7].institutions[0].display_name | Chinese Academy of Medical Sciences & Peking Union Medical College |
| authorships[7].institutions[1].id | https://openalex.org/I4210161528 |
| authorships[7].institutions[1].ror | https://ror.org/056ef9489 |
| authorships[7].institutions[1].type | healthcare |
| authorships[7].institutions[1].lineage | https://openalex.org/I4210161528 |
| authorships[7].institutions[1].country_code | CN |
| authorships[7].institutions[1].display_name | Qilu Hospital of Shandong University |
| authorships[7].institutions[2].id | https://openalex.org/I154099455 |
| authorships[7].institutions[2].ror | https://ror.org/0207yh398 |
| authorships[7].institutions[2].type | education |
| authorships[7].institutions[2].lineage | https://openalex.org/I154099455 |
| authorships[7].institutions[2].country_code | CN |
| authorships[7].institutions[2].display_name | Shandong University |
| authorships[7].author_position | middle |
| authorships[7].raw_author_name | Xiangling Xing |
| authorships[7].is_corresponding | False |
| authorships[7].raw_affiliation_strings | Department of Dermatology, Qilu Hospital of Shandong University, Jinan, 250012, Shandong, Department of Radiation Oncology, Qilu Hospital of Shandong University, Jinan, 250012, Shandong, Qilu Hospital, Shandong University, Qilu Hospital, Shandong University Can Can Qilu Hospital, Shandong University, Qilu Hospital, Shandong University Jinfeng Chen Center for Systems Medicine, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China, Qilu Hospital, Shandong University Ke Xiao Qilu Hospital, Shandong University Na He Qilu Hospital, Shandong University, Qilu Hospital, Shandong University Wancheng Liu Qilu Hospital, Shandong University, Qilu Hospital, Shandong University Xinyu Yang Qilu Hospital, Shandong University |
| authorships[8].author.id | https://openalex.org/A5066112841 |
| authorships[8].author.orcid | https://orcid.org/0009-0003-3364-5120 |
| authorships[8].author.display_name | X. W. Liu |
| authorships[8].countries | CN |
| authorships[8].affiliations[0].institution_ids | https://openalex.org/I4210161528 |
| authorships[8].affiliations[0].raw_affiliation_string | Qilu Hospital, Shandong University |
| authorships[8].affiliations[1].institution_ids | https://openalex.org/I4210161528 |
| authorships[8].affiliations[1].raw_affiliation_string | Qilu Hospital, Shandong University Ke Xiao Qilu Hospital, Shandong University Na He Qilu Hospital, Shandong University |
| authorships[8].affiliations[2].institution_ids | https://openalex.org/I4210161528 |
| authorships[8].affiliations[2].raw_affiliation_string | Qilu Hospital, Shandong University Can Can Qilu Hospital, Shandong University |
| authorships[8].affiliations[3].institution_ids | https://openalex.org/I4210161528 |
| authorships[8].affiliations[3].raw_affiliation_string | Department of Radiation Oncology, Qilu Hospital of Shandong University, Jinan, 250012, Shandong |
| authorships[8].affiliations[4].institution_ids | https://openalex.org/I4210161528 |
| authorships[8].affiliations[4].raw_affiliation_string | Qilu Hospital, Shandong University Xinyu Yang Qilu Hospital, Shandong University |
| authorships[8].affiliations[5].institution_ids | https://openalex.org/I4210161528 |
| authorships[8].affiliations[5].raw_affiliation_string | Department of Dermatology, Qilu Hospital of Shandong University, Jinan, 250012, Shandong |
| authorships[8].affiliations[6].institution_ids | https://openalex.org/I4210161528 |
| authorships[8].affiliations[6].raw_affiliation_string | Qilu Hospital, Shandong University Wancheng Liu Qilu Hospital, Shandong University |
| authorships[8].affiliations[7].institution_ids | https://openalex.org/I154099455, https://openalex.org/I200296433 |
| authorships[8].affiliations[7].raw_affiliation_string | Qilu Hospital, Shandong University Jinfeng Chen Center for Systems Medicine, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China |
| authorships[8].institutions[0].id | https://openalex.org/I200296433 |
| authorships[8].institutions[0].ror | https://ror.org/02drdmm93 |
| authorships[8].institutions[0].type | education |
| authorships[8].institutions[0].lineage | https://openalex.org/I200296433 |
| authorships[8].institutions[0].country_code | CN |
| authorships[8].institutions[0].display_name | Chinese Academy of Medical Sciences & Peking Union Medical College |
| authorships[8].institutions[1].id | https://openalex.org/I4210161528 |
| authorships[8].institutions[1].ror | https://ror.org/056ef9489 |
| authorships[8].institutions[1].type | healthcare |
| authorships[8].institutions[1].lineage | https://openalex.org/I4210161528 |
| authorships[8].institutions[1].country_code | CN |
| authorships[8].institutions[1].display_name | Qilu Hospital of Shandong University |
| authorships[8].institutions[2].id | https://openalex.org/I154099455 |
| authorships[8].institutions[2].ror | https://ror.org/0207yh398 |
| authorships[8].institutions[2].type | education |
| authorships[8].institutions[2].lineage | https://openalex.org/I154099455 |
| authorships[8].institutions[2].country_code | CN |
| authorships[8].institutions[2].display_name | Shandong University |
| authorships[8].author_position | middle |
| authorships[8].raw_author_name | Xiaomin Liu |
| authorships[8].is_corresponding | False |
| authorships[8].raw_affiliation_strings | Department of Dermatology, Qilu Hospital of Shandong University, Jinan, 250012, Shandong, Department of Radiation Oncology, Qilu Hospital of Shandong University, Jinan, 250012, Shandong, Qilu Hospital, Shandong University, Qilu Hospital, Shandong University Can Can Qilu Hospital, Shandong University, Qilu Hospital, Shandong University Jinfeng Chen Center for Systems Medicine, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China, Qilu Hospital, Shandong University Ke Xiao Qilu Hospital, Shandong University Na He Qilu Hospital, Shandong University, Qilu Hospital, Shandong University Wancheng Liu Qilu Hospital, Shandong University, Qilu Hospital, Shandong University Xinyu Yang Qilu Hospital, Shandong University |
| authorships[9].author.id | https://openalex.org/A5101879056 |
| authorships[9].author.orcid | https://orcid.org/0000-0003-0099-9400 |
| authorships[9].author.display_name | Xiaodong Guo |
| authorships[9].countries | CN |
| authorships[9].affiliations[0].institution_ids | https://openalex.org/I4210161528 |
| authorships[9].affiliations[0].raw_affiliation_string | Qilu Hospital, Shandong University Xinyu Yang Qilu Hospital, Shandong University |
| authorships[9].affiliations[1].institution_ids | https://openalex.org/I4210161528 |
| authorships[9].affiliations[1].raw_affiliation_string | Qilu Hospital, Shandong University Ke Xiao Qilu Hospital, Shandong University Na He Qilu Hospital, Shandong University |
| authorships[9].affiliations[2].institution_ids | https://openalex.org/I4210161528 |
| authorships[9].affiliations[2].raw_affiliation_string | Department of Dermatology, Qilu Hospital of Shandong University, Jinan, 250012, Shandong |
| authorships[9].affiliations[3].institution_ids | https://openalex.org/I4210161528 |
| authorships[9].affiliations[3].raw_affiliation_string | Qilu Hospital, Shandong University Wancheng Liu Qilu Hospital, Shandong University |
| authorships[9].affiliations[4].institution_ids | https://openalex.org/I154099455, https://openalex.org/I200296433 |
| authorships[9].affiliations[4].raw_affiliation_string | Qilu Hospital, Shandong University Jinfeng Chen Center for Systems Medicine, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China |
| authorships[9].affiliations[5].institution_ids | https://openalex.org/I4210161528 |
| authorships[9].affiliations[5].raw_affiliation_string | Qilu Hospital, Shandong University Can Can Qilu Hospital, Shandong University |
| authorships[9].affiliations[6].institution_ids | https://openalex.org/I4210161528 |
| authorships[9].affiliations[6].raw_affiliation_string | Department of Radiation Oncology, Qilu Hospital of Shandong University, Jinan, 250012, Shandong |
| authorships[9].affiliations[7].institution_ids | https://openalex.org/I4210161528 |
| authorships[9].affiliations[7].raw_affiliation_string | Qilu Hospital, Shandong University |
| authorships[9].institutions[0].id | https://openalex.org/I200296433 |
| authorships[9].institutions[0].ror | https://ror.org/02drdmm93 |
| authorships[9].institutions[0].type | education |
| authorships[9].institutions[0].lineage | https://openalex.org/I200296433 |
| authorships[9].institutions[0].country_code | CN |
| authorships[9].institutions[0].display_name | Chinese Academy of Medical Sciences & Peking Union Medical College |
| authorships[9].institutions[1].id | https://openalex.org/I4210161528 |
| authorships[9].institutions[1].ror | https://ror.org/056ef9489 |
| authorships[9].institutions[1].type | healthcare |
| authorships[9].institutions[1].lineage | https://openalex.org/I4210161528 |
| authorships[9].institutions[1].country_code | CN |
| authorships[9].institutions[1].display_name | Qilu Hospital of Shandong University |
| authorships[9].institutions[2].id | https://openalex.org/I154099455 |
| authorships[9].institutions[2].ror | https://ror.org/0207yh398 |
| authorships[9].institutions[2].type | education |
| authorships[9].institutions[2].lineage | https://openalex.org/I154099455 |
| authorships[9].institutions[2].country_code | CN |
| authorships[9].institutions[2].display_name | Shandong University |
| authorships[9].author_position | middle |
| authorships[9].raw_author_name | Xiaodong Guo |
| authorships[9].is_corresponding | False |
| authorships[9].raw_affiliation_strings | Department of Dermatology, Qilu Hospital of Shandong University, Jinan, 250012, Shandong, Department of Radiation Oncology, Qilu Hospital of Shandong University, Jinan, 250012, Shandong, Qilu Hospital, Shandong University, Qilu Hospital, Shandong University Can Can Qilu Hospital, Shandong University, Qilu Hospital, Shandong University Jinfeng Chen Center for Systems Medicine, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China, Qilu Hospital, Shandong University Ke Xiao Qilu Hospital, Shandong University Na He Qilu Hospital, Shandong University, Qilu Hospital, Shandong University Wancheng Liu Qilu Hospital, Shandong University, Qilu Hospital, Shandong University Xinyu Yang Qilu Hospital, Shandong University |
| authorships[10].author.id | https://openalex.org/A5058476047 |
| authorships[10].author.orcid | |
| authorships[10].author.display_name | Can Can |
| authorships[10].countries | CN |
| authorships[10].affiliations[0].institution_ids | https://openalex.org/I4210161528 |
| authorships[10].affiliations[0].raw_affiliation_string | Qilu Hospital, Shandong University |
| authorships[10].institutions[0].id | https://openalex.org/I4210161528 |
| authorships[10].institutions[0].ror | https://ror.org/056ef9489 |
| authorships[10].institutions[0].type | healthcare |
| authorships[10].institutions[0].lineage | https://openalex.org/I4210161528 |
| authorships[10].institutions[0].country_code | CN |
| authorships[10].institutions[0].display_name | Qilu Hospital of Shandong University |
| authorships[10].author_position | middle |
| authorships[10].raw_author_name | Can Can |
| authorships[10].is_corresponding | False |
| authorships[10].raw_affiliation_strings | Qilu Hospital, Shandong University |
| authorships[11].author.id | https://openalex.org/A5081393530 |
| authorships[11].author.orcid | https://orcid.org/0000-0002-8006-4615 |
| authorships[11].author.display_name | Amin Zhang |
| authorships[11].countries | CN |
| authorships[11].affiliations[0].institution_ids | https://openalex.org/I4210161528 |
| authorships[11].affiliations[0].raw_affiliation_string | Qilu Hospital, Shandong University Wancheng Liu Qilu Hospital, Shandong University |
| authorships[11].affiliations[1].institution_ids | https://openalex.org/I154099455, https://openalex.org/I200296433 |
| authorships[11].affiliations[1].raw_affiliation_string | Qilu Hospital, Shandong University Jinfeng Chen Center for Systems Medicine, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China |
| authorships[11].affiliations[2].institution_ids | https://openalex.org/I4210161528 |
| authorships[11].affiliations[2].raw_affiliation_string | Qilu Hospital, Shandong University Ke Xiao Qilu Hospital, Shandong University Na He Qilu Hospital, Shandong University |
| authorships[11].affiliations[3].institution_ids | https://openalex.org/I4210161528 |
| authorships[11].affiliations[3].raw_affiliation_string | Qilu Hospital, Shandong University Xinyu Yang Qilu Hospital, Shandong University |
| authorships[11].affiliations[4].institution_ids | https://openalex.org/I4210161528 |
| authorships[11].affiliations[4].raw_affiliation_string | Qilu Hospital, Shandong University |
| authorships[11].affiliations[5].institution_ids | https://openalex.org/I4210161528 |
| authorships[11].affiliations[5].raw_affiliation_string | Department of Radiation Oncology, Qilu Hospital of Shandong University, Jinan, 250012, Shandong |
| authorships[11].affiliations[6].institution_ids | https://openalex.org/I4210161528 |
| authorships[11].affiliations[6].raw_affiliation_string | Qilu Hospital, Shandong University Can Can Qilu Hospital, Shandong University |
| authorships[11].affiliations[7].institution_ids | https://openalex.org/I4210161528 |
| authorships[11].affiliations[7].raw_affiliation_string | Department of Dermatology, Qilu Hospital of Shandong University, Jinan, 250012, Shandong |
| authorships[11].institutions[0].id | https://openalex.org/I200296433 |
| authorships[11].institutions[0].ror | https://ror.org/02drdmm93 |
| authorships[11].institutions[0].type | education |
| authorships[11].institutions[0].lineage | https://openalex.org/I200296433 |
| authorships[11].institutions[0].country_code | CN |
| authorships[11].institutions[0].display_name | Chinese Academy of Medical Sciences & Peking Union Medical College |
| authorships[11].institutions[1].id | https://openalex.org/I4210161528 |
| authorships[11].institutions[1].ror | https://ror.org/056ef9489 |
| authorships[11].institutions[1].type | healthcare |
| authorships[11].institutions[1].lineage | https://openalex.org/I4210161528 |
| authorships[11].institutions[1].country_code | CN |
| authorships[11].institutions[1].display_name | Qilu Hospital of Shandong University |
| authorships[11].institutions[2].id | https://openalex.org/I154099455 |
| authorships[11].institutions[2].ror | https://ror.org/0207yh398 |
| authorships[11].institutions[2].type | education |
| authorships[11].institutions[2].lineage | https://openalex.org/I154099455 |
| authorships[11].institutions[2].country_code | CN |
| authorships[11].institutions[2].display_name | Shandong University |
| authorships[11].author_position | middle |
| authorships[11].raw_author_name | Amin Zhang |
| authorships[11].is_corresponding | False |
| authorships[11].raw_affiliation_strings | Department of Dermatology, Qilu Hospital of Shandong University, Jinan, 250012, Shandong, Department of Radiation Oncology, Qilu Hospital of Shandong University, Jinan, 250012, Shandong, Qilu Hospital, Shandong University, Qilu Hospital, Shandong University Can Can Qilu Hospital, Shandong University, Qilu Hospital, Shandong University Jinfeng Chen Center for Systems Medicine, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China, Qilu Hospital, Shandong University Ke Xiao Qilu Hospital, Shandong University Na He Qilu Hospital, Shandong University, Qilu Hospital, Shandong University Wancheng Liu Qilu Hospital, Shandong University, Qilu Hospital, Shandong University Xinyu Yang Qilu Hospital, Shandong University |
| authorships[12].author.id | https://openalex.org/A5101872903 |
| authorships[12].author.orcid | https://orcid.org/0000-0002-2628-246X |
| authorships[12].author.display_name | Ke Xiao |
| authorships[12].countries | CN |
| authorships[12].affiliations[0].institution_ids | https://openalex.org/I4210161528 |
| authorships[12].affiliations[0].raw_affiliation_string | Qilu Hospital, Shandong University Xinyu Yang Qilu Hospital, Shandong University |
| authorships[12].affiliations[1].institution_ids | https://openalex.org/I4210161528 |
| authorships[12].affiliations[1].raw_affiliation_string | Department of Dermatology, Qilu Hospital of Shandong University, Jinan, 250012, Shandong |
| authorships[12].affiliations[2].institution_ids | https://openalex.org/I4210161528 |
| authorships[12].affiliations[2].raw_affiliation_string | Qilu Hospital, Shandong University Ke Xiao Qilu Hospital, Shandong University Na He Qilu Hospital, Shandong University |
| authorships[12].affiliations[3].institution_ids | https://openalex.org/I4210161528 |
| authorships[12].affiliations[3].raw_affiliation_string | Qilu Hospital, Shandong University Wancheng Liu Qilu Hospital, Shandong University |
| authorships[12].affiliations[4].institution_ids | https://openalex.org/I154099455, https://openalex.org/I200296433 |
| authorships[12].affiliations[4].raw_affiliation_string | Qilu Hospital, Shandong University Jinfeng Chen Center for Systems Medicine, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China |
| authorships[12].affiliations[5].institution_ids | https://openalex.org/I4210161528 |
| authorships[12].affiliations[5].raw_affiliation_string | Department of Radiation Oncology, Qilu Hospital of Shandong University, Jinan, 250012, Shandong |
| authorships[12].affiliations[6].institution_ids | https://openalex.org/I4210161528 |
| authorships[12].affiliations[6].raw_affiliation_string | Qilu Hospital, Shandong University |
| authorships[12].affiliations[7].institution_ids | https://openalex.org/I4210161528 |
| authorships[12].affiliations[7].raw_affiliation_string | Qilu Hospital, Shandong University Can Can Qilu Hospital, Shandong University |
| authorships[12].institutions[0].id | https://openalex.org/I200296433 |
| authorships[12].institutions[0].ror | https://ror.org/02drdmm93 |
| authorships[12].institutions[0].type | education |
| authorships[12].institutions[0].lineage | https://openalex.org/I200296433 |
| authorships[12].institutions[0].country_code | CN |
| authorships[12].institutions[0].display_name | Chinese Academy of Medical Sciences & Peking Union Medical College |
| authorships[12].institutions[1].id | https://openalex.org/I4210161528 |
| authorships[12].institutions[1].ror | https://ror.org/056ef9489 |
| authorships[12].institutions[1].type | healthcare |
| authorships[12].institutions[1].lineage | https://openalex.org/I4210161528 |
| authorships[12].institutions[1].country_code | CN |
| authorships[12].institutions[1].display_name | Qilu Hospital of Shandong University |
| authorships[12].institutions[2].id | https://openalex.org/I154099455 |
| authorships[12].institutions[2].ror | https://ror.org/0207yh398 |
| authorships[12].institutions[2].type | education |
| authorships[12].institutions[2].lineage | https://openalex.org/I154099455 |
| authorships[12].institutions[2].country_code | CN |
| authorships[12].institutions[2].display_name | Shandong University |
| authorships[12].author_position | middle |
| authorships[12].raw_author_name | Ke Xiao |
| authorships[12].is_corresponding | False |
| authorships[12].raw_affiliation_strings | Department of Dermatology, Qilu Hospital of Shandong University, Jinan, 250012, Shandong, Department of Radiation Oncology, Qilu Hospital of Shandong University, Jinan, 250012, Shandong, Qilu Hospital, Shandong University, Qilu Hospital, Shandong University Can Can Qilu Hospital, Shandong University, Qilu Hospital, Shandong University Jinfeng Chen Center for Systems Medicine, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China, Qilu Hospital, Shandong University Ke Xiao Qilu Hospital, Shandong University Na He Qilu Hospital, Shandong University, Qilu Hospital, Shandong University Wancheng Liu Qilu Hospital, Shandong University, Qilu Hospital, Shandong University Xinyu Yang Qilu Hospital, Shandong University |
| authorships[13].author.id | https://openalex.org/A5088988915 |
| authorships[13].author.orcid | https://orcid.org/0000-0002-9712-7782 |
| authorships[13].author.display_name | Na He |
| authorships[13].countries | CN |
| authorships[13].affiliations[0].institution_ids | https://openalex.org/I4210161528 |
| authorships[13].affiliations[0].raw_affiliation_string | Qilu Hospital, Shandong University Wancheng Liu Qilu Hospital, Shandong University |
| authorships[13].affiliations[1].institution_ids | https://openalex.org/I4210161528 |
| authorships[13].affiliations[1].raw_affiliation_string | Qilu Hospital, Shandong University Ke Xiao Qilu Hospital, Shandong University Na He Qilu Hospital, Shandong University |
| authorships[13].affiliations[2].institution_ids | https://openalex.org/I4210161528 |
| authorships[13].affiliations[2].raw_affiliation_string | Qilu Hospital, Shandong University Xinyu Yang Qilu Hospital, Shandong University |
| authorships[13].affiliations[3].institution_ids | https://openalex.org/I154099455, https://openalex.org/I200296433 |
| authorships[13].affiliations[3].raw_affiliation_string | Qilu Hospital, Shandong University Jinfeng Chen Center for Systems Medicine, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China |
| authorships[13].affiliations[4].institution_ids | https://openalex.org/I4210161528 |
| authorships[13].affiliations[4].raw_affiliation_string | Department of Radiation Oncology, Qilu Hospital of Shandong University, Jinan, 250012, Shandong |
| authorships[13].affiliations[5].institution_ids | https://openalex.org/I4210161528 |
| authorships[13].affiliations[5].raw_affiliation_string | Department of Dermatology, Qilu Hospital of Shandong University, Jinan, 250012, Shandong |
| authorships[13].affiliations[6].institution_ids | https://openalex.org/I4210161528 |
| authorships[13].affiliations[6].raw_affiliation_string | Qilu Hospital, Shandong University |
| authorships[13].affiliations[7].institution_ids | https://openalex.org/I4210161528 |
| authorships[13].affiliations[7].raw_affiliation_string | Qilu Hospital, Shandong University Can Can Qilu Hospital, Shandong University |
| authorships[13].institutions[0].id | https://openalex.org/I200296433 |
| authorships[13].institutions[0].ror | https://ror.org/02drdmm93 |
| authorships[13].institutions[0].type | education |
| authorships[13].institutions[0].lineage | https://openalex.org/I200296433 |
| authorships[13].institutions[0].country_code | CN |
| authorships[13].institutions[0].display_name | Chinese Academy of Medical Sciences & Peking Union Medical College |
| authorships[13].institutions[1].id | https://openalex.org/I4210161528 |
| authorships[13].institutions[1].ror | https://ror.org/056ef9489 |
| authorships[13].institutions[1].type | healthcare |
| authorships[13].institutions[1].lineage | https://openalex.org/I4210161528 |
| authorships[13].institutions[1].country_code | CN |
| authorships[13].institutions[1].display_name | Qilu Hospital of Shandong University |
| authorships[13].institutions[2].id | https://openalex.org/I154099455 |
| authorships[13].institutions[2].ror | https://ror.org/0207yh398 |
| authorships[13].institutions[2].type | education |
| authorships[13].institutions[2].lineage | https://openalex.org/I154099455 |
| authorships[13].institutions[2].country_code | CN |
| authorships[13].institutions[2].display_name | Shandong University |
| authorships[13].author_position | middle |
| authorships[13].raw_author_name | Na He |
| authorships[13].is_corresponding | False |
| authorships[13].raw_affiliation_strings | Department of Dermatology, Qilu Hospital of Shandong University, Jinan, 250012, Shandong, Department of Radiation Oncology, Qilu Hospital of Shandong University, Jinan, 250012, Shandong, Qilu Hospital, Shandong University, Qilu Hospital, Shandong University Can Can Qilu Hospital, Shandong University, Qilu Hospital, Shandong University Jinfeng Chen Center for Systems Medicine, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China, Qilu Hospital, Shandong University Ke Xiao Qilu Hospital, Shandong University Na He Qilu Hospital, Shandong University, Qilu Hospital, Shandong University Wancheng Liu Qilu Hospital, Shandong University, Qilu Hospital, Shandong University Xinyu Yang Qilu Hospital, Shandong University |
| authorships[14].author.id | https://openalex.org/A5103144349 |
| authorships[14].author.orcid | https://orcid.org/0000-0002-8733-4817 |
| authorships[14].author.display_name | Hailei Zhang |
| authorships[14].countries | CN |
| authorships[14].affiliations[0].institution_ids | https://openalex.org/I4210161528 |
| authorships[14].affiliations[0].raw_affiliation_string | Qilu Hospital, Shandong University Ke Xiao Qilu Hospital, Shandong University Na He Qilu Hospital, Shandong University |
| authorships[14].affiliations[1].institution_ids | https://openalex.org/I4210161528 |
| authorships[14].affiliations[1].raw_affiliation_string | Qilu Hospital, Shandong University |
| authorships[14].affiliations[2].institution_ids | https://openalex.org/I4210161528 |
| authorships[14].affiliations[2].raw_affiliation_string | Qilu Hospital, Shandong University Can Can Qilu Hospital, Shandong University |
| authorships[14].affiliations[3].institution_ids | https://openalex.org/I4210161528 |
| authorships[14].affiliations[3].raw_affiliation_string | Department of Dermatology, Qilu Hospital of Shandong University, Jinan, 250012, Shandong |
| authorships[14].affiliations[4].institution_ids | https://openalex.org/I4210161528 |
| authorships[14].affiliations[4].raw_affiliation_string | Qilu Hospital, Shandong University Xinyu Yang Qilu Hospital, Shandong University |
| authorships[14].affiliations[5].institution_ids | https://openalex.org/I4210161528 |
| authorships[14].affiliations[5].raw_affiliation_string | Department of Radiation Oncology, Qilu Hospital of Shandong University, Jinan, 250012, Shandong |
| authorships[14].affiliations[6].institution_ids | https://openalex.org/I4210161528 |
| authorships[14].affiliations[6].raw_affiliation_string | Qilu Hospital, Shandong University Wancheng Liu Qilu Hospital, Shandong University |
| authorships[14].affiliations[7].institution_ids | https://openalex.org/I154099455, https://openalex.org/I200296433 |
| authorships[14].affiliations[7].raw_affiliation_string | Qilu Hospital, Shandong University Jinfeng Chen Center for Systems Medicine, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China |
| authorships[14].institutions[0].id | https://openalex.org/I200296433 |
| authorships[14].institutions[0].ror | https://ror.org/02drdmm93 |
| authorships[14].institutions[0].type | education |
| authorships[14].institutions[0].lineage | https://openalex.org/I200296433 |
| authorships[14].institutions[0].country_code | CN |
| authorships[14].institutions[0].display_name | Chinese Academy of Medical Sciences & Peking Union Medical College |
| authorships[14].institutions[1].id | https://openalex.org/I4210161528 |
| authorships[14].institutions[1].ror | https://ror.org/056ef9489 |
| authorships[14].institutions[1].type | healthcare |
| authorships[14].institutions[1].lineage | https://openalex.org/I4210161528 |
| authorships[14].institutions[1].country_code | CN |
| authorships[14].institutions[1].display_name | Qilu Hospital of Shandong University |
| authorships[14].institutions[2].id | https://openalex.org/I154099455 |
| authorships[14].institutions[2].ror | https://ror.org/0207yh398 |
| authorships[14].institutions[2].type | education |
| authorships[14].institutions[2].lineage | https://openalex.org/I154099455 |
| authorships[14].institutions[2].country_code | CN |
| authorships[14].institutions[2].display_name | Shandong University |
| authorships[14].author_position | last |
| authorships[14].raw_author_name | Hailei Zhang |
| authorships[14].is_corresponding | False |
| authorships[14].raw_affiliation_strings | Department of Dermatology, Qilu Hospital of Shandong University, Jinan, 250012, Shandong, Department of Radiation Oncology, Qilu Hospital of Shandong University, Jinan, 250012, Shandong, Qilu Hospital, Shandong University, Qilu Hospital, Shandong University Can Can Qilu Hospital, Shandong University, Qilu Hospital, Shandong University Jinfeng Chen Center for Systems Medicine, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China, Qilu Hospital, Shandong University Ke Xiao Qilu Hospital, Shandong University Na He Qilu Hospital, Shandong University, Qilu Hospital, Shandong University Wancheng Liu Qilu Hospital, Shandong University, Qilu Hospital, Shandong University Xinyu Yang Qilu Hospital, Shandong University |
| has_content.pdf | True |
| has_content.grobid_xml | False |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://www.researchsquare.com/article/rs-4352052/latest.pdf |
| open_access.oa_status | gold |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | Inhibition of NAT10 Enhances the Antitumor Immunity by Increasing Type I Interferon Responses |
| has_fulltext | False |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T11482 |
| primary_topic.field.id | https://openalex.org/fields/13 |
| primary_topic.field.display_name | Biochemistry, Genetics and Molecular Biology |
| primary_topic.score | 1.0 |
| primary_topic.domain.id | https://openalex.org/domains/1 |
| primary_topic.domain.display_name | Life Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/1312 |
| primary_topic.subfield.display_name | Molecular Biology |
| primary_topic.display_name | RNA modifications and cancer |
| related_works | https://openalex.org/W2063062622, https://openalex.org/W2294221646, https://openalex.org/W4312201105, https://openalex.org/W2985479685, https://openalex.org/W4361826906, https://openalex.org/W2286673285, https://openalex.org/W4213197580, https://openalex.org/W4387745385, https://openalex.org/W4397010472, https://openalex.org/W2318608430 |
| cited_by_count | 1 |
| counts_by_year[0].year | 2025 |
| counts_by_year[0].cited_by_count | 1 |
| locations_count | 1 |
| best_oa_location.id | doi:10.21203/rs.3.rs-4352052/v1 |
| best_oa_location.is_oa | True |
| best_oa_location.source | |
| best_oa_location.license | cc-by |
| best_oa_location.pdf_url | https://www.researchsquare.com/article/rs-4352052/latest.pdf |
| best_oa_location.version | acceptedVersion |
| best_oa_location.raw_type | posted-content |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | False |
| best_oa_location.raw_source_name | |
| best_oa_location.landing_page_url | https://doi.org/10.21203/rs.3.rs-4352052/v1 |
| primary_location.id | doi:10.21203/rs.3.rs-4352052/v1 |
| primary_location.is_oa | True |
| primary_location.source | |
| primary_location.license | cc-by |
| primary_location.pdf_url | https://www.researchsquare.com/article/rs-4352052/latest.pdf |
| primary_location.version | acceptedVersion |
| primary_location.raw_type | posted-content |
| primary_location.license_id | https://openalex.org/licenses/cc-by |
| primary_location.is_accepted | True |
| primary_location.is_published | False |
| primary_location.raw_source_name | |
| primary_location.landing_page_url | https://doi.org/10.21203/rs.3.rs-4352052/v1 |
| publication_date | 2024-08-23 |
| publication_year | 2024 |
| referenced_works | https://openalex.org/W2744365130, https://openalex.org/W3046869151, https://openalex.org/W2558219863, https://openalex.org/W3214913540, https://openalex.org/W3022486080, https://openalex.org/W4205344005, https://openalex.org/W2883220169, https://openalex.org/W4387834133, https://openalex.org/W1953890763, https://openalex.org/W3215094494, https://openalex.org/W3138259150, https://openalex.org/W4366272345, https://openalex.org/W2107458751, https://openalex.org/W4200061372, https://openalex.org/W4378528245, https://openalex.org/W2946657092, https://openalex.org/W2008052894, https://openalex.org/W2788142646, https://openalex.org/W3189383967, https://openalex.org/W2968972266, https://openalex.org/W2770893462, https://openalex.org/W2921780799, https://openalex.org/W4360949797, https://openalex.org/W2904945363, https://openalex.org/W3128313348, https://openalex.org/W4391533363, https://openalex.org/W3210356515, https://openalex.org/W2120158787, https://openalex.org/W2589046367, https://openalex.org/W2949203101, https://openalex.org/W4389955598, https://openalex.org/W2986357513, https://openalex.org/W4362576491, https://openalex.org/W3204264733, https://openalex.org/W2952481429, https://openalex.org/W2800488651 |
| referenced_works_count | 36 |
| abstract_inverted_index.I | 136 |
| abstract_inverted_index.T | 145 |
| abstract_inverted_index.a | 109, 200, 211 |
| abstract_inverted_index.In | 147 |
| abstract_inverted_index.an | 30 |
| abstract_inverted_index.as | 108 |
| abstract_inverted_index.by | 192 |
| abstract_inverted_index.in | 12, 55, 82, 182, 189, 205, 217 |
| abstract_inverted_index.of | 21, 33, 46, 69, 100, 113, 122, 143, 149, 156, 180, 203 |
| abstract_inverted_index.on | 38, 44 |
| abstract_inverted_index.or | 160 |
| abstract_inverted_index.to | 6, 97, 133 |
| abstract_inverted_index.we | 28, 49, 105, 152 |
| abstract_inverted_index.IFN | 137 |
| abstract_inverted_index.MYC | 107 |
| abstract_inverted_index.Our | 197 |
| abstract_inverted_index.RNA | 36 |
| abstract_inverted_index.add | 3 |
| abstract_inverted_index.and | 17, 58, 64, 77, 90, 115, 139, 172, 209 |
| abstract_inverted_index.for | 214 |
| abstract_inverted_index.key | 110 |
| abstract_inverted_index.the | 15, 98 |
| abstract_inverted_index.was | 53 |
| abstract_inverted_index.RNAs | 130 |
| abstract_inverted_index.gaps | 10 |
| abstract_inverted_index.mRNA | 24 |
| abstract_inverted_index.role | 32, 202 |
| abstract_inverted_index.that | 51, 154 |
| abstract_inverted_index.then | 116 |
| abstract_inverted_index.type | 135 |
| abstract_inverted_index.with | 61, 164 |
| abstract_inverted_index.Based | 43 |
| abstract_inverted_index.Here, | 27 |
| abstract_inverted_index.NAT10 | 52, 70, 80, 123, 157, 181, 204, 216 |
| abstract_inverted_index.cells | 66, 84, 88, 184 |
| abstract_inverted_index.found | 50 |
| abstract_inverted_index.newly | 22 |
| abstract_inverted_index.novel | 212 |
| abstract_inverted_index.study | 198 |
| abstract_inverted_index.terms | 148 |
| abstract_inverted_index.tumor | 40, 56, 73, 169, 174, 186, 190, 207 |
| abstract_inverted_index.using | 158 |
| abstract_inverted_index.which | 127 |
| abstract_inverted_index.(ac4C) | 35 |
| abstract_inverted_index.NAT10, | 114 |
| abstract_inverted_index.cancer | 7, 83, 183, 218 |
| abstract_inverted_index.cells. | 146 |
| abstract_inverted_index.growth | 74 |
| abstract_inverted_index.immune | 18, 41, 65, 87, 94, 141, 170, 195 |
| abstract_inverted_index.induce | 134 |
| abstract_inverted_index.remain | 11 |
| abstract_inverted_index.robust | 101 |
| abstract_inverted_index.target | 112 |
| abstract_inverted_index.(IFN-I) | 138 |
| abstract_inverted_index.(dsRNA) | 131 |
| abstract_inverted_index.concept | 213 |
| abstract_inverted_index.crucial | 201 |
| abstract_inverted_index.improve | 185 |
| abstract_inverted_index.induced | 117 |
| abstract_inverted_index.leading | 96 |
| abstract_inverted_index.overall | 62 |
| abstract_inverted_index.patient | 47 |
| abstract_inverted_index.trigger | 140 |
| abstract_inverted_index.analyses | 45 |
| abstract_inverted_index.anti-PD1 | 165 |
| abstract_inverted_index.cellular | 93 |
| abstract_inverted_index.clinical | 150 |
| abstract_inverted_index.combined | 163 |
| abstract_inverted_index.enhanced | 128 |
| abstract_inverted_index.function | 16 |
| abstract_inverted_index.however, | 9 |
| abstract_inverted_index.improved | 168 |
| abstract_inverted_index.survival | 63 |
| abstract_inverted_index.tissues, | 57 |
| abstract_inverted_index.uncovers | 199 |
| abstract_inverted_index.Remodelin | 159 |
| abstract_inverted_index.datasets, | 48 |
| abstract_inverted_index.enhancing | 193 |
| abstract_inverted_index.formation | 132 |
| abstract_inverted_index.immunity. | 103 |
| abstract_inverted_index.knowledge | 13 |
| abstract_inverted_index.mechanism | 20 |
| abstract_inverted_index.regarding | 14 |
| abstract_inverted_index.repressed | 173 |
| abstract_inverted_index.reshaping | 39 |
| abstract_inverted_index.responses | 142 |
| abstract_inverted_index.resulting | 188 |
| abstract_inverted_index.targeting | 215 |
| abstract_inverted_index.treatment | 166 |
| abstract_inverted_index.<italic>in | 75, 78, 176 |
| abstract_inverted_index.CDK2-DNMT1 | 118 |
| abstract_inverted_index.Inhibition | 68 |
| abstract_inverted_index.Meanwhile, | 120 |
| abstract_inverted_index.Therefore, | 178 |
| abstract_inverted_index.anti-tumor | 102, 194 |
| abstract_inverted_index.complexity | 5 |
| abstract_inverted_index.correlated | 60 |
| abstract_inverted_index.deficiency | 81 |
| abstract_inverted_index.discovered | 23, 29 |
| abstract_inverted_index.downstream | 111 |
| abstract_inverted_index.identified | 106 |
| abstract_inverted_index.inhibition | 121, 155, 179 |
| abstract_inverted_index.negatively | 59 |
| abstract_inverted_index.regulatory | 19 |
| abstract_inverted_index.responses, | 95 |
| abstract_inverted_index.responses. | 196 |
| abstract_inverted_index.stimulated | 91 |
| abstract_inverted_index.suppressed | 72 |
| abstract_inverted_index.tremendous | 4 |
| abstract_inverted_index.unexpected | 31 |
| abstract_inverted_index.acetylation | 25 |
| abstract_inverted_index.expression, | 126 |
| abstract_inverted_index.expression. | 119 |
| abstract_inverted_index.progression | 175 |
| abstract_inverted_index.suppression | 191 |
| abstract_inverted_index.upregulated | 54, 86 |
| abstract_inverted_index.demonstrated | 153 |
| abstract_inverted_index.demonstrates | 210 |
| abstract_inverted_index.infiltration | 89 |
| abstract_inverted_index.progression; | 8 |
| abstract_inverted_index.establishment | 99 |
| abstract_inverted_index.infiltration. | 67 |
| abstract_inverted_index.modification. | 26 |
| abstract_inverted_index.modifications | 2 |
| abstract_inverted_index.nanoparticles | 162 |
| abstract_inverted_index.re-modulating | 206 |
| abstract_inverted_index.significance, | 151 |
| abstract_inverted_index.significantly | 71, 85 |
| abstract_inverted_index.vivo</italic> | 76 |
| abstract_inverted_index.MYC-CDK2-DNMT1 | 125 |
| abstract_inverted_index.PEI/PC7A/siRNA | 161 |
| abstract_inverted_index.down-regulated | 124 |
| abstract_inverted_index.immunogenicity | 208 |
| abstract_inverted_index.immunotherapy. | 219 |
| abstract_inverted_index.tumor-specific | 92 |
| abstract_inverted_index.vivo</italic>. | 177 |
| abstract_inverted_index.CD8<sup>+</sup> | 144 |
| abstract_inverted_index.double-stranded | 129 |
| abstract_inverted_index.immunogenicity, | 187 |
| abstract_inverted_index.synergistically | 167 |
| abstract_inverted_index.vitro.</italic> | 79 |
| abstract_inverted_index.Mechanistically, | 104 |
| abstract_inverted_index.microenvironment | 171 |
| abstract_inverted_index.N4-acetylcytidine | 34 |
| abstract_inverted_index.Posttranslational | 1 |
| abstract_inverted_index.microenvironment. | 42 |
| abstract_inverted_index.<title>Abstract</title> | 0 |
| abstract_inverted_index.acetyltransferase-NAT10 | 37 |
| cited_by_percentile_year.max | 95 |
| cited_by_percentile_year.min | 91 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 15 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.7799999713897705 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.60876368 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |