Inhibition of SENP2-mediated Akt deSUMOylation promotes cardiac regeneration via activating Akt pathway Article Swipe
Yijin Chen
,
Tong Xu
,
Mengsha Li
,
Chuling Li
,
Yusheng Ma
,
Guojun Chen
,
Yili Sun
,
Hao Zheng
,
Guangkai Wu
,
Wangjun Liao
,
Yulin Liao
,
Yanmei Chen
,
Jianping Bin
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1042/cs20201408
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1042/cs20201408
Post-translational modification (PTM) by small ubiquitin-like modifier (SUMO) is a key regulator of cell proliferation and can be readily reversed by a family of SUMO-specific proteases (SENPs), making SUMOylation an ideal regulatory mechanism for developing novel therapeutic strategies for promoting a cardiac regenerative response. However, the role of SUMOylation in cardiac regeneration remains unknown. In the present study, we assessed whether targeting protein kinase B (Akt) SUMOylation can promote cardiac regeneration. Quantitative PCR and Western blotting results showed that small ubiquitin-like modifier-specific protease 2 (SENP2) is up-regulated during postnatal heart development. SENP2 deficiency promoted P7 and adult cardiomyocyte (CM) dedifferentiation and proliferation both in vitro and in vivo. Mice with SENP2 deficiency exhibited improved cardiac function after MI due to CM proliferation and angiogenesis. Mechanistically, the loss of SENP2 up-regulated Akt SUMOylation levels and increased Akt kinase activity, leading to a decrease in GSK3β levels and subsequently promoting CM proliferation and angiogenesis. In summary, inhibition of SENP2-mediated Akt deSUMOylation promotes CM differentiation and proliferation by activating the Akt pathway. Our results provide new insights into the role of SUMOylation in cardiac regeneration.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1042/cs20201408
- OA Status
- hybrid
- Cited By
- 22
- References
- 38
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3135463587
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W3135463587Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1042/cs20201408Digital Object Identifier
- Title
-
Inhibition of SENP2-mediated Akt deSUMOylation promotes cardiac regeneration via activating Akt pathwayWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2021Year of publication
- Publication date
-
2021-03-01Full publication date if available
- Authors
-
Yijin Chen, Tong Xu, Mengsha Li, Chuling Li, Yusheng Ma, Guojun Chen, Yili Sun, Hao Zheng, Guangkai Wu, Wangjun Liao, Yulin Liao, Yanmei Chen, Jianping BinList of authors in order
- Landing page
-
https://doi.org/10.1042/cs20201408Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
hybridOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.1042/cs20201408Direct OA link when available
- Concepts
-
SUMO protein, Protein kinase B, Angiogenesis, Cell biology, Biology, PI3K/AKT/mTOR pathway, Regeneration (biology), Proteases, Ubiquitin, Signal transduction, Cancer research, Biochemistry, Enzyme, GeneTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
22Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 2, 2024: 5, 2023: 5, 2022: 4, 2021: 6Per-year citation counts (last 5 years)
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38Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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