Innate Biomineralization Article Swipe
Erming Tian
,
Fumiya Watanabe
,
Betty Martin
,
Maurizio Zangari
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.3390/ijms21144820
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.3390/ijms21144820
In vertebrates, biomineralization is a feature considered unique to mature osteoblasts and odontoblasts by which they synthesize hydroxyapatite (HAP), which is deposited in the collagen matrix to construct endoskeleton. For many decades, the mechanisms that modulate differentiation and maturation of these specialized cells have been sought as a key to understanding bone-remodeling defects. Here, we report that biomineralization is an innate ability of all mammalian cells, irrespective of cell type or maturation stage. This innate biomineralization is triggered by the concomitant exposure of living cells to three indispensable elements: calcium ion, phosphoester salt, and alkaline phosphatase. Any given somatic cell, including undifferentiated mononuclear cells, can undergo a biomineralization process to produce calcium-phosphate agglomerates. The biologically generated minerals under such conditions are composed of genuine HAP crystallites of Ca10(PO4)6(OH)2 and 5–10 nanometer (nm) in size. This discovery will profoundly improve our understanding of bone metabolism and ectopic calcifications.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/ijms21144820
- https://www.mdpi.com/1422-0067/21/14/4820/pdf?version=1594201676
- OA Status
- gold
- Cited By
- 11
- References
- 39
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4250255230
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4250255230Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/ijms21144820Digital Object Identifier
- Title
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Innate BiomineralizationWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2020Year of publication
- Publication date
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2020-07-08Full publication date if available
- Authors
-
Erming Tian, Fumiya Watanabe, Betty Martin, Maurizio ZangariList of authors in order
- Landing page
-
https://doi.org/10.3390/ijms21144820Publisher landing page
- PDF URL
-
https://www.mdpi.com/1422-0067/21/14/4820/pdf?version=1594201676Direct link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.mdpi.com/1422-0067/21/14/4820/pdf?version=1594201676Direct OA link when available
- Concepts
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Biomineralization, Cell biology, Innate immune system, Chemistry, Osteoblast, Biology, Biochemistry, In vitro, Receptor, PaleontologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
11Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 3, 2024: 3, 2023: 2, 2021: 2, 2020: 1Per-year citation counts (last 5 years)
- References (count)
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39Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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