Initial contact between SARS-CoV-2 spike S1 protein and cell surface glycans involves multiple binding modes Article Swipe
Michela Parafioriti
,
Minghong Ni
,
Maurice Petitou
,
Courtney J. Mycroft‐West
,
Timothy R. Rudd
,
Neha S. Gandhi
,
Vito Ferro
,
Jeremy E. Turnbull
,
Marcelo A. Lima
,
Mark A. Skidmore
,
David G. Fernig
,
Edwin A. Yates
,
Antonella Bisio
,
Marco Guerrini
,
Stefano Elli
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.26434/chemrxiv-2022-21brb
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.26434/chemrxiv-2022-21brb
Infection of host cells by SARS-CoV-2 begins with recognition by the virus S (spike) protein of cell surface heparan sulfate (HS), tethering the virus to the extracellular matrix environment, and causing the subunit S1-RBD to undergo a conformational change into the ‘open’ conformation. These two events promote the binding of S1-RBD to the angiotensin converting enzyme 2 (ACE2) receptor, a preliminary step toward viral-cell membrane fusion. Combining ligand-based NMR spectroscopy with molecular dynamics, oligosaccharide analogues were used to explore the interactions between S1-RBD of SARS CoV-2 and HS, revealing several low-specificity binding modes and previously unidentified potential sites for the binding of extended HS polysaccharide chains. The evident multiplicity of binding modes also suggests that highly specific inhibitors will not be optimal against protein S but, rather, diverse HS-based structures, characterized by high affinity and including multi-valent compounds, may be required
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- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.26434/chemrxiv-2022-21brb
- https://chemrxiv.org/engage/api-gateway/chemrxiv/assets/orp/resource/item/62667590368ab6b7788c5dfc/original/initial-contact-between-sars-co-v-2-spike-s1-protein-and-cell-surface-glycans-involves-multiple-binding-modes.pdf
- OA Status
- gold
- References
- 9
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4224861359
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Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4224861359Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.26434/chemrxiv-2022-21brbDigital Object Identifier
- Title
-
Initial contact between SARS-CoV-2 spike S1 protein and cell surface glycans involves multiple binding modesWork title
- Type
-
preprintOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2022Year of publication
- Publication date
-
2022-04-26Full publication date if available
- Authors
-
Michela Parafioriti, Minghong Ni, Maurice Petitou, Courtney J. Mycroft‐West, Timothy R. Rudd, Neha S. Gandhi, Vito Ferro, Jeremy E. Turnbull, Marcelo A. Lima, Mark A. Skidmore, David G. Fernig, Edwin A. Yates, Antonella Bisio, Marco Guerrini, Stefano ElliList of authors in order
- Landing page
-
https://doi.org/10.26434/chemrxiv-2022-21brbPublisher landing page
- PDF URL
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https://chemrxiv.org/engage/api-gateway/chemrxiv/assets/orp/resource/item/62667590368ab6b7788c5dfc/original/initial-contact-between-sars-co-v-2-spike-s1-protein-and-cell-surface-glycans-involves-multiple-binding-modes.pdfDirect link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
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https://chemrxiv.org/engage/api-gateway/chemrxiv/assets/orp/resource/item/62667590368ab6b7788c5dfc/original/initial-contact-between-sars-co-v-2-spike-s1-protein-and-cell-surface-glycans-involves-multiple-binding-modes.pdfDirect OA link when available
- Concepts
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Chemistry, Biophysics, Glycan, Heparan sulfate, Lipid bilayer fusion, Binding site, Ligand (biochemistry), Protein subunit, Oligosaccharide, Plasma protein binding, Nuclear magnetic resonance spectroscopy, Cell biology, Receptor, Biochemistry, Cell, Membrane, Biology, Stereochemistry, Glycoprotein, GeneTop concepts (fields/topics) attached by OpenAlex
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0Total citation count in OpenAlex
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9Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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