Insights into potential targeted nonsurgical therapies for the treatment of moyamoya disease. Article Swipe

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Moyamoya disease Medicine Pathophysiology Disease Therapeutic angiogenesis Angiogenesis Bioinformatics Neuroscience Pathology Surgery Internal medicine Biology Neovascularization

Dylan Goehner , Sandeep Kandregula , Christopher P. Carroll , Mario Zuccarello , Bharat Guthikonda , Jennifer Kosty ·

YOU? · · 2021 · Open Access · · DOI: https://doi.org/10.3171/2021.6.focus21289 · OA: W3198580009

Since its initial description in 1957 as an idiopathic disease, moyamoya disease has proved challenging to treat. Although the basic pathophysiology of this disease involves narrowing of the terminal carotid artery with compensatory angiogenesis, the molecular and cellular mechanisms underlying these changes are far more complex. In this article, the authors review the literature on the molecular and cellular pathophysiology of moyamoya disease with an emphasis on potential therapeutic targets.