Intensive single-cell analysis reveals immune-cell diversity among healthy individuals Article Swipe
Yukie Kashima
,
Keiya Kaneko
,
Patrick Reteng
,
Nina Yoshitake
,
Lucky Ronald Runtuwene
,
Satoi Nagasawa
,
Masaya Onishi
,
Masahide Seki
,
Ayako Suzuki
,
Sumio Sugano
,
Mamiko Sakata‐Yanagimoto
,
Yumiko Imai
,
Kaori Nakayama‐Hosoya
,
Ai Kawana‐Tachikawa
,
Taketoshi Mizutani
,
Yutaka Suzuki
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.26508/lsa.202201398
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.26508/lsa.202201398
Immune responses are different between individuals and personal health histories and unique environmental conditions should collectively determine the present state of immune cells. However, the molecular systems underlying such heterogeneity remain elusive. Here, we conducted a systematic time-lapse single-cell analysis, using 171 single-cell libraries and 30 mass cytometry datasets intensively for seven healthy individuals. We found substantial diversity in immune-cell profiles between different individuals. These patterns showed daily fluctuations even within the same individual. Similar diversities were also observed for the T-cell and B-cell receptor repertoires. Detailed immune-cell profiles at healthy statuses should give essential background information to understand their immune responses, when the individual is exposed to various environmental conditions. To demonstrate this idea, we conducted the similar analysis for the same individuals on the vaccination of influenza and SARS-CoV-2. In fact, we detected distinct responses to vaccines between individuals, although key responses are common. Single-cell immune-cell profile data should make fundamental data resource to understand variable immune responses, which are unique to each individual.
Related Topics
Concepts
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.26508/lsa.202201398
- https://www.life-science-alliance.org/content/lsa/5/7/e202201398.full.pdf
- OA Status
- gold
- Cited By
- 8
- References
- 40
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4226150303
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4226150303Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.26508/lsa.202201398Digital Object Identifier
- Title
-
Intensive single-cell analysis reveals immune-cell diversity among healthy individualsWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2022Year of publication
- Publication date
-
2022-04-05Full publication date if available
- Authors
-
Yukie Kashima, Keiya Kaneko, Patrick Reteng, Nina Yoshitake, Lucky Ronald Runtuwene, Satoi Nagasawa, Masaya Onishi, Masahide Seki, Ayako Suzuki, Sumio Sugano, Mamiko Sakata‐Yanagimoto, Yumiko Imai, Kaori Nakayama‐Hosoya, Ai Kawana‐Tachikawa, Taketoshi Mizutani, Yutaka SuzukiList of authors in order
- Landing page
-
https://doi.org/10.26508/lsa.202201398Publisher landing page
- PDF URL
-
https://www.life-science-alliance.org/content/lsa/5/7/e202201398.full.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.life-science-alliance.org/content/lsa/5/7/e202201398.full.pdfDirect OA link when available
- Concepts
-
Immune system, Mass cytometry, Biology, Cell, Single-cell analysis, Immunology, Genetics, Phenotype, GeneTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
8Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 1, 2024: 4, 2023: 2, 2022: 1Per-year citation counts (last 5 years)
- References (count)
-
40Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W4226150303 |
|---|---|
| doi | https://doi.org/10.26508/lsa.202201398 |
| ids.doi | https://doi.org/10.26508/lsa.202201398 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/35383111 |
| ids.openalex | https://openalex.org/W4226150303 |
| fwci | 0.98455326 |
| mesh[0].qualifier_ui | |
| mesh[0].descriptor_ui | D000086382 |
| mesh[0].is_major_topic | True |
| mesh[0].qualifier_name | |
| mesh[0].descriptor_name | COVID-19 |
| mesh[1].qualifier_ui | |
| mesh[1].descriptor_ui | D000086663 |
| mesh[1].is_major_topic | False |
| mesh[1].qualifier_name | |
| mesh[1].descriptor_name | COVID-19 Vaccines |
| mesh[2].qualifier_ui | |
| mesh[2].descriptor_ui | D006801 |
| mesh[2].is_major_topic | False |
| mesh[2].qualifier_name | |
| mesh[2].descriptor_name | Humans |
| mesh[3].qualifier_ui | |
| mesh[3].descriptor_ui | D000086402 |
| mesh[3].is_major_topic | False |
| mesh[3].qualifier_name | |
| mesh[3].descriptor_name | SARS-CoV-2 |
| mesh[4].qualifier_ui | |
| mesh[4].descriptor_ui | D059010 |
| mesh[4].is_major_topic | True |
| mesh[4].qualifier_name | |
| mesh[4].descriptor_name | Single-Cell Analysis |
| mesh[5].qualifier_ui | |
| mesh[5].descriptor_ui | D014611 |
| mesh[5].is_major_topic | False |
| mesh[5].qualifier_name | |
| mesh[5].descriptor_name | Vaccination |
| mesh[6].qualifier_ui | |
| mesh[6].descriptor_ui | D000086382 |
| mesh[6].is_major_topic | True |
| mesh[6].qualifier_name | |
| mesh[6].descriptor_name | COVID-19 |
| mesh[7].qualifier_ui | |
| mesh[7].descriptor_ui | D000086663 |
| mesh[7].is_major_topic | False |
| mesh[7].qualifier_name | |
| mesh[7].descriptor_name | COVID-19 Vaccines |
| mesh[8].qualifier_ui | |
| mesh[8].descriptor_ui | D006801 |
| mesh[8].is_major_topic | False |
| mesh[8].qualifier_name | |
| mesh[8].descriptor_name | Humans |
| mesh[9].qualifier_ui | |
| mesh[9].descriptor_ui | D000086402 |
| mesh[9].is_major_topic | False |
| mesh[9].qualifier_name | |
| mesh[9].descriptor_name | SARS-CoV-2 |
| mesh[10].qualifier_ui | |
| mesh[10].descriptor_ui | D059010 |
| mesh[10].is_major_topic | True |
| mesh[10].qualifier_name | |
| mesh[10].descriptor_name | Single-Cell Analysis |
| mesh[11].qualifier_ui | |
| mesh[11].descriptor_ui | D014611 |
| mesh[11].is_major_topic | False |
| mesh[11].qualifier_name | |
| mesh[11].descriptor_name | Vaccination |
| type | article |
| title | Intensive single-cell analysis reveals immune-cell diversity among healthy individuals |
| biblio.issue | 7 |
| biblio.volume | 5 |
| biblio.last_page | e202201398 |
| biblio.first_page | e202201398 |
| topics[0].id | https://openalex.org/T11289 |
| topics[0].field.id | https://openalex.org/fields/13 |
| topics[0].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[0].score | 0.9998000264167786 |
| topics[0].domain.id | https://openalex.org/domains/1 |
| topics[0].domain.display_name | Life Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/1312 |
| topics[0].subfield.display_name | Molecular Biology |
| topics[0].display_name | Single-cell and spatial transcriptomics |
| topics[1].id | https://openalex.org/T10031 |
| topics[1].field.id | https://openalex.org/fields/24 |
| topics[1].field.display_name | Immunology and Microbiology |
| topics[1].score | 0.9977999925613403 |
| topics[1].domain.id | https://openalex.org/domains/1 |
| topics[1].domain.display_name | Life Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/2403 |
| topics[1].subfield.display_name | Immunology |
| topics[1].display_name | T-cell and B-cell Immunology |
| topics[2].id | https://openalex.org/T11020 |
| topics[2].field.id | https://openalex.org/fields/24 |
| topics[2].field.display_name | Immunology and Microbiology |
| topics[2].score | 0.9951000213623047 |
| topics[2].domain.id | https://openalex.org/domains/1 |
| topics[2].domain.display_name | Life Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/2403 |
| topics[2].subfield.display_name | Immunology |
| topics[2].display_name | Immune Cell Function and Interaction |
| is_xpac | False |
| apc_list.value | 3500 |
| apc_list.currency | USD |
| apc_list.value_usd | 3500 |
| apc_paid.value | 3500 |
| apc_paid.currency | USD |
| apc_paid.value_usd | 3500 |
| concepts[0].id | https://openalex.org/C8891405 |
| concepts[0].level | 2 |
| concepts[0].score | 0.8729074001312256 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q1059 |
| concepts[0].display_name | Immune system |
| concepts[1].id | https://openalex.org/C2778015335 |
| concepts[1].level | 4 |
| concepts[1].score | 0.8294827938079834 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q17051163 |
| concepts[1].display_name | Mass cytometry |
| concepts[2].id | https://openalex.org/C86803240 |
| concepts[2].level | 0 |
| concepts[2].score | 0.6841059923171997 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q420 |
| concepts[2].display_name | Biology |
| concepts[3].id | https://openalex.org/C1491633281 |
| concepts[3].level | 2 |
| concepts[3].score | 0.5785367488861084 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q7868 |
| concepts[3].display_name | Cell |
| concepts[4].id | https://openalex.org/C2776950831 |
| concepts[4].level | 3 |
| concepts[4].score | 0.5189213752746582 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q15635432 |
| concepts[4].display_name | Single-cell analysis |
| concepts[5].id | https://openalex.org/C203014093 |
| concepts[5].level | 1 |
| concepts[5].score | 0.5123683214187622 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q101929 |
| concepts[5].display_name | Immunology |
| concepts[6].id | https://openalex.org/C54355233 |
| concepts[6].level | 1 |
| concepts[6].score | 0.23512229323387146 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q7162 |
| concepts[6].display_name | Genetics |
| concepts[7].id | https://openalex.org/C127716648 |
| concepts[7].level | 3 |
| concepts[7].score | 0.21587899327278137 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q104053 |
| concepts[7].display_name | Phenotype |
| concepts[8].id | https://openalex.org/C104317684 |
| concepts[8].level | 2 |
| concepts[8].score | 0.08698475360870361 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q7187 |
| concepts[8].display_name | Gene |
| keywords[0].id | https://openalex.org/keywords/immune-system |
| keywords[0].score | 0.8729074001312256 |
| keywords[0].display_name | Immune system |
| keywords[1].id | https://openalex.org/keywords/mass-cytometry |
| keywords[1].score | 0.8294827938079834 |
| keywords[1].display_name | Mass cytometry |
| keywords[2].id | https://openalex.org/keywords/biology |
| keywords[2].score | 0.6841059923171997 |
| keywords[2].display_name | Biology |
| keywords[3].id | https://openalex.org/keywords/cell |
| keywords[3].score | 0.5785367488861084 |
| keywords[3].display_name | Cell |
| keywords[4].id | https://openalex.org/keywords/single-cell-analysis |
| keywords[4].score | 0.5189213752746582 |
| keywords[4].display_name | Single-cell analysis |
| keywords[5].id | https://openalex.org/keywords/immunology |
| keywords[5].score | 0.5123683214187622 |
| keywords[5].display_name | Immunology |
| keywords[6].id | https://openalex.org/keywords/genetics |
| keywords[6].score | 0.23512229323387146 |
| keywords[6].display_name | Genetics |
| keywords[7].id | https://openalex.org/keywords/phenotype |
| keywords[7].score | 0.21587899327278137 |
| keywords[7].display_name | Phenotype |
| keywords[8].id | https://openalex.org/keywords/gene |
| keywords[8].score | 0.08698475360870361 |
| keywords[8].display_name | Gene |
| language | en |
| locations[0].id | doi:10.26508/lsa.202201398 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S4210202458 |
| locations[0].source.issn | 2575-1077 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | True |
| locations[0].source.issn_l | 2575-1077 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | True |
| locations[0].source.display_name | Life Science Alliance |
| locations[0].source.host_organization | |
| locations[0].source.host_organization_name | |
| locations[0].source.host_organization_lineage | |
| locations[0].license | cc-by |
| locations[0].pdf_url | https://www.life-science-alliance.org/content/lsa/5/7/e202201398.full.pdf |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | https://openalex.org/licenses/cc-by |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Life Science Alliance |
| locations[0].landing_page_url | https://doi.org/10.26508/lsa.202201398 |
| locations[1].id | pmid:35383111 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | Life science alliance |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/35383111 |
| locations[2].id | pmh:oai:pubmedcentral.nih.gov:8983398 |
| locations[2].is_oa | True |
| locations[2].source.id | https://openalex.org/S2764455111 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | PubMed Central |
| locations[2].source.host_organization | https://openalex.org/I1299303238 |
| locations[2].source.host_organization_name | National Institutes of Health |
| locations[2].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[2].license | cc-by |
| locations[2].pdf_url | |
| locations[2].version | submittedVersion |
| locations[2].raw_type | Text |
| locations[2].license_id | https://openalex.org/licenses/cc-by |
| locations[2].is_accepted | False |
| locations[2].is_published | False |
| locations[2].raw_source_name | Life Sci Alliance |
| locations[2].landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/8983398 |
| indexed_in | crossref, doaj, pubmed |
| authorships[0].author.id | https://openalex.org/A5047933529 |
| authorships[0].author.orcid | |
| authorships[0].author.display_name | Yukie Kashima |
| authorships[0].countries | JP |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I74801974 |
| authorships[0].affiliations[0].raw_affiliation_string | Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Japan |
| authorships[0].institutions[0].id | https://openalex.org/I74801974 |
| authorships[0].institutions[0].ror | https://ror.org/057zh3y96 |
| authorships[0].institutions[0].type | education |
| authorships[0].institutions[0].lineage | https://openalex.org/I74801974 |
| authorships[0].institutions[0].country_code | JP |
| authorships[0].institutions[0].display_name | The University of Tokyo |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Yukie Kashima |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Japan |
| authorships[1].author.id | https://openalex.org/A5061523093 |
| authorships[1].author.orcid | |
| authorships[1].author.display_name | Keiya Kaneko |
| authorships[1].countries | JP |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I74801974 |
| authorships[1].affiliations[0].raw_affiliation_string | Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Japan |
| authorships[1].institutions[0].id | https://openalex.org/I74801974 |
| authorships[1].institutions[0].ror | https://ror.org/057zh3y96 |
| authorships[1].institutions[0].type | education |
| authorships[1].institutions[0].lineage | https://openalex.org/I74801974 |
| authorships[1].institutions[0].country_code | JP |
| authorships[1].institutions[0].display_name | The University of Tokyo |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Keiya Kaneko |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Japan |
| authorships[2].author.id | https://openalex.org/A5059932250 |
| authorships[2].author.orcid | https://orcid.org/0000-0002-3711-1375 |
| authorships[2].author.display_name | Patrick Reteng |
| authorships[2].countries | JP |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I205349734 |
| authorships[2].affiliations[0].raw_affiliation_string | Division of Collaboration and Education, International Institute for Zoonosis Control, Hokkaido University, Sapporo, Japan |
| authorships[2].institutions[0].id | https://openalex.org/I205349734 |
| authorships[2].institutions[0].ror | https://ror.org/02e16g702 |
| authorships[2].institutions[0].type | education |
| authorships[2].institutions[0].lineage | https://openalex.org/I205349734 |
| authorships[2].institutions[0].country_code | JP |
| authorships[2].institutions[0].display_name | Hokkaido University |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Patrick Reteng |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Division of Collaboration and Education, International Institute for Zoonosis Control, Hokkaido University, Sapporo, Japan |
| authorships[3].author.id | https://openalex.org/A5033559013 |
| authorships[3].author.orcid | |
| authorships[3].author.display_name | Nina Yoshitake |
| authorships[3].countries | JP |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I74801974 |
| authorships[3].affiliations[0].raw_affiliation_string | Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Japan |
| authorships[3].institutions[0].id | https://openalex.org/I74801974 |
| authorships[3].institutions[0].ror | https://ror.org/057zh3y96 |
| authorships[3].institutions[0].type | education |
| authorships[3].institutions[0].lineage | https://openalex.org/I74801974 |
| authorships[3].institutions[0].country_code | JP |
| authorships[3].institutions[0].display_name | The University of Tokyo |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Nina Yoshitake |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Japan |
| authorships[4].author.id | https://openalex.org/A5037338533 |
| authorships[4].author.orcid | https://orcid.org/0000-0003-3782-3628 |
| authorships[4].author.display_name | Lucky Ronald Runtuwene |
| authorships[4].countries | JP |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I4210086300 |
| authorships[4].affiliations[0].raw_affiliation_string | AIDS Research Center, National Institute of Infectious Disease, Tokyo, Japan |
| authorships[4].institutions[0].id | https://openalex.org/I4210086300 |
| authorships[4].institutions[0].ror | https://ror.org/001ggbx22 |
| authorships[4].institutions[0].type | government |
| authorships[4].institutions[0].lineage | https://openalex.org/I1333985979, https://openalex.org/I4210086300 |
| authorships[4].institutions[0].country_code | JP |
| authorships[4].institutions[0].display_name | National Institute of Infectious Diseases |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Lucky Ronald Runtuwene |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | AIDS Research Center, National Institute of Infectious Disease, Tokyo, Japan |
| authorships[5].author.id | https://openalex.org/A5059103569 |
| authorships[5].author.orcid | https://orcid.org/0000-0003-3967-7644 |
| authorships[5].author.display_name | Satoi Nagasawa |
| authorships[5].countries | JP |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I163917720 |
| authorships[5].affiliations[0].raw_affiliation_string | Division of Breast and Endocrine Surgery, Department of Surgery, St. Marianna University School of Medicine, Kawasaki, Japan |
| authorships[5].affiliations[1].institution_ids | https://openalex.org/I74801974 |
| authorships[5].affiliations[1].raw_affiliation_string | Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Japan |
| authorships[5].institutions[0].id | https://openalex.org/I163917720 |
| authorships[5].institutions[0].ror | https://ror.org/043axf581 |
| authorships[5].institutions[0].type | education |
| authorships[5].institutions[0].lineage | https://openalex.org/I163917720 |
| authorships[5].institutions[0].country_code | JP |
| authorships[5].institutions[0].display_name | St. Marianna University School of Medicine |
| authorships[5].institutions[1].id | https://openalex.org/I74801974 |
| authorships[5].institutions[1].ror | https://ror.org/057zh3y96 |
| authorships[5].institutions[1].type | education |
| authorships[5].institutions[1].lineage | https://openalex.org/I74801974 |
| authorships[5].institutions[1].country_code | JP |
| authorships[5].institutions[1].display_name | The University of Tokyo |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Satoi Nagasawa |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Japan, Division of Breast and Endocrine Surgery, Department of Surgery, St. Marianna University School of Medicine, Kawasaki, Japan |
| authorships[6].author.id | https://openalex.org/A5109474359 |
| authorships[6].author.orcid | |
| authorships[6].author.display_name | Masaya Onishi |
| authorships[6].countries | JP |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I74801974 |
| authorships[6].affiliations[0].raw_affiliation_string | Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Japan |
| authorships[6].institutions[0].id | https://openalex.org/I74801974 |
| authorships[6].institutions[0].ror | https://ror.org/057zh3y96 |
| authorships[6].institutions[0].type | education |
| authorships[6].institutions[0].lineage | https://openalex.org/I74801974 |
| authorships[6].institutions[0].country_code | JP |
| authorships[6].institutions[0].display_name | The University of Tokyo |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Masaya Onishi |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Japan |
| authorships[7].author.id | https://openalex.org/A5045649013 |
| authorships[7].author.orcid | https://orcid.org/0000-0001-6091-8698 |
| authorships[7].author.display_name | Masahide Seki |
| authorships[7].countries | JP |
| authorships[7].affiliations[0].institution_ids | https://openalex.org/I74801974 |
| authorships[7].affiliations[0].raw_affiliation_string | Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Japan |
| authorships[7].institutions[0].id | https://openalex.org/I74801974 |
| authorships[7].institutions[0].ror | https://ror.org/057zh3y96 |
| authorships[7].institutions[0].type | education |
| authorships[7].institutions[0].lineage | https://openalex.org/I74801974 |
| authorships[7].institutions[0].country_code | JP |
| authorships[7].institutions[0].display_name | The University of Tokyo |
| authorships[7].author_position | middle |
| authorships[7].raw_author_name | Masahide Seki |
| authorships[7].is_corresponding | False |
| authorships[7].raw_affiliation_strings | Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Japan |
| authorships[8].author.id | https://openalex.org/A5090411353 |
| authorships[8].author.orcid | https://orcid.org/0000-0001-9917-2280 |
| authorships[8].author.display_name | Ayako Suzuki |
| authorships[8].countries | JP |
| authorships[8].affiliations[0].institution_ids | https://openalex.org/I74801974 |
| authorships[8].affiliations[0].raw_affiliation_string | Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Japan |
| authorships[8].institutions[0].id | https://openalex.org/I74801974 |
| authorships[8].institutions[0].ror | https://ror.org/057zh3y96 |
| authorships[8].institutions[0].type | education |
| authorships[8].institutions[0].lineage | https://openalex.org/I74801974 |
| authorships[8].institutions[0].country_code | JP |
| authorships[8].institutions[0].display_name | The University of Tokyo |
| authorships[8].author_position | middle |
| authorships[8].raw_author_name | Ayako Suzuki |
| authorships[8].is_corresponding | False |
| authorships[8].raw_affiliation_strings | Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Japan |
| authorships[9].author.id | https://openalex.org/A5056627631 |
| authorships[9].author.orcid | https://orcid.org/0000-0001-8058-2861 |
| authorships[9].author.display_name | Sumio Sugano |
| authorships[9].countries | JP |
| authorships[9].affiliations[0].institution_ids | https://openalex.org/I159385669 |
| authorships[9].affiliations[0].raw_affiliation_string | Future Medicine Education and Research Organization at Chiba University, Chiba-city, Japan |
| authorships[9].affiliations[1].raw_affiliation_string | Institute of Kashiwa-no-ha Omics Gate, Kashiwa, Japan |
| authorships[9].institutions[0].id | https://openalex.org/I159385669 |
| authorships[9].institutions[0].ror | https://ror.org/01hjzeq58 |
| authorships[9].institutions[0].type | education |
| authorships[9].institutions[0].lineage | https://openalex.org/I159385669 |
| authorships[9].institutions[0].country_code | JP |
| authorships[9].institutions[0].display_name | Chiba University |
| authorships[9].author_position | middle |
| authorships[9].raw_author_name | Sumio Sugano |
| authorships[9].is_corresponding | False |
| authorships[9].raw_affiliation_strings | Future Medicine Education and Research Organization at Chiba University, Chiba-city, Japan, Institute of Kashiwa-no-ha Omics Gate, Kashiwa, Japan |
| authorships[10].author.id | https://openalex.org/A5014405945 |
| authorships[10].author.orcid | https://orcid.org/0000-0001-7310-8045 |
| authorships[10].author.display_name | Mamiko Sakata‐Yanagimoto |
| authorships[10].countries | JP |
| authorships[10].affiliations[0].institution_ids | https://openalex.org/I146399215 |
| authorships[10].affiliations[0].raw_affiliation_string | Department of Hematology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan |
| authorships[10].institutions[0].id | https://openalex.org/I146399215 |
| authorships[10].institutions[0].ror | https://ror.org/02956yf07 |
| authorships[10].institutions[0].type | education |
| authorships[10].institutions[0].lineage | https://openalex.org/I146399215 |
| authorships[10].institutions[0].country_code | JP |
| authorships[10].institutions[0].display_name | University of Tsukuba |
| authorships[10].author_position | middle |
| authorships[10].raw_author_name | Mamiko Sakata-Yanagimoto |
| authorships[10].is_corresponding | False |
| authorships[10].raw_affiliation_strings | Department of Hematology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan |
| authorships[11].author.id | https://openalex.org/A5101995033 |
| authorships[11].author.orcid | https://orcid.org/0000-0003-4615-4833 |
| authorships[11].author.display_name | Yumiko Imai |
| authorships[11].countries | JP |
| authorships[11].affiliations[0].institution_ids | https://openalex.org/I4210086383 |
| authorships[11].affiliations[0].raw_affiliation_string | Laboratory of Regulation for Intractable Infectious Diseases, National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN), Osaka, Japan |
| authorships[11].institutions[0].id | https://openalex.org/I4210086383 |
| authorships[11].institutions[0].ror | https://ror.org/001rkbe13 |
| authorships[11].institutions[0].type | facility |
| authorships[11].institutions[0].lineage | https://openalex.org/I4210086383 |
| authorships[11].institutions[0].country_code | JP |
| authorships[11].institutions[0].display_name | National Institute of Biomedical Innovation, Health and Nutrition |
| authorships[11].author_position | middle |
| authorships[11].raw_author_name | Yumiko Imai |
| authorships[11].is_corresponding | False |
| authorships[11].raw_affiliation_strings | Laboratory of Regulation for Intractable Infectious Diseases, National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN), Osaka, Japan |
| authorships[12].author.id | https://openalex.org/A5017329071 |
| authorships[12].author.orcid | |
| authorships[12].author.display_name | Kaori Nakayama‐Hosoya |
| authorships[12].countries | JP |
| authorships[12].affiliations[0].institution_ids | https://openalex.org/I4210086300 |
| authorships[12].affiliations[0].raw_affiliation_string | AIDS Research Center, National Institute of Infectious Disease, Tokyo, Japan |
| authorships[12].institutions[0].id | https://openalex.org/I4210086300 |
| authorships[12].institutions[0].ror | https://ror.org/001ggbx22 |
| authorships[12].institutions[0].type | government |
| authorships[12].institutions[0].lineage | https://openalex.org/I1333985979, https://openalex.org/I4210086300 |
| authorships[12].institutions[0].country_code | JP |
| authorships[12].institutions[0].display_name | National Institute of Infectious Diseases |
| authorships[12].author_position | middle |
| authorships[12].raw_author_name | Kaori Nakayama-Hosoya |
| authorships[12].is_corresponding | False |
| authorships[12].raw_affiliation_strings | AIDS Research Center, National Institute of Infectious Disease, Tokyo, Japan |
| authorships[13].author.id | https://openalex.org/A5049896667 |
| authorships[13].author.orcid | https://orcid.org/0000-0002-3082-5324 |
| authorships[13].author.display_name | Ai Kawana‐Tachikawa |
| authorships[13].countries | JP |
| authorships[13].affiliations[0].institution_ids | https://openalex.org/I4210086300 |
| authorships[13].affiliations[0].raw_affiliation_string | AIDS Research Center, National Institute of Infectious Disease, Tokyo, Japan |
| authorships[13].institutions[0].id | https://openalex.org/I4210086300 |
| authorships[13].institutions[0].ror | https://ror.org/001ggbx22 |
| authorships[13].institutions[0].type | government |
| authorships[13].institutions[0].lineage | https://openalex.org/I1333985979, https://openalex.org/I4210086300 |
| authorships[13].institutions[0].country_code | JP |
| authorships[13].institutions[0].display_name | National Institute of Infectious Diseases |
| authorships[13].author_position | middle |
| authorships[13].raw_author_name | Ai Kawana-Tachikawa |
| authorships[13].is_corresponding | False |
| authorships[13].raw_affiliation_strings | AIDS Research Center, National Institute of Infectious Disease, Tokyo, Japan |
| authorships[14].author.id | https://openalex.org/A5050778947 |
| authorships[14].author.orcid | https://orcid.org/0000-0002-1329-6512 |
| authorships[14].author.display_name | Taketoshi Mizutani |
| authorships[14].countries | JP |
| authorships[14].affiliations[0].institution_ids | https://openalex.org/I74801974 |
| authorships[14].affiliations[0].raw_affiliation_string | Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Japan |
| authorships[14].institutions[0].id | https://openalex.org/I74801974 |
| authorships[14].institutions[0].ror | https://ror.org/057zh3y96 |
| authorships[14].institutions[0].type | education |
| authorships[14].institutions[0].lineage | https://openalex.org/I74801974 |
| authorships[14].institutions[0].country_code | JP |
| authorships[14].institutions[0].display_name | The University of Tokyo |
| authorships[14].author_position | middle |
| authorships[14].raw_author_name | Taketoshi Mizutani |
| authorships[14].is_corresponding | False |
| authorships[14].raw_affiliation_strings | Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Japan |
| authorships[15].author.id | https://openalex.org/A5019488402 |
| authorships[15].author.orcid | https://orcid.org/0000-0002-7559-5139 |
| authorships[15].author.display_name | Yutaka Suzuki |
| authorships[15].countries | JP |
| authorships[15].affiliations[0].institution_ids | https://openalex.org/I74801974 |
| authorships[15].affiliations[0].raw_affiliation_string | Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Japan |
| authorships[15].institutions[0].id | https://openalex.org/I74801974 |
| authorships[15].institutions[0].ror | https://ror.org/057zh3y96 |
| authorships[15].institutions[0].type | education |
| authorships[15].institutions[0].lineage | https://openalex.org/I74801974 |
| authorships[15].institutions[0].country_code | JP |
| authorships[15].institutions[0].display_name | The University of Tokyo |
| authorships[15].author_position | last |
| authorships[15].raw_author_name | Yutaka Suzuki |
| authorships[15].is_corresponding | True |
| authorships[15].raw_affiliation_strings | Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Japan |
| has_content.pdf | True |
| has_content.grobid_xml | True |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://www.life-science-alliance.org/content/lsa/5/7/e202201398.full.pdf |
| open_access.oa_status | gold |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | Intensive single-cell analysis reveals immune-cell diversity among healthy individuals |
| has_fulltext | True |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T11289 |
| primary_topic.field.id | https://openalex.org/fields/13 |
| primary_topic.field.display_name | Biochemistry, Genetics and Molecular Biology |
| primary_topic.score | 0.9998000264167786 |
| primary_topic.domain.id | https://openalex.org/domains/1 |
| primary_topic.domain.display_name | Life Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/1312 |
| primary_topic.subfield.display_name | Molecular Biology |
| primary_topic.display_name | Single-cell and spatial transcriptomics |
| related_works | https://openalex.org/W3170087659, https://openalex.org/W4225983840, https://openalex.org/W4387871881, https://openalex.org/W2387281789, https://openalex.org/W2980678829, https://openalex.org/W4313373490, https://openalex.org/W4387115112, https://openalex.org/W3093527915, https://openalex.org/W3165424022, https://openalex.org/W4255938438 |
| cited_by_count | 8 |
| counts_by_year[0].year | 2025 |
| counts_by_year[0].cited_by_count | 1 |
| counts_by_year[1].year | 2024 |
| counts_by_year[1].cited_by_count | 4 |
| counts_by_year[2].year | 2023 |
| counts_by_year[2].cited_by_count | 2 |
| counts_by_year[3].year | 2022 |
| counts_by_year[3].cited_by_count | 1 |
| locations_count | 3 |
| best_oa_location.id | doi:10.26508/lsa.202201398 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S4210202458 |
| best_oa_location.source.issn | 2575-1077 |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | True |
| best_oa_location.source.issn_l | 2575-1077 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | True |
| best_oa_location.source.display_name | Life Science Alliance |
| best_oa_location.source.host_organization | |
| best_oa_location.source.host_organization_name | |
| best_oa_location.source.host_organization_lineage | |
| best_oa_location.license | cc-by |
| best_oa_location.pdf_url | https://www.life-science-alliance.org/content/lsa/5/7/e202201398.full.pdf |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | Life Science Alliance |
| best_oa_location.landing_page_url | https://doi.org/10.26508/lsa.202201398 |
| primary_location.id | doi:10.26508/lsa.202201398 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S4210202458 |
| primary_location.source.issn | 2575-1077 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | True |
| primary_location.source.issn_l | 2575-1077 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | True |
| primary_location.source.display_name | Life Science Alliance |
| primary_location.source.host_organization | |
| primary_location.source.host_organization_name | |
| primary_location.source.host_organization_lineage | |
| primary_location.license | cc-by |
| primary_location.pdf_url | https://www.life-science-alliance.org/content/lsa/5/7/e202201398.full.pdf |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | https://openalex.org/licenses/cc-by |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Life Science Alliance |
| primary_location.landing_page_url | https://doi.org/10.26508/lsa.202201398 |
| publication_date | 2022-04-05 |
| publication_year | 2022 |
| referenced_works | https://openalex.org/W3024149019, https://openalex.org/W2907514116, https://openalex.org/W3097390342, https://openalex.org/W3002623081, https://openalex.org/W3084198005, https://openalex.org/W2279588067, https://openalex.org/W2461928138, https://openalex.org/W3035982525, https://openalex.org/W3108666979, https://openalex.org/W2990308980, https://openalex.org/W3164692211, https://openalex.org/W2129080097, https://openalex.org/W3042860993, https://openalex.org/W3008241868, https://openalex.org/W3189893840, https://openalex.org/W2792588868, https://openalex.org/W2518536270, https://openalex.org/W3045157310, https://openalex.org/W3080652108, https://openalex.org/W3045190597, https://openalex.org/W2955369607, https://openalex.org/W2911922390, https://openalex.org/W2524387459, https://openalex.org/W3149009232, https://openalex.org/W2163230514, https://openalex.org/W3156994935, https://openalex.org/W2008448390, https://openalex.org/W2752126733, https://openalex.org/W2346039638, https://openalex.org/W2949177718, https://openalex.org/W2763051133, https://openalex.org/W2980897730, https://openalex.org/W3105546145, https://openalex.org/W2969579093, https://openalex.org/W2479362027, https://openalex.org/W2073300038, https://openalex.org/W2133687564, https://openalex.org/W3048884493, https://openalex.org/W3019068524, https://openalex.org/W4255658650 |
| referenced_works_count | 40 |
| abstract_inverted_index.a | 35 |
| abstract_inverted_index.30 | 45 |
| abstract_inverted_index.In | 131 |
| abstract_inverted_index.To | 111 |
| abstract_inverted_index.We | 54 |
| abstract_inverted_index.at | 89 |
| abstract_inverted_index.in | 58 |
| abstract_inverted_index.is | 105 |
| abstract_inverted_index.of | 20, 127 |
| abstract_inverted_index.on | 124 |
| abstract_inverted_index.to | 97, 107, 137, 155, 163 |
| abstract_inverted_index.we | 33, 115, 133 |
| abstract_inverted_index.171 | 41 |
| abstract_inverted_index.and | 6, 10, 44, 82, 129 |
| abstract_inverted_index.are | 2, 144, 161 |
| abstract_inverted_index.for | 50, 79, 120 |
| abstract_inverted_index.key | 142 |
| abstract_inverted_index.the | 17, 24, 71, 80, 103, 117, 121, 125 |
| abstract_inverted_index.also | 77 |
| abstract_inverted_index.data | 149, 153 |
| abstract_inverted_index.each | 164 |
| abstract_inverted_index.even | 69 |
| abstract_inverted_index.give | 93 |
| abstract_inverted_index.make | 151 |
| abstract_inverted_index.mass | 46 |
| abstract_inverted_index.same | 72, 122 |
| abstract_inverted_index.such | 28 |
| abstract_inverted_index.this | 113 |
| abstract_inverted_index.were | 76 |
| abstract_inverted_index.when | 102 |
| abstract_inverted_index.Here, | 32 |
| abstract_inverted_index.These | 64 |
| abstract_inverted_index.daily | 67 |
| abstract_inverted_index.fact, | 132 |
| abstract_inverted_index.found | 55 |
| abstract_inverted_index.idea, | 114 |
| abstract_inverted_index.seven | 51 |
| abstract_inverted_index.state | 19 |
| abstract_inverted_index.their | 99 |
| abstract_inverted_index.using | 40 |
| abstract_inverted_index.which | 160 |
| abstract_inverted_index.B-cell | 83 |
| abstract_inverted_index.Immune | 0 |
| abstract_inverted_index.T-cell | 81 |
| abstract_inverted_index.cells. | 22 |
| abstract_inverted_index.health | 8 |
| abstract_inverted_index.immune | 21, 100, 158 |
| abstract_inverted_index.remain | 30 |
| abstract_inverted_index.should | 14, 92, 150 |
| abstract_inverted_index.showed | 66 |
| abstract_inverted_index.unique | 11, 162 |
| abstract_inverted_index.within | 70 |
| abstract_inverted_index.Similar | 74 |
| abstract_inverted_index.between | 4, 61, 139 |
| abstract_inverted_index.common. | 145 |
| abstract_inverted_index.exposed | 106 |
| abstract_inverted_index.healthy | 52, 90 |
| abstract_inverted_index.present | 18 |
| abstract_inverted_index.profile | 148 |
| abstract_inverted_index.similar | 118 |
| abstract_inverted_index.systems | 26 |
| abstract_inverted_index.various | 108 |
| abstract_inverted_index.Detailed | 86 |
| abstract_inverted_index.However, | 23 |
| abstract_inverted_index.although | 141 |
| abstract_inverted_index.analysis | 119 |
| abstract_inverted_index.datasets | 48 |
| abstract_inverted_index.detected | 134 |
| abstract_inverted_index.distinct | 135 |
| abstract_inverted_index.elusive. | 31 |
| abstract_inverted_index.observed | 78 |
| abstract_inverted_index.patterns | 65 |
| abstract_inverted_index.personal | 7 |
| abstract_inverted_index.profiles | 60, 88 |
| abstract_inverted_index.receptor | 84 |
| abstract_inverted_index.resource | 154 |
| abstract_inverted_index.statuses | 91 |
| abstract_inverted_index.vaccines | 138 |
| abstract_inverted_index.variable | 157 |
| abstract_inverted_index.analysis, | 39 |
| abstract_inverted_index.conducted | 34, 116 |
| abstract_inverted_index.cytometry | 47 |
| abstract_inverted_index.determine | 16 |
| abstract_inverted_index.different | 3, 62 |
| abstract_inverted_index.diversity | 57 |
| abstract_inverted_index.essential | 94 |
| abstract_inverted_index.histories | 9 |
| abstract_inverted_index.influenza | 128 |
| abstract_inverted_index.libraries | 43 |
| abstract_inverted_index.molecular | 25 |
| abstract_inverted_index.responses | 1, 136, 143 |
| abstract_inverted_index.background | 95 |
| abstract_inverted_index.conditions | 13 |
| abstract_inverted_index.individual | 104 |
| abstract_inverted_index.responses, | 101, 159 |
| abstract_inverted_index.systematic | 36 |
| abstract_inverted_index.time-lapse | 37 |
| abstract_inverted_index.underlying | 27 |
| abstract_inverted_index.understand | 98, 156 |
| abstract_inverted_index.SARS-CoV-2. | 130 |
| abstract_inverted_index.Single-cell | 146 |
| abstract_inverted_index.conditions. | 110 |
| abstract_inverted_index.demonstrate | 112 |
| abstract_inverted_index.diversities | 75 |
| abstract_inverted_index.fundamental | 152 |
| abstract_inverted_index.immune-cell | 59, 87, 147 |
| abstract_inverted_index.individual. | 73, 165 |
| abstract_inverted_index.individuals | 5, 123 |
| abstract_inverted_index.information | 96 |
| abstract_inverted_index.intensively | 49 |
| abstract_inverted_index.single-cell | 38, 42 |
| abstract_inverted_index.substantial | 56 |
| abstract_inverted_index.vaccination | 126 |
| abstract_inverted_index.collectively | 15 |
| abstract_inverted_index.fluctuations | 68 |
| abstract_inverted_index.individuals, | 140 |
| abstract_inverted_index.individuals. | 53, 63 |
| abstract_inverted_index.repertoires. | 85 |
| abstract_inverted_index.environmental | 12, 109 |
| abstract_inverted_index.heterogeneity | 29 |
| cited_by_percentile_year.max | 98 |
| cited_by_percentile_year.min | 89 |
| corresponding_author_ids | https://openalex.org/A5019488402 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 16 |
| corresponding_institution_ids | https://openalex.org/I74801974 |
| citation_normalized_percentile.value | 0.68730051 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |