Injectable hydrogels in central nervous system: Unique and novel platforms for promoting extracellular matrix remodeling and tissue engineering Article Swipe
Elham Hasanzadeh
,
Alexander M. Seifalian
,
Amir Mellati
,
Jamileh Saremi
,
Shiva Asadpour
,
Seyed Ehsan Enderami
,
Houra Nekounam
,
Narges Mahmoodi
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1016/j.mtbio.2023.100614
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1016/j.mtbio.2023.100614
Repairing central nervous system (CNS) is difficult due to the inability of neurons to recover after damage. A clinically acceptable treatment to promote CNS functional recovery and regeneration is currently unavailable. According to recent studies, injectable hydrogels as biodegradable scaffolds for CNS tissue engineering and regeneration have exceptionally desirable attributes. Hydrogel has a biomimetic structure similar to extracellular matrix, hence has been considered a 3D scaffold for CNS regeneration. An interesting new type of hydrogel, injectable hydrogels, can be injected into target areas with little invasiveness and imitate several aspects of CNS. Injectable hydrogels are being researched as therapeutic agents because they may imitate numerous properties of CNS tissues and hence reduce subsequent injury and regenerate neural tissue. Because of their less adverse effects and cost, easier use and implantation with less pain, and faster regeneration capacity, injectable hydrogels, are more desirable than non-injectable hydrogels. This article discusses the pathophysiology of CNS and the use of several kinds of injectable hydrogels for brain and spinal cord tissue engineering, paying particular emphasis to recent experimental studies.
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Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.1016/j.mtbio.2023.100614
- OA Status
- gold
- Cited By
- 76
- References
- 248
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4353094503
All OpenAlex metadata
Raw OpenAlex JSON
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https://openalex.org/W4353094503Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1016/j.mtbio.2023.100614Digital Object Identifier
- Title
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Injectable hydrogels in central nervous system: Unique and novel platforms for promoting extracellular matrix remodeling and tissue engineeringWork title
- Type
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reviewOpenAlex work type
- Language
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enPrimary language
- Publication year
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2023Year of publication
- Publication date
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2023-03-22Full publication date if available
- Authors
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Elham Hasanzadeh, Alexander M. Seifalian, Amir Mellati, Jamileh Saremi, Shiva Asadpour, Seyed Ehsan Enderami, Houra Nekounam, Narges MahmoodiList of authors in order
- Landing page
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https://doi.org/10.1016/j.mtbio.2023.100614Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
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https://doi.org/10.1016/j.mtbio.2023.100614Direct OA link when available
- Concepts
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Self-healing hydrogels, Regeneration (biology), Extracellular matrix, Tissue engineering, Central nervous system, Scaffold, Neuroscience, Neural tissue engineering, Regenerative medicine, Biomedical engineering, Medicine, Chemistry, Biology, Cell biology, Stem cell, Organic chemistryTop concepts (fields/topics) attached by OpenAlex
- Cited by
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76Total citation count in OpenAlex
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2025: 23, 2024: 39, 2023: 14Per-year citation counts (last 5 years)
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248Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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| countries_distinct_count | 2 |
| institutions_distinct_count | 8 |
| corresponding_institution_ids | https://openalex.org/I70640408, https://openalex.org/I88085062 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/6 |
| sustainable_development_goals[0].score | 0.4300000071525574 |
| sustainable_development_goals[0].display_name | Clean water and sanitation |
| citation_normalized_percentile.value | 0.99478668 |
| citation_normalized_percentile.is_in_top_1_percent | True |
| citation_normalized_percentile.is_in_top_10_percent | True |