Clinical and Translational Medicine • Vol 14 • No 6
Integrative genomic analyses of European intrahepatic cholangiocarcinoma: Novel <i>ROS1</i> fusion gene and PBX1 as prognostic marker
June 2024 • Patrick Sven Plum, Timo Hess, Denis Bertrand, Isabelle Morgenstern, Oscar Velázquez Camacho, Christoph Jonas, Christina Alidousty, B. Wagner, Stéphan…
Abstract Background Cholangiocarcinoma (CCA) is a fatal cancer of the bile duct with a poor prognosis owing to limited therapeutic options. The incidence of intrahepatic CCA (iCCA) is increasing worldwide, and its molecular basis is emerging. Environmental factors may contribute to regional differences in the mutation spectrum of European patients with iCCA, which are underrepresented in systematic genomic and transcriptomic studies of the disease. Methods We describe an integrated whole‐exome sequencing and trans…