bioRxiv (Cold Spring Harbor Laboratory)
Integrated multiomics implicates dysregulation of ECM and cell adhesion pathways as drivers of severe COVID-associated kidney injury
March 2024 • Nanditha Anandakrishnan, Zhengzi Yi, Zeguo Sun, Ying Liu, Jonathan C. Haydak, Sean Eddy, Pushkala Jayaraman, Stefanie DeFronzo, Aparna Saha, Qian Sun…
Abstract COVID-19 has been a significant public health concern for the last four years; however, little is known about the mechanisms that lead to severe COVID-associated kidney injury. In this multicenter study, we combined quantitative deep urinary proteomics and machine learning to predict severe acute outcomes in hospitalized COVID-19 patients. Using a 10-fold cross-validated random forest algorithm, we identified a set of urinary proteins that demonstrated predictive power for both discovery and validation se…