Inside Front Cover: PRM technology enables detection and reliable automated quantification of low tracer incorporation into circulating apolipoproteins for HDL metabolism studies Article Swipe
Lang Ho Lee
,
Allison B. Andraski
,
Brett Pieper
,
Hideyuki Higashi
,
Frank M. Sacks
,
Masanori Aikawa
,
Sasha A. Singh
·
YOU?
·
· 2017
· Open Access
·
· DOI: https://doi.org/10.1002/pmic.201770014
YOU?
·
· 2017
· Open Access
·
· DOI: https://doi.org/10.1002/pmic.201770014
DOI: 10.1002/pmic.201600085 Metabolism studies traditionally use D3-Leu tracer for endogenous labeling of circulating proteins such as those on lipoproteins (yellow, low density apoB lipoproteins; blue, high density apoA-I lipoproteins or HDL). However, there are several challenges for reliable enrichment detection—low incorporation rates into nascent proteins; the overlap of tracer and tracee isotopes; and the retention time shift of the tracer and tracee peptides. We demonstrate that HR/AM-PRM scans permit reliable automated quantification of enrichment by extracting the tracer and tracee PRM peak intensities (XPIs) themselves in lieu of the XIC method. For more details, see the article by Lang Ho Lee et al. (https://doi.org/10.1002/pmic.201600085).
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Metadata
- Type
- paratext
- Language
- en
- Landing Page
- https://doi.org/10.1002/pmic.201770014
- https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/pmic.201770014
- OA Status
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- Related Works
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- OpenAlex ID
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All OpenAlex metadata
Raw OpenAlex JSON
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https://openalex.org/W2574735517Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1002/pmic.201770014Digital Object Identifier
- Title
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Inside Front Cover: PRM technology enables detection and reliable automated quantification of low tracer incorporation into circulating apolipoproteins for HDL metabolism studiesWork title
- Type
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paratextOpenAlex work type
- Language
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enPrimary language
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2017Year of publication
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2017-01-01Full publication date if available
- Authors
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Lang Ho Lee, Allison B. Andraski, Brett Pieper, Hideyuki Higashi, Frank M. Sacks, Masanori Aikawa, Sasha A. SinghList of authors in order
- Landing page
-
https://doi.org/10.1002/pmic.201770014Publisher landing page
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/pmic.201770014Direct link to full text PDF
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YesWhether a free full text is available
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bronzeOpen access status per OpenAlex
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/pmic.201770014Direct OA link when available
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TRACER, Chemistry, Chromatography, Front cover, Metabolism, Isotope, Biochemistry, Cover (algebra), Physics, Nuclear physics, Mechanical engineering, Engineering, Quantum mechanicsTop concepts (fields/topics) attached by OpenAlex
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0Total citation count in OpenAlex
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10Other works algorithmically related by OpenAlex
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