InSillyClo, a user-friendly web application to assist large-scale Golden Gate Cloning and MoClo workflows Article Swipe
Henri Galez
,
Bryan Brancotte
,
Juliette Bonche
,
Julien Fumey
,
Sara Napolitano
,
Grégory Batt
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1101/2025.07.31.667881
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1101/2025.07.31.667881
Systems and synthetic biology developments often require the construction of many variants of a genetic circuit of interest, resulting in large-scale cloning campaigns. Golden Gate and Modular Cloning (MoClo), two powerful technologies enabling the scale-up of cloning workflows, play a central role for efficient circuit construction. These workflows include a number of dry-lab tasks, which are time-consuming and error-prone at scale. Currently, no software tool is available to handle these tasks in a dedicated, time-saving, and user-friendly manner. We present InSillyClo, an open-source web application to assist large-scale Golden Gate cloning and MoClo workflows. It supports an easy specification of genetic designs at any scale, followed by the automated generation of comprehensive workflow-related data. Moreover, InSillyClo leverages Modular Cloning with a versatile typing system of parts to generate user-defined workflows. InSillyClo is open source, accessible with or without user registration, and can also be used locally.
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Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.1101/2025.07.31.667881
- https://www.biorxiv.org/content/biorxiv/early/2025/07/31/2025.07.31.667881.full.pdf
- OA Status
- green
- References
- 24
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4412817846
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4412817846Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1101/2025.07.31.667881Digital Object Identifier
- Title
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InSillyClo, a user-friendly web application to assist large-scale Golden Gate Cloning and MoClo workflowsWork title
- Type
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preprintOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
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2025-07-31Full publication date if available
- Authors
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Henri Galez, Bryan Brancotte, Juliette Bonche, Julien Fumey, Sara Napolitano, Grégory BattList of authors in order
- Landing page
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https://doi.org/10.1101/2025.07.31.667881Publisher landing page
- PDF URL
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https://www.biorxiv.org/content/biorxiv/early/2025/07/31/2025.07.31.667881.full.pdfDirect link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
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https://www.biorxiv.org/content/biorxiv/early/2025/07/31/2025.07.31.667881.full.pdfDirect OA link when available
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Golden gate, Workflow, Scale (ratio), Cloning (programming), Computer science, World Wide Web, Web application, Engineering, Programming language, Database, Geography, Cartography, Civil engineering, Span (engineering)Top concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
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24Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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