Innovative Nanotechnology in Drug Delivery Systems for Advanced Treatment of Posterior Segment Ocular Diseases Article Swipe
Yue Wu
,
Xin Li
,
Xueyu Fu
,
Xiaomin Huang
,
Shenrong Zhang
,
Nan Zhao
,
Xiaowei Ma
,
Qimanguli Saiding
,
Mei Yang
,
Wei Tao
,
Xingtao Zhou
,
Jinhai Huang
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1002/advs.202403399
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1002/advs.202403399
Funduscopic diseases, including diabetic retinopathy (DR) and age‐related macular degeneration (AMD), significantly impact global visual health, leading to impaired vision and irreversible blindness. Delivering drugs to the posterior segment of the eye remains a challenge due to the presence of multiple physiological and anatomical barriers. Conventional drug delivery methods often prove ineffective and may cause side effects. Nanomaterials, characterized by their small size, large surface area, tunable properties, and biocompatibility, enhance the permeability, stability, and targeting of drugs. Ocular nanomaterials encompass a wide range, including lipid nanomaterials, polymer nanomaterials, metal nanomaterials, carbon nanomaterials, quantum dot nanomaterials, and so on. These innovative materials, often combined with hydrogels and exosomes, are engineered to address multiple mechanisms, including macrophage polarization, reactive oxygen species (ROS) scavenging, and anti‐vascular endothelial growth factor (VEGF). Compared to conventional modalities, nanomedicines achieve regulated and sustained delivery, reduced administration frequency, prolonged drug action, and minimized side effects. This study delves into the obstacles encountered in drug delivery to the posterior segment and highlights the progress facilitated by nanomedicine. Prospectively, these findings pave the way for next‐generation ocular drug delivery systems and deeper clinical research, aiming to refine treatments, alleviate the burden on patients, and ultimately improve visual health globally.
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Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.1002/advs.202403399
- OA Status
- gold
- Cited By
- 45
- References
- 210
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4399880333
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4399880333Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1002/advs.202403399Digital Object Identifier
- Title
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Innovative Nanotechnology in Drug Delivery Systems for Advanced Treatment of Posterior Segment Ocular DiseasesWork title
- Type
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reviewOpenAlex work type
- Language
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enPrimary language
- Publication year
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2024Year of publication
- Publication date
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2024-06-21Full publication date if available
- Authors
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Yue Wu, Xin Li, Xueyu Fu, Xiaomin Huang, Shenrong Zhang, Nan Zhao, Xiaowei Ma, Qimanguli Saiding, Mei Yang, Wei Tao, Xingtao Zhou, Jinhai HuangList of authors in order
- Landing page
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https://doi.org/10.1002/advs.202403399Publisher landing page
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://doi.org/10.1002/advs.202403399Direct OA link when available
- Concepts
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Drug delivery, Posterior segment of eyeball, Nanotechnology, Delivery system, Medicine, Materials science, Biomedical engineering, OphthalmologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
45Total citation count in OpenAlex
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2025: 33, 2024: 12Per-year citation counts (last 5 years)
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210Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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