Integrating Multiple Database Resources to Elucidate the Gene Flow in Southeast Asian Pig Populations Article Swipe
YOU?
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· 2024
· Open Access
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· DOI: https://doi.org/10.3390/ijms25115689
The domestic pig (Sus scrofa) and its subfamilies have experienced long-term and extensive gene flow, particularly in Southeast Asia. Here, we analyzed 236 pigs, focusing on Yunnan indigenous, European commercial, East Asian, and Southeast Asian breeds, using the Pig Genomics Reference Panel (PGRP v1) of Pig Genotype-Tissue Expression (PigGTEx) to investigate gene flow and associated complex traits by integrating multiple database resources. In this study, we discovered evidence of admixtures from European pigs into the genome of Yunnan indigenous pigs. Additionally, we hypothesized that a potential conceptual gene flow route that may have contributed to the genetic composition of the Diannan small-ear pig is a gene exchange from the Vietnamese pig. Based on the most stringent gene introgression scan using the fd statistic, we identified three specific loci on chromosome 8, ranging from 51.65 to 52.45 Mb, which exhibited strong signatures of selection and harbored the NAF1, NPY1R, and NPY5R genes. These genes are associated with complex traits, such as fat mass, immunity, and litter weight, in pigs, as supported by multiple bio-functionalization databases. We utilized multiple databases to explore the potential dynamics of genetic exchange in Southeast Asian pig populations and elucidated specific gene functionalities.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/ijms25115689
- https://www.mdpi.com/1422-0067/25/11/5689/pdf?version=1716468447
- OA Status
- gold
- References
- 74
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4398236630
Raw OpenAlex JSON
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https://openalex.org/W4398236630Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/ijms25115689Digital Object Identifier
- Title
-
Integrating Multiple Database Resources to Elucidate the Gene Flow in Southeast Asian Pig PopulationsWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
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2024Year of publication
- Publication date
-
2024-05-23Full publication date if available
- Authors
-
Guangzhen Li, Yuqiang Liu, Xueyan Feng, Shuqi Diao, Zhanming Zhong, Bolang Li, Jinyan Teng, Wenjing Zhang, Haonan Zeng, Xiaodian Cai, Yahui Gao, Xiaohong Liu, Xiaolong Yuan, Jiaqi Li, Zhe ZhangList of authors in order
- Landing page
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https://doi.org/10.3390/ijms25115689Publisher landing page
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https://www.mdpi.com/1422-0067/25/11/5689/pdf?version=1716468447Direct link to full text PDF
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
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https://www.mdpi.com/1422-0067/25/11/5689/pdf?version=1716468447Direct OA link when available
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Gene flow, Database, Biology, Southeast asia, Domestic pig, Gene, Evolutionary biology, Computational biology, Genetics, Geography, Computer science, Ethnology, Genetic variation, History, ForestryTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
- References (count)
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74Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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