Integrating computational insights in gold nanoparticle-mediated drug delivery: enhancing efficacy and precision Article Swipe
Amnah Alalmaie
,
Hend Faye AL-shahrani
,
Manar Alqahtani
,
Zeyad Alshahrani
,
Shahad Alahmari
,
Abdullah M. Asiri
,
Bandar Alqadi
,
Abdulrahman Alshahrani
,
Safar A. AlShahrani
,
Md Habban Akhter
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3389/fmedt.2025.1528826
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3389/fmedt.2025.1528826
Gold nanoparticles (AuNPs) have emerged as a versatile platform in biomedical applications, particularly in drug delivery, cancer therapy, and diagnostics, due to their unique physicochemical properties. This review focuses on the integration of computational methods and artificial intelligence (AI) with nanotechnology to optimize AuNP-based therapies. Computational modeling is essential for understanding the interactions between AuNPs and biological molecules, guiding nanoparticle design for improved targeting, stability, and therapeutic efficacy. Recent advancements, including AI-driven models in precision cancer therapy and the combination of AuNPs with antimicrobial peptides (AMPs) to combat drug-resistant pathogens, are highlighted. The review also discusses challenges such as toxicity, targeting efficiency, and the need for scalable synthesis, alongside the limitations of computational modeling in capturing complex biological environments. Emphasizing the importance of ongoing research and interdisciplinary collaboration, this review underscores the potential of integrating computational insights with AuNP technology to enhance the precision, safety, and effectiveness of therapeutic and diagnostic approaches.
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Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.3389/fmedt.2025.1528826
- https://www.frontiersin.org/journals/medical-technology/articles/10.3389/fmedt.2025.1528826/pdf
- OA Status
- gold
- Cited By
- 7
- References
- 91
- Related Works
- 10
- OpenAlex ID
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All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4407902895Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3389/fmedt.2025.1528826Digital Object Identifier
- Title
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Integrating computational insights in gold nanoparticle-mediated drug delivery: enhancing efficacy and precisionWork title
- Type
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reviewOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
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2025-02-24Full publication date if available
- Authors
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Amnah Alalmaie, Hend Faye AL-shahrani, Manar Alqahtani, Zeyad Alshahrani, Shahad Alahmari, Abdullah M. Asiri, Bandar Alqadi, Abdulrahman Alshahrani, Safar A. AlShahrani, Md Habban AkhterList of authors in order
- Landing page
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https://doi.org/10.3389/fmedt.2025.1528826Publisher landing page
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https://www.frontiersin.org/journals/medical-technology/articles/10.3389/fmedt.2025.1528826/pdfDirect link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
- OA URL
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https://www.frontiersin.org/journals/medical-technology/articles/10.3389/fmedt.2025.1528826/pdfDirect OA link when available
- Concepts
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Nanotechnology, Drug delivery, Computer science, Cancer therapy, Colloidal gold, Biochemical engineering, Nanoparticle, Engineering, Materials science, Cancer, Medicine, Internal medicineTop concepts (fields/topics) attached by OpenAlex
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7Total citation count in OpenAlex
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2025: 7Per-year citation counts (last 5 years)
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91Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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