Integrin Activation Controls Regulatory T Cell–Mediated Peripheral Tolerance Article Swipe
Jane Elizabeth Klann
,
Stephanie H. Kim
,
Kelly A. Remedios
,
Zhaoren He
,
Patrick J Metz
,
Justine Lopez
,
Tiffani Tysl
,
Jocelyn G. Olvera
,
Jailal Ablack
,
Joseph M. Cantor
,
Brigid S. Boland
,
G Yeo
,
Ye Zheng
,
Li‐Fan Lu
,
Jack D. Bui
,
Mark H. Ginsberg
,
Brian G. Petrich
,
John T. Chang
·
YOU?
·
· 2018
· Open Access
·
· DOI: https://doi.org/10.4049/jimmunol.1800112
YOU?
·
· 2018
· Open Access
·
· DOI: https://doi.org/10.4049/jimmunol.1800112
Maintenance of the regulatory T (Treg) cell pool is essential for peripheral tolerance and prevention of autoimmunity. Integrins, heterodimeric transmembrane proteins consisting of α and β subunits that mediate cell-to-cell and cell-to-extracellular matrix interactions, play an important role in facilitating Treg cell contact–mediated suppression. In this article, we show that integrin activation plays an essential, previously unappreciated role in maintaining murine Treg cell function. Treg cell–specific loss of talin, a β integrin–binding protein, or expression of talin(L325R), a mutant that selectively abrogates integrin activation, resulted in lethal systemic autoimmunity. This dysfunction could be attributed, in part, to a global dysregulation of the Treg cell transcriptome. Activation of integrin α4β1 led to increased suppressive capacity of the Treg cell pool, suggesting that modulating integrin activation on Treg cells may be a useful therapeutic strategy for autoimmune and inflammatory disorders. Taken together, these results reveal a critical role for integrin-mediated signals in controlling peripheral tolerance by virtue of maintaining Treg cell function.
Related Topics
Concepts
Integrin
Cell biology
Peripheral tolerance
Peripheral
Chemistry
Cell
Biology
Medicine
Immunology
T cell
Internal medicine
Genetics
Immune system
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.4049/jimmunol.1800112
- https://www.jimmunol.org/content/jimmunol/200/12/4012.full.pdf
- OA Status
- bronze
- Cited By
- 36
- References
- 55
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2799968483
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W2799968483Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.4049/jimmunol.1800112Digital Object Identifier
- Title
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Integrin Activation Controls Regulatory T Cell–Mediated Peripheral ToleranceWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2018Year of publication
- Publication date
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2018-04-27Full publication date if available
- Authors
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Jane Elizabeth Klann, Stephanie H. Kim, Kelly A. Remedios, Zhaoren He, Patrick J Metz, Justine Lopez, Tiffani Tysl, Jocelyn G. Olvera, Jailal Ablack, Joseph M. Cantor, Brigid S. Boland, G Yeo, Ye Zheng, Li‐Fan Lu, Jack D. Bui, Mark H. Ginsberg, Brian G. Petrich, John T. ChangList of authors in order
- Landing page
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https://doi.org/10.4049/jimmunol.1800112Publisher landing page
- PDF URL
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https://www.jimmunol.org/content/jimmunol/200/12/4012.full.pdfDirect link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
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bronzeOpen access status per OpenAlex
- OA URL
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https://www.jimmunol.org/content/jimmunol/200/12/4012.full.pdfDirect OA link when available
- Concepts
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Integrin, Cell biology, Peripheral tolerance, Peripheral, Chemistry, Cell, Biology, Medicine, Immunology, T cell, Internal medicine, Genetics, Immune systemTop concepts (fields/topics) attached by OpenAlex
- Cited by
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36Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 6, 2024: 3, 2023: 5, 2022: 3, 2021: 9Per-year citation counts (last 5 years)
- References (count)
-
55Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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| referenced_works | https://openalex.org/W1870664662, https://openalex.org/W2734694910, https://openalex.org/W2090659127, https://openalex.org/W2130123417, https://openalex.org/W2081177433, https://openalex.org/W2105183595, https://openalex.org/W2029599639, https://openalex.org/W1562441478, https://openalex.org/W2155942922, https://openalex.org/W2616640062, https://openalex.org/W1992662011, https://openalex.org/W1486722793, https://openalex.org/W1499151513, https://openalex.org/W2087637747, https://openalex.org/W2079439641, https://openalex.org/W2027415000, https://openalex.org/W1962132325, https://openalex.org/W2063966481, https://openalex.org/W2106190040, https://openalex.org/W2084416533, https://openalex.org/W2157012084, https://openalex.org/W2025101860, https://openalex.org/W1966835463, https://openalex.org/W2111803487, https://openalex.org/W2130486201, https://openalex.org/W2030284768, https://openalex.org/W2128433513, https://openalex.org/W2084302112, https://openalex.org/W2005532545, https://openalex.org/W1922600631, https://openalex.org/W2128856901, https://openalex.org/W2063648700, https://openalex.org/W2160167330, https://openalex.org/W2068639447, https://openalex.org/W2134591209, https://openalex.org/W1966073503, https://openalex.org/W2149093044, https://openalex.org/W2109188553, https://openalex.org/W2134053452, https://openalex.org/W2050106278, https://openalex.org/W1594207045, https://openalex.org/W2065840402, https://openalex.org/W2294118174, https://openalex.org/W2994234715, https://openalex.org/W2433805774, https://openalex.org/W2136384184, https://openalex.org/W1974313653, https://openalex.org/W2141649011, https://openalex.org/W2026552675, https://openalex.org/W2743329177, https://openalex.org/W2135990933, https://openalex.org/W2573554064, https://openalex.org/W2577764248, https://openalex.org/W2271164797, https://openalex.org/W2737785069 |
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| corresponding_author_ids | https://openalex.org/A5086030999, https://openalex.org/A5012998783 |
| countries_distinct_count | 2 |
| institutions_distinct_count | 18 |
| corresponding_institution_ids | https://openalex.org/I150468666, https://openalex.org/I36258959, https://openalex.org/I4210110477 |
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| sustainable_development_goals[0].display_name | Good health and well-being |
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