Injectable platelet-rich fibrin promotes proliferation and trichogenic inductivityof dermal papilla cells through activating TGF-β/Smad signaling pathway Article Swipe
Kai Xu
,
Xueqin Deng
,
Minmin Ye
,
Baolin Cheng
,
Lili Zhu
,
Chunming Ding
,
Tuanjie Hou
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.14715/cmb/2024.70.4.25
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.14715/cmb/2024.70.4.25
Dermal papilla cell (DPC) belongs to a specialized mesenchymal stem cell for hair follicle regeneration. Maintaining the ability of DPCs to stimulate hair in vitro culture is important for hair follicle morphogenesis and regeneration. As the third generation of platelet concentrate, injectable platelet-rich fibrin (i-PRF) is a novel biomaterial containing many growth factors and showing promising effects on tissue reconstruction. We aimed to explore the influences of i-PRF on the proliferative, migratory, as well as trichogenic ability of DPCs and compared the effects of i-PRF and platelet-rich plasma (PRP), the first generation of platelet concentrate. Both PRP and i-PRF facilitated DPCs proliferation, and migration, along with trichogenic inductivity as well as stimulated the TGF-β/Smad pathway, while the impacts of i-PRF were more significant than PRP. A small molecule inhibitor of TGF-beta receptor I, Galunisertib, was also applied to treat DPCs, and it rescued the impacts of i-PRF on the proliferative, migratory, trichogenic inductivity, and proteins-associated with TGF-β/Smad pathway in DPCs. These findings revealed that i-PRF had better effects than PRP in enhancing the proliferative, migratory, and hair-inducing abilities of DPCs by the TGF-β/Smad pathway, which indicated the beneficial role of i-PRF in hair follicle regeneration.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.14715/cmb/2024.70.4.25
- https://cellmolbiol.org/index.php/CMB/article/download/5462/3220
- OA Status
- hybrid
- Cited By
- 3
- References
- 33
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4396227519
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4396227519Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.14715/cmb/2024.70.4.25Digital Object Identifier
- Title
-
Injectable platelet-rich fibrin promotes proliferation and trichogenic inductivityof dermal papilla cells through activating TGF-β/Smad signaling pathwayWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-04-28Full publication date if available
- Authors
-
Kai Xu, Xueqin Deng, Minmin Ye, Baolin Cheng, Lili Zhu, Chunming Ding, Tuanjie HouList of authors in order
- Landing page
-
https://doi.org/10.14715/cmb/2024.70.4.25Publisher landing page
- PDF URL
-
https://cellmolbiol.org/index.php/CMB/article/download/5462/3220Direct link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
-
hybridOpen access status per OpenAlex
- OA URL
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https://cellmolbiol.org/index.php/CMB/article/download/5462/3220Direct OA link when available
- Concepts
-
SMAD, Dermal papillae, Transforming growth factor, Cell biology, Fibrin, Signal transduction, Platelet-rich fibrin, Chemistry, Biology, Immunology, Hair follicleTop concepts (fields/topics) attached by OpenAlex
- Cited by
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3Total citation count in OpenAlex
- Citations by year (recent)
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2025: 3Per-year citation counts (last 5 years)
- References (count)
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33Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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