Insights of Endocytosis Signaling in Health and Disease Article Swipe
Chandramani Pathak
,
Foram U. Vaidya
,
Bhargav N. Waghela
,
Pradip Kumar Jaiswara
,
Vishal Gupta
,
Ajay Kumar
,
Barani Kumar Rajendran
,
Kishu Ranjan
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3390/ijms24032971
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3390/ijms24032971
Endocytosis in mammalian cells is a fundamental cellular machinery that regulates vital physiological processes, such as the absorption of metabolites, release of neurotransmitters, uptake of hormone cellular defense, and delivery of biomolecules across the plasma membrane. A remarkable characteristic of the endocytic machinery is the sequential assembly of the complex proteins at the plasma membrane, followed by internalization and fusion of various biomolecules to different cellular compartments. In all eukaryotic cells, functional characterization of endocytic pathways is based on dynamics of the protein complex and signal transduction modules. To coordinate the assembly and functions of the numerous parts of the endocytic machinery, the endocytic proteins interact significantly within and between the modules. Clathrin-dependent and -independent endocytosis, caveolar pathway, and receptor mediated endocytosis have been attributed to a greater variety of physiological and pathophysiological roles such as, autophagy, metabolism, cell division, apoptosis, cellular defense, and intestinal permeabilization. Notably, any defect or alteration in the endocytic machinery results in the development of pathological consequences associated with human diseases such as cancer, cardiovascular diseases, neurological diseases, and inflammatory diseases. In this review, an in-depth endeavor has been made to illustrate the process of endocytosis, and associated mechanisms describing pathological manifestation associated with dysregulated endocytosis machinery.
Related Topics
Concepts
Endocytic cycle
Endocytosis
Cell biology
Biology
Internalization
Signal transduction
Receptor-mediated endocytosis
Endosome
Clathrin
Cell
Biochemistry
Intracellular
Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.3390/ijms24032971
- https://www.mdpi.com/1422-0067/24/3/2971/pdf?version=1675407378
- OA Status
- gold
- Cited By
- 47
- References
- 208
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4319158657
All OpenAlex metadata
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https://doi.org/10.3390/ijms24032971Digital Object Identifier
- Title
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Insights of Endocytosis Signaling in Health and DiseaseWork title
- Type
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reviewOpenAlex work type
- Language
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enPrimary language
- Publication year
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2023Year of publication
- Publication date
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2023-02-03Full publication date if available
- Authors
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Chandramani Pathak, Foram U. Vaidya, Bhargav N. Waghela, Pradip Kumar Jaiswara, Vishal Gupta, Ajay Kumar, Barani Kumar Rajendran, Kishu RanjanList of authors in order
- Landing page
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https://doi.org/10.3390/ijms24032971Publisher landing page
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https://www.mdpi.com/1422-0067/24/3/2971/pdf?version=1675407378Direct link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://www.mdpi.com/1422-0067/24/3/2971/pdf?version=1675407378Direct OA link when available
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Endocytic cycle, Endocytosis, Cell biology, Biology, Internalization, Signal transduction, Receptor-mediated endocytosis, Endosome, Clathrin, Cell, Biochemistry, IntracellularTop concepts (fields/topics) attached by OpenAlex
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47Total citation count in OpenAlex
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2025: 19, 2024: 18, 2023: 10Per-year citation counts (last 5 years)
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208Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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| cited_by_percentile_year.min | 99 |
| corresponding_author_ids | https://openalex.org/A5068990409, https://openalex.org/A5041310808 |
| countries_distinct_count | 2 |
| institutions_distinct_count | 8 |
| corresponding_institution_ids | https://openalex.org/I32971472, https://openalex.org/I4210107677 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.7099999785423279 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.99128401 |
| citation_normalized_percentile.is_in_top_1_percent | True |
| citation_normalized_percentile.is_in_top_10_percent | True |