Insights into the T-cell response to SARS-CoV-2 Article Swipe
Chaimae Kadi
,
Nouhaila Najimi
,
M. Zakaria
,
Youssef Bakri
,
Elmtili Noureddine
,
Seghrouchni Fouad
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1177/1721727x231211458
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1177/1721727x231211458
Following infection with SARS-CoV-2, cellular components of the adaptive immune system play a crucial role in eliminating the virus. Specifically, virus-specific CD4+ and CD8+ T cells generate effector cytokines and display cytotoxic activity. A number of studies carried out during the COVID-19 pandemic highlighted the importance of CD4+ T cells, CD8+ T cells, and memory cells in this process. T-cell responses emerge early and contribute to protection, but are comparatively impaired in severe cases, often accompanied by intense activation or lymphopenia. Since December 2020, SARS-CoV-2 vaccines have been licensed and administered worldwide. These vaccines induce a targeted T-cell response against SARS-CoV-2. The cellular response after the third dose was strong and superior to that obtained with the second dose. COVID-19 multiple vaccines elicit a robust CD4+ and CD8+ T cell response after the short-term booster. While, the T-cell response induced by COVID-19 vaccines has been shown to decline within 6-12 months of vaccination. In addition, the long-term persistence of cellular immunity may protect against the development of severe disease. In addition, adoptive T-cell therapies have shown considerable potential in the development of COVID-19 traitement. These therapies involve the transfer of T cells with specific antiviral properties into patients to boost their immune response against SARS-CoV-2.
Related Topics
Concepts
Cytotoxic T cell
Immunology
Immune system
CD8
Adoptive cell transfer
T cell
Acquired immune system
Immunity
Cellular immunity
Medicine
Biology
Virology
In vitro
Biochemistry
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1177/1721727x231211458
- OA Status
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- References
- 62
- Related Works
- 10
- OpenAlex ID
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All OpenAlex metadata
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- OpenAlex ID
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https://openalex.org/W4388312198Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1177/1721727x231211458Digital Object Identifier
- Title
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Insights into the T-cell response to SARS-CoV-2Work title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2023Year of publication
- Publication date
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2023-06-01Full publication date if available
- Authors
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Chaimae Kadi, Nouhaila Najimi, M. Zakaria, Youssef Bakri, Elmtili Noureddine, Seghrouchni FouadList of authors in order
- Landing page
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https://doi.org/10.1177/1721727x231211458Publisher landing page
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
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https://doi.org/10.1177/1721727x231211458Direct OA link when available
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Cytotoxic T cell, Immunology, Immune system, CD8, Adoptive cell transfer, T cell, Acquired immune system, Immunity, Cellular immunity, Medicine, Biology, Virology, In vitro, BiochemistryTop concepts (fields/topics) attached by OpenAlex
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0Total citation count in OpenAlex
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