Integrating surgical intervention and watch-and-wait approach in dMMR metastatic rectal cancer with pembrolizumab: a case report Article Swipe
Yohei Ando
,
Tsubasa Sakurai
,
Kosuke Ozaki
,
Shimpei Matsui
,
Toshiki Mukai
,
Tomohiro Yamaguchi
,
Takashi Akiyoshi
,
Izuma Nakayama
,
Yasuyuki Shigematsu
,
Atsushi Oba
,
Akiko Chino
,
Yosuke Fukunaga
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1186/s40792-024-01994-8
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1186/s40792-024-01994-8
Background Treating rectal cancer presents challenges due to postoperative complications and reduced quality of life (QOL). Recent evidence supports the watch-and-wait (WW) approach for patients with a clinical complete response (cCR) following preoperative treatment. In this report, we discuss a case of metastatic rectal cancer with deficient mismatch repair (dMMR) treated successfully with pembrolizumab. Case presentation A 47-year-old male with dMMR rectal cancer and a single liver metastasis underwent treatment with pembrolizumab as neoadjuvant therapy. After 10 courses, the rectal lesion achieved cCR, prompting the selection of the WW approach. The liver metastasis showed significant shrinkage; however, the presence of a residual tumor was suspected, leading to a metastasectomy. A pathological complete response (pCR) was confirmed via histological examination. During a 24-month follow-up, there was no evidence of tumor regrowth, local recurrence, or distant metastasis. Conclusions The WW strategy is increasingly accepted for patients achieving cCR after preoperative treatment. While pCR in dMMR rectal cancer patients treated with immune checkpoint inhibitors (ICIs) has been documented, accurately predicting pCR from imaging remains challenging. This case illustrates that integrating ICI therapy, surgical interventions, and the WW approach can effectively achieve both oncological safety and improved QOL in the treatment of dMMR metastatic rectal cancer.
Related Topics
Concepts
Pembrolizumab
Medicine
Colorectal cancer
Metastasectomy
Metastasis
Cancer
Oncology
Internal medicine
Radiology
Surgery
Immunotherapy
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1186/s40792-024-01994-8
- OA Status
- gold
- Cited By
- 4
- References
- 32
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4401868374
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4401868374Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1186/s40792-024-01994-8Digital Object Identifier
- Title
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Integrating surgical intervention and watch-and-wait approach in dMMR metastatic rectal cancer with pembrolizumab: a case reportWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2024Year of publication
- Publication date
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2024-08-26Full publication date if available
- Authors
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Yohei Ando, Tsubasa Sakurai, Kosuke Ozaki, Shimpei Matsui, Toshiki Mukai, Tomohiro Yamaguchi, Takashi Akiyoshi, Izuma Nakayama, Yasuyuki Shigematsu, Atsushi Oba, Akiko Chino, Yosuke FukunagaList of authors in order
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https://doi.org/10.1186/s40792-024-01994-8Publisher landing page
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://doi.org/10.1186/s40792-024-01994-8Direct OA link when available
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Pembrolizumab, Medicine, Colorectal cancer, Metastasectomy, Metastasis, Cancer, Oncology, Internal medicine, Radiology, Surgery, ImmunotherapyTop concepts (fields/topics) attached by OpenAlex
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4Total citation count in OpenAlex
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2025: 4Per-year citation counts (last 5 years)
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10Other works algorithmically related by OpenAlex
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